How do cells navigate up gradients of adhesive proteins?
🤔

Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood

We show that passive friction directs cells & explains complex trajectories on gradients

👉 www.nature.com/articles/s41...

This is so upsetting. Outsourcing writing does not "free up time to do more science" it's just a step further toward becoming the CSO at the top of a managerial pyramid rather than being a scientist

OMG, this is such a cool paper from Patrick Caswell's lab. They express Rab25-mCherry-GFP-nanobody in cells, microinject GFP-magnetic particles, then use a magnet to pull Rab25 to the plasma membrane to show that it can trigger actin protrusions! I want this system.
www.science.org/doi/10.1126/...

Our paper describing the creation of a nationwide core facility for bioimage analysis if out in @plos Computational Biology!
🎉✌️

journals.plos.org/ploscompbiol...

So happy about this paper and how the work turned out.
A small thread 👇

#bioimageanalysis #corefacility

@gounismichalis.bsky.social‬ et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...

Check out our new work @natcomms.nature.com! @mayorlab.bsky.social discovered that cells perform durotaxis even without focal adhesions. How? Well, we found that they actually follow friction gradients — a new mode of directed cell migration that we call frictiotaxis!

www.nature.com/articles/s41...

In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...

Looking for #MaterialStiffness of #BasementMembrane across tissues?
Excellent literature resource here😆👇

The basement membrane as a structured surface – role in vascular health and disease

@claireleclech.bsky.social @jcellsci.bsky.social 2020
journals.biologists.com/jcs/article/...

New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs).
www.nature.com/articles/s41...
@ibecbarcelona.eu

Villeneuve, C., Hashmi, A., ...,Manning, M. L., & Wickström, S. A. (2024). Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture. Nature cell biology, 26(2), 207–218. #EpithelialMechanics
https://www.nature.com/articles/s41556-023-01332-4

How is metabolism interconnected with cellular dynamics? We are @emaniou.bsky.social and @hpscenthusiast.bsky.social and through an energy inexpensive process, we will highlight advances in mechano-metabolism and related fields. @epimechfc.bsky.social

For the dev bio crowd : there is a call for junior group leader at Institut Pasteur in Paris and one of the axis covered is related to development. Come and join us in this exciting place and become one of our colleague @devstempasteur.bsky.social
Please RT !!
research.pasteur.fr/fr/call/call...