Heiko Lickert
@heikolickert.bsky.social
Developmental, stem cell and islet biologist, Professor for Beta Cell Biology @ Technical University Munich, Director of Institute for Diabetes and Regeneration Research @HelmholtzMunich
Pinned
Heiko Lickert
@heikolickert.bsky.social
· Nov 25
Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
doi.org
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Reposted by Heiko Lickert
Obviously special shoutout to our great Proteomics and Genomics core facilities at @helmholtzmunich.bsky.social and of course the boss @heikolickert.bsky.social for his continuous support! Grateful to the @humboldt-foundation.de for supporting this work with a postdoctoral fellowship.
November 5, 2025 at 7:50 PM
Obviously special shoutout to our great Proteomics and Genomics core facilities at @helmholtzmunich.bsky.social and of course the boss @heikolickert.bsky.social for his continuous support! Grateful to the @humboldt-foundation.de for supporting this work with a postdoctoral fellowship.
Reposted by Heiko Lickert
New resource online! 🐖 Benchmarking porcine #PancreaticDuctalOrganoids for #DrugScreening applications
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
November 4, 2025 at 7:47 PM
New resource online! 🐖 Benchmarking porcine #PancreaticDuctalOrganoids for #DrugScreening applications
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
Reposted by Heiko Lickert
🔬 Breakthrough in Diabetes Research: An international team led by @heikolickert.bsky.social has published the first single-cell atlas comparing pancreas development across humans, pigs, and mice — marking a milestone in translational medicine.
@helmholtzmunich.bsky.social
t1p.de/dqwer
@helmholtzmunich.bsky.social
t1p.de/dqwer
An Evolutionary Comparison of Pancreas Development: A Milestone in Translational Research and Diabetes Therapies
Neuherberg
Pancreas development in pigs resembles humans much more closely than does the established mouse model. An international team headed by Helmholtz Munich and the German Center for Diabetes Re...
t1p.de
November 4, 2025 at 9:34 AM
🔬 Breakthrough in Diabetes Research: An international team led by @heikolickert.bsky.social has published the first single-cell atlas comparing pancreas development across humans, pigs, and mice — marking a milestone in translational medicine.
@helmholtzmunich.bsky.social
t1p.de/dqwer
@helmholtzmunich.bsky.social
t1p.de/dqwer
Reposted by Heiko Lickert
Comparing Pancreas Development Across Species to Advance Diabetes Research
New insights from international researchers led by #HelmholtzMunich & #DZD could reshape the future of #diabetes modeling & #RegenerativeMedicine.
👉 t1p.de/zg0ra
@diabresearch-dzd.bsky.social @heikolickert.bsky.social
New insights from international researchers led by #HelmholtzMunich & #DZD could reshape the future of #diabetes modeling & #RegenerativeMedicine.
👉 t1p.de/zg0ra
@diabresearch-dzd.bsky.social @heikolickert.bsky.social
November 3, 2025 at 2:22 PM
Comparing Pancreas Development Across Species to Advance Diabetes Research
New insights from international researchers led by #HelmholtzMunich & #DZD could reshape the future of #diabetes modeling & #RegenerativeMedicine.
👉 t1p.de/zg0ra
@diabresearch-dzd.bsky.social @heikolickert.bsky.social
New insights from international researchers led by #HelmholtzMunich & #DZD could reshape the future of #diabetes modeling & #RegenerativeMedicine.
👉 t1p.de/zg0ra
@diabresearch-dzd.bsky.social @heikolickert.bsky.social
Reposted by Heiko Lickert
Check out the latest manuscript from the @heikolickert.bsky.social lab on generating a defined stem-cell derived islet product for transplantation.
A thorough characterization of the system particularly by our star PhD students Nike and Nicole! #PancSky
www.biorxiv.org/content/10.1...
A thorough characterization of the system particularly by our star PhD students Nike and Nicole! #PancSky
www.biorxiv.org/content/10.1...
Endocrine-enriched stem cell-derived islets improve long-term safety in vivo
Fully differentiated stem cell-derived islets (SC-islets) are proven to normalise blood glucose in type 1 diabetic patients. However, the presence of off-target cell types and the immature SC-islet fu...
www.biorxiv.org
August 24, 2025 at 4:19 PM
Check out the latest manuscript from the @heikolickert.bsky.social lab on generating a defined stem-cell derived islet product for transplantation.
A thorough characterization of the system particularly by our star PhD students Nike and Nicole! #PancSky
www.biorxiv.org/content/10.1...
A thorough characterization of the system particularly by our star PhD students Nike and Nicole! #PancSky
www.biorxiv.org/content/10.1...
Reposted by Heiko Lickert
Happy to share a new tool from the @heikolickert.bsky.social lab!
We generated human iPSC fluorescent reporter lines to monitor Wnt/PCP signaling activity by Flattop in stem cell derived β-cells.
doi.org/10.1016/j.sc...
Thanks to all the co-authors that helped in the present and the past!
We generated human iPSC fluorescent reporter lines to monitor Wnt/PCP signaling activity by Flattop in stem cell derived β-cells.
doi.org/10.1016/j.sc...
Thanks to all the co-authors that helped in the present and the past!
Redirecting
doi.org
September 26, 2025 at 10:01 AM
Happy to share a new tool from the @heikolickert.bsky.social lab!
We generated human iPSC fluorescent reporter lines to monitor Wnt/PCP signaling activity by Flattop in stem cell derived β-cells.
doi.org/10.1016/j.sc...
Thanks to all the co-authors that helped in the present and the past!
We generated human iPSC fluorescent reporter lines to monitor Wnt/PCP signaling activity by Flattop in stem cell derived β-cells.
doi.org/10.1016/j.sc...
Thanks to all the co-authors that helped in the present and the past!
Reposted by Heiko Lickert
New from the @heikolickert.bsky.social clan and great work from Carina together with all collaborators and the Theis lab to study pancreas development across species, bringing new insights into conserved pathways using multimodal computational analysis www.nature.com/articles/s41... #PancSky
A multimodal cross-species comparison of pancreas development - Nature Communications
This study establishes the pig as a complementary model for studying human pancreas development. It shows pigs mimic human developmental tempo, gene regulation, and endocrine cell emergence, offering ...
www.nature.com
October 23, 2025 at 7:03 PM
New from the @heikolickert.bsky.social clan and great work from Carina together with all collaborators and the Theis lab to study pancreas development across species, bringing new insights into conserved pathways using multimodal computational analysis www.nature.com/articles/s41... #PancSky
Congratulations Nike, Nicole, Kathy and the whole team to get this important study into the pipeline. If you womder if stem cell-derived islet compositions matters for safety and efficacy for the graft, our tissue engineering approach gives an answer. Check it out….
Check out the latest manuscript from the @heikolickert.bsky.social lab on generating a defined stem-cell derived islet product for transplantation.
A thorough characterization of the system particularly by our star PhD students Nike and Nicole! #PancSky
www.biorxiv.org/content/10.1...
A thorough characterization of the system particularly by our star PhD students Nike and Nicole! #PancSky
www.biorxiv.org/content/10.1...
Endocrine-enriched stem cell-derived islets improve long-term safety in vivo
Fully differentiated stem cell-derived islets (SC-islets) are proven to normalise blood glucose in type 1 diabetic patients. However, the presence of off-target cell types and the immature SC-islet fu...
www.biorxiv.org
August 26, 2025 at 8:04 PM
Congratulations Nike, Nicole, Kathy and the whole team to get this important study into the pipeline. If you womder if stem cell-derived islet compositions matters for safety and efficacy for the graft, our tissue engineering approach gives an answer. Check it out….
Reposted by Heiko Lickert
Billionaire philanthropist Bill Gates ratcheted up his feud with Elon Musk, accusing the world’s richest man of “killing the world’s poorest children” through what he said were misguided cuts to US development assistance
www.ft.com/content/bdd9...
www.ft.com/content/bdd9...
Bill Gates accuses Elon Musk of ‘killing’ children with USAID cuts
Billionaire reopens feud with Tesla chief as he unveils plan to spend $200bn on philanthropy and close foundation in 2045
www.ft.com
May 8, 2025 at 9:39 PM
Billionaire philanthropist Bill Gates ratcheted up his feud with Elon Musk, accusing the world’s richest man of “killing the world’s poorest children” through what he said were misguided cuts to US development assistance
www.ft.com/content/bdd9...
www.ft.com/content/bdd9...
Looking forward…
@heikolickert.bsky.social and Julian Heuberger speak at the hybrid Stem Cell Club on 15 May.
👉 bit.ly/3BT9pVE
#diabetes #organoids #stemcells #stammzellen
@mdc-bimsb.bsky.social @mdc-berlin.bsky.social @bihatcharite.bsky.social @tuberlin.bsky.social @www.helmholtz-munich.de @dkfz.bsky.social
👉 bit.ly/3BT9pVE
#diabetes #organoids #stemcells #stammzellen
@mdc-bimsb.bsky.social @mdc-berlin.bsky.social @bihatcharite.bsky.social @tuberlin.bsky.social @www.helmholtz-munich.de @dkfz.bsky.social
May 1, 2025 at 6:42 PM
Looking forward…
Reposted by Heiko Lickert
Zum Frühlingsanfang eine kleine Frühlingsgeschichte: Über frostige Nächte und aufplatzende Knospen, über Abschiede und Schmetterlinge im Bauch, Ostseemuscheln und Eselsohren und warum Tauben Tauben heißen
Requiem auf ein Fahrrad
Über frostige Nächte und aufplatzende Knospen, über Abschiede und Schmetterlinge im Bauch, Ostseemuscheln und Eselsohren und warum Tauben Tauben heißen
steadyhq.com
March 23, 2025 at 6:04 AM
Zum Frühlingsanfang eine kleine Frühlingsgeschichte: Über frostige Nächte und aufplatzende Knospen, über Abschiede und Schmetterlinge im Bauch, Ostseemuscheln und Eselsohren und warum Tauben Tauben heißen
Reposted by Heiko Lickert
taking a dive into Andy Kaufman's career, and nothing prepared me for this: www.youtube.com/watch?v=TSYV...
Andy Kaufman: "I Trusted You"
YouTube video by Pete Peterson
www.youtube.com
March 29, 2025 at 10:28 PM
taking a dive into Andy Kaufman's career, and nothing prepared me for this: www.youtube.com/watch?v=TSYV...
Reposted by Heiko Lickert
My prior home towns, like Manhattan and San Francisco, never had the burst of flowering trees every Spring, like the DC area.
It’s dazzling each time.
It’s dazzling each time.
March 29, 2025 at 10:59 PM
My prior home towns, like Manhattan and San Francisco, never had the burst of flowering trees every Spring, like the DC area.
It’s dazzling each time.
It’s dazzling each time.
This clearly will get worse with our dependency on computers, mobile phones, social media, AI, and even worse, we will be manipulated without having a chance - so for me it is clear, this trend will continue and we will lose our natural Intelligence…
NEW 🧵 Is human intelligence starting to decline?
Recent results from major international tests show that the average person’s capacity to process information, use reasoning and solve novel problems has been falling since around the mid 2010s
What should we make of this?
www.ft.com/content/a801...
Recent results from major international tests show that the average person’s capacity to process information, use reasoning and solve novel problems has been falling since around the mid 2010s
What should we make of this?
www.ft.com/content/a801...
March 15, 2025 at 7:30 AM
This clearly will get worse with our dependency on computers, mobile phones, social media, AI, and even worse, we will be manipulated without having a chance - so for me it is clear, this trend will continue and we will lose our natural Intelligence…
Great complementary pig organoid model pioneered and established from the one and only @ckarampelias.bsky.social. Excellent work, check it out…
Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1
Benchmarking porcine pancreatic ductal organoids for drug screening applications
Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...
www.biorxiv.org
March 14, 2025 at 10:30 PM
Great complementary pig organoid model pioneered and established from the one and only @ckarampelias.bsky.social. Excellent work, check it out…
Reposted by Heiko Lickert
Some thoughts on the new dynamic uncertain status and need for US-Canada Science diplomacy www.science.org/doi/10.1126/...
Uphold US-Canada science
A partnership can be demanding, and as with any couple, can have good days and bad. The United States–Canada relationship is most definitely having a bad one. It’s difficult to fully comprehend all th...
www.science.org
March 13, 2025 at 7:59 PM
Some thoughts on the new dynamic uncertain status and need for US-Canada Science diplomacy www.science.org/doi/10.1126/...
Reposted by Heiko Lickert
Excited to share our recent review on the insulin-IGF receptor signaling!
New Online! Regulation and function of insulin and insulin-like growth factor receptor signalling
Regulation and function of insulin and insulin-like growth factor receptor signalling
Nature Reviews Molecular Cell Biology, Published online: 10 February 2025; doi:10.1038/s41580-025-00826-3Insulin and insulin-like growth factor (IGF) signalling regulates metabolism, cell growth and proliferation and diverse cell-specific processes. This…
bit.ly
February 10, 2025 at 10:54 PM
Excited to share our recent review on the insulin-IGF receptor signaling!
Fantastic work - congratulations Scott and team!
I mean what an encyclopaedia of a paper was that by @soleimanpourlab.bsky.social and colleagues www.science.org/doi/10.1126/... amazing work and a compendium for mitochondrial biology in metabolic tissues. Have you seen this @heikolickert.bsky.social ? #PancSky
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. Here, we report that dysfunctiona...
www.science.org
February 22, 2025 at 10:01 PM
Fantastic work - congratulations Scott and team!
Final count down, just a few more days until registration closes…
Application deadline is get closer - make sure you do not miss this exciting EMBO workshop on liver and pancreatic biology and disease 😉
meetings.embo.org/event/25-liv...
meetings.embo.org/event/25-liv...
Liver and pancreas in metabolic disease: from pathways to therapies
The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…
meetings.embo.org
February 21, 2025 at 7:37 PM
Final count down, just a few more days until registration closes…
Exciting new tool to make the most out of multimodal single-cell data from our friends and long-term collaborators of the @fabian_theis lab - check it out, it works beautifully and really makes sense out of your complex data! 👇👍😉
Excited to see Moscot (moscot-tools.org) published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at www.nature.com/articles/s41...
Mapping cells through time and space with moscot - Nature
Moscot is an optimal transport approach that overcomes current limitations of similar methods to enable multimodal, scalable and consistent single-cell analyses of datasets across spatial and temporal...
www.nature.com
January 23, 2025 at 6:43 AM
Exciting new tool to make the most out of multimodal single-cell data from our friends and long-term collaborators of the @fabian_theis lab - check it out, it works beautifully and really makes sense out of your complex data! 👇👍😉
Application deadline is get closer - make sure you do not miss this exciting EMBO workshop on liver and pancreatic biology and disease 😉
meetings.embo.org/event/25-liv...
meetings.embo.org/event/25-liv...
Liver and pancreas in metabolic disease: from pathways to therapies
The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…
meetings.embo.org
January 21, 2025 at 9:10 PM
Application deadline is get closer - make sure you do not miss this exciting EMBO workshop on liver and pancreatic biology and disease 😉
meetings.embo.org/event/25-liv...
meetings.embo.org/event/25-liv...
Reposted by Heiko Lickert
Want to delve deep into liver and pancreas biology in a beautiful setting? Join us April 1–4 at the EMBO Workshop in the beautiful coastal town of Sant Feliu de Guíxols (Girona), Spain! Organized w/ Ines Cebola, @jorge-ferrer.bsky.social @heikolickert.bsky.social & Ludovic Vallier.
bit.ly/4g8zajj
bit.ly/4g8zajj
January 20, 2025 at 12:29 PM
Want to delve deep into liver and pancreas biology in a beautiful setting? Join us April 1–4 at the EMBO Workshop in the beautiful coastal town of Sant Feliu de Guíxols (Girona), Spain! Organized w/ Ines Cebola, @jorge-ferrer.bsky.social @heikolickert.bsky.social & Ludovic Vallier.
bit.ly/4g8zajj
bit.ly/4g8zajj
Reposted by Heiko Lickert
our newest preprint! Led by Zoe Grant in my lab and Shuzen Kuang in Katie Pollard's lab here at Gladstone. "Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor" 1/n www.biorxiv.org/content/10.1...
January 13, 2025 at 5:07 PM
our newest preprint! Led by Zoe Grant in my lab and Shuzen Kuang in Katie Pollard's lab here at Gladstone. "Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor" 1/n www.biorxiv.org/content/10.1...
Reposted by Heiko Lickert
Exciting news from BlueRock Therapeutics & Bayer on upcoming phase III trial for our DA neuron cell therapy in Parkinson’s disease. www.bluerocktx.com/bluerock-the...
BlueRock Therapeutics advances investigational cell therapy bemdaneprocel for treating Parkinson’s disease to registrational Phase III clinical trial - BlueRock Therapeutics LP
BlueRock will initiate a Phase III clinical trial for bemdaneprocel, its investigational cell therapy for Parkinson’s disease. It is expected to begin in the first half of 2025 and will represent a si...
www.bluerocktx.com
January 13, 2025 at 7:01 PM
Exciting news from BlueRock Therapeutics & Bayer on upcoming phase III trial for our DA neuron cell therapy in Parkinson’s disease. www.bluerocktx.com/bluerock-the...
Reposted by Heiko Lickert
Nice findings on Beta cell dysfunction studied in human pancreatic slices during type 1 diabetes progression, interesting findings on calcium dynamics #BetaSky @eaphelps.bsky.social www.biorxiv.org/content/10.1...
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
During type 1 diabetes (T1D) progression, beta cells become dysfunctional and exhibit reduced first-phase insulin release. While this period of beta cell dysfunction is well established, its cause and...
www.biorxiv.org
December 30, 2024 at 6:21 AM
Nice findings on Beta cell dysfunction studied in human pancreatic slices during type 1 diabetes progression, interesting findings on calcium dynamics #BetaSky @eaphelps.bsky.social www.biorxiv.org/content/10.1...