Worboys Lab
@worboyslab.bsky.social
Pinned
Worboys Lab
@worboyslab.bsky.social
· May 14
Inhibitory TIGIT signalling is dependent on T cell receptor activation
TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...
www.biorxiv.org
Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.
#ImmunoSky
www.biorxiv.org/content/10.1...
#ImmunoSky
www.biorxiv.org/content/10.1...
It was fantastic to contribute to the latest research from @owenlabuob.bsky.social now out at @natcomms.nature.com. This is a great initiative and could be an important resource for the SMLM community.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nano-org, a functional resource for single-molecule localisation microscopy data - Nature Communications
An open-access resource, nano-org, enables researchers to explore and compare the nanoscale 2 organisation of proteins imaged using single-molecule localisation microscopy, advancing insights 3 into cell biology, disease, and drug response.
www.nature.com
October 2, 2025 at 4:02 PM
It was fantastic to contribute to the latest research from @owenlabuob.bsky.social now out at @natcomms.nature.com. This is a great initiative and could be an important resource for the SMLM community.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Worboys Lab
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix):Oxford Road
Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:
www.jobs.manchester.ac.uk
September 12, 2025 at 3:47 PM
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Worboys Lab
Our new paper is out! Khodor Hazime led the brilliant work at the @dandavis101.bsky.social lab that shows *how* engagers that bring NK cell receptors together at the immune synapse boost activation against tumour cells
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 19, 2025 at 2:42 PM
Our new paper is out! Khodor Hazime led the brilliant work at the @dandavis101.bsky.social lab that shows *how* engagers that bring NK cell receptors together at the immune synapse boost activation against tumour cells
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Worboys Lab
🧩 Antigen presentation is complex - but imaging is bringing clarity.
@doreenlau.bsky.social & @timmunologist.bsky.social review how advanced imaging illuminates T-cell–APC interactions, peptide-MHC dynamics, and more in cancer immunity.
📖 https://bit.ly/3TkIasN
##CancerImmunology
@doreenlau.bsky.social & @timmunologist.bsky.social review how advanced imaging illuminates T-cell–APC interactions, peptide-MHC dynamics, and more in cancer immunity.
📖 https://bit.ly/3TkIasN
##CancerImmunology
July 6, 2025 at 1:27 PM
🧩 Antigen presentation is complex - but imaging is bringing clarity.
@doreenlau.bsky.social & @timmunologist.bsky.social review how advanced imaging illuminates T-cell–APC interactions, peptide-MHC dynamics, and more in cancer immunity.
📖 https://bit.ly/3TkIasN
##CancerImmunology
@doreenlau.bsky.social & @timmunologist.bsky.social review how advanced imaging illuminates T-cell–APC interactions, peptide-MHC dynamics, and more in cancer immunity.
📖 https://bit.ly/3TkIasN
##CancerImmunology
Delighted to advertise a collaborative postdoc position available in the lab to develop new proximity labelling tools, funded by a BBSRC Transformative Research Technology grant:
www.jobs.manchester.ac.uk/Job/JobDetai...
#ChemicalBiology #SyntheticChemistry
www.jobs.manchester.ac.uk/Job/JobDetai...
#ChemicalBiology #SyntheticChemistry
Research Associate in Synthetic Chemistry and Chemical Biology:Oxford Road
www.jobs.manchester.ac.uk
July 14, 2025 at 11:38 AM
Delighted to advertise a collaborative postdoc position available in the lab to develop new proximity labelling tools, funded by a BBSRC Transformative Research Technology grant:
www.jobs.manchester.ac.uk/Job/JobDetai...
#ChemicalBiology #SyntheticChemistry
www.jobs.manchester.ac.uk/Job/JobDetai...
#ChemicalBiology #SyntheticChemistry
Reposted by Worboys Lab
🚨 The Menon lab is hiring a postdoc!
Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social
Please help spread the word #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social
Please help spread the word #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in Mucosal Immunology :Manchester
www.jobs.manchester.ac.uk
June 20, 2025 at 3:13 PM
🚨 The Menon lab is hiring a postdoc!
Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social
Please help spread the word #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social
Please help spread the word #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
Delighted to have visited the Dept. of Pathology at the University of Cambridge today to present our work. Some fantastic discussions!
June 9, 2025 at 4:00 PM
Delighted to have visited the Dept. of Pathology at the University of Cambridge today to present our work. Some fantastic discussions!
More evidence that TIGIT is an important player in autoimmunity and independent of its effect on CD226
www.nature.com/articles/s41...
#immunosky
www.nature.com/articles/s41...
#immunosky
TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis - Nature Communications
Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the aut...
www.nature.com
June 2, 2025 at 7:22 AM
More evidence that TIGIT is an important player in autoimmunity and independent of its effect on CD226
www.nature.com/articles/s41...
#immunosky
www.nature.com/articles/s41...
#immunosky
Reposted by Worboys Lab
The subfornical organ is a nucleus for gut-derived T cells that regulate behavior @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
May 28, 2025 at 5:54 PM
The subfornical organ is a nucleus for gut-derived T cells that regulate behavior @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
The deadline for this PhD is fast approaching. We are looking for a promising synthetic chemist to make new chemical biology tools to learn more about nucleic acid interactions. This is a collaborative project with the Trowbridge Lab in @uomscieng.bsky.social. If interested, get in touch soon!
We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!
#ChemSky #ChemBio
www.findaphd.com/phds/project...
#ChemSky #ChemBio
www.findaphd.com/phds/project...
(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com
PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
May 29, 2025 at 3:30 PM
The deadline for this PhD is fast approaching. We are looking for a promising synthetic chemist to make new chemical biology tools to learn more about nucleic acid interactions. This is a collaborative project with the Trowbridge Lab in @uomscieng.bsky.social. If interested, get in touch soon!
Reposted by Worboys Lab
Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.
#ImmunoSky
www.biorxiv.org/content/10.1...
#ImmunoSky
www.biorxiv.org/content/10.1...
Inhibitory TIGIT signalling is dependent on T cell receptor activation
TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...
www.biorxiv.org
May 14, 2025 at 7:50 AM
Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.
#ImmunoSky
www.biorxiv.org/content/10.1...
#ImmunoSky
www.biorxiv.org/content/10.1...
Reposted by Worboys Lab
After the success of our 2023 Imaging Cell Dynamics conference, we’ll be hosting a second #JCSImaging meeting in 2026, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti.
To register your interest: www.biologists.com/meetings/jcs...
To register your interest: www.biologists.com/meetings/jcs...
May 19, 2025 at 1:01 PM
After the success of our 2023 Imaging Cell Dynamics conference, we’ll be hosting a second #JCSImaging meeting in 2026, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti.
To register your interest: www.biologists.com/meetings/jcs...
To register your interest: www.biologists.com/meetings/jcs...
We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!
#ChemSky #ChemBio
www.findaphd.com/phds/project...
#ChemSky #ChemBio
www.findaphd.com/phds/project...
(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com
PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
May 16, 2025 at 3:07 PM
We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!
#ChemSky #ChemBio
www.findaphd.com/phds/project...
#ChemSky #ChemBio
www.findaphd.com/phds/project...
Reposted by Worboys Lab
Hi everyone 👋 I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky
BSI committee elections 2025 | British Society for Immunology
www.immunology.org
May 8, 2025 at 9:50 AM
Hi everyone 👋 I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky
Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.
#ImmunoSky
www.biorxiv.org/content/10.1...
#ImmunoSky
www.biorxiv.org/content/10.1...
Inhibitory TIGIT signalling is dependent on T cell receptor activation
TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...
www.biorxiv.org
May 14, 2025 at 7:50 AM
Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.
#ImmunoSky
www.biorxiv.org/content/10.1...
#ImmunoSky
www.biorxiv.org/content/10.1...
Reposted by Worboys Lab
Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.
Please get in touch if interested in applying.
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky #Imaging #Microscopy
Please get in touch if interested in applying.
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky #Imaging #Microscopy
Research Associate in Imaging Human Immunology:Oxford Road
www.jobs.manchester.ac.uk
March 26, 2025 at 4:15 PM
Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.
Please get in touch if interested in applying.
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky #Imaging #Microscopy
Please get in touch if interested in applying.
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky #Imaging #Microscopy
Wow
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 28, 2025 at 8:59 AM
Wow
Reposted by Worboys Lab
New postdoc position in @frances-turrell.bsky.social lab. Great opportunity to join a new group, doing exciting work 🧪
Get in touch if you want to chat about life in the lab (it's fab)!
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky
Get in touch if you want to chat about life in the lab (it's fab)!
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky
Research Associate in Breast Cancer Metastasis:CRUK Oglesby Cancer Research Building, 555 Wilmslow Road, M20 4GJ
www.jobs.manchester.ac.uk
March 26, 2025 at 8:46 AM
New postdoc position in @frances-turrell.bsky.social lab. Great opportunity to join a new group, doing exciting work 🧪
Get in touch if you want to chat about life in the lab (it's fab)!
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky
Get in touch if you want to chat about life in the lab (it's fab)!
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky
Reposted by Worboys Lab
Explore #CRISPR screening in our two-part course! #CRISPRAnalysis25
Blends online learning with in-person training, to help you master the methods and applications of CRISPR screening and analysis.🧬
Focusing on:
▶️ #Oncology
▶️ #Neurodegeneration
▶️ #Immunology
Apply by 3 June
📎Info: bit.ly/4iBpEah
Blends online learning with in-person training, to help you master the methods and applications of CRISPR screening and analysis.🧬
Focusing on:
▶️ #Oncology
▶️ #Neurodegeneration
▶️ #Immunology
Apply by 3 June
📎Info: bit.ly/4iBpEah
March 27, 2025 at 9:30 AM
Explore #CRISPR screening in our two-part course! #CRISPRAnalysis25
Blends online learning with in-person training, to help you master the methods and applications of CRISPR screening and analysis.🧬
Focusing on:
▶️ #Oncology
▶️ #Neurodegeneration
▶️ #Immunology
Apply by 3 June
📎Info: bit.ly/4iBpEah
Blends online learning with in-person training, to help you master the methods and applications of CRISPR screening and analysis.🧬
Focusing on:
▶️ #Oncology
▶️ #Neurodegeneration
▶️ #Immunology
Apply by 3 June
📎Info: bit.ly/4iBpEah
Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.
Please get in touch if interested in applying.
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky #Imaging #Microscopy
Please get in touch if interested in applying.
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky #Imaging #Microscopy
Research Associate in Imaging Human Immunology:Oxford Road
www.jobs.manchester.ac.uk
March 26, 2025 at 4:15 PM
Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.
Please get in touch if interested in applying.
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky #Imaging #Microscopy
Please get in touch if interested in applying.
www.jobs.manchester.ac.uk/Job/JobDetai...
#ImmunoSky #Imaging #Microscopy
A recent study we were involved in is now online showing distinct populations of NK cells with different killing potential:
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Frontiers | CD8α and CD70 mark human natural killer cell populations which differ in cytotoxicity
www.frontiersin.org
February 19, 2025 at 8:08 AM
A recent study we were involved in is now online showing distinct populations of NK cells with different killing potential:
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Reposted by Worboys Lab
🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨
February 5, 2025 at 12:02 AM
🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨
Reposted by Worboys Lab
If you're a T cell enthusiast, check out our latest findings published recently in #Science Magazine | #Immunology.
Uncovering the mechanism of CAR trogocytosis between T cells has been extremely fun.
www.science.org/doi/10.1126/...
Uncovering the mechanism of CAR trogocytosis between T cells has been extremely fun.
www.science.org/doi/10.1126/...
Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains
Chimeric antigen receptor trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain.
www.science.org
February 2, 2025 at 3:26 PM
If you're a T cell enthusiast, check out our latest findings published recently in #Science Magazine | #Immunology.
Uncovering the mechanism of CAR trogocytosis between T cells has been extremely fun.
www.science.org/doi/10.1126/...
Uncovering the mechanism of CAR trogocytosis between T cells has been extremely fun.
www.science.org/doi/10.1126/...
Reposted by Worboys Lab
I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
February 3, 2025 at 4:18 PM
I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...