Alessandro 🌈
@alessandro-1.bsky.social
Perpetual learner. Physicist exploring the biology world of glucagon and pancreatic islets. Plant daddy and happy gardener. Wildly curious, I would love to learn everything I can. Migrating is not for the faint of heart.
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Reposted by Alessandro 🌈
Redesign of Calmodulin for Genetically Encoded Zn2+ Sensing with High Dynamic Range
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Redesign of Calmodulin for Genetically Encoded Zn2+ Sensing with High Dynamic Range
The development of genetically encoded Zn2+ probes (GEZPs) has been hindered by the limited signal transduction efficiency of natural zinc-binding domains, but the encoded Ca2+ indicators utilize the ...
pubs.acs.org
November 25, 2025 at 8:35 AM
Redesign of Calmodulin for Genetically Encoded Zn2+ Sensing with High Dynamic Range
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Reposted by Alessandro 🌈
Reposted by Alessandro 🌈
“I had hemophilia for nearly five decades. I went to Philadelphia and had a 45-minute infusion, and my hemophilia was gone.”
Genes-> Medicine
nature.com/articles/s41...
Genes-> Medicine
nature.com/articles/s41...
November 21, 2025 at 9:45 PM
“I had hemophilia for nearly five decades. I went to Philadelphia and had a 45-minute infusion, and my hemophilia was gone.”
Genes-> Medicine
nature.com/articles/s41...
Genes-> Medicine
nature.com/articles/s41...
Reposted by Alessandro 🌈
In a new phase 3 trial, people randomly assigned to receive a flu shot made with modified mRNA were 34.5% less likely to be diagnosed with an influenza-like illness than people given a standard flu shot made with inactivated virus.
We need to stop the anti-science attacks against mRNA vaccines!
We need to stop the anti-science attacks against mRNA vaccines!
November 20, 2025 at 1:03 AM
In a new phase 3 trial, people randomly assigned to receive a flu shot made with modified mRNA were 34.5% less likely to be diagnosed with an influenza-like illness than people given a standard flu shot made with inactivated virus.
We need to stop the anti-science attacks against mRNA vaccines!
We need to stop the anti-science attacks against mRNA vaccines!
Reposted by Alessandro 🌈
🌹🔬🤩
Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡
StayRose: A photostable StayGold derivative redshifted by genetic code expansion
Photobleaching of fluorescent proteins often limits the acquisition of high-quality
images in microscopy. StayGold, a novel dimeric GFP recently monomerized through sequence
engineering, addresses thi...
www.jbc.org
November 17, 2025 at 9:37 AM
🌹🔬🤩
Reposted by Alessandro 🌈
Thanks for sharing @piatkevich.bsky.social! 💡 These red calcium indicators and more are featured in our Fluorescent Protein Biosensors Collection: www.addgene.org/fluorescent-...
Our red calcium indicator, FRCaMPi, and its soma-localized version, SomaFRCaMPi, are now available from @addgene.bsky.social in various vectors, along with all the sensors used for benchmarking. www.addgene.org/browse/artic...
November 12, 2025 at 10:56 AM
Thanks for sharing @piatkevich.bsky.social! 💡 These red calcium indicators and more are featured in our Fluorescent Protein Biosensors Collection: www.addgene.org/fluorescent-...
Reposted by Alessandro 🌈
No clear evidence to support any link between maternal acetaminophen (Tylenol) intake and autism or ADHD in offspring, a new umbrella, systematic review
@bmj.com
@bmj.com
November 10, 2025 at 12:19 AM
No clear evidence to support any link between maternal acetaminophen (Tylenol) intake and autism or ADHD in offspring, a new umbrella, systematic review
@bmj.com
@bmj.com
Reposted by Alessandro 🌈
The new Ground Truths today is based on an important paper just published @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries - Nature Aging
In cross-sectional and longitudinal analyses of 86,149 participants across 27 European countries, Amoruso, Hernandez and colleagues identify multilingualism as a protective factor against accelerated ...
www.nature.com
November 10, 2025 at 5:15 PM
The new Ground Truths today is based on an important paper just published @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Alessandro 🌈
not using ian's secure shoelace knot is a sign of a weak moral character, poor constitution, and an unserious attitude towards quality workmanship
October 20, 2025 at 5:58 PM
not using ian's secure shoelace knot is a sign of a weak moral character, poor constitution, and an unserious attitude towards quality workmanship
Reposted by Alessandro 🌈
sorry but it's really funny that the same type of centrist pundit freaks who are like "mamdani won't make good on his campaign promises so DON'T vote for him!" were the same ones who said "trump won't make good on his campaign promises so it's fine if he wins"
November 4, 2025 at 11:49 PM
sorry but it's really funny that the same type of centrist pundit freaks who are like "mamdani won't make good on his campaign promises so DON'T vote for him!" were the same ones who said "trump won't make good on his campaign promises so it's fine if he wins"
Reposted by Alessandro 🌈
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
October 15, 2025 at 4:17 PM
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
Reposted by Alessandro 🌈
The importance of basic research
“no one wants to see taxpayers’ monies being misspent. But world-changing discoveries often occur unexpectedly and are built on years…decades — of fundamental research that expanded our knowledge of the world”
🧪 #Research #Scicomm
www.nature.com/articles/d41...
“no one wants to see taxpayers’ monies being misspent. But world-changing discoveries often occur unexpectedly and are built on years…decades — of fundamental research that expanded our knowledge of the world”
🧪 #Research #Scicomm
www.nature.com/articles/d41...
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
www.nature.com
October 31, 2025 at 2:33 AM
The importance of basic research
“no one wants to see taxpayers’ monies being misspent. But world-changing discoveries often occur unexpectedly and are built on years…decades — of fundamental research that expanded our knowledge of the world”
🧪 #Research #Scicomm
www.nature.com/articles/d41...
“no one wants to see taxpayers’ monies being misspent. But world-changing discoveries often occur unexpectedly and are built on years…decades — of fundamental research that expanded our knowledge of the world”
🧪 #Research #Scicomm
www.nature.com/articles/d41...
Reposted by Alessandro 🌈
🧠✨ Genetic Tools Atlas 3.0 is here!
The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets.
🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas
#neuroskyence
The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets.
🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas
#neuroskyence
October 28, 2025 at 9:52 PM
🧠✨ Genetic Tools Atlas 3.0 is here!
The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets.
🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas
#neuroskyence
The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets.
🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas
#neuroskyence
Reposted by Alessandro 🌈
Live cell ACTIN imaging has never been easier with SPY650-FastAct_X!
1. Add the probe to the cells
2. Image 1h later
SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell.
image credits: @stephanlab.bsky.social
1. Add the probe to the cells
2. Image 1h later
SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell.
image credits: @stephanlab.bsky.social
October 29, 2025 at 9:30 AM
Live cell ACTIN imaging has never been easier with SPY650-FastAct_X!
1. Add the probe to the cells
2. Image 1h later
SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell.
image credits: @stephanlab.bsky.social
1. Add the probe to the cells
2. Image 1h later
SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell.
image credits: @stephanlab.bsky.social
Reposted by Alessandro 🌈
Spectacular time-lapse image of Comet Lemmon (C/2025 A6), taken by astrophotographer Michael Jäger.
There might have been, um, a few satellites passing by during the long exposure. 🧪🔭
forum.vdsastro.de/viewtopic.ph...
There might have been, um, a few satellites passing by during the long exposure. 🧪🔭
forum.vdsastro.de/viewtopic.ph...
October 28, 2025 at 7:31 PM
Spectacular time-lapse image of Comet Lemmon (C/2025 A6), taken by astrophotographer Michael Jäger.
There might have been, um, a few satellites passing by during the long exposure. 🧪🔭
forum.vdsastro.de/viewtopic.ph...
There might have been, um, a few satellites passing by during the long exposure. 🧪🔭
forum.vdsastro.de/viewtopic.ph...
Reposted by Alessandro 🌈
Reposted by Alessandro 🌈
Physics teachers! This E and B field game is fantastic. By Mr Gravell:
#iTeachPhysics
#Science 🧪
scratch.mit.edu/projects/183...
#iTeachPhysics
#Science 🧪
scratch.mit.edu/projects/183...
Your browser has Javascript disabled. Please go to your browser preferences and enable Javascript in order to use Scratch.
scratch.mit.edu
October 25, 2025 at 5:22 PM
Physics teachers! This E and B field game is fantastic. By Mr Gravell:
#iTeachPhysics
#Science 🧪
scratch.mit.edu/projects/183...
#iTeachPhysics
#Science 🧪
scratch.mit.edu/projects/183...
Reposted by Alessandro 🌈
So the US military is privately funded now? Trump’s friend is gonna pay the military. Who do you think the military will be loyal to then? This is insane.
New: The Pentagon confirms to CNN it will funnel $130M from an anonymous Trump “friend” toward military pay.
Asked about the donor’s identity and any foreign or domestic entanglements, the WH referred questions to DoD. DoD then referred questions back to the WH
www.cnn.com/2025/10/24/p...
Asked about the donor’s identity and any foreign or domestic entanglements, the WH referred questions to DoD. DoD then referred questions back to the WH
www.cnn.com/2025/10/24/p...
Pentagon to use $130 million donation from anonymous Trump ‘friend’ to pay military members | CNN Politics
The Trump administration plans to funnel a $130 million donation from an anonymous ally of President Donald Trump toward paying military service members during the government shutdown, the Defense Dep...
www.cnn.com
October 24, 2025 at 8:24 PM
So the US military is privately funded now? Trump’s friend is gonna pay the military. Who do you think the military will be loyal to then? This is insane.
Reposted by Alessandro 🌈
Not clickbait 🖱️ build and explore proteins and other biological components faster than ever! Professor Mark Howarth defines Click Biology — standards for building biological tools that’s analogous to Click Chemistry — in our latest blog post! @HowarthSci
blog.addgene.org
Click Biology: How to Click and Play to Explore Biology
twp.ai
October 22, 2025 at 8:00 PM
Not clickbait 🖱️ build and explore proteins and other biological components faster than ever! Professor Mark Howarth defines Click Biology — standards for building biological tools that’s analogous to Click Chemistry — in our latest blog post! @HowarthSci
Reposted by Alessandro 🌈
First proof of synthetic DNA-encoded antibodies vs SARS-CoV-2 with expression lasting at least 72 weeks from 1-dose, scalable vs other pathogens www.nature.com/articles/s41...
October 21, 2025 at 7:16 PM
First proof of synthetic DNA-encoded antibodies vs SARS-CoV-2 with expression lasting at least 72 weeks from 1-dose, scalable vs other pathogens www.nature.com/articles/s41...
Reposted by Alessandro 🌈
NOW WOULD BE A GOOD TIME TO TAKE DOWN FAT SATAN AND HIS MINIONS‼️
NOBODY IS GOING TO COME AND SAVE US, WE HAVE TO SAVE OURSELVES‼️‼️‼️
THE ONLY WAY TO STOP THEM IS TO SHUTDOWN COMPLETELY‼️
BY SIGNING UP HERE👇🏻👇🏻👇🏻
generalstrikeus.com
NOBODY IS GOING TO COME AND SAVE US, WE HAVE TO SAVE OURSELVES‼️‼️‼️
THE ONLY WAY TO STOP THEM IS TO SHUTDOWN COMPLETELY‼️
BY SIGNING UP HERE👇🏻👇🏻👇🏻
generalstrikeus.com
October 20, 2025 at 4:09 PM
NOW WOULD BE A GOOD TIME TO TAKE DOWN FAT SATAN AND HIS MINIONS‼️
NOBODY IS GOING TO COME AND SAVE US, WE HAVE TO SAVE OURSELVES‼️‼️‼️
THE ONLY WAY TO STOP THEM IS TO SHUTDOWN COMPLETELY‼️
BY SIGNING UP HERE👇🏻👇🏻👇🏻
generalstrikeus.com
NOBODY IS GOING TO COME AND SAVE US, WE HAVE TO SAVE OURSELVES‼️‼️‼️
THE ONLY WAY TO STOP THEM IS TO SHUTDOWN COMPLETELY‼️
BY SIGNING UP HERE👇🏻👇🏻👇🏻
generalstrikeus.com
Reposted by Alessandro 🌈
States have to step up because the rethuglicans won’t help.
October 17, 2025 at 12:56 AM
States have to step up because the rethuglicans won’t help.
Reposted by Alessandro 🌈
Are you studying synapses in electron microscopy? Tired of annotating vesicles? We have the tool for you! SynapseNet implements automatic segmentation and analysis of vesicles and other synaptic structures and has now been published:
www.molbiolcell.org/doi/full/10....
www.molbiolcell.org/doi/full/10....
October 17, 2025 at 11:09 AM
Are you studying synapses in electron microscopy? Tired of annotating vesicles? We have the tool for you! SynapseNet implements automatic segmentation and analysis of vesicles and other synaptic structures and has now been published:
www.molbiolcell.org/doi/full/10....
www.molbiolcell.org/doi/full/10....
Reposted by Alessandro 🌈
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Alessandro 🌈
Periodic reminder that the fluorescent compound in mammalian cell culture media, such as DMEM, is riboflavin (not phenol red)
October 14, 2025 at 7:51 PM
Periodic reminder that the fluorescent compound in mammalian cell culture media, such as DMEM, is riboflavin (not phenol red)