@xiuqichen.bsky.social
Postdoctoral researcher at TU Delft.
Trying to sequence proteins with #nanopore
Trying to sequence proteins with #nanopore
Reposted
I recently wrote a 1page "Highlight" article for the Swiss Journal @chimiajournal.bsky.social about the #single-molecule perspective on biomolecular dynamics and experiments:
Beyond 3D Structures: New Ways to Study Biomolecular Gymnastics
www.chimia.ch/chimia/artic...
Beyond 3D Structures: New Ways to Study Biomolecular Gymnastics
www.chimia.ch/chimia/artic...
November 10, 2025 at 5:13 PM
I recently wrote a 1page "Highlight" article for the Swiss Journal @chimiajournal.bsky.social about the #single-molecule perspective on biomolecular dynamics and experiments:
Beyond 3D Structures: New Ways to Study Biomolecular Gymnastics
www.chimia.ch/chimia/artic...
Beyond 3D Structures: New Ways to Study Biomolecular Gymnastics
www.chimia.ch/chimia/artic...
Reposted
#paperalert
Very happy to share our new paper in Chemical Science @chemicalscience.rsc.org
Great work by Yuri Damen (now at BioChem in Oss), @joresfu.bsky.social, Judith Firet, and Han Zuilhof @w-u-r.bsky.social
Especially for those of you who use strained alkynes in their click reactions!
Very happy to share our new paper in Chemical Science @chemicalscience.rsc.org
Great work by Yuri Damen (now at BioChem in Oss), @joresfu.bsky.social, Judith Firet, and Han Zuilhof @w-u-r.bsky.social
Especially for those of you who use strained alkynes in their click reactions!
Temperature–dependent reaction rates of quinone-alkene cycloaddition reveal that only entropy determines the rate of SPOCQ reactions
Second-order rate constants and thermodynamic activation parameters for the strain-promoted oxidation-controlled quinone (SPOCQ) click reaction of an ortho-quinone with various trans-cyclooctene and c...
pubs.rsc.org
November 10, 2025 at 12:19 PM
#paperalert
Very happy to share our new paper in Chemical Science @chemicalscience.rsc.org
Great work by Yuri Damen (now at BioChem in Oss), @joresfu.bsky.social, Judith Firet, and Han Zuilhof @w-u-r.bsky.social
Especially for those of you who use strained alkynes in their click reactions!
Very happy to share our new paper in Chemical Science @chemicalscience.rsc.org
Great work by Yuri Damen (now at BioChem in Oss), @joresfu.bsky.social, Judith Firet, and Han Zuilhof @w-u-r.bsky.social
Especially for those of you who use strained alkynes in their click reactions!
Reposted
I am thrilled with the news that our ERC Synergy proposal GeneMotors was granted!!
This prestigious grant allows Leonid Mirny (MIT), Wendy Bickmore (Edinburgh), Benjamin Rowland (NKI) and me to study the DNA-looping SMC motors proteins that control our chromosomes in the next 6 years
This prestigious grant allows Leonid Mirny (MIT), Wendy Bickmore (Edinburgh), Benjamin Rowland (NKI) and me to study the DNA-looping SMC motors proteins that control our chromosomes in the next 6 years
📣 Meet the new ERC Synergy Grant awardees!
Sixty-six research teams have been selected for funding, bringing together 239 scientists. Congratulations to all!
➡️ buff.ly/PSn3bi9
#EUfunded #HorizonEurope #ERCSyG
Sixty-six research teams have been selected for funding, bringing together 239 scientists. Congratulations to all!
➡️ buff.ly/PSn3bi9
#EUfunded #HorizonEurope #ERCSyG
November 6, 2025 at 11:57 AM
I am thrilled with the news that our ERC Synergy proposal GeneMotors was granted!!
This prestigious grant allows Leonid Mirny (MIT), Wendy Bickmore (Edinburgh), Benjamin Rowland (NKI) and me to study the DNA-looping SMC motors proteins that control our chromosomes in the next 6 years
This prestigious grant allows Leonid Mirny (MIT), Wendy Bickmore (Edinburgh), Benjamin Rowland (NKI) and me to study the DNA-looping SMC motors proteins that control our chromosomes in the next 6 years
Reposted
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
🤯
Talk about an in-flight meal.
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
October 28, 2025 at 12:15 PM
🤯
Results from Nature’s 2025 global survey of more than 3,700 doctoral students:
Supervisors who make a conscious effort to support and mentor their PhD candidates have more-satisfied students
www.nature.com/articles/d41...
Supervisors who make a conscious effort to support and mentor their PhD candidates have more-satisfied students
www.nature.com/articles/d41...
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
www.nature.com
October 27, 2025 at 12:53 PM
Results from Nature’s 2025 global survey of more than 3,700 doctoral students:
Supervisors who make a conscious effort to support and mentor their PhD candidates have more-satisfied students
www.nature.com/articles/d41...
Supervisors who make a conscious effort to support and mentor their PhD candidates have more-satisfied students
www.nature.com/articles/d41...
Reposted
Check out our paper from @christ3na.bsky.social in G+D. DIO3, which degrades thyroid hormone/TH, is expressed in progenitors and turns off in neurons. As the progenitor:neuron ratio decreases, DIO3 decreases and TH increases, triggering photoreceptor generation.
genesdev.cshlp.org/content/earl...
genesdev.cshlp.org/content/earl...
DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
October 21, 2025 at 1:10 PM
Check out our paper from @christ3na.bsky.social in G+D. DIO3, which degrades thyroid hormone/TH, is expressed in progenitors and turns off in neurons. As the progenitor:neuron ratio decreases, DIO3 decreases and TH increases, triggering photoreceptor generation.
genesdev.cshlp.org/content/earl...
genesdev.cshlp.org/content/earl...
Reposted
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
October 9, 2025 at 2:43 PM
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
Reposted
Next week GIIN webinar will feature @fmattiroli.bsky.social and Marco Tigano. Join us on Tuesday, October 7th at 5 PM Rome / 11 AM NYC via zoom: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Register here to become part of our community: docs.google.com/forms/d/e/1F...
September 30, 2025 at 5:24 PM
Next week GIIN webinar will feature @fmattiroli.bsky.social and Marco Tigano. Join us on Tuesday, October 7th at 5 PM Rome / 11 AM NYC via zoom: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Reposted
Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.
Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds
September 28, 2025 at 9:43 AM
Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.
Reposted
Now published! Phosphorylation patterns modulate transient secondary structures of the intrinsically disordered CTD of RNA polymerase II www.sciencedirect.com/science/arti...
Phosphorylation modulates secondary structure of intrinsically disorder regions in RNA polymerase II
The intrinsically disordered C-terminal domain (CTD) of RNA polymerase II contains tandem repeats with the consensus sequence YSPTSPS and coordinates …
www.sciencedirect.com
May 27, 2025 at 4:16 PM
Now published! Phosphorylation patterns modulate transient secondary structures of the intrinsically disordered CTD of RNA polymerase II www.sciencedirect.com/science/arti...
Reposted
ICYMI: New online: The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
Nature Structural & Molecular Biology, Published online: 19 September 2025; doi:10.1038/s41594-025-01676-5By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding interdomain misfolding.
go.nature.com
September 20, 2025 at 10:13 AM
ICYMI: New online: The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
Reposted
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 2:59 PM
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
Reposted
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
Home | Research Group Schmid | University of Basel
schmid.chemie.unibas.ch
July 31, 2025 at 2:34 PM
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
Open position in @ceesdekker.bsky.social lab! Apply if you are interested in nanopore sequencing!
Applicants wanted 3:
Open position for Postdoc Researcher for Single-molecule Protein Sequencing with Origami Nanopores
careers.tudelft.nl/job/Delft-Po...
Open position for Postdoc Researcher for Single-molecule Protein Sequencing with Origami Nanopores
careers.tudelft.nl/job/Delft-Po...
August 22, 2025 at 9:03 AM
Open position in @ceesdekker.bsky.social lab! Apply if you are interested in nanopore sequencing!
Come join us!
WORK!
I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:
- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-us/
RT=👍
I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:
- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-us/
RT=👍
August 13, 2025 at 3:28 PM
Come join us!
Reposted
Building a synthetic cell together - nice common perspective written by many leading scientists who gathered in Shenzhen China for the inaugural ‘SynCell Global Summit’.
Check it out in Nature Comm: www.nature.com/articles/s41...
Check it out in Nature Comm: www.nature.com/articles/s41...
August 13, 2025 at 7:19 AM
Building a synthetic cell together - nice common perspective written by many leading scientists who gathered in Shenzhen China for the inaugural ‘SynCell Global Summit’.
Check it out in Nature Comm: www.nature.com/articles/s41...
Check it out in Nature Comm: www.nature.com/articles/s41...
🏖️Back from an amazing vacation in 🌴Sanya🐟. Refreshed and recharged, ready to dive back to research!
August 12, 2025 at 8:48 AM
🏖️Back from an amazing vacation in 🌴Sanya🐟. Refreshed and recharged, ready to dive back to research!
Reposted
Telomeres stall DNA loop extrusion by condensin
Telomeres stall DNA loop extrusion by condensin
Analikwu et al. show that dense linear arrays of the telomeric protein Rap1 on DNA block DNA loop extrusion by condensin. Rap1-induced stalling depends on array length and protein density and leads to a local chromatin decompaction during anaphase, revealing how protein arrays can regulate SMC-driven genome organization.
dlvr.it
July 2, 2025 at 7:50 PM
Telomeres stall DNA loop extrusion by condensin
🤔 How do proteins fold while they're still being made? As the main project in my PhD, I developed "Arrest Peptide Profiling" to record proteins folding with as they emerge from ribosomes in living cells 🦠 - with single codon resolution! @natcomms.nature.com 🧵 1/6
#ProteinFolding
#ProteinFolding
July 24, 2025 at 8:34 PM
🤔 How do proteins fold while they're still being made? As the main project in my PhD, I developed "Arrest Peptide Profiling" to record proteins folding with as they emerge from ribosomes in living cells 🦠 - with single codon resolution! @natcomms.nature.com 🧵 1/6
#ProteinFolding
#ProteinFolding
Really appreciate your support on this project @ceesdekker.bsky.social ! Excited to make new discoveries!
Congrats to our #CDlab postdoc @xiuqichen.bsky.social for winning an NWO VENI grant for his research on histone epigenetics with nanopore sequencing!
Congrats to all other winners as well www.nwo.nl/en/researchp... inclusing ex-CDlab member @thedneva.bsky.social, now PI at Utrecht
Congrats to all other winners as well www.nwo.nl/en/researchp... inclusing ex-CDlab member @thedneva.bsky.social, now PI at Utrecht
July 21, 2025 at 8:55 PM
Really appreciate your support on this project @ceesdekker.bsky.social ! Excited to make new discoveries!
Reposted
New online: Q&A with Francesca Mattiroli
Q&A with Francesca Mattiroli
Nature Structural & Molecular Biology, Published online: 21 July 2025; doi:10.1038/s41594-025-01620-7Francesca Mattiroli leads a research group at the Hubrecht Institute in Utrecht in the Netherlands, delving into the dynamics of chromatin during DNA synthesis. Here we ask her about her research ethos, experience and interests.
go.nature.com
July 21, 2025 at 12:59 PM
New online: Q&A with Francesca Mattiroli
Reposted
Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...
July 10, 2025 at 6:10 PM
Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...
Reposted
Here's a new very exciting paper from our #CDlab: www.cell.com/cell-reports...
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
June 25, 2025 at 6:59 AM
Here's a new very exciting paper from our #CDlab: www.cell.com/cell-reports...
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
Reposted
The energy landscape of a single disordered protein (tau) and the impact of PTMs is resolved. An important step to understanding the function and dysfunction of disordered proteins from their conformational ensemble. Not yet peer reviewed. www.biorxiv.org/content/10.1...
Direct observation of conformational dynamics of intrinsically disordered proteins at the single-molecule level
Intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) are integral to many biological processes, including neurotransmitter regulation, microtubule regulat...
www.biorxiv.org
May 28, 2025 at 6:56 PM
The energy landscape of a single disordered protein (tau) and the impact of PTMs is resolved. An important step to understanding the function and dysfunction of disordered proteins from their conformational ensemble. Not yet peer reviewed. www.biorxiv.org/content/10.1...