Wei-Ting Lu
@weitinglu.bsky.social
Tea addict and scientist, in that order. Incoming Group Leader, Dept of Oncology, University of Oxford. All views my own.
Pinned
Job Details
shorturl.at
We are hiring a postdoc at Oxford!
Are you:
🔥 Passionate about genomic and chromosomal instability?
❓Curious about the relationship between whole genome doubling, cancer evolution and drug resistance?
🩺Want to have close collaboration with clinical facing groups?
Apply at: shorturl.at/0fPmD
Are you:
🔥 Passionate about genomic and chromosomal instability?
❓Curious about the relationship between whole genome doubling, cancer evolution and drug resistance?
🩺Want to have close collaboration with clinical facing groups?
Apply at: shorturl.at/0fPmD
We are hiring a postdoc at Oxford!
Are you:
🔥 Passionate about genomic and chromosomal instability?
❓Curious about the relationship between whole genome doubling, cancer evolution and drug resistance?
🩺Want to have close collaboration with clinical facing groups?
Apply at: shorturl.at/0fPmD
Are you:
🔥 Passionate about genomic and chromosomal instability?
❓Curious about the relationship between whole genome doubling, cancer evolution and drug resistance?
🩺Want to have close collaboration with clinical facing groups?
Apply at: shorturl.at/0fPmD
Job Details
shorturl.at
November 11, 2025 at 2:51 PM
We are hiring a postdoc at Oxford!
Are you:
🔥 Passionate about genomic and chromosomal instability?
❓Curious about the relationship between whole genome doubling, cancer evolution and drug resistance?
🩺Want to have close collaboration with clinical facing groups?
Apply at: shorturl.at/0fPmD
Are you:
🔥 Passionate about genomic and chromosomal instability?
❓Curious about the relationship between whole genome doubling, cancer evolution and drug resistance?
🩺Want to have close collaboration with clinical facing groups?
Apply at: shorturl.at/0fPmD
Reposted by Wei-Ting Lu
www.nature.com/articles/s41... saw @lablegube.bsky.social present this last week. Provides important clarity on RNA at chromosomal DSBs. Including rigorously debunking the nascent synthesis idea.
Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks - Nature Cell Biology
Saur, Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes, independently of de novo recruitment of RNA polymerase II/III, as a result of DSB-induced transcriptional repression.
www.nature.com
September 30, 2025 at 7:26 PM
www.nature.com/articles/s41... saw @lablegube.bsky.social present this last week. Provides important clarity on RNA at chromosomal DSBs. Including rigorously debunking the nascent synthesis idea.
Reposted by Wei-Ting Lu
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse
YouTube video by Stowers Institute for Medical Research
youtu.be
September 24, 2025 at 6:48 PM
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
Reposted by Wei-Ting Lu
📢OUT @natgenet.nature.com
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution - Nature Genetics
Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.
www.nature.com
September 15, 2025 at 11:53 AM
📢OUT @natgenet.nature.com
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
Reposted by Wei-Ting Lu
💫NEW: @brianstrahl.bsky.social & co report a non-catalytic function of the methyltransferase SETD2 in regulating nuclear morphology and genome integrity.
👉https://rdcu.be/eBW3D
bit.ly/3Vff6DO
👉https://rdcu.be/eBW3D
bit.ly/3Vff6DO
A SETD2–CDK1–lamin axis maintains nuclear morphology and genome stability - Nature Cell Biology
Khan et al. report a non-catalytic function of the methyltransferase SETD2 in regulating nuclear morphology and genome integrity. The SETD2 amino terminus functions as a scaffold helping CDK1 associat...
bit.ly
August 22, 2025 at 5:28 PM
💫NEW: @brianstrahl.bsky.social & co report a non-catalytic function of the methyltransferase SETD2 in regulating nuclear morphology and genome integrity.
👉https://rdcu.be/eBW3D
bit.ly/3Vff6DO
👉https://rdcu.be/eBW3D
bit.ly/3Vff6DO
Reposted by Wei-Ting Lu
Using snRNA-sequencing (Izar lab @columbiauniversity.bsky.social) with matched multiplex immunophenotypic profiling (@jleslie1.bsky.social) we found tumor cell-intrinsic innate immune activation and intratumoral myeloid infiltration as phenotypic consequences of ongoing micronucleation in EAC. 7/11
May 12, 2025 at 12:08 PM
Using snRNA-sequencing (Izar lab @columbiauniversity.bsky.social) with matched multiplex immunophenotypic profiling (@jleslie1.bsky.social) we found tumor cell-intrinsic innate immune activation and intratumoral myeloid infiltration as phenotypic consequences of ongoing micronucleation in EAC. 7/11
Reposted by Wei-Ting Lu
Wei-ting Lu presents data from the TRACERx lung cancer study on FAT1 alterations and chromosomal instability.
#AACR2025 | @weitinglu.bsky.social | @crick.ac.uk
#AACR2025 | @weitinglu.bsky.social | @crick.ac.uk
April 27, 2025 at 3:33 PM
Wei-ting Lu presents data from the TRACERx lung cancer study on FAT1 alterations and chromosomal instability.
#AACR2025 | @weitinglu.bsky.social | @crick.ac.uk
#AACR2025 | @weitinglu.bsky.social | @crick.ac.uk
Reposted by Wei-Ting Lu
We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️
www.cell.com/cell-reports...
www.cell.com/cell-reports...
The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability
Graham et al. demonstrate that BRCA2 and PALB2 protect centromere integrity in non-cancerous
cells through distinct mechanisms, partly counteracting the mismatch repair factor
MLH1. In cancer cells, B...
www.cell.com
February 25, 2025 at 5:56 PM
We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️
www.cell.com/cell-reports...
www.cell.com/cell-reports...
We’re thrilled to see our research has been highlighted as the cover of NCB this month 🎉 🎉. We are honoured to share this issue with thought-provoking articles investigating multiple aspects of chromosomal instability and mitosis @dfachinetti.bsky.social
@thecesarelab.bsky.social 🧵 1/4
@thecesarelab.bsky.social 🧵 1/4
👋🏿Happy new year and our first 2025 issue's out!
Cover: #chromosomal instability in #cancer
👉Review on #TranscriptionFactors and #cell quiescence
🔬#heterochromatin #embryo #DNArepair #pluripotency #proteostasis #obesity #CellCycle #CellDeath & more!
www.nature.com/ncb/volumes/...
Cover: #chromosomal instability in #cancer
👉Review on #TranscriptionFactors and #cell quiescence
🔬#heterochromatin #embryo #DNArepair #pluripotency #proteostasis #obesity #CellCycle #CellDeath & more!
www.nature.com/ncb/volumes/...
January 17, 2025 at 3:17 PM
We’re thrilled to see our research has been highlighted as the cover of NCB this month 🎉 🎉. We are honoured to share this issue with thought-provoking articles investigating multiple aspects of chromosomal instability and mitosis @dfachinetti.bsky.social
@thecesarelab.bsky.social 🧵 1/4
@thecesarelab.bsky.social 🧵 1/4
I am happy to see that our paper is out just before the new year!!! We have a lab tweetorial out for anyone interested! Got to say it was an exciting journey working with CharlesSwanton, the wider TRACERx and PEACE team, and @nnennayakanu.bsky.social Jiri Bartek labs. 🧵1/14
💫NEW by Lu, Bartek, Kanu & Swanton & co: analyses of data from the TRACERx cohort of #LungCancer patients delineate how FAT1 regulates homologous recombination repair, chromosomal instability & whole-genome doubling with distinct mechanisms.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling - Nature Cell Biology
Lu et al. perform systematic functional analyses using data from the TRACERx cohort of patients with non-small-cell lung cancer and delineate how FAT1 regulates homologous recombination repair, chromo...
www.nature.com
January 3, 2025 at 11:24 AM
I am happy to see that our paper is out just before the new year!!! We have a lab tweetorial out for anyone interested! Got to say it was an exciting journey working with CharlesSwanton, the wider TRACERx and PEACE team, and @nnennayakanu.bsky.social Jiri Bartek labs. 🧵1/14
Congratulations Simone and team!! Great work!! 🎉🎉🎉
🚨So proud to present the first study from our @ccg-ucl.bsky.social group together with @charlesswanton.bsky.social @NnennayaKanu and led by @ojlucas.bsky.social with key collaboration @sophie-ward.bsky.social and fundamental support @rijazaidi.bsky.social @abibunkum.bsky.social & others
Out now👇
🧵👇
Out now👇
🧵👇
Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER - Nature Genetics
Single-cell Proliferation Rate Inference in Non-homogeneous Tumors through Evolutionary Routes (SPRINTER) allows users to infer proliferation rates of individual clones within a tumor from single-cell...
doi.org
November 29, 2024 at 2:10 PM
Congratulations Simone and team!! Great work!! 🎉🎉🎉