Pinned
Chris Fell
@cfell.bsky.social
· Apr 9
Reprogramming site-specific retrotransposon activity to new DNA sites - Nature
A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...
www.nature.com
So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Chris Fell
If you like transposons...
If you you love genome editing...
Or if you just like random bird animations,
we have the paper for you!
We (@kedmonds.bsky.social et al) are happy to share our work turning a songbird retrotransposon into a genome editing tool. 🐣 (1/n)
If you you love genome editing...
Or if you just like random bird animations,
we have the paper for you!
We (@kedmonds.bsky.social et al) are happy to share our work turning a songbird retrotransposon into a genome editing tool. 🐣 (1/n)
July 3, 2025 at 3:21 AM
If you like transposons...
If you you love genome editing...
Or if you just like random bird animations,
we have the paper for you!
We (@kedmonds.bsky.social et al) are happy to share our work turning a songbird retrotransposon into a genome editing tool. 🐣 (1/n)
If you you love genome editing...
Or if you just like random bird animations,
we have the paper for you!
We (@kedmonds.bsky.social et al) are happy to share our work turning a songbird retrotransposon into a genome editing tool. 🐣 (1/n)
Reposted by Chris Fell
STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions. Plasmids here www.addgene.org/browse/artic...
April 10, 2025 at 8:06 PM
STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions. Plasmids here www.addgene.org/browse/artic...
So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reprogramming site-specific retrotransposon activity to new DNA sites - Nature
A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...
www.nature.com
April 9, 2025 at 5:10 PM
So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🚨 Interested in precise, multi-kilobase scale insertions into the genome?
Check out our detailed protocol describing PASTE, out in Nature Protocols @natureportfolio.bsky.social
⬇️
www.nature.com/articles/s41...
Check out our detailed protocol describing PASTE, out in Nature Protocols @natureportfolio.bsky.social
⬇️
www.nature.com/articles/s41...
Precise kilobase-scale genomic insertions in mammalian cells using PASTE - Nature Protocols
Programmable addition via site-specific targeting elements (PASTE) combines the specificity, efficiency and cargo size benefits of site-specific integrases with the programmability of prime editing fo...
www.nature.com
December 16, 2024 at 3:17 PM
🚨 Interested in precise, multi-kilobase scale insertions into the genome?
Check out our detailed protocol describing PASTE, out in Nature Protocols @natureportfolio.bsky.social
⬇️
www.nature.com/articles/s41...
Check out our detailed protocol describing PASTE, out in Nature Protocols @natureportfolio.bsky.social
⬇️
www.nature.com/articles/s41...