Ali Haidar
@ahaidar.bsky.social
PhD Student in Martine Simonelig's lab at the IGH in Montpellier - CNRS - UMontpellier
mRNA Regulation and Development.
Me ♡ Imaging, Condensates, Translation, RNA
RNAstuff.com
mRNA Regulation and Development.
Me ♡ Imaging, Condensates, Translation, RNA
RNAstuff.com
Reposted by Ali Haidar
Postdoctoral position in the team of Alessandro Barducci in the CBS, focusing on multiscale simulations of RNA-driven condensates, with applications in synthetic biology.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
November 5, 2025 at 5:43 PM
Postdoctoral position in the team of Alessandro Barducci in the CBS, focusing on multiscale simulations of RNA-driven condensates, with applications in synthetic biology.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
Reposted by Ali Haidar
Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...
July 11, 2025 at 5:35 AM
Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...
Reposted by Ali Haidar
Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
August 28, 2025 at 4:18 AM
Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Ali Haidar
RNA droplets that grow and segregate by ribozyme catalysis. Check out our latest preprint www.biorxiv.org/content/10.1101/2025.08.29.673008v1
September 2, 2025 at 7:03 AM
RNA droplets that grow and segregate by ribozyme catalysis. Check out our latest preprint www.biorxiv.org/content/10.1101/2025.08.29.673008v1
Reposted by Ali Haidar
Happy to share our community note published in Nature Communications @natcomms.nature.com. In this 14-page article (34 authors from 9 countries), we discuss current practices in phase separation. We hope it will be useful to the biomolecular condensate community.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 20, 2025 at 3:34 AM
Happy to share our community note published in Nature Communications @natcomms.nature.com. In this 14-page article (34 authors from 9 countries), we discuss current practices in phase separation. We hope it will be useful to the biomolecular condensate community.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ali Haidar
What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com with @yaotianzhang.bsky.social Denes Hnisz & team.
www.nature.com
June 4, 2025 at 3:29 PM
What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com with @yaotianzhang.bsky.social Denes Hnisz & team.
Reposted by Ali Haidar
New method drop:
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...
June 2, 2025 at 10:30 AM
New method drop:
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...
Reposted by Ali Haidar
We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
May 23, 2025 at 3:01 PM
We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
Reposted by Ali Haidar
#mRNADecay #Ribosome #Frameshift #Scerevisiae #NMD #CodonOptimality
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay: Molecular Cell www.cell.com/molecular-ce...
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay: Molecular Cell www.cell.com/molecular-ce...
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay
Zhang et al. identify a regulatory mechanism for how cells adapt to nutrient scarcity
through widespread −1 ribosomal frameshifts, culminating in accelerated mRNA decay.
This process, dependent on cod...
www.cell.com
May 19, 2025 at 12:21 PM
#mRNADecay #Ribosome #Frameshift #Scerevisiae #NMD #CodonOptimality
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay: Molecular Cell www.cell.com/molecular-ce...
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay: Molecular Cell www.cell.com/molecular-ce...
Reposted by Ali Haidar
1/
Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
May 14, 2025 at 5:58 PM
1/
Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
Reposted by Ali Haidar
Very excited to have been a part of this great work with @matteomazzocca.bsky.social, Simon Grosse-Holz, @jessematthias.bsky.social, and @andersshansen.bsky.social. Please check it out now! www.biorxiv.org/content/10.1...
May 14, 2025 at 6:03 PM
Very excited to have been a part of this great work with @matteomazzocca.bsky.social, Simon Grosse-Holz, @jessematthias.bsky.social, and @andersshansen.bsky.social. Please check it out now! www.biorxiv.org/content/10.1...
Reposted by Ali Haidar
Forget liquid-liquid phase separation, here comes solid phase transition 😱
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Solid phase transitions as a solution to the genome folding paradox - Nature
In vitro reconstitution and in vivo live-cell imaging of LHX2–EBF1–LDB1 enhancer hubs in olfactory sensory neurons reveals that these transcription factors form condensates with solid, rathe...
www.nature.com
May 14, 2025 at 6:41 PM
Forget liquid-liquid phase separation, here comes solid phase transition 😱
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ali Haidar
Hiro's paper is out! @hiro-cg5445.bsky.social
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!
www.nature.com/articles/s41...
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!
www.nature.com/articles/s41...
Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology
Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...
www.nature.com
May 14, 2025 at 2:44 PM
Hiro's paper is out! @hiro-cg5445.bsky.social
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!
www.nature.com/articles/s41...
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!
www.nature.com/articles/s41...
Reposted by Ali Haidar
👏new paper👏 ! Our preprint is now accepted at MBoC @ascbiology.bsky.social
Congrats to co-1st authors Junnan (new PI at OSU!) and Weiyi (now a Yale grad student) and 🙏 to collaborators Melissa & Jordan @myosincity.bsky.social
Funded by NIH grants & NSF GRFP!
www.biorxiv.org/content/10.1...
Congrats to co-1st authors Junnan (new PI at OSU!) and Weiyi (now a Yale grad student) and 🙏 to collaborators Melissa & Jordan @myosincity.bsky.social
Funded by NIH grants & NSF GRFP!
www.biorxiv.org/content/10.1...
The PCM scaffold enables RNA localization to centrosomes
As microtubule-organizing centers, centrosomes direct assembly of the bipolar mitotic spindle required for chromosome segregation and genome stability. Centrosome activity requires the dynamic assembl...
www.biorxiv.org
April 25, 2025 at 5:49 PM
👏new paper👏 ! Our preprint is now accepted at MBoC @ascbiology.bsky.social
Congrats to co-1st authors Junnan (new PI at OSU!) and Weiyi (now a Yale grad student) and 🙏 to collaborators Melissa & Jordan @myosincity.bsky.social
Funded by NIH grants & NSF GRFP!
www.biorxiv.org/content/10.1...
Congrats to co-1st authors Junnan (new PI at OSU!) and Weiyi (now a Yale grad student) and 🙏 to collaborators Melissa & Jordan @myosincity.bsky.social
Funded by NIH grants & NSF GRFP!
www.biorxiv.org/content/10.1...
Reposted by Ali Haidar
I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....
April 25, 2025 at 5:43 PM
I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....
Reposted by Ali Haidar
Reposted by Ali Haidar
Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 15, 2025 at 7:27 PM
Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ali Haidar
Not sure if anyone posted this on BSky, but here is a 'condensate' (pun intended) of the latest #RNA granules papers 'en vogue':
www.cell.com/molecular-ce...
#RNAsky #RNAbiology #MolCondensates
www.cell.com/molecular-ce...
#RNAsky #RNAbiology #MolCondensates
Biomolecular condensates: It was RNA all along!
In this issue of Molecular Cell, Trussina et al. and Parker et al. present complementary
lines of evidence that suggest that stress granules regulate trans RNA-RNA interactions
through the action of h...
www.cell.com
February 14, 2025 at 8:36 AM
Not sure if anyone posted this on BSky, but here is a 'condensate' (pun intended) of the latest #RNA granules papers 'en vogue':
www.cell.com/molecular-ce...
#RNAsky #RNAbiology #MolCondensates
www.cell.com/molecular-ce...
#RNAsky #RNAbiology #MolCondensates
Reposted by Ali Haidar
1/n Excited to share our new preprint! Using live imaging in Drosophila embryos, we show that RNA Pol II clusters switch from sites of initiation to elongation during zygotic genome activation and that they are stably associated with an active gene: www.biorxiv.org/content/10.1...
February 12, 2025 at 11:36 AM
1/n Excited to share our new preprint! Using live imaging in Drosophila embryos, we show that RNA Pol II clusters switch from sites of initiation to elongation during zygotic genome activation and that they are stably associated with an active gene: www.biorxiv.org/content/10.1...
Reposted by Ali Haidar
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 12, 2025 at 6:28 AM
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ali Haidar
📢 The Dormann Lab is looking for a PhD student interested in the molecular mechanisms of neurodegeneration and biomolecular condensation!
Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?
Apply to this fantastic PhD program by February 7 👇
Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?
Apply to this fantastic PhD program by February 7 👇
We are on the home stretch! 🏁
Only 1.5 weeks left to #apply for our #gradschool!
Don't miss this great opportunity if you are looking for a #PhD student position in the life sciences! Get your documents ready and apply now!
👉 imprs-cbp.mpg.de/call-for-app...
#imprs_cbp #imprs2impress #science
Only 1.5 weeks left to #apply for our #gradschool!
Don't miss this great opportunity if you are looking for a #PhD student position in the life sciences! Get your documents ready and apply now!
👉 imprs-cbp.mpg.de/call-for-app...
#imprs_cbp #imprs2impress #science
January 29, 2025 at 7:36 PM
📢 The Dormann Lab is looking for a PhD student interested in the molecular mechanisms of neurodegeneration and biomolecular condensation!
Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?
Apply to this fantastic PhD program by February 7 👇
Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?
Apply to this fantastic PhD program by February 7 👇
Reposted by Ali Haidar
I am thrilled to share the first manuscript from my group on identifying sequence and structural features promoting the condensation of RNAs that are organising highly interconnected RNA networks, thereby expanding our understanding of higher-order transcriptome assemblage.
shorturl.at/pmLIj #RNASky
shorturl.at/pmLIj #RNASky
Integrative profiling of condensation-prone RNAs during early development
Complex RNA–protein networks play a pivotal role in the formation of many types of biomolecular condensates. How intrinsic RNA features contribute to condensate formation however remains unclear. Here...
www.biorxiv.org
February 6, 2025 at 9:44 AM
I am thrilled to share the first manuscript from my group on identifying sequence and structural features promoting the condensation of RNAs that are organising highly interconnected RNA networks, thereby expanding our understanding of higher-order transcriptome assemblage.
shorturl.at/pmLIj #RNASky
shorturl.at/pmLIj #RNASky
Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 7, 2025 at 10:03 AM
Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Reposted by Ali Haidar
We are looking for a post-doc to join us in Oxford @biology.ox.ac.uk to study epigenetic inheritance! The project will use Cut&Run and RNA-seq to map and track new epimutations as they arise in Drosophila populations across multiple generations. Feel free to share!
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
February 5, 2025 at 4:59 PM
We are looking for a post-doc to join us in Oxford @biology.ox.ac.uk to study epigenetic inheritance! The project will use Cut&Run and RNA-seq to map and track new epimutations as they arise in Drosophila populations across multiple generations. Feel free to share!
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
Reposted by Ali Haidar
Check out our most recent preprint where we describe Mecp2 as a régulatrice of cGAS-STING associated signaling. 🧪🔥
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling https://www.biorxiv.org/content/10.1101/2025.01.30.635818v1
February 5, 2025 at 7:48 PM
Check out our most recent preprint where we describe Mecp2 as a régulatrice of cGAS-STING associated signaling. 🧪🔥