Silvana Novelli
@snovelli.bsky.social
Hematologist. #Lymphoma #immunotherapy #ITP 🏥 Institut Català d’Oncologia- Barcelona. Tap dancer 🎼
Selection of a Salvage Regimen for Relapsed or Refractory Classic Hodgkin Lymphoma in the Era of Novel Therapies - Hematology/Oncology Clinics www.hemonc.theclinics.com/article/S088...
Selection of a Salvage Regimen for Relapsed or Refractory Classic Hodgkin Lymphoma in the Era of Novel Therapies
The treatment landscape of classical Hodgkin lymphoma continues to evolve with earlier
use of novel agents. Most recently, the addition of PD-1 inhibitors into frontline
therapy has improved cure rate...
www.hemonc.theclinics.com
January 7, 2026 at 8:58 PM
Selection of a Salvage Regimen for Relapsed or Refractory Classic Hodgkin Lymphoma in the Era of Novel Therapies - Hematology/Oncology Clinics www.hemonc.theclinics.com/article/S088...
Reposted by Silvana Novelli
The @pathologists.bsky.social published a guideline for the laboratory workup of #amyloidosis in the Archives of Pathology & Laboratory Medicine.
https://bit.ly/496t2I9
https://bit.ly/496t2I9
CAP Aims to Improve Early Diagnosis of Amyloidosis With New Guideline
The College of American Pathologists published a guideline for the laboratory workup of amyloidosis.
bit.ly
January 5, 2026 at 6:13 PM
The @pathologists.bsky.social published a guideline for the laboratory workup of #amyloidosis in the Archives of Pathology & Laboratory Medicine.
https://bit.ly/496t2I9
https://bit.ly/496t2I9
Reposted by Silvana Novelli
Microbiota utilization of intestinal amino acids modulates cancer
Bacteroides asparaginase, bo-ansB, modulates host tumor responses to dietary asparagine by depleting Asn w/in TME. Reduced Asn impacts stemness of intratumoral CD8 T cells & tumor burden
www.cell.com/cell-host-mi...
Bacteroides asparaginase, bo-ansB, modulates host tumor responses to dietary asparagine by depleting Asn w/in TME. Reduced Asn impacts stemness of intratumoral CD8 T cells & tumor burden
www.cell.com/cell-host-mi...
Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity
Qiao et al. identify gut microbes and amino acid-metabolizing genes that influence
tumor burden. A Bacteroides asparaginase, bo-ansB, modulates host tumor responses
to dietary asparagine (Asn) by depl...
www.cell.com
January 6, 2026 at 4:48 PM
Microbiota utilization of intestinal amino acids modulates cancer
Bacteroides asparaginase, bo-ansB, modulates host tumor responses to dietary asparagine by depleting Asn w/in TME. Reduced Asn impacts stemness of intratumoral CD8 T cells & tumor burden
www.cell.com/cell-host-mi...
Bacteroides asparaginase, bo-ansB, modulates host tumor responses to dietary asparagine by depleting Asn w/in TME. Reduced Asn impacts stemness of intratumoral CD8 T cells & tumor burden
www.cell.com/cell-host-mi...
Reposted by Silvana Novelli
CD8+ T-cell activation, function, and metabolic reprogramming are suppressed by hypoxia, linked to decreased mTOR activity. Read in Blood Advances: buff.ly/ttZb0at #BloodAdvances #MultipleMyeloma
December 17, 2025 at 4:30 PM
CD8+ T-cell activation, function, and metabolic reprogramming are suppressed by hypoxia, linked to decreased mTOR activity. Read in Blood Advances: buff.ly/ttZb0at #BloodAdvances #MultipleMyeloma
Reposted by Silvana Novelli
Method of the Year 2025: In her feature, @vivienm.bsky.social asks scientists about their strategies and decision-making as they scale EM-based approaches for larger brains.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Method of the Year: EM connectomics - Nature Methods
Using electron microscopy, scientists mapped a Caenorhabditis elegans nervous system and Drosophila brain at single-neuron resolution. Connectomics work on bigger brains takes new methods strategies.
www.nature.com
December 8, 2025 at 10:26 PM
Method of the Year 2025: In her feature, @vivienm.bsky.social asks scientists about their strategies and decision-making as they scale EM-based approaches for larger brains.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hans IHC discrimination of Cell-of-Origin Subtype is a valid method for predicting Polatuzumab response in DLBCL aacrjournals.org/clincancerre...
Cell-of-Origin Subtype Predicts Response to Polatuzumab Vedotin in Large B-cell Lymphoma
AbstractPurpose:. Polatuzumab vedotin (polatuzumab) was approved for up-front treatment of diffuse large B-cell lymphoma in combination with chemoimmunotherapy (Pola-R-CHP) based on the POLARIX trial....
aacrjournals.org
November 30, 2025 at 4:32 PM
Hans IHC discrimination of Cell-of-Origin Subtype is a valid method for predicting Polatuzumab response in DLBCL aacrjournals.org/clincancerre...
Should we start seeking clonal hematopoiesis before B-Cell Maturation Antigen–Directed Chimeric Antigen Receptor T-cell Therapy? aacrjournals.org/clincancerre...
Clonal Hematopoiesis and Inflammation Predict Hematologic Toxicity and Secondary Myeloid Malignancies after B-Cell Maturation Antigen–Directed Chimeric Antigen Receptor T-cell Therapy
AbstractPurpose:. Chimeric antigen receptor T cells (CAR-T) have demonstrated remarkable efficacy in multiple myeloma, but prolonged hematologic toxicity remains a common adverse event, and secondary ...
aacrjournals.org
November 30, 2025 at 4:29 PM
Should we start seeking clonal hematopoiesis before B-Cell Maturation Antigen–Directed Chimeric Antigen Receptor T-cell Therapy? aacrjournals.org/clincancerre...
Reposted by Silvana Novelli
#FoodInsecurity affects #healthcare workers too.
Efforts like #HCWvsHunger can help.
hcwvshunger.org
Efforts like #HCWvsHunger can help.
hcwvshunger.org
November 30, 2025 at 1:52 AM
#FoodInsecurity affects #healthcare workers too.
Efforts like #HCWvsHunger can help.
hcwvshunger.org
Efforts like #HCWvsHunger can help.
hcwvshunger.org
Now it is imperative to include CLIPI in the routine evaluation of advanced stages Mycosis Fungoides & Sézary syndrome; especially when considering for alloSCT #ctcl
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
A new prognostic index (CLIPI) for advanced cutaneous lymphoma enables precise patient risk stratification
Key PointsThere is poor survival in advanced stage MF/SS.CLIPI stratifies patients with advanced MF/SS into risk groups for survival and has been validated
ashpublications.org
October 29, 2025 at 7:14 PM
Now it is imperative to include CLIPI in the routine evaluation of advanced stages Mycosis Fungoides & Sézary syndrome; especially when considering for alloSCT #ctcl
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
Reposted by Silvana Novelli
Reviewing this classic article @bmj.com
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
doi.org/10.1136/bmj....
I still teach it all the time
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
doi.org/10.1136/bmj....
I still teach it all the time
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
In this article by Robert Yeh and colleagues ( BMJ 2018;363:k5094, doi:10.1136/bmj.k5094), the final sentence of the Methods section should …
doi.org
October 21, 2025 at 5:45 PM
Reviewing this classic article @bmj.com
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
doi.org/10.1136/bmj....
I still teach it all the time
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
doi.org/10.1136/bmj....
I still teach it all the time
Reposted by Silvana Novelli
Our comprehensive Review on MGUS: Monoclonal Gammopathy of Undetermined Significance @NEJM
5% of people over age 50 have MGUS. Every physician needs to know and understand MGUS. Lots of Tables and Figures. www.nejm.org/doi/abs/10.1...
5% of people over age 50 have MGUS. Every physician needs to know and understand MGUS. Lots of Tables and Figures. www.nejm.org/doi/abs/10.1...
October 18, 2025 at 12:57 PM
Our comprehensive Review on MGUS: Monoclonal Gammopathy of Undetermined Significance @NEJM
5% of people over age 50 have MGUS. Every physician needs to know and understand MGUS. Lots of Tables and Figures. www.nejm.org/doi/abs/10.1...
5% of people over age 50 have MGUS. Every physician needs to know and understand MGUS. Lots of Tables and Figures. www.nejm.org/doi/abs/10.1...
Lo mejor de escuchar a otros especialistas es cuando te encuentras con inmunólogas como la Dra. Silvia Vidal y te da una clase de #XPO #selinexor en el #mieloma
#Hemato2025 @sehhematologia.bsky.social
#Hemato2025 @sehhematologia.bsky.social
October 11, 2025 at 12:46 PM
Lo mejor de escuchar a otros especialistas es cuando te encuentras con inmunólogas como la Dra. Silvia Vidal y te da una clase de #XPO #selinexor en el #mieloma
#Hemato2025 @sehhematologia.bsky.social
#Hemato2025 @sehhematologia.bsky.social
“Manejo periquirúrgico de los pacientes con coagulopatías adquiridas inmunológicas” con Eva Mingot, un enfoque práctico. @hospitaluvrocio.bsky.social @sehhematologia.bsky.social #Hemato2025
October 11, 2025 at 7:50 AM
“Manejo periquirúrgico de los pacientes con coagulopatías adquiridas inmunológicas” con Eva Mingot, un enfoque práctico. @hospitaluvrocio.bsky.social @sehhematologia.bsky.social #Hemato2025
“Perfil molecular en la leucemia linfática crónica: más allá del TP53”. @ferrannadeu.bsky.social nos revela el universo de complejidad biológica de la #LLC @idibaps.bsky.social @sehhematologia.bsky.social #Hemato2025
October 11, 2025 at 7:05 AM
“Perfil molecular en la leucemia linfática crónica: más allá del TP53”. @ferrannadeu.bsky.social nos revela el universo de complejidad biológica de la #LLC @idibaps.bsky.social @sehhematologia.bsky.social #Hemato2025
Rafael de la Cámara nos revela la inmensa cantidad de fármacos antivirales en ensayo para mejorar el cuidado de nuestros pacientes. @sehhematologia.bsky.social #Hemato2025
October 11, 2025 at 6:55 AM
Rafael de la Cámara nos revela la inmensa cantidad de fármacos antivirales en ensayo para mejorar el cuidado de nuestros pacientes. @sehhematologia.bsky.social #Hemato2025
CART de la Mano de Dr. Olalekan O. Oluwole - #Kite #hemato2025 @sehhematologia.bsky.social
October 9, 2025 at 12:39 PM
CART de la Mano de Dr. Olalekan O. Oluwole - #Kite #hemato2025 @sehhematologia.bsky.social
Secuenciación de tercera generación en el diagnóstico hematológico. Dr. Javier Corral de la Calle repasando la evolución de la NGS. #hemato2025 @sehhematologia.bsky.social
October 9, 2025 at 8:38 AM
Secuenciación de tercera generación en el diagnóstico hematológico. Dr. Javier Corral de la Calle repasando la evolución de la NGS. #hemato2025 @sehhematologia.bsky.social
Platelet transcriptomic-powered scientific discovery in Thrombosis and Hemostasis Dr. Matthew T. Rondina
Huntsman Cancer Institute & University of Utah Health,
Salt Lake City, Utah (USA). #sepsis #inflamación #hemato2025 ❤️
Huntsman Cancer Institute & University of Utah Health,
Salt Lake City, Utah (USA). #sepsis #inflamación #hemato2025 ❤️
October 9, 2025 at 7:51 AM
Platelet transcriptomic-powered scientific discovery in Thrombosis and Hemostasis Dr. Matthew T. Rondina
Huntsman Cancer Institute & University of Utah Health,
Salt Lake City, Utah (USA). #sepsis #inflamación #hemato2025 ❤️
Huntsman Cancer Institute & University of Utah Health,
Salt Lake City, Utah (USA). #sepsis #inflamación #hemato2025 ❤️
“Selection of best donor in allogeneic stem cell transplantation: beyond HLA typing” por la Dra. Effie Wang Petersdorf #hemato2025 #educacional @sehhematologia.bsky.social
October 9, 2025 at 6:45 AM
“Selection of best donor in allogeneic stem cell transplantation: beyond HLA typing” por la Dra. Effie Wang Petersdorf #hemato2025 #educacional @sehhematologia.bsky.social
Es un lujo poder escuchar al Dr. Orfao hablando de la EMR en ls distintas neoplasias hematológicas #Hemato2025 @sehhematologia.bsky.social
October 9, 2025 at 6:27 AM
Es un lujo poder escuchar al Dr. Orfao hablando de la EMR en ls distintas neoplasias hematológicas #Hemato2025 @sehhematologia.bsky.social
Administration of SUMOylation inhibitor could eradicate #Burkitt’s #lymphoma treated with CD19 CAR-T.
rdcu.be/eJu9C
rdcu.be/eJu9C
Limited SUMOylation inhibitor administration enhances eradication of Burkitt’s lymphoma with CD19 CAR-T therapy
Signal Transduction and Targeted Therapy - Limited SUMOylation inhibitor administration enhances eradication of Burkitt’s lymphoma with CD19 CAR-T therapy
rdcu.be
October 4, 2025 at 9:03 PM
Administration of SUMOylation inhibitor could eradicate #Burkitt’s #lymphoma treated with CD19 CAR-T.
rdcu.be/eJu9C
rdcu.be/eJu9C
What a beautiful work from our colleagues from Navarra! @unav.edu #CUN
Increasing glutamine uptake may enhance anti-tumor BCMA-CAR T-cell functionality #MM
ashpublications.org/blood/articl...
Increasing glutamine uptake may enhance anti-tumor BCMA-CAR T-cell functionality #MM
ashpublications.org/blood/articl...
Reprogramming glutamine metabolism enhances BCMA-CART cell fitness and therapeutic efficacy in multiple myeloma
Key Points. Glutamine deprivation in the tumor microenvironment might limit CAR T-cell therapeutic efficacy in cancer patients.ASCT2 overexpression improve
ashpublications.org
September 21, 2025 at 8:23 PM
What a beautiful work from our colleagues from Navarra! @unav.edu #CUN
Increasing glutamine uptake may enhance anti-tumor BCMA-CAR T-cell functionality #MM
ashpublications.org/blood/articl...
Increasing glutamine uptake may enhance anti-tumor BCMA-CAR T-cell functionality #MM
ashpublications.org/blood/articl...
Improved PFS with Moga-Chop for elderly ATL patients. I wonder how the Moga
-Pembro would work in the same scenario 🧐
ashpublications.org/blood/articl...
-Pembro would work in the same scenario 🧐
ashpublications.org/blood/articl...
A phase 2 trial of CHOP with anti-CCR4 antibody mogamulizumab for older patients with adult T-cell leukemia/lymphoma
Key PointsMoga-CHOP significantly improved 1-year PFS in older patients with aggressive ATL.CCR4 mutations and Moga-associated cAEs were related to better
ashpublications.org
September 21, 2025 at 8:10 PM
Improved PFS with Moga-Chop for elderly ATL patients. I wonder how the Moga
-Pembro would work in the same scenario 🧐
ashpublications.org/blood/articl...
-Pembro would work in the same scenario 🧐
ashpublications.org/blood/articl...
Reposted by Silvana Novelli
🧠 Neurotoxicity in Cancer Therapy
New review (Nat Rev Clin Oncol)
✅ Pathophysiology of chemo-, RT- & IO-induced neurotoxicity
✅ Clinical recognition & biomarkers
✅ Prevention & management strategies
🔍 Key messages – Cavaletti, Cámara, DeAngelis et al. Nat Rev Clin Oncol 2025
New review (Nat Rev Clin Oncol)
✅ Pathophysiology of chemo-, RT- & IO-induced neurotoxicity
✅ Clinical recognition & biomarkers
✅ Prevention & management strategies
🔍 Key messages – Cavaletti, Cámara, DeAngelis et al. Nat Rev Clin Oncol 2025
September 15, 2025 at 2:36 PM
🧠 Neurotoxicity in Cancer Therapy
New review (Nat Rev Clin Oncol)
✅ Pathophysiology of chemo-, RT- & IO-induced neurotoxicity
✅ Clinical recognition & biomarkers
✅ Prevention & management strategies
🔍 Key messages – Cavaletti, Cámara, DeAngelis et al. Nat Rev Clin Oncol 2025
New review (Nat Rev Clin Oncol)
✅ Pathophysiology of chemo-, RT- & IO-induced neurotoxicity
✅ Clinical recognition & biomarkers
✅ Prevention & management strategies
🔍 Key messages – Cavaletti, Cámara, DeAngelis et al. Nat Rev Clin Oncol 2025