Wei-Ting Lu
@weitinglu.bsky.social
Tea addict and scientist, in that order. Incoming Group Leader, Dept of Oncology, University of Oxford. All views my own.
How does FAT1 loss cause WGD? Using the FUCCI system in RPE1 cells (thanks to John Diffley lab @crick.ac.uk ) we could track the fidelity of cell division in real-time. The cell without FAT1 failed cytokinesis, could not finish mitosis and remained as 1 daughter cell with 2x the genome content 7/14
January 3, 2025 at 11:24 AM
How does FAT1 loss cause WGD? Using the FUCCI system in RPE1 cells (thanks to John Diffley lab @crick.ac.uk ) we could track the fidelity of cell division in real-time. The cell without FAT1 failed cytokinesis, could not finish mitosis and remained as 1 daughter cell with 2x the genome content 7/14
We also used live cell imaging to quantify mitotic errors. 6/14
January 3, 2025 at 11:24 AM
We also used live cell imaging to quantify mitotic errors. 6/14