Vishal Mohanakrishnan
@vishalmkrishnan.bsky.social
EMBO Postdoctoral fellow @makinenlab | PhD @ralfhadams | Interested in Arteries, Veins, Capillaries, Lymphatics and Food. x.com/vishalmkrishnan
Pinned
Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries". 🦴🔬😍
Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology.
www.nature.com/articles/s41...
Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology.
www.nature.com/articles/s41...
Reposted by Vishal Mohanakrishnan
We have asked the new EMBO Members to tell us about themselves and what makes it so compelling to work in #science today. 🧪
In the eighth video of the series, EMBO Members tell us what part of their #research process they enjoy the most and why.
#LifeSciences
In the eighth video of the series, EMBO Members tell us what part of their #research process they enjoy the most and why.
#LifeSciences
October 11, 2025 at 8:16 AM
We have asked the new EMBO Members to tell us about themselves and what makes it so compelling to work in #science today. 🧪
In the eighth video of the series, EMBO Members tell us what part of their #research process they enjoy the most and why.
#LifeSciences
In the eighth video of the series, EMBO Members tell us what part of their #research process they enjoy the most and why.
#LifeSciences
Reposted by Vishal Mohanakrishnan
❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...
July 15, 2025 at 4:11 PM
❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...
Reposted by Vishal Mohanakrishnan
I am honoured to be elected as a Member of EMBO and look forward to contributing to its mission and community!
Welcome and congratulations to the 60 new members and 9 associate members who have been elected to the EMBO Membership! This honour celebrates #research excellence and outstanding achievements in the #LifeSciences. 🧪
Learn more here:
www.embo.org/press-releas... #EMBOMembers2025
Learn more here:
www.embo.org/press-releas... #EMBOMembers2025
Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO
Sixty-nine new members join the community of leading life scientists in Europe and beyond
www.embo.org
July 1, 2025 at 12:32 PM
I am honoured to be elected as a Member of EMBO and look forward to contributing to its mission and community!
Reposted by Vishal Mohanakrishnan
Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. Read our work in @natcardiovascres.nature.com by Marle Kraft et al.
rdcu.be/enhST
rdcu.be/enhST
Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations
Nature Cardiovascular Research - Kraft et al. identify TIE2 activation as a key driver of PIK3CA-related venous malformations and demonstrate that inhibiting TIE2 signaling can suppress the growth...
rdcu.be
May 25, 2025 at 2:34 PM
Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. Read our work in @natcardiovascres.nature.com by Marle Kraft et al.
rdcu.be/enhST
rdcu.be/enhST
Reposted by Vishal Mohanakrishnan
📢 #GRC_Angiogenesis program is up! We have an amazing lineup of speakers ready to dive into the "social life" of vessels! How they engage with their neighbors, how they connect, and why they break up! Plus we have ~15 slots available for short talks! Apply (link 👇) and see you in Newport in July!
March 25, 2025 at 11:25 AM
📢 #GRC_Angiogenesis program is up! We have an amazing lineup of speakers ready to dive into the "social life" of vessels! How they engage with their neighbors, how they connect, and why they break up! Plus we have ~15 slots available for short talks! Apply (link 👇) and see you in Newport in July!
Reposted by Vishal Mohanakrishnan
Not every organ ages the same🤠
With Age, Skull bone marrow Vasculature+HSPC Expand & ⏫ contribution to peripheral leukocyte
Skull BM expands with Pregnancy CML PTH Stroke
@bikohcello.bsky.social
@vishalmkrishnan.bsky.social
@ralfhadams.bsky.social
@nature.com 2024
www.nature.com/articles/s41...
With Age, Skull bone marrow Vasculature+HSPC Expand & ⏫ contribution to peripheral leukocyte
Skull BM expands with Pregnancy CML PTH Stroke
@bikohcello.bsky.social
@vishalmkrishnan.bsky.social
@ralfhadams.bsky.social
@nature.com 2024
www.nature.com/articles/s41...
March 21, 2025 at 11:40 AM
Not every organ ages the same🤠
With Age, Skull bone marrow Vasculature+HSPC Expand & ⏫ contribution to peripheral leukocyte
Skull BM expands with Pregnancy CML PTH Stroke
@bikohcello.bsky.social
@vishalmkrishnan.bsky.social
@ralfhadams.bsky.social
@nature.com 2024
www.nature.com/articles/s41...
With Age, Skull bone marrow Vasculature+HSPC Expand & ⏫ contribution to peripheral leukocyte
Skull BM expands with Pregnancy CML PTH Stroke
@bikohcello.bsky.social
@vishalmkrishnan.bsky.social
@ralfhadams.bsky.social
@nature.com 2024
www.nature.com/articles/s41...
I am a bit biased, but check out the beautiful work and thread by @hansschoofs.bsky.social @taijamakinenlab.bsky.social on why lymphatic endothelial cells have their jigsaw puzzle-like shape 😍😍😍
• Happy to announce that our paper in @nature.com is finally out! Thanks to the perseverance of @taijamakinenlab.bsky.social and our many collaborators we finally pulled it off! A small 🧵
www.nature.com/articles/s41...
Laymen video:
www.nature.com/articles/d41...
www.nature.com/articles/s41...
Laymen video:
www.nature.com/articles/d41...
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature
Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous...
www.nature.com
March 20, 2025 at 3:03 PM
I am a bit biased, but check out the beautiful work and thread by @hansschoofs.bsky.social @taijamakinenlab.bsky.social on why lymphatic endothelial cells have their jigsaw puzzle-like shape 😍😍😍
Reposted by Vishal Mohanakrishnan
My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email
Cell and Tissue Dynamics (Wickström)
www.mpi-muenster.mpg.de
February 15, 2025 at 8:42 PM
My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email
Reposted by Vishal Mohanakrishnan
#EVBOSummerSchool 2025: Please help spread the news!
10-11 June 2025 | Biomedicum Helsinki, Finland
Registration will open soon. Stay tuned!
The summer school will be preceded by the excellent and free-of-charge Wihuri Research Symposium on Cardiovascular Biology!
More info buff.ly/42I9fvY
10-11 June 2025 | Biomedicum Helsinki, Finland
Registration will open soon. Stay tuned!
The summer school will be preceded by the excellent and free-of-charge Wihuri Research Symposium on Cardiovascular Biology!
More info buff.ly/42I9fvY
February 4, 2025 at 2:51 PM
#EVBOSummerSchool 2025: Please help spread the news!
10-11 June 2025 | Biomedicum Helsinki, Finland
Registration will open soon. Stay tuned!
The summer school will be preceded by the excellent and free-of-charge Wihuri Research Symposium on Cardiovascular Biology!
More info buff.ly/42I9fvY
10-11 June 2025 | Biomedicum Helsinki, Finland
Registration will open soon. Stay tuned!
The summer school will be preceded by the excellent and free-of-charge Wihuri Research Symposium on Cardiovascular Biology!
More info buff.ly/42I9fvY
Reposted by Vishal Mohanakrishnan
Type R capillary #EndothelialCell in Bone
Cav1+ Efnb2+Flt4-Emcn+
B/w Sinusoid EC & Artery
👉Close to trabecular🦴 osteoprogenitor osteoclast
👉Angiocrine SEMA7A+
⏫by #Aging anti-osteoporosis therapy
@vishalmkrishnan.bsky.social l @ralfhadams.bsky.social #NatCellBio 2024
www.nature.com/articles/s41...
Cav1+ Efnb2+Flt4-Emcn+
B/w Sinusoid EC & Artery
👉Close to trabecular🦴 osteoprogenitor osteoclast
👉Angiocrine SEMA7A+
⏫by #Aging anti-osteoporosis therapy
@vishalmkrishnan.bsky.social l @ralfhadams.bsky.social #NatCellBio 2024
www.nature.com/articles/s41...
January 31, 2025 at 7:58 PM
Type R capillary #EndothelialCell in Bone
Cav1+ Efnb2+Flt4-Emcn+
B/w Sinusoid EC & Artery
👉Close to trabecular🦴 osteoprogenitor osteoclast
👉Angiocrine SEMA7A+
⏫by #Aging anti-osteoporosis therapy
@vishalmkrishnan.bsky.social l @ralfhadams.bsky.social #NatCellBio 2024
www.nature.com/articles/s41...
Cav1+ Efnb2+Flt4-Emcn+
B/w Sinusoid EC & Artery
👉Close to trabecular🦴 osteoprogenitor osteoclast
👉Angiocrine SEMA7A+
⏫by #Aging anti-osteoporosis therapy
@vishalmkrishnan.bsky.social l @ralfhadams.bsky.social #NatCellBio 2024
www.nature.com/articles/s41...
Reposted by Vishal Mohanakrishnan
Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ
https://go.nature.com/3PwtwN2
https://go.nature.com/3PwtwN2
How the brain cleans itself during deep sleep
Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ.
go.nature.com
January 13, 2025 at 11:11 AM
Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ
https://go.nature.com/3PwtwN2
https://go.nature.com/3PwtwN2
Reposted by Vishal Mohanakrishnan
Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)
The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes
Nature Metabolism - Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.
rdcu.be
January 13, 2025 at 11:00 AM
Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)
Reposted by Vishal Mohanakrishnan
Aaaaand finally:
#NCB2024
In November, @ralfhadams.bsky.social & co identified a distinct subset of post-arterial #capillaries, termed type R, which contribute to trabecular #bone formation in the diaphysis and respond to anti-#osteoporosis treatments.
www.nature.com/articles/s41...
#NCB2024
In November, @ralfhadams.bsky.social & co identified a distinct subset of post-arterial #capillaries, termed type R, which contribute to trabecular #bone formation in the diaphysis and respond to anti-#osteoporosis treatments.
www.nature.com/articles/s41...
Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology
Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to ...
www.nature.com
December 31, 2024 at 3:50 PM
Aaaaand finally:
#NCB2024
In November, @ralfhadams.bsky.social & co identified a distinct subset of post-arterial #capillaries, termed type R, which contribute to trabecular #bone formation in the diaphysis and respond to anti-#osteoporosis treatments.
www.nature.com/articles/s41...
#NCB2024
In November, @ralfhadams.bsky.social & co identified a distinct subset of post-arterial #capillaries, termed type R, which contribute to trabecular #bone formation in the diaphysis and respond to anti-#osteoporosis treatments.
www.nature.com/articles/s41...
Reposted by Vishal Mohanakrishnan
Pleased to share the work of Mitzy Cowdin and others in our lab showing the requirement for the Hippo pathway kinases Lats1 and 2 for endothelial sensing of hemodynamic flow and for vascular remodeling during embryogenesis 🎉🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stress
Blood vessels in mammalian embryos develop from initial aggregates of endothelial cell (EC) progenitors, which coordinate the opening and stabilization of central vascular lumens, all while under prog...
www.biorxiv.org
December 2, 2024 at 1:08 PM
Pleased to share the work of Mitzy Cowdin and others in our lab showing the requirement for the Hippo pathway kinases Lats1 and 2 for endothelial sensing of hemodynamic flow and for vascular remodeling during embryogenesis 🎉🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Vishal Mohanakrishnan
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
November 25, 2024 at 12:38 PM
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
Reposted by Vishal Mohanakrishnan
🥂Congratulations to @ralfhadams.bsky.social @vishalmkrishnan.bsky.social & co for their new Open Access study in our journal (@naturecellbiology.bsky.social) identifying type R #capillaries and showing their role in trabecular #bone formation in the diaphysis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology
Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to ...
www.nature.com
November 23, 2024 at 12:27 PM
🥂Congratulations to @ralfhadams.bsky.social @vishalmkrishnan.bsky.social & co for their new Open Access study in our journal (@naturecellbiology.bsky.social) identifying type R #capillaries and showing their role in trabecular #bone formation in the diaphysis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vishal Mohanakrishnan
💫NEW: @ralfhadams.bsky.social & co identify a distinct subset of post-arterial #capillaries, termed type R. They show that type R capillaries contribute to trabecular #bone formation in the diaphysis and respond to anti- #osteoporosis treatments.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology
Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to ...
www.nature.com
November 21, 2024 at 1:31 PM
💫NEW: @ralfhadams.bsky.social & co identify a distinct subset of post-arterial #capillaries, termed type R. They show that type R capillaries contribute to trabecular #bone formation in the diaphysis and respond to anti- #osteoporosis treatments.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries". 🦴🔬😍
Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology.
www.nature.com/articles/s41...
Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology.
www.nature.com/articles/s41...
November 19, 2024 at 5:48 PM
Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries". 🦴🔬😍
Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology.
www.nature.com/articles/s41...
Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology.
www.nature.com/articles/s41...
Reposted by Vishal Mohanakrishnan
Here's a starter pack focusing on cardiovascular research.
I'm sure the pack is incomplete. If you'd like to be added to the list, please let me know!
go.bsky.app/SgaGkv5
I'm sure the pack is incomplete. If you'd like to be added to the list, please let me know!
go.bsky.app/SgaGkv5
November 18, 2024 at 4:55 PM
Here's a starter pack focusing on cardiovascular research.
I'm sure the pack is incomplete. If you'd like to be added to the list, please let me know!
go.bsky.app/SgaGkv5
I'm sure the pack is incomplete. If you'd like to be added to the list, please let me know!
go.bsky.app/SgaGkv5