Walko Lab
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walkolab.bsky.social
Walko Lab
@walkolab.bsky.social
We are a research lab of skin and oral biology enthusiasts led by Dr Gernot Walko. Fascinated about stem cells, squamous cell carcinoma, and Hippo/YAP/TAZ signalling. Based at @blizardinstitute.bsky.social @qmul-coirm.bsky.social. All opinions our own.
Reposted by Walko Lab
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 6, 2025 at 11:05 PM
Reposted by Walko Lab
The Nuvvuagittuq Greenstone Belt— a complex geological sequence in northeastern Canada—harbors surviving fragments of Earth’s oldest crust, dating back to ~4.16 billion years old, according to a new Science study.

Learn more: scim.ag/3FXN8sq
Evidence for Hadean mafic intrusions in the Nuvvuagittuq Greenstone Belt, Canada
Many questions remain regarding Earth’s earliest crust owing to the rarity of Hadean (>4.03 billion-year-old) rocks and minerals. The Nuvvuagittuq Greenstone Belt (NGB) in Canada may be the only known...
scim.ag
June 26, 2025 at 7:22 PM
Reposted by Walko Lab
Targeted p63 isoform switch corrects dominant mutations in AEC syndrome without disrupting epidermal homeostasis https://www.biorxiv.org/content/10.1101/2025.06.24.661308v1
June 26, 2025 at 9:17 PM
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Please join us for our 2025 mini-symposium on translational biomarkers and clinical prediction.

www.qmul.ac.uk/bcsc/events/...
Barts Centre for Squamous Cancer mini-symposium 2025 Translational biomarkers and clinical prediction.
www.qmul.ac.uk
May 8, 2025 at 5:44 PM
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#InTheNews: Read in @reuters.com about how high UK visa fees for scientists are impacting our research institutes and our mission to beat cancer 👇 www.reuters.com/world/uk/hig...
High UK visa costs deter international scientists and engineers
It took Ed Roberts over a year to find a senior scientist to work at his cancer research laboratory in Scotland, a delay he blames on high UK visa costs that made it harder to attract international workers.
www.reuters.com
April 15, 2025 at 3:58 PM
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#LocationLocationLocation! Wang Eisenstein Waizman @yaleschoolofmed.bsky.social &co show @ Science Immunology that physical, chemical, & radiation skin damage induces IL33 activating ILC2 & transferring to distal barrier tissues the capacity to induce antibodies causing #allergic responses!
Skin damage signals mediate allergic sensitization to spatially unlinked antigen
Skin injury releases damage-encoded systemic signals that can initiate immunity to novel antigens introduced at distal barrier sites.
www.science.org
April 4, 2025 at 8:06 PM
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We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪

www.nature.com/articles/d41...
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
www.nature.com
March 27, 2025 at 2:19 PM
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Celebrating 20 Years of the International Pachyonychia Congenita Consortium.
Read Coulombe et al's News & Perspective Commentary in the April issue.
doi.org/10.1016/j.ji...
#DermatologyJournal #dermatology #dermsky #dermatologists #dermresearch #dermscience #dermatologyresearch
March 27, 2025 at 4:12 PM
Reposted by Walko Lab
Nature research paper: Matrix-producing neutrophils populate and shield the skin

https://go.nature.com/4iJSgy5
Matrix-producing neutrophils populate and shield the skin - Nature
A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.
go.nature.com
March 21, 2025 at 11:00 AM
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📢 Calling all undergraduates looking for hands-on academic research experience!
There’s still time to apply for the LMB’s Student Placement Scheme.
Visit our website to learn more and get your applications in by 30th March.
www2.mrc-lmb.cam.ac.uk/students/stu...
March 21, 2025 at 12:12 PM
A big thank you to Carsten Gram Hansen and @edinburgh-uni.bsky.social, Institute for Regeneration and Repair for hosting me. Really enjoyed my stay and learning all about the fantastic research in the Centre for Inflammation Research.
March 18, 2025 at 10:43 PM
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A peptic ulcer is a break in the lining of the lower esophagus, stomach, or upper small intestine. This JAMA Patient Page describes peptic ulcers and their causes, signs and symptoms, diagnosis, and treatment options. https://ja.ma/4bzikcU
March 15, 2025 at 3:00 PM
Reposted by Walko Lab
Wrestling with the RAS cancer drug pipeline
tinyurl.com/54faf7kv

Alice Shaw of the Dana-Farber Cancer Institute discusses the newly launched Center for RAS Therapeutics and the key role of combination strategies in building on the initial breakthroughs with RAS inhibitors
@danafarber.bsky.social
March 14, 2025 at 3:33 PM
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NIH officials were told this morning that approximately 1,000 more grants would be targeted for termination www.theatlantic.com/health/archi...
A Decade of Cuts in a Matter of Days
The Trump administration’s rapid terminations of NIH grants is its most aggressive attempt yet to control American science.
www.theatlantic.com
March 14, 2025 at 3:03 PM
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🚨This week, many Columbia scientists lost grants that funded over half their annual income. Others will no longer be able to do research that helps treat thousands of sick patients across the US.

"It hurts," they told me.

My story for @nature.com 🧪

www.nature.com/articles/d41...
‘My career is over’: Columbia University scientists hit hard by Trump team’s cuts
The US government has begun slashing US$400 million in research grants at Columbia University over pro-Palestinian campus protests.
www.nature.com
March 14, 2025 at 5:11 PM
It is shocking and saddening to see how the two former global science powerhouses, USA and UK are collapsing in front of our eyes. For different reasons, but ultimately it’s about politics in both cases.
March 14, 2025 at 6:49 PM
Happy #InternationalWomensDay2025 from a PI with an all-female team of fantastic scientists 🇫🇷🇸🇦🇮🇹🇬🇷
March 8, 2025 at 10:44 PM
Reposted by Walko Lab
I’ve been yearning to put in this out of office reply 😎
March 2, 2025 at 5:43 PM
Reposted by Walko Lab
QWENDY: Gene Regulatory Network Inference Enhanced by Large Language Model and Transformer https://www.biorxiv.org/content/10.1101/2025.02.22.639640v1
February 25, 2025 at 4:33 PM
Reposted by Walko Lab
Implantation of engineered adipocytes suppresses tumor progression in cancer models - @nadavahituv.bsky.social go.nature.com/4gqhxvw
Implantation of engineered adipocytes suppresses tumor progression in cancer models - Nature Biotechnology
Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.
go.nature.com
February 4, 2025 at 3:48 PM
Reposted by Walko Lab
Postdocs and PhD students - the future of the US research - hit hard by Trump’s crackdown on science

🧪 #academicSky #ECRs

@nature.com

www.nature.com/articles/d41...
Postdocs and PhD students hit hard by Trump’s crackdown on science
As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.
www.nature.com
February 24, 2025 at 10:09 PM
Reposted by Walko Lab
Are PhDs losing their lustre? Why fewer students are enrolling in doctoral degrees www.nature.com/articles/d41...
Are PhDs losing their lustre? Why fewer students are enrolling in doctoral degrees
High living costs paired with stagnant stipends are being blamed for a drop in PhD enrolments in several countries.
www.nature.com
February 24, 2025 at 10:24 AM