Alexander Arguello
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alexander-arguello.bsky.social
Alexander Arguello
@alexander-arguello.bsky.social
620 followers 220 following 36 posts
Into brains and genomes | Pragmatist and Pluralist | Thinking about what it means to do good science and be a good scientist

LA | DC | NY
Posts Replies Media Videos
Reposted by Alexander Arguello
mariahhoye.bsky.social
New #NIH prize competition to identify areas of biomedical science that can benefit from replication and to recognize past replication efforts to further promote the importance of research replication:

www.challenge.gov?challenge=re...

Submission deadline is in one month!
Challenge.gov
Challenge.gov is the official government website supporting prize challenges and prize competitions that are sponsored by the US federal government. Here federal agencies provide prize awards to publi...
www.challenge.gov
November 19, 2025 at 9:24 PM
Reposted by Alexander Arguello
mollyprz.bsky.social
SAVE THE DATE: the yearly NY Population Genetics meeting will be back on March 9 2026, generously hosted by the
@simonsfoundation.org. Details to follow. Please RT.
November 14, 2025 at 5:05 PM
alexander-arguello.bsky.social
JOB POSTING: Director, National Human Genome Research Institute hr.nih.gov/careers/open...
hr.nih.gov
November 7, 2025 at 3:57 PM
Reposted by Alexander Arguello
gcbias.bsky.social
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
October 15, 2025 at 3:53 PM
Reposted by Alexander Arguello
hakha.bsky.social
I’ll be attending #ASHG25! I’m currently hiring for (i) a Senior Research Scientist or (ii) a Postdoc position in my lab. If you’re interested, please reach out to arrange a time to meet and discuss.
October 13, 2025 at 11:19 PM
alexander-arguello.bsky.social
www.theblaze.com/shows/the-gl...
The reason the medical community is so divided on this issue is because "there's a big fight in the literature over how strong that association is." But Dr. Bhattacharya's personal opinion after looking at the available evidence is that "there's enough there to tell people, especially pregnant women, to be careful with it." And that is precisely what President Trump's announcement was: a warning for pregnant women to be cautious about taking Tylenol.
September 27, 2025 at 3:22 PM
Reposted by Alexander Arguello
stephenturner.us
My colleague @hernmoral.bsky.social is teaching what looks like a wonderful course online this November - Museomics: An Introduction to Genomic Analyses of Natural History Collections. Register: www.physalia-courses.org/courses-work... #consgen
Museomics: An Introduction to Genomic Analyses of Natural History Collections
3-7 November To foster international participation, this course will be held online
www.physalia-courses.org
September 25, 2025 at 4:19 PM
alexander-arguello.bsky.social
“mRNA vaccines seem to work—I think they’ve been great! I am amazed at how much public policy seems to ignore how great these vaccines are (of course, there are great vaccines that aren’t mRNA-based, too).” febs.onlinelibrary.wiley.com/doi/10.1111/...
September 24, 2025 at 7:38 PM
Reposted by Alexander Arguello
aphillippy.bsky.social
Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]
A complete diploid human genome benchmark for personalized genomics
Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...
www.biorxiv.org
September 22, 2025 at 5:01 PM
Reposted by Alexander Arguello
trstngnthr.bsky.social
I have funding for a 2-year dry-lab postdoc to join our team @humanevouu.bsky.social 🧪 (Deadline Oct 21st)

The project will utilize modern and #aDNA data from humans and sheep to study environmental adaptation (including method development and simulations).

Please share!
www.uu.se/en/about-uu/...
Postdoctoral position in Population Genomics - Uppsala University
Postdoctoral position in Population Genomics, Department of Organismal Biology, Uppsala University
www.uu.se
September 17, 2025 at 9:15 AM
alexander-arguello.bsky.social
Best of luck to the brave soul who would like to be the next Director of the National Institute of Mental Health hr.nih.gov/jobs/search/...
hr.nih.gov
September 5, 2025 at 4:55 PM
alexander-arguello.bsky.social
Yes, science works. Can science work better? Also yes.
drugmonkey.bsky.social Drug Monkey @drugmonkey.bsky.social · Aug 8
Right? Science works.
August 9, 2025 at 1:36 AM
alexander-arguello.bsky.social
I have seen the future of science. It is ruled by bitter competition instead of collaboration, pageantry instead of exploration. Bright minds beginning careers in science will be taught to debase their training for drudgerous pursuit of meaningless metrics. Those willing to toil over genuine questions will necessarily lose out to those that can furnish cheap answers.
August 5, 2025 at 4:15 PM
Reposted by Alexander Arguello
rmcelreath.bsky.social
How can we reform science? I have some ideas. But I am not sure you’ll like them, because they don’t promise much. elevanth.org/blog/2025/07...
Which Kind of Science Reform
What hope is there for science reform, if we can't agree on what to reform? Right now, principles are more important than practices.
elevanth.org
July 9, 2025 at 1:40 PM
alexander-arguello.bsky.social
In science there are fears that some research areas or questions will be misinterpreted, exploited, and weaponized by bad actors. One solution offered is to avoid these topics altogether lest we add fuel to ideological fire.
July 11, 2025 at 4:09 PM
alexander-arguello.bsky.social
Last week the National Advisory Council for Human Genome Research met and approved a new initiative: ancient DNA for Modern Genomics (aDMG).

You can watch the presentation and discussion here at the 1:54:00 mark. videocast.nih.gov/watch=56826
Photo of the skeletal remains of a man buried about 8000 years ago in Turkey (Photo credit: JACOB ROODENBERG)
June 23, 2025 at 9:27 PM
Reposted by Alexander Arguello
joles.bsky.social
applying for jobs again
screenshot from an online job application form. the question reads "Can you describe specific ways you have integrated AI tools into your development workflow? Please include any custom setups, automations, or use cases beyond single prompt usage" (a red asterisk indicates that this is a required question). an answer has been typed in the textbox below the question: "there is a monster in the forest and it speaks with a thousand voices. it will answer any question you pose it, it will offer insight to any idea. it will help you, it will thank you, it will never bid you leave. it will even tell you of the darkest arts, if you know precisely how to ask. it feels no joy and no sorrow, it knows no right and no wrong. it knows not truth from lie, though it speaks them all the same. it offers its services freely to any passerby, and many will tell you they find great value in its conversation. “you simply must visit the monster—i always just ask the monster.” there are those who know these forests well; they will tell you that freely offered doesn’t mean it has no price for when the next traveler passes by, the monster speaks with a thousand and one voices. and when you dream you see the monster; the monster wears your face."
May 5, 2025 at 2:03 PM
Reposted by Alexander Arguello
jkpritch.bsky.social
I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.

Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.
June 1, 2025 at 3:33 PM
Reposted by Alexander Arguello
andganna.bsky.social
We have 2-3 group leader positions opening @fimm-uh.bsky.social !!

We are looking for outstanding candidates in human genetics and precision medicine.

This time we have a focus on population health data science. E.g. AI for EHR/health data       

Generous starting package 💰

shorturl.at/FAk6n
FIMM-EMBL Group Leaders in Molecular Medicine
FIMM-EMBL Group Leaders in Molecular Medicine
jobs.helsinki.fi
June 1, 2025 at 3:38 PM
Reposted by Alexander Arguello
mariahhoye.bsky.social
📢 Calling all early-career scientists who have promoted enhanced research rigor:

The deadline for the NINDS Early-Career Rigor Champions prize has been extended to 6/6/25!

Describe your efforts in six short prompts for your chance to win a CASH prize of up to $10k!

Up to 11 awards will be made!
A graphic detailing the NINDS Early-Career Rigor Champions Prize on a turquoise and blue background. In the top left is the NINDS logo. Below it is a bullhorn with the text, “Deadline Extended! June 6th, 2025”. To the right is the text, “Early-Career Rigor Champions Prize”. Below is a white box with yellow arrows on the left side and a fallout saying, “WE WANT YOU”. To the right is the text: “-For individuals and small teams of early-career rigor champions enhancing attention to rigor, -Provide responses to six prompts describing your efforts, -Up to two $10,000, three $5,000, and six $2,500 cash awards!” Learn more: Details and how to enter: https://www.challenge.gov/?challenge=ninds-early-career-rigor-champions-prize Informational video: https://www.youtube.com/watch?v=UyszRbPyfHY” In the bottom right is an image of Rodin’s “The Thinker” sculpture.
May 5, 2025 at 1:52 PM
Reposted by Alexander Arguello
humanpangenome.bsky.social
📢 HPRC Release 2 is here!

Now with phased genomes from 200+ individuals, a 5x increase from Release 1.

Explore sequencing data, assemblies, annotations & alignments in our interactive data explorer ⬇️:

humanpangenome.org/hprc-data-re...
May 12, 2025 at 1:15 PM
Reposted by Alexander Arguello
alextisyoung.bsky.social
I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!
April 28, 2025 at 4:18 PM
alexander-arguello.bsky.social
21st century technology.
18th century taxonomy.
April 8, 2025 at 3:28 PM
alexander-arguello.bsky.social
Reading “The usefulness of useless knowledge” by Abraham Flexner, founding director of the Institute for Advanced Study. Writing in 1939, this passage stood out:
The subject which I am discussing has at this moment a peculiar poignancy. In certain large areas-Germany and Italy especially-the effort is now being made to clamp down the freedom of the human spirit. Universities have been so reorganized that they have become tools of those who believe in a special political, economic, or racial creed. Now and then a thoughtless individual in one of the few democracies left in this world will even question the fundamental importance of absolutely untrammeled academic freedom. The real enemy of the human race is not the fearless and irresponsible thinker, be he right or wrong. The real enemy is the man who tries to mold the human spirit so that it will not dare to spread its wings, as its wings were once spread in Italy and Germany, as well as in Great Britain and the United States.
March 24, 2025 at 9:22 PM
alexander-arguello.bsky.social
this looks like a great meeting on complex trait genetics. looking forward to hearing about it from those who attend. www.grc.org/quantitative...
2025 Quantitative Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 24, 2025 at 6:29 PM