Aida Martinez-Sanchez
@aidamartinezs.bsky.social
Researching miRNAs in pancreatic islets @Imperialcollege.
Enjoying living and working in London
#RNAbiology #miRNAs #Betacells #Isletbiology #diabetes
Enjoying living and working in London
#RNAbiology #miRNAs #Betacells #Isletbiology #diabetes
Our lab members are joining forces for this one...a wonderful excuse to keep active this summer and contribute to the great work that the DUK does in supporting those living with diabetes. If you want to contribute, check out our team:
step.diabetes.org.uk/teams/the-im...
step.diabetes.org.uk/teams/the-im...
The Imperial MiR-acles
We are a team of researchers working at Imperial College London. We study how insulin-producing cells (beta cells) in the pancreas work — and what goes wrong in diabetes. Our research focuses on tiny ...
step.diabetes.org.uk
July 1, 2025 at 8:56 PM
Our lab members are joining forces for this one...a wonderful excuse to keep active this summer and contribute to the great work that the DUK does in supporting those living with diabetes. If you want to contribute, check out our team:
step.diabetes.org.uk/teams/the-im...
step.diabetes.org.uk/teams/the-im...
Big Congrats to talented postdoc @ralen30 (Rosa Alen) and her former group at @FatlivL (Led by Angela Valverde) for this fantastic work!!!
A liver-derived lipotoxic extracellular vesicle-macrophage TLR4 axis producing liver and pancreas inflammation and beta cell dysfunction @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Effect of lipotoxic hepatocyte-derived extracellular vesicles in pancreas inflammation: essential role of macrophage TLR4 in beta cell functionality - Diabetologia
Aims/hypothesis Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common feature of obesity and type 2 diabetes. Under lipotoxic stress, hepatocytes release small extracellular ves...
link.springer.com
May 20, 2025 at 7:04 AM
Big Congrats to talented postdoc @ralen30 (Rosa Alen) and her former group at @FatlivL (Led by Angela Valverde) for this fantastic work!!!
Reposted by Aida Martinez-Sanchez
🚨🚨 New pre-print from the lab. led by the amazing @alejotorrescano.bsky.social !
Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪
Check-it out ⤵️
Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪
Check-it out ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas https://www.biorxiv.org/content/10.1101/2025.04.16.649169v1
April 17, 2025 at 9:12 PM
🚨🚨 New pre-print from the lab. led by the amazing @alejotorrescano.bsky.social !
Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪
Check-it out ⤵️
Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪
Check-it out ⤵️
Reposted by Aida Martinez-Sanchez
Still time to apply!
Applications from US welcome – four years can feel longer or shorter depending on where you are 😉
Applications from US welcome – four years can feel longer or shorter depending on where you are 😉
📣 Hiring, please forward widely!!
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Postdoctoral scientist, gene regulatory mechanisms and diabetes | CRG Online Recruitment Portal
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
shorturl.at
February 2, 2025 at 8:18 PM
Still time to apply!
Applications from US welcome – four years can feel longer or shorter depending on where you are 😉
Applications from US welcome – four years can feel longer or shorter depending on where you are 😉
Reposted by Aida Martinez-Sanchez
An interview with the CRG's Fátima Gebauer, who has just taken up the mantle as the 26th President of the RNA Society, and her plans for steering the community of over 1,800 scientists into a future where RNA biology vaults to the forefront of medicine: www.crg.eu/en/news/inte...
January 13, 2025 at 3:39 PM
An interview with the CRG's Fátima Gebauer, who has just taken up the mantle as the 26th President of the RNA Society, and her plans for steering the community of over 1,800 scientists into a future where RNA biology vaults to the forefront of medicine: www.crg.eu/en/news/inte...
Reposted by Aida Martinez-Sanchez
Just a few days left to apply! Start 2025 by joining is at @imperialcollegeldn.bsky.social
We’re hiring! UHPLC-HRMS metabolomics to investigate the microbiome-metabolite-immune axis in the transition from health to disease with the IMMEDIATE consortium. Deadline 10th Jan:
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
January 5, 2025 at 10:02 PM
Just a few days left to apply! Start 2025 by joining is at @imperialcollegeldn.bsky.social
Reposted by Aida Martinez-Sanchez
Join us in a beautiful location for this multidisciplinary experience. Top speakers linking topics such as organoid modeling, synthetic biology, gene regulation or genetics with disease mechanisms & new therapies for T1D, T2D, and MASLD
meetings.embo.org/event/25-liver-pancreas
meetings.embo.org/event/25-liver-pancreas
Liver and pancreas in metabolic disease: from pathways to therapies
The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…
meetings.embo.org
December 21, 2024 at 8:17 AM
Join us in a beautiful location for this multidisciplinary experience. Top speakers linking topics such as organoid modeling, synthetic biology, gene regulation or genetics with disease mechanisms & new therapies for T1D, T2D, and MASLD
meetings.embo.org/event/25-liver-pancreas
meetings.embo.org/event/25-liver-pancreas
Looking forward to visiting Kings tomorrow!
Excited to hear about Dr. Aida Martinez research (@aidamartinezs.bsky.social) next CGTRM Stem cells @ Lunch seminar on Tuesday 10th Dec 2PM BST!
December 9, 2024 at 10:47 PM
Looking forward to visiting Kings tomorrow!
Last couple of days to apply!!
We are recruiting a postdoctoral research associate! Have a look at the flyer and/or the links below and get in touch if you have any questions! And please, share widely!!
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
December 6, 2024 at 7:42 AM
Last couple of days to apply!!
Had the first Christmas celebration of the year with the team!we had a fantastic time chatting and playing board games in the pub, with loads of laughs!simple things are the best when in great company...feeling a very lucky PI!
December 6, 2024 at 12:42 AM
Had the first Christmas celebration of the year with the team!we had a fantastic time chatting and playing board games in the pub, with loads of laughs!simple things are the best when in great company...feeling a very lucky PI!
Reposted by Aida Martinez-Sanchez
Very happy to share the latest preprint from the lab. We find that during cell competition, winners induce an increase in proline metabolism in loser cells, and this drives their elimination through repression of the integrated stress response.
biorxiv.org/cgi/content/...
biorxiv.org/cgi/content/...
Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition
Cell competition is a quality control acting from development to the adult that eliminates cells that are less-fit than their neighbours. How winner cells induce the elimination of losers during this ...
biorxiv.org
December 3, 2024 at 7:36 AM
Very happy to share the latest preprint from the lab. We find that during cell competition, winners induce an increase in proline metabolism in loser cells, and this drives their elimination through repression of the integrated stress response.
biorxiv.org/cgi/content/...
biorxiv.org/cgi/content/...
We are recruiting a postdoctoral research associate! Have a look at the flyer and/or the links below and get in touch if you have any questions! And please, share widely!!
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
November 27, 2024 at 5:50 PM
We are recruiting a postdoctoral research associate! Have a look at the flyer and/or the links below and get in touch if you have any questions! And please, share widely!!
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Reposted by Aida Martinez-Sanchez
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
doi.org
November 25, 2024 at 11:16 AM
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social