Alan Bince Jacob
@alanbince.bsky.social
Doctoral Candidate - Dept. of Neuropsychology & Psychopharmacology, Maastricht University | Neuroscience in Human Movement | Research: Cognitive Control, Predictive Coding, Posture/Gait | Personal views only
Pinned
Alan Bince Jacob
@alanbince.bsky.social
· Mar 27
Today, I got to do an elevator pitch about my research with @tjeerdwboonstra.bsky.social at our departmental research day. I presented a sneak peek of my preliminary behavioral results as a good buildup to #ispgr2025 in June 💪. Anticipation levels are high !
Reposted by Alan Bince Jacob
*13th MindBrainBody Symposium*
📆 Mar 9-11, 2026
🏠 #Berlin & virtual
(deadline: Jan 8, 2026)
Keynotes:
- @ulrikebingel.bsky.social
- Karl Friston (online)
- @tinalonsdorf.bsky.social
- Sonja Kotz
- Julian Thayer
...& so much more: prizes, posters, talks, food, drinks, encounters.
Let's meet!
📆 Mar 9-11, 2026
🏠 #Berlin & virtual
(deadline: Jan 8, 2026)
Keynotes:
- @ulrikebingel.bsky.social
- Karl Friston (online)
- @tinalonsdorf.bsky.social
- Sonja Kotz
- Julian Thayer
...& so much more: prizes, posters, talks, food, drinks, encounters.
Let's meet!
December 1, 2025 at 7:28 AM
*13th MindBrainBody Symposium*
📆 Mar 9-11, 2026
🏠 #Berlin & virtual
(deadline: Jan 8, 2026)
Keynotes:
- @ulrikebingel.bsky.social
- Karl Friston (online)
- @tinalonsdorf.bsky.social
- Sonja Kotz
- Julian Thayer
...& so much more: prizes, posters, talks, food, drinks, encounters.
Let's meet!
📆 Mar 9-11, 2026
🏠 #Berlin & virtual
(deadline: Jan 8, 2026)
Keynotes:
- @ulrikebingel.bsky.social
- Karl Friston (online)
- @tinalonsdorf.bsky.social
- Sonja Kotz
- Julian Thayer
...& so much more: prizes, posters, talks, food, drinks, encounters.
Let's meet!
Reposted by Alan Bince Jacob
Insular neural interfaces
Cognitive error signals in the anterior insula propagate toward prefrontal cortex when a BCI fails to follow the user’s intention. Real-time integration enables a self-correcting neural interface that compensates for its own decoder misclassifications
#neuroskyence
Cognitive error signals in the anterior insula propagate toward prefrontal cortex when a BCI fails to follow the user’s intention. Real-time integration enables a self-correcting neural interface that compensates for its own decoder misclassifications
#neuroskyence
Insular error network enables self-correcting intracranial brain-computer interface
Error recognition is fundamental to adaptive behavior, enabling rapid compensatory action when outcomes deviate from expectations. Central to this function are neural circuits for performance monitori...
www.biorxiv.org
November 27, 2025 at 9:40 AM
Insular neural interfaces
Cognitive error signals in the anterior insula propagate toward prefrontal cortex when a BCI fails to follow the user’s intention. Real-time integration enables a self-correcting neural interface that compensates for its own decoder misclassifications
#neuroskyence
Cognitive error signals in the anterior insula propagate toward prefrontal cortex when a BCI fails to follow the user’s intention. Real-time integration enables a self-correcting neural interface that compensates for its own decoder misclassifications
#neuroskyence
Reposted by Alan Bince Jacob
Reposted by Alan Bince Jacob
New preprint:
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
November 9, 2025 at 9:33 PM
New preprint:
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Reposted by Alan Bince Jacob
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Sensory expectations shape neural population dynamics in motor circuits
Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...
www.nature.com
October 29, 2025 at 4:11 PM
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Reposted by Alan Bince Jacob
Here at #Indian academy of #neuroscience meeting in the beautiful city of Kovalam in Kerala share.google/EzLqUeTwCeDw... ♥️
@sbaulac.bsky.social is giving the opening talk on brain mosaicism in epilepsy and cortical malformations #epilepsy.
@sbaulac.bsky.social is giving the opening talk on brain mosaicism in epilepsy and cortical malformations #epilepsy.
share.google
share.google
October 29, 2025 at 8:41 AM
Here at #Indian academy of #neuroscience meeting in the beautiful city of Kovalam in Kerala share.google/EzLqUeTwCeDw... ♥️
@sbaulac.bsky.social is giving the opening talk on brain mosaicism in epilepsy and cortical malformations #epilepsy.
@sbaulac.bsky.social is giving the opening talk on brain mosaicism in epilepsy and cortical malformations #epilepsy.
Reposted by Alan Bince Jacob
The Farage Factor.
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Racist incidents against UK nurses surge by 55%
Royal College of Nursing calls on government to stop using anti-migrant rhetoric, which it says emboldens racist behaviour
www.theguardian.com
October 27, 2025 at 8:56 AM
The Farage Factor.
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Reposted by Alan Bince Jacob
We were honoured to award Prof Bradford McFadyen @bjmcfadyen.bsky.social ISPGR's Honorary Membership at our 2025 World Congress. Prof McFadyen reflects on this award - and what it takes to make a meaningful career in posture and gait research - in our latest #ISPGRBlog.
tinyurl.com/5n7ces5h
tinyurl.com/5n7ces5h
A Lifetime Member's reflections on making a meaningful career in posture and gait research - ISPGR
tinyurl.com
October 28, 2025 at 8:27 AM
We were honoured to award Prof Bradford McFadyen @bjmcfadyen.bsky.social ISPGR's Honorary Membership at our 2025 World Congress. Prof McFadyen reflects on this award - and what it takes to make a meaningful career in posture and gait research - in our latest #ISPGRBlog.
tinyurl.com/5n7ces5h
tinyurl.com/5n7ces5h
Reposted by Alan Bince Jacob
Revised-TLDR:
Using the hidden multivariate pattern method we show how we capture 5 (!) recurrent EEG topographies in participants' decisions.
We show how these events parse the single-trial reaction time into:
- sensory processes
- attention orientation
- evidence accumulation
- motor execution
Using the hidden multivariate pattern method we show how we capture 5 (!) recurrent EEG topographies in participants' decisions.
We show how these events parse the single-trial reaction time into:
- sensory processes
- attention orientation
- evidence accumulation
- motor execution
October 27, 2025 at 10:09 AM
Revised-TLDR:
Using the hidden multivariate pattern method we show how we capture 5 (!) recurrent EEG topographies in participants' decisions.
We show how these events parse the single-trial reaction time into:
- sensory processes
- attention orientation
- evidence accumulation
- motor execution
Using the hidden multivariate pattern method we show how we capture 5 (!) recurrent EEG topographies in participants' decisions.
We show how these events parse the single-trial reaction time into:
- sensory processes
- attention orientation
- evidence accumulation
- motor execution
Reposted by Alan Bince Jacob
April and I finished The Pitt last night, and man...what an amazing show. I can't speak to the medical accuracy, which I've heard is good, but I can speak to the depictions of PTSD/anxiety. I also want to give a shout out to a scene in the final episode between Noah Wyle and Shawn Hatosy that
October 13, 2025 at 3:12 PM
April and I finished The Pitt last night, and man...what an amazing show. I can't speak to the medical accuracy, which I've heard is good, but I can speak to the depictions of PTSD/anxiety. I also want to give a shout out to a scene in the final episode between Noah Wyle and Shawn Hatosy that
Reposted by Alan Bince Jacob
Started watching The Pitt finally. Hot damn, it’s great. I miss this kind of episodic TV.
October 24, 2025 at 7:54 AM
Started watching The Pitt finally. Hot damn, it’s great. I miss this kind of episodic TV.
Reposted by Alan Bince Jacob
Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics
Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...
pubs.acs.org
October 24, 2025 at 12:17 PM
Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Reposted by Alan Bince Jacob
@dotproduct.bsky.social's first first author paper is finally out in @sfnjournals.bsky.social! Her findings show that content-specific predictions fluctuate with alpha frequencies, suggesting a more specific role for alpha oscillations than we may have thought. With @jhaarsma.bsky.social. 🧠🟦 🧠🤖
Contents of visual predictions oscillate at alpha frequencies
Predictions of future events have a major impact on how we process sensory signals. However, it remains unclear how the brain keeps predictions online in anticipation of future inputs. Here, we combin...
www.jneurosci.org
October 21, 2025 at 11:05 AM
@dotproduct.bsky.social's first first author paper is finally out in @sfnjournals.bsky.social! Her findings show that content-specific predictions fluctuate with alpha frequencies, suggesting a more specific role for alpha oscillations than we may have thought. With @jhaarsma.bsky.social. 🧠🟦 🧠🤖
Reposted by Alan Bince Jacob
Please RT! 🙏🙏🙏
1/3 How do you correct for multiple comparisons? Do you take into account *all* comparisons that can render the paper publishable? Most of us don’t. In this NHB piece, Yoav Benjamini, Yoav Zeevi and I argue that it’s time to change our practices >>
www.nature.com/articles/s41...
1/3 How do you correct for multiple comparisons? Do you take into account *all* comparisons that can render the paper publishable? Most of us don’t. In this NHB piece, Yoav Benjamini, Yoav Zeevi and I argue that it’s time to change our practices >>
www.nature.com/articles/s41...
Correction for multiple comparisons should be ubiquitous - Nature Human Behaviour
Nature Human Behaviour - Correction for multiple comparisons should be ubiquitous
www.nature.com
October 16, 2025 at 5:28 PM
Please RT! 🙏🙏🙏
1/3 How do you correct for multiple comparisons? Do you take into account *all* comparisons that can render the paper publishable? Most of us don’t. In this NHB piece, Yoav Benjamini, Yoav Zeevi and I argue that it’s time to change our practices >>
www.nature.com/articles/s41...
1/3 How do you correct for multiple comparisons? Do you take into account *all* comparisons that can render the paper publishable? Most of us don’t. In this NHB piece, Yoav Benjamini, Yoav Zeevi and I argue that it’s time to change our practices >>
www.nature.com/articles/s41...
Reposted by Alan Bince Jacob
heartbroken to learn the pope sympathizes with the poor. how can i continue to believe in god
October 17, 2025 at 5:43 PM
heartbroken to learn the pope sympathizes with the poor. how can i continue to believe in god
Reposted by Alan Bince Jacob
P.S. The procedure seems like it can be replicated by in-house engineers for low costs at university hospitals ;)
October 16, 2025 at 12:59 PM
P.S. The procedure seems like it can be replicated by in-house engineers for low costs at university hospitals ;)
Reposted by Alan Bince Jacob
Ever slam on the brakes after seeing a speed trap? Or better yet, slow down ahead in anticipation?
In our new paper w/ @anask07.bsky.social in @cp-iscience.bsky.social, we use #iEEG to study the neural basis of reactive and proactive control in medial and lateral PFC.
tinyurl.com/4bbwbffv
In our new paper w/ @anask07.bsky.social in @cp-iscience.bsky.social, we use #iEEG to study the neural basis of reactive and proactive control in medial and lateral PFC.
tinyurl.com/4bbwbffv
October 8, 2025 at 9:00 PM
Ever slam on the brakes after seeing a speed trap? Or better yet, slow down ahead in anticipation?
In our new paper w/ @anask07.bsky.social in @cp-iscience.bsky.social, we use #iEEG to study the neural basis of reactive and proactive control in medial and lateral PFC.
tinyurl.com/4bbwbffv
In our new paper w/ @anask07.bsky.social in @cp-iscience.bsky.social, we use #iEEG to study the neural basis of reactive and proactive control in medial and lateral PFC.
tinyurl.com/4bbwbffv
Reposted by Alan Bince Jacob
This model lets us see how indeterminacy allows macroscopic causation and agential control to emerge. Our actions are not fully predetermined but they’re also not caused by specific random events – instead, they are genuinely *up to us*. philarchive.org/rec/POTCCA-6
October 3, 2025 at 4:11 PM
This model lets us see how indeterminacy allows macroscopic causation and agential control to emerge. Our actions are not fully predetermined but they’re also not caused by specific random events – instead, they are genuinely *up to us*. philarchive.org/rec/POTCCA-6
Reposted by Alan Bince Jacob
And we can see, in creatures that developed nervous systems especially, that they can act *for reasons*, based on the meaning of neural patterns. Living systems literally incorporate knowledge about the world to guide their behavior adaptively. onlinelibrary.wiley.com/doi/10.1111/...
Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience
The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c....
onlinelibrary.wiley.com
October 3, 2025 at 9:03 AM
And we can see, in creatures that developed nervous systems especially, that they can act *for reasons*, based on the meaning of neural patterns. Living systems literally incorporate knowledge about the world to guide their behavior adaptively. onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Alan Bince Jacob
Carefully reading the papers you cite is like a superpower. You might be surprised what you actually find! 😜
October 1, 2025 at 5:43 AM
Carefully reading the papers you cite is like a superpower. You might be surprised what you actually find! 😜
Reposted by Alan Bince Jacob
Ignoring fluctuations in criterion is problematic: simulations show that criterion fluctuations induce apparent history biases (panel C), lead to underestimated psychometric slopes (panel D) and underestimated measures of sensitivity, such as d' (panel D)
September 25, 2025 at 9:13 AM
Ignoring fluctuations in criterion is problematic: simulations show that criterion fluctuations induce apparent history biases (panel C), lead to underestimated psychometric slopes (panel D) and underestimated measures of sensitivity, such as d' (panel D)
Reposted by Alan Bince Jacob
Common neural choice signals reflect accumulated evidence, not confidence! Now out in @cerebralcortex.bsky.social w @helenevanmarcke.bsky.social @pierreledenmat.bsky.social @yfvisser.bsky.social @denizerdil.bsky.social a.o.
Paper: desenderlab.com/wp-content/u... Thread ↓↓↓
Paper: desenderlab.com/wp-content/u... Thread ↓↓↓
September 19, 2025 at 10:47 AM
Common neural choice signals reflect accumulated evidence, not confidence! Now out in @cerebralcortex.bsky.social w @helenevanmarcke.bsky.social @pierreledenmat.bsky.social @yfvisser.bsky.social @denizerdil.bsky.social a.o.
Paper: desenderlab.com/wp-content/u... Thread ↓↓↓
Paper: desenderlab.com/wp-content/u... Thread ↓↓↓
Reposted by Alan Bince Jacob
🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research. @uclqsion.bsky.social @ucl-hd.bsky.social
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.co.uk
September 24, 2025 at 2:25 PM
🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research. @uclqsion.bsky.social @ucl-hd.bsky.social
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Reposted by Alan Bince Jacob
I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 24, 2025 at 12:04 PM
I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alan Bince Jacob
1/
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
September 17, 2025 at 7:33 PM
1/
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence