@aflaki.bsky.social
TOR complex | Epigenetics | Chromatin | Developmental biology| lipogenesis|
Also artist, poet
Biology centre (Czechia) | former MSCAcz fellow
Also artist, poet
Biology centre (Czechia) | former MSCAcz fellow
Reposted
There's a super line up next March for the Keystone meeting in Geneva for anyone interested in chromatin and epigenetics! Not a bad spot for a Spring trip!
🧬👇🇨🇭
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
🧬👇🇨🇭
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
Join us in Geneva (March, 2026) for the Keystone Symposium Epigenetics & Gene Regulation in Health and Disease, co-organized with @ckadoch.bsky.social — linking epigenetic mechanisms with therapeutic innovation. Apply for a short talk!
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
keysym.us
October 14, 2025 at 9:31 AM
There's a super line up next March for the Keystone meeting in Geneva for anyone interested in chromatin and epigenetics! Not a bad spot for a Spring trip!
🧬👇🇨🇭
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
🧬👇🇨🇭
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
Reposted
Deadlines are approaching for @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February in Keystone! See scholarship, abstract and discount reg dates: keysym.us/KSAutophagy26 #KSAutophagy26
Autophagy: Mechanisms to Therapy | Keystone Symposia
Join us at the Keystone Symposia on Autophagy: Mechanisms to Therapy, February 2026, in Keystone, with field leaders!
keysym.us
October 5, 2025 at 4:46 PM
Deadlines are approaching for @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February in Keystone! See scholarship, abstract and discount reg dates: keysym.us/KSAutophagy26 #KSAutophagy26
The Motamedi lab shows that Clr4 is recruited de novo to the ncRNA locus SPNCRNA230 even without Ago1 and pre-existing H3K9me. Sir2 and Clr3 (H3K9 HDACs) also accumulate there, and iterative cycles of H3K9 deacetylation then methylation spread a basal H3K9me state, which RNAi subsequently amplifies.
October 3, 2025 at 11:02 AM
The Motamedi lab shows that Clr4 is recruited de novo to the ncRNA locus SPNCRNA230 even without Ago1 and pre-existing H3K9me. Sir2 and Clr3 (H3K9 HDACs) also accumulate there, and iterative cycles of H3K9 deacetylation then methylation spread a basal H3K9me state, which RNAi subsequently amplifies.
Reposted
📆📣Join us for journal club tomorrow as Dr. Claudia Puri presents her work on "Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis", a recent work published in Developmental Cell!
Email wiajournalclub@gmail.com for Zoom link
Email wiajournalclub@gmail.com for Zoom link
September 23, 2025 at 8:47 PM
📆📣Join us for journal club tomorrow as Dr. Claudia Puri presents her work on "Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis", a recent work published in Developmental Cell!
Email wiajournalclub@gmail.com for Zoom link
Email wiajournalclub@gmail.com for Zoom link
Reposted
Our first release in the attempt to build the Transcription Factor Binding (TFB)-OMICS during #DevBio is now out in Development @dev-journal.bsky.social
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue
We are using CUT&RUN-LoV-U to map effectors of Signaling Pathways across tissue and stages of Mouse #DevBio🐭🧬
Do you want to join forces and collaborate to build the future of the TranscriptionFactorBinding(TFB)-OMICS?
www.biorxiv.org/content/10.1...
Do you want to join forces and collaborate to build the future of the TranscriptionFactorBinding(TFB)-OMICS?
www.biorxiv.org/content/10.1...
March 18, 2025 at 7:18 AM
Our first release in the attempt to build the Transcription Factor Binding (TFB)-OMICS during #DevBio is now out in Development @dev-journal.bsky.social
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue
Reposted
In the most recent episode we talked with @korblab.bsky.social from @upenn.edu about her work on BRD4 and the histone variant H2BE, which influences synaptic genes and neuronal activity. #podcast #epigenetics #chromatin
Listen here: www.activemotif.com/podcasts-eri...
Listen here: www.activemotif.com/podcasts-eri...
August 11, 2025 at 7:00 AM
In the most recent episode we talked with @korblab.bsky.social from @upenn.edu about her work on BRD4 and the histone variant H2BE, which influences synaptic genes and neuronal activity. #podcast #epigenetics #chromatin
Listen here: www.activemotif.com/podcasts-eri...
Listen here: www.activemotif.com/podcasts-eri...
Reposted
Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.
mpi-muenster.mpg.de/career
mpi-muenster.mpg.de/career
We are looking for a #Postdoc with a great interest in biological robustness to lead a project investigating the self-correction capabilities of the developing nervous system. Join us at the @rocha-lab.bsky.social Rocha lab @mpi-muenster.bsky.social!
jobs.mpi-muenster.mpg.de/jobposting/0...
jobs.mpi-muenster.mpg.de/jobposting/0...
July 10, 2025 at 12:10 PM
Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.
mpi-muenster.mpg.de/career
mpi-muenster.mpg.de/career
Reposted
WSTF nuclear autophagy regulates chronic but not acute inflammation is published in Nature😀 nature.com/articles/s41...
Congratulations to all collaborating groups! Fantastic effort by first author Yu Wang! Kudos to Zixhun Dou for leading the entire project!😀
Congratulations to all collaborating groups! Fantastic effort by first author Yu Wang! Kudos to Zixhun Dou for leading the entire project!😀
July 6, 2025 at 11:45 AM
WSTF nuclear autophagy regulates chronic but not acute inflammation is published in Nature😀 nature.com/articles/s41...
Congratulations to all collaborating groups! Fantastic effort by first author Yu Wang! Kudos to Zixhun Dou for leading the entire project!😀
Congratulations to all collaborating groups! Fantastic effort by first author Yu Wang! Kudos to Zixhun Dou for leading the entire project!😀
Reposted
WSTF nuclear autophagy regulates chronic but not acute inflammation @nature.com @terjejohansen.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 2, 2025 at 7:51 PM
WSTF nuclear autophagy regulates chronic but not acute inflammation @nature.com @terjejohansen.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
🧬 ⚙️ REVIEW ⚙️ 🧬
TORquing chromatin: the regulatory role of TOR kinase in chromatin function - Dong et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪
TORquing chromatin: the regulatory role of TOR kinase in chromatin function - Dong et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪
June 25, 2025 at 3:46 PM
🧬 ⚙️ REVIEW ⚙️ 🧬
TORquing chromatin: the regulatory role of TOR kinase in chromatin function - Dong et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪
TORquing chromatin: the regulatory role of TOR kinase in chromatin function - Dong et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪
Reposted
If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc.
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
Beetween
app.beetween.com
June 13, 2025 at 1:28 PM
If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc.
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
Reposted
So proud of this work by #rukmini mukherjee on intersection of Cell Biology and Microbiology
Autophagy-lysosome pathways are known targets of intracellular bacteria – Ivan Đikić @idikic.bsky.social et al find Legionella uses phosphoribosyl-ubiquitination via SidE to alter autophagic SNAREs & create a bacteria-containing vacuole unable to fuse with lysosomes
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
June 12, 2025 at 7:34 PM
So proud of this work by #rukmini mukherjee on intersection of Cell Biology and Microbiology
Reposted
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
DMF: Tenure Track Assistant Professor towards Associate Professor in Molecular Microbiology - Site des postulations FBM
wwwfbm.unil.ch
June 10, 2025 at 1:53 PM
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
Reposted
Reposting - please consider applying for a lab head role @wehi-research.bsky.social in Australia. It is a wonderful place to work, in a great country and with lovely colleagues. Clearly I’m biased on all of those counts. Please repost and/or apply!
www.wehi.edu.au/careers/make...
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
Make your future Melbourne | WEHI
Lead the next wave of biomedical discovery
www.wehi.edu.au
June 4, 2025 at 9:22 AM
Reposting - please consider applying for a lab head role @wehi-research.bsky.social in Australia. It is a wonderful place to work, in a great country and with lovely colleagues. Clearly I’m biased on all of those counts. Please repost and/or apply!
Reposted
Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
May 21, 2025 at 5:22 PM
Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇
Reposted
Thrilled to share our work now published on @cp-immunity.bsky.social . Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
Online now: Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (ILC3s) is impaired, compromising gut barrier integrity. Saturated fatty acids intrinsically suppress ILC3 function, reducing their ability to control gut inflammation.
dlvr.it
April 15, 2025 at 1:25 AM
Thrilled to share our work now published on @cp-immunity.bsky.social . Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
Reposted
Delighted to share the latest preprint from the lab led by Janith Seneviratne
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
April 28, 2025 at 11:07 AM
Delighted to share the latest preprint from the lab led by Janith Seneviratne
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
Reposted
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance?
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
March 15, 2025 at 12:12 AM
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance?
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
Absolutely thrilled to read this paper on how MORG1 limits TORC1 signaling! Fascinating insights into autophagy, revealing how WDR83 facilitates basal autophagy. Science at its best!
@terjejohansen.bsky.social
#TORC1 #MORG1 #Autophagy
@terjejohansen.bsky.social
#TORC1 #MORG1 #Autophagy
February 15, 2025 at 8:45 PM
Absolutely thrilled to read this paper on how MORG1 limits TORC1 signaling! Fascinating insights into autophagy, revealing how WDR83 facilitates basal autophagy. Science at its best!
@terjejohansen.bsky.social
#TORC1 #MORG1 #Autophagy
@terjejohansen.bsky.social
#TORC1 #MORG1 #Autophagy
How does TOR kinase signaling affect chromatin state in plants? Our latest review explores the intricate link between TOR & H3K27me3, a key epigenetic mark.
Check it out!
www.researchgate.net/publication/...
Check it out!
www.researchgate.net/publication/...
February 11, 2025 at 5:16 PM
How does TOR kinase signaling affect chromatin state in plants? Our latest review explores the intricate link between TOR & H3K27me3, a key epigenetic mark.
Check it out!
www.researchgate.net/publication/...
Check it out!
www.researchgate.net/publication/...