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labspagnoli.bsky.social
Spagnoli_Lab.
@labspagnoli.bsky.social
Developmental and stem cell biology lab. @KCLstemcells
@kingscollegelondon.bsky.social‬ www.spagnolilab.org
Unlocking the control of cell identity and plasticity
Also on the otherside: @LabSpagnoli on the bird & @SpagnoliLab@mas.to
Pinned
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social

➡️ doi.org/10.1126/scia...

short 🧵 below & more acknowledgments ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas
Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.
doi.org
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social

➡️ doi.org/10.1126/scia...

short 🧵 below & more acknowledgments ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas
Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.
doi.org
November 13, 2025 at 3:56 PM
Reposted by Spagnoli_Lab.
🌍Open call: Junior Group Leader positions!

Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.

Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
Reposted by Spagnoli_Lab.
Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26
Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery | Keystone Symposia
Join us at the Keystone Symposia on Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery, March 2026, in Breckenridge, with field leaders!
keysym.us
November 10, 2025 at 10:59 PM
Reposted by Spagnoli_Lab.
Are you thinking of enrolling in graduate school next year? The @lsiexeter.bsky.social is a fantastic place for multidisciplinary research... and my group is also hiring!
Apply here 👇
Are you looking for a PhD starting in September 2026/27? Then do not miss the fantastic opportunity to be part of the LSI PhD Community. New positions for the LSI PhD Programme are out now. www.exeter.ac.uk/research/ins... Deadline: 26.11.2025
November 3, 2025 at 9:11 AM
Reposted by Spagnoli_Lab.
We are looking for: PhD Student (starting as Research Assistant) and Postdoctoral Researcher in Stem Cell Biology and Mechanobiology. Please RT💕
🔗 About our lab: renew.science/principal_in...
🎓 PhD position: jobportal.ku.dk/phd/?show=15...
🧪 Postdoc position: jobportal.ku.dk/videnskabeli...
November 3, 2025 at 7:05 PM
Reposted by Spagnoli_Lab.
We hiring! Please share this post with your talented ECRs

We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome

Based at @lmcb-ucl.bsky.social at University College London

Apply here:
www.jobs.ac.uk/job/DPD418/r...
October 21, 2025 at 3:57 PM
Reposted by Spagnoli_Lab.
Exciting collaborative post doc opportunity to study lung disease mechanisms working with 2 friendly labs @jennydickens41.bsky.social @labrawlins.bsky.social and GSK colleagues www.jobs.cam.ac.uk/job/52936/
October 13, 2025 at 1:31 PM
Reposted by Spagnoli_Lab.
New publication :
Despite being a core member of the PCP pathway, Vangl2 can play roles unrelated to planar polarity. This is the case during mouse heart morphogenesis.
VANGL2 shapes the mouse heart tube from adjacent epithelia and without planar polarity https://www.biorxiv.org/content/10.1101/2025.09.05.674213v1
September 26, 2025 at 7:22 PM
Reposted by Spagnoli_Lab.
Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!
October 10, 2025 at 1:26 PM
Reposted by Spagnoli_Lab.
It is with great sadness that we heard of John Gurdon’s passing this week. Not just one of our 100 extraordinary biologists, but truly one of a kind, he was a pioneer, whose vision and personality inspired biologists worldwide.
October 10, 2025 at 2:11 PM
Reposted by Spagnoli_Lab.
The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
Reposted by Spagnoli_Lab.
Looking for a PhD for 2026? We have 2 projects in collaboration with Clare Bennett (UCL) looking at macrophage metabolism in breast cancer. Check them out! @cruk-cityoflondon.bsky.social

www.colcc.ac.uk/2026-phd-pro...

crukradnet.colcc.ac.uk/phd-students...
October 9, 2025 at 7:04 AM
Reposted by Spagnoli_Lab.
Don’t miss the exciting ISSCR Webinar: Integrating Biophysics into Stem Cell Biology next Tuesday October 14!
The webinar features paired tandem talks that brings together experimentalists and theorists working at the interface of stem cell biology and biophysics. 1/2
www.isscr.org/upcoming-pro...
www.isscr.org
October 9, 2025 at 8:57 AM
Reposted by Spagnoli_Lab.
We're funding doctoral programmes to train the next generation of clinically-active academic leaders. 🩺

This call continues our commitment to supporting healthcare professionals in research careers.

Applications are open now. Here’s what you need to know 🧵
October 8, 2025 at 4:04 PM
Reposted by Spagnoli_Lab.
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
October 8, 2025 at 8:49 AM
Reposted by Spagnoli_Lab.
Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
www.magd.cam.ac.uk
October 7, 2025 at 4:02 PM
Reposted by Spagnoli_Lab.
“For Gurdon to continue in biology would be a complete waste of time both for him and for those who would have to teach him”

He proved them wrong! RIP John Gurdon

www.cell.com/current-biol...
John Gurdon
John Gurdon is at the Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology in Cambridge. Educated at Eton and Christ Church, Oxford, he changed from classics to zoology. Dur...
www.cell.com
October 7, 2025 at 4:21 PM
Reposted by Spagnoli_Lab.
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/3VNrH1s
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
October 6, 2025 at 10:52 AM
Reposted by Spagnoli_Lab.
Latent plasticity of the human pancreas across development, health, and disease. https://www.biorxiv.org/content/10.1101/2025.10.01.679230v1
October 3, 2025 at 2:34 PM
Reposted by Spagnoli_Lab.
We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375
The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).
www.nature.com
March 10, 2025 at 11:48 PM
Reposted by Spagnoli_Lab.
#ChooseEurope for Science is live!

With €22.5 million under #MSCA, we’re funding organisations to:

🔬 Host postdoctoral researchers in all fields
🔬 Offer stable jobs and great working conditions
🔬 Create long-term career prospects

Europe is where science thrives.

More → link.europa.eu/6JhtHp
October 2, 2025 at 8:23 AM
Reposted by Spagnoli_Lab.
Looking forward to working with new colleagues on a collaborative project in lung disease modelling and transcriptomics - please share! And email Jenny @jennydickens41.bsky.social, or me, with any questions. 😀

www.jobs.cam.ac.uk/job/52936/
Research Associate: Human Lung Disease Mechanisms (Fixed Term) - Job Opportunities - University of Cambridge
Research Associate: Human Lung Disease Mechanisms (Fixed Term) in the Gurdon Institute at the University of Cambridge.
www.jobs.cam.ac.uk
October 2, 2025 at 3:14 PM
Reposted by Spagnoli_Lab.
🚀 Exciting news!

Islet Biology is back @keystonesymposia.bsky.social !!!
Don’t miss the chance to register for this exciting conference!

🚨Early-bird registration is NOW OPEN --- see below ⤵️
#KSDiabetes26 🌲🌲🌲
Join us for the revival of the Islet Biology and Diabetes Keystone symposia in Breckenridge, Colorado on March 16-19, 2026, for great science and great skiing. You can register now for early bird rates: lnkd.in/dw59T7tc Joint with Gut-Brain Axis. @linnemannlab.bsky.social Erica Nishimura, Barak Blum
September 25, 2025 at 8:42 AM
🚀 Exciting news!

Islet Biology is back @keystonesymposia.bsky.social !!!
Don’t miss the chance to register for this exciting conference!

🚨Early-bird registration is NOW OPEN --- see below ⤵️
#KSDiabetes26 🌲🌲🌲
Join us for the revival of the Islet Biology and Diabetes Keystone symposia in Breckenridge, Colorado on March 16-19, 2026, for great science and great skiing. You can register now for early bird rates: lnkd.in/dw59T7tc Joint with Gut-Brain Axis. @linnemannlab.bsky.social Erica Nishimura, Barak Blum
September 25, 2025 at 8:42 AM