Wen Ding
@wyd20.bsky.social
Paediatric nephrologist in Bristol, progressing kidney gene 🧬therapy, mum of boys, loves ballet/ gymnastics/ dance
Kidney disease affects 1 in 10 of the UK population and has largely been overlooked in the UK 10 Year Health Plan. Please sign this petition by Thursday 9th October to emphasise the importance of a national strategy for kidney disease. www.ukkidney.org/prime-minist...
Add Your Name: Call on the Prime Minister to Tackle Kidney Disease
Kidney disease affects more than 7 million people in the UK, yet was largely overlooked in the Government’s new 10-year health plan for the NHS. Without action, it will place an unsustainable burden o...
www.ukkidney.org
October 3, 2025 at 7:21 AM
Kidney disease affects 1 in 10 of the UK population and has largely been overlooked in the UK 10 Year Health Plan. Please sign this petition by Thursday 9th October to emphasise the importance of a national strategy for kidney disease. www.ukkidney.org/prime-minist...
Great talk about the Hidden initiative from Kate Bramham and detecting CKD in the community in London. Absolutely inspirational @kidneyresearchuk.org
September 25, 2025 at 1:55 PM
Great talk about the Hidden initiative from Kate Bramham and detecting CKD in the community in London. Absolutely inspirational @kidneyresearchuk.org
Having a fantastic time listening to all the progress in kidney research in the UK @kidneyresearchuk.org driving discoveries. Fantastic talk @willkidney.bsky.social about how large well designed trials have changed our practice in nephrology
September 25, 2025 at 11:16 AM
Having a fantastic time listening to all the progress in kidney research in the UK @kidneyresearchuk.org driving discoveries. Fantastic talk @willkidney.bsky.social about how large well designed trials have changed our practice in nephrology
Reposted by Wen Ding
Your kidneys are working hard for you every day, every hour. Return the favor with these small habits that lead to lifelong health. 💬 Which of these do you already do? Which one could you start this week? #KidneyFacts #HealthyKidneys #NephrologyTips #BIGKiDsStudy #KidneyHealthAwareness #sampsonlab
July 24, 2025 at 5:02 PM
Your kidneys are working hard for you every day, every hour. Return the favor with these small habits that lead to lifelong health. 💬 Which of these do you already do? Which one could you start this week? #KidneyFacts #HealthyKidneys #NephrologyTips #BIGKiDsStudy #KidneyHealthAwareness #sampsonlab
Reposted by Wen Ding
Sibeprenlimab inches closer to approval
www.hcplive.com/view/fda-acc... feat @brendonneuen.bsky.social
Phase 3 RCT next week at #ERA25 (& some journal?)
www.hcplive.com/view/fda-acc... feat @brendonneuen.bsky.social
Phase 3 RCT next week at #ERA25 (& some journal?)
FDA Accepts, Grants Priority Review to Sibeprenlimab BLA for IgA Nephropathy
With the priority review acceptance of the Biologics License Application, the FDA has assigned a PDUFA target action date of November 28, 2025.
www.hcplive.com
May 29, 2025 at 10:28 AM
Sibeprenlimab inches closer to approval
www.hcplive.com/view/fda-acc... feat @brendonneuen.bsky.social
Phase 3 RCT next week at #ERA25 (& some journal?)
www.hcplive.com/view/fda-acc... feat @brendonneuen.bsky.social
Phase 3 RCT next week at #ERA25 (& some journal?)
Reposted by Wen Ding
Sparsentan for FSGS?? It's alive....
ir.travere.com/press-releas...
ir.travere.com/press-releas...
Travere Therapeutics Announces FDA Acceptance of sNDA for FILSPARI® (sparsentan) in FSGS
PDUFA target action date of January 13, 2026 If approved, FILSPARI would be the first and only FDA-approved treatment for FSGS, a rare kidney condition and a leading cause of kidney failure Travere Th...
ir.travere.com
May 20, 2025 at 5:53 PM
Sparsentan for FSGS?? It's alive....
ir.travere.com/press-releas...
ir.travere.com/press-releas...
Reposted by Wen Ding
It’s #WorldImmunizationWeek
Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.
A reminder of what is #HumanlyPossible. Science saves lives.
#VaccinesWork
bit.ly/wiw2025
Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.
A reminder of what is #HumanlyPossible. Science saves lives.
#VaccinesWork
bit.ly/wiw2025
April 24, 2025 at 5:50 AM
It’s #WorldImmunizationWeek
Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.
A reminder of what is #HumanlyPossible. Science saves lives.
#VaccinesWork
bit.ly/wiw2025
Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.
A reminder of what is #HumanlyPossible. Science saves lives.
#VaccinesWork
bit.ly/wiw2025
Reposted by Wen Ding
So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reprogramming site-specific retrotransposon activity to new DNA sites - Nature
A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...
www.nature.com
April 9, 2025 at 5:10 PM
So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interesting!
1️⃣ Now this is amazing! 🎉 My PhD student Gráinne Butler led a groundbreaking study using Epic EMR data to detect genetic kidney disease before symptoms appeared!
April 2, 2025 at 7:34 AM
Interesting!
Reposted by Wen Ding
Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...
February 23, 2025 at 4:30 PM
Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...
What an exciting time to be a nephrologist. Yet another really promising therapy for IgA. Decreases proteinuria significantly, likely will be spoilt for choice soon but how will be choose the right meds for the right patient?
Among patients with IgA nephropathy, treatment with iptacopan, which inhibits the alternative complement pathway, resulted in a significant reduction in proteinuria as compared with placebo. Full APPLAUSE-IgAN trial results and Research Summary: nej.md/3UmrOkh
#MedSky #Nephrology
#MedSky #Nephrology
February 10, 2025 at 10:32 PM
What an exciting time to be a nephrologist. Yet another really promising therapy for IgA. Decreases proteinuria significantly, likely will be spoilt for choice soon but how will be choose the right meds for the right patient?
Not apologising for posting this paper twice as really excited about ProtGPS. Logical next step in protein modelling after the success of alphafold2. Not only will help predict pathogenicity of genetic variants but can incorporate elements for subcellular compartmentalisation in gene therapy design
Researchers in the Young Lab at Whitehead Institute and the Barzilay Lab in MIT's CSAIL have developed ProtGPS, a machine learning model that predicts which cellular compartments a protein will reside in.
This tool could inform the development of more effective therapies. shorturl.at/5KdVE
This tool could inform the development of more effective therapies. shorturl.at/5KdVE
February 10, 2025 at 9:12 AM
Not apologising for posting this paper twice as really excited about ProtGPS. Logical next step in protein modelling after the success of alphafold2. Not only will help predict pathogenicity of genetic variants but can incorporate elements for subcellular compartmentalisation in gene therapy design
Reposted by Wen Ding
🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 8, 2025 at 11:39 PM
🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social
Reposted by Wen Ding
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
February 8, 2025 at 1:45 PM
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
No idea how the academic world would cope without pubmed
If they pull PubMed, do we have a plan B? #academicsky?
January 29, 2025 at 3:58 PM
No idea how the academic world would cope without pubmed
Fascinating read: history of ISKDC. Our current management of nephrotic syndrome not very different from this first nephrotic syndrome RCT. (Other than AZA which was shown not to be useful in iNS)
media.springernature.com/full/springe...
media.springernature.com/full/springe...
January 21, 2025 at 2:49 PM
Fascinating read: history of ISKDC. Our current management of nephrotic syndrome not very different from this first nephrotic syndrome RCT. (Other than AZA which was shown not to be useful in iNS)
media.springernature.com/full/springe...
media.springernature.com/full/springe...
Reposted by Wen Ding
Why we need to start monitoring #BP before adulthood for #cardiovascular #prevention #CvPrev
Adolescent #BloodPressure & Early Age #Stroke in @nejm.org Evidence
evidence.nejm.org/doi/full/10....
Adolescent #BloodPressure & Early Age #Stroke in @nejm.org Evidence
evidence.nejm.org/doi/full/10....
Adolescent Blood Pressure and Early Age Stroke
Underdiagnosis of relevant risk factors has contributed to the increasing stroke incidence
in young adults. Blood pressure cut-off values for adolescents are neither sex specific
nor based on cardi...
evidence.nejm.org
January 8, 2025 at 11:48 PM
Why we need to start monitoring #BP before adulthood for #cardiovascular #prevention #CvPrev
Adolescent #BloodPressure & Early Age #Stroke in @nejm.org Evidence
evidence.nejm.org/doi/full/10....
Adolescent #BloodPressure & Early Age #Stroke in @nejm.org Evidence
evidence.nejm.org/doi/full/10....
Reposted by Wen Ding
This 13-year-old received 3 antivirals and plasma exchange for #H5N1. In over a decade as an ID doctor, I've never used such measures for #Influenza— not even during H1N1.
#H5N1 is alarming; we must boost surveillance, testing, prevention, and education to control it.
www.nejm.org/doi/full/10....
#H5N1 is alarming; we must boost surveillance, testing, prevention, and education to control it.
www.nejm.org/doi/full/10....
Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection | NEJM
Influenza A(H5N1) viruses are an emerging zoonotic threat and have spread widely throughout birds in North America. Recently, influenza A(H5N1) infection led to serious illness in a teenager in Canada.
www.nejm.org
January 1, 2025 at 4:14 AM
This 13-year-old received 3 antivirals and plasma exchange for #H5N1. In over a decade as an ID doctor, I've never used such measures for #Influenza— not even during H1N1.
#H5N1 is alarming; we must boost surveillance, testing, prevention, and education to control it.
www.nejm.org/doi/full/10....
#H5N1 is alarming; we must boost surveillance, testing, prevention, and education to control it.
www.nejm.org/doi/full/10....
Chronic Kidney Disease is rising in prevalence--I have signed this petition for the World Health Organisation to recognise kidney health as a priority, do consider signing to prioritise preventing premature death from kidney disease
#nephsky #medsky #pedsky
#nephsky #medsky #pedsky
Guatemala is leading a historic effort at the @who.int to recognize kidney disease as a global health priority. This will drive global strategies to improve care and reduce the burden of kidney disease.
Sign the petition: ow.ly/a7J350Tfpjp #KidneyHealthMatters #UHCDay
TY @momenabbasi.bsky.social
Sign the petition: ow.ly/a7J350Tfpjp #KidneyHealthMatters #UHCDay
TY @momenabbasi.bsky.social
December 28, 2024 at 5:07 PM
😱
Have never dared to use any of these but surely you would check through carefully if you did! Worrying that these passed peer review, editorial boards etc 🤔
Have never dared to use any of these but surely you would check through carefully if you did! Worrying that these passed peer review, editorial boards etc 🤔
THREAD
This Is The Story Of The The Pernicious Rise of AI-Generated Papers and their Online Impact
An Incomplete History Told In The Voice of Documentarian Adam Curtis
1/31
This Is The Story Of The The Pernicious Rise of AI-Generated Papers and their Online Impact
An Incomplete History Told In The Voice of Documentarian Adam Curtis
1/31
December 20, 2024 at 8:04 PM
😱
Have never dared to use any of these but surely you would check through carefully if you did! Worrying that these passed peer review, editorial boards etc 🤔
Have never dared to use any of these but surely you would check through carefully if you did! Worrying that these passed peer review, editorial boards etc 🤔
Reposted by Wen Ding
#PedSky appreciation post: Dr. Weyand’s posts are why I now check ferritin/CRP for every anemia screen (w CBC + retic)! I’ve caught so many w single digit ferritin levels even if Hgb is “normal” 😱 It’s also an issue in “picky eaters” even if they’re not menstruating
Just your regular reminder that iron deficiency affects ~40% of 12-21 yo females and still no one cares.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Prevalence of Iron Deficiency and Iron-Deficiency Anemia in US Females Aged 12-21 Years, 2003-2020
This study examines prevalence of iron deficiency among females aged 12 to 21 years to inform future screening strategies for iron deficiency and iron-deficiency anemia.
jamanetwork.com
December 16, 2024 at 2:33 PM
#PedSky appreciation post: Dr. Weyand’s posts are why I now check ferritin/CRP for every anemia screen (w CBC + retic)! I’ve caught so many w single digit ferritin levels even if Hgb is “normal” 😱 It’s also an issue in “picky eaters” even if they’re not menstruating
Reposted by Wen Ding
A great keynote by Moin Saleem from Bristol UK, followed by a terrific discussion @rfsgsinitiative.bsky.social @genetickidneydoc.bsky.social @opeyemiolabisi.bsky.social @gbadegesinlab.bsky.social
December 9, 2024 at 6:57 PM
A great keynote by Moin Saleem from Bristol UK, followed by a terrific discussion @rfsgsinitiative.bsky.social @genetickidneydoc.bsky.social @opeyemiolabisi.bsky.social @gbadegesinlab.bsky.social
Reposted by Wen Ding
Some papers are very difficult to read but that doesn’t necessarily mean they're deeper than other papers. Authors must work very hard to make their story easy to read and understand by others. Or as Stephen King says: "the shorter the book, the less bullshit".
December 8, 2024 at 5:54 PM
Some papers are very difficult to read but that doesn’t necessarily mean they're deeper than other papers. Authors must work very hard to make their story easy to read and understand by others. Or as Stephen King says: "the shorter the book, the less bullshit".
Reposted by Wen Ding
Hello and thank you to all who have followed us so far! Look out for some of our posts coming to #Bluesky soon 😍
In the meantime, if you are living with #ChronicKidneyDisease and need support from us, please visit our website: kidneycareuk.org/get-support/
#KidneyCareUK #CKD #CKDSupport #Dialysis
In the meantime, if you are living with #ChronicKidneyDisease and need support from us, please visit our website: kidneycareuk.org/get-support/
#KidneyCareUK #CKD #CKDSupport #Dialysis
Help and support
Find out about our free patient services for kidney patients and their families: financial grants, advocacy and expert advice and specialist renal counselling sessions.
kidneycareuk.org
November 29, 2024 at 4:11 PM
Hello and thank you to all who have followed us so far! Look out for some of our posts coming to #Bluesky soon 😍
In the meantime, if you are living with #ChronicKidneyDisease and need support from us, please visit our website: kidneycareuk.org/get-support/
#KidneyCareUK #CKD #CKDSupport #Dialysis
In the meantime, if you are living with #ChronicKidneyDisease and need support from us, please visit our website: kidneycareuk.org/get-support/
#KidneyCareUK #CKD #CKDSupport #Dialysis
Reposted by Wen Ding
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
November 25, 2024 at 12:38 PM
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/