The Motamedi lab shows that Clr4 is recruited de novo to the ncRNA locus SPNCRNA230 even without Ago1 and pre-existing H3K9me. Sir2 and Clr3 (H3K9 HDACs) also accumulate there, and iterative cycles of H3K9 deacetylation then methylation spread a basal H3K9me state, which RNAi subsequently amplifies.

Absolutely thrilled to read this paper on how MORG1 limits TORC1 signaling! Fascinating insights into autophagy, revealing how WDR83 facilitates basal autophagy. Science at its best!

@terjejohansen.bsky.social
#TORC1 #MORG1 #Autophagy

How does TOR kinase signaling affect chromatin state in plants? Our latest review explores the intricate link between TOR & H3K27me3, a key epigenetic mark.

Check it out!

www.researchgate.net/publication/...