Xiuzhen Chen
@xiuzhenchen.bsky.social
RNA biologist, Cell biologist,
Assistant Professor at NYU
www.xiuzhenchen.com
Assistant Professor at NYU
www.xiuzhenchen.com
Reposted by Xiuzhen Chen
Nature research paper: Targeting FOXM1 condensates reduces breast tumour growth and metastasis
https://go.nature.com/4g7BNC8
https://go.nature.com/4g7BNC8
Targeting FOXM1 condensates reduces breast tumour growth and metastasis - Nature
The transcription factor FOXM1 forms functional condensates, the formation of which can be targeted with a specific peptide to suppress breast cancer growth and metastasis.
go.nature.com
January 16, 2025 at 8:58 PM
Nature research paper: Targeting FOXM1 condensates reduces breast tumour growth and metastasis
https://go.nature.com/4g7BNC8
https://go.nature.com/4g7BNC8
Reposted by Xiuzhen Chen
Y'all, there is now a Paperpile extension for Word. This should be useful for a lot of us who have heavy Word users and heavy Google Doc users on the same writing teams. paperpile.com/word-plugin/
Paperpile for Word - Paperpile
paperpile.com
January 11, 2025 at 2:51 PM
Y'all, there is now a Paperpile extension for Word. This should be useful for a lot of us who have heavy Word users and heavy Google Doc users on the same writing teams. paperpile.com/word-plugin/
Reposted by Xiuzhen Chen
1/ In March 2023, I received a lumbar puncture. This was key to receiving my chronic inflammatory demyelinating polyneuropathy #cidp diagnosis. This 🧵 is on my experience with identifying and treating #autoimmunedisease. I'll also be sharing some 🧵s I posted previously on the Other Place.
December 17, 2024 at 3:29 AM
1/ In March 2023, I received a lumbar puncture. This was key to receiving my chronic inflammatory demyelinating polyneuropathy #cidp diagnosis. This 🧵 is on my experience with identifying and treating #autoimmunedisease. I'll also be sharing some 🧵s I posted previously on the Other Place.
An interesting read on the alternative history of GLP1 www.nytimes.com/2024/12/25/o...
Opinion | Pfizer Stopped Us From Getting Ozempic Decades Ago (Gift Article)
Researchers identified one key breakthrough for GLP-1 drugs in the 1980s, but Pfizer walked away.
www.nytimes.com
December 26, 2024 at 5:14 AM
An interesting read on the alternative history of GLP1 www.nytimes.com/2024/12/25/o...
Reposted by Xiuzhen Chen
Cellular RNAs directly regulate the activity of an antiviral immune signaling complex
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org @nandangokhale.bsky.social @ramlabuw.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org @nandangokhale.bsky.social @ramlabuw.bsky.social
December 19, 2024 at 8:03 PM
Cellular RNAs directly regulate the activity of an antiviral immune signaling complex
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org @nandangokhale.bsky.social @ramlabuw.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org @nandangokhale.bsky.social @ramlabuw.bsky.social
Reposted by Xiuzhen Chen
The life of each of us began when a sperm and an egg came together. But what happens at a molecular level?
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
December 13, 2024 at 7:43 PM
The life of each of us began when a sperm and an egg came together. But what happens at a molecular level?
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
RNA looping!
First paper of our lab today @natureportfolio.bsky.social by Nussi!
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
December 7, 2024 at 5:22 AM
RNA looping!
Reposted by Xiuzhen Chen
We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer 🧬💊!
Preprint led by Disha
#chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...
Preprint led by Disha
#chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...
Going nuclear: Improved antisense oligonucleotide activity through conjugation with a nuclear importer
Antisense oligonucleotides (ASOs) are a promising class of therapeutics designed to modulate gene expression. Both key mechanisms of action for ASOs operate in the nucleus: splice-switching ASOs modif...
chemrxiv.org
December 5, 2024 at 9:41 AM
We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer 🧬💊!
Preprint led by Disha
#chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...
Preprint led by Disha
#chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...
Reposted by Xiuzhen Chen
We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs.
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
November 30, 2024 at 8:48 PM
We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs.
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
Reposted by Xiuzhen Chen
We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stereochemistry in the disorder–order continuum of protein interactions - Nature
Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.
www.nature.com
November 27, 2024 at 8:31 PM
We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Xiuzhen Chen
Reposted by Xiuzhen Chen
Nifty, innovative approach
RNA programmable cell targeting and manipulation with CellREADR https://www.biorxiv.org/content/10.1101/2024.11.26.625312v1
RNA programmable cell targeting and manipulation with CellREADR https://www.biorxiv.org/content/10.1101/2024.11.26.625312v1
Methods that provide specific, easy, and scalable experimental access to animal cell types and cell
www.biorxiv.org
November 27, 2024 at 3:33 AM
Nifty, innovative approach
Came to a new understanding of 'colocalization' since starting STED microcopy: there is no colocalizaiton, objects cannot occupy the same physical space!
November 27, 2024 at 3:31 AM
Came to a new understanding of 'colocalization' since starting STED microcopy: there is no colocalizaiton, objects cannot occupy the same physical space!
Reposted by Xiuzhen Chen
How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...
November 21, 2024 at 2:56 PM
How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...
Reposted by Xiuzhen Chen
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....
www.science.org
November 22, 2024 at 6:09 PM
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Xiuzhen Chen
A report made counterintuitive claims that PRC2 binds
→ more RNA than PTBP1 & hnRNPU
→ RNAs that do not exist in the cell
We found a simple explanation: the authors ignore most RNA in the sample, leading to inflated background & misleading conclusions.
www.biorxiv.org/content/10.1...
→ more RNA than PTBP1 & hnRNPU
→ RNAs that do not exist in the cell
We found a simple explanation: the authors ignore most RNA in the sample, leading to inflated background & misleading conclusions.
www.biorxiv.org/content/10.1...
Failing to account for RNA quantity inflates background and leads to the misleading appearance that PRC2 and GFP bind to RNA in vivo
We recently published biochemical and quantitative evidence that challenges the widespread claims that PRC2 binds directly to many RNAs in vivo . A recent preprint performs a re-analysis of some of ou...
www.biorxiv.org
November 18, 2024 at 1:11 AM
A report made counterintuitive claims that PRC2 binds
→ more RNA than PTBP1 & hnRNPU
→ RNAs that do not exist in the cell
We found a simple explanation: the authors ignore most RNA in the sample, leading to inflated background & misleading conclusions.
www.biorxiv.org/content/10.1...
→ more RNA than PTBP1 & hnRNPU
→ RNAs that do not exist in the cell
We found a simple explanation: the authors ignore most RNA in the sample, leading to inflated background & misleading conclusions.
www.biorxiv.org/content/10.1...
Reposted by Xiuzhen Chen
Missed the woodpecker sweep by 1 at Green-Wood Cemetery this morning. Tallied Yellow-bellied Sapsucker, Red-headed Woodpecker, Red-bellied Woodpecker, Downy Woodpecker & Northern Flicker. Oddly, Hairy Woodpecker is rare here despite breeding at nearby Prospect Park #birds #birdsNYC
November 15, 2024 at 8:28 PM
Reposted by Xiuzhen Chen
REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers.
New preprint from a collaboration led by Grace Bower and Evgeny Kvon.
doi.org/10.1101/2024...
New preprint from a collaboration led by Grace Bower and Evgeny Kvon.
doi.org/10.1101/2024...
May 27, 2024 at 4:26 PM
REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers.
New preprint from a collaboration led by Grace Bower and Evgeny Kvon.
doi.org/10.1101/2024...
New preprint from a collaboration led by Grace Bower and Evgeny Kvon.
doi.org/10.1101/2024...
Reposted by Xiuzhen Chen
I've been meaning to write a lengthy thread about our experiences with DNA methylation editing in mouse ESCs if that would be useful (or interesting?) for a niche audience here. tl;dr: it was frustrating but we learned a lot, and it ended with our shiny new pub (1/17) www.nature.com/articles/s41...
November 12, 2024 at 9:38 PM
I've been meaning to write a lengthy thread about our experiences with DNA methylation editing in mouse ESCs if that would be useful (or interesting?) for a niche audience here. tl;dr: it was frustrating but we learned a lot, and it ended with our shiny new pub (1/17) www.nature.com/articles/s41...
A beautiful example of mRNA-mRNA interaction demonstrating architectural role for RNP granule formation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
November 12, 2024 at 11:48 PM
A beautiful example of mRNA-mRNA interaction demonstrating architectural role for RNP granule formation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Xiuzhen Chen
Happy to announce our new preprint "A green lifetime biosensor for calcium that remains bright over its full dynamic range" which is now available on bioRxiv:
www.biorxiv.org/content/10.1...
Why yet another biosensor for Ca2+? Here's a thread 🧵
www.biorxiv.org/content/10.1...
Why yet another biosensor for Ca2+? Here's a thread 🧵
A green lifetime biosensor for calcium that remains bright over its full dynamic range
Fluorescent biosensors toggle between two states and for the vast majority of biosensors one state is bright and the other state is dim. As a consequence, there is a substantial difference in the sign...
www.biorxiv.org
November 8, 2024 at 10:40 AM
Happy to announce our new preprint "A green lifetime biosensor for calcium that remains bright over its full dynamic range" which is now available on bioRxiv:
www.biorxiv.org/content/10.1...
Why yet another biosensor for Ca2+? Here's a thread 🧵
www.biorxiv.org/content/10.1...
Why yet another biosensor for Ca2+? Here's a thread 🧵