Geert Carmeliet
@geertlab.bsky.social
cell metabolism of skeletal cells in bone development, metabolic disorders, bone metastasis and bone repair @KU Leuven. www.mebodd.com
Reposted by Geert Carmeliet
The European Calcified Tissue Society is thrilled to announce the upcoming Clinical Training Course in Metabolic Bone Diseases, set to take place online from November 14 to 17, 2025, with on-demand access available until February 15, 2026.
buff.ly/GJ9eS1d
buff.ly/GJ9eS1d
September 10, 2025 at 2:28 PM
The European Calcified Tissue Society is thrilled to announce the upcoming Clinical Training Course in Metabolic Bone Diseases, set to take place online from November 14 to 17, 2025, with on-demand access available until February 15, 2026.
buff.ly/GJ9eS1d
buff.ly/GJ9eS1d
Reposted by Geert Carmeliet
"Being a scientist is not easy but it is an amazing job. With the new technology available there are so many questions you can answer, so much you can accomplish and contribute. Keep the dream."
Congratulations Sylvia Christakos, Ph.D.!
Congratulations Sylvia Christakos, Ph.D.!
August 6, 2025 at 2:33 PM
"Being a scientist is not easy but it is an amazing job. With the new technology available there are so many questions you can answer, so much you can accomplish and contribute. Keep the dream."
Congratulations Sylvia Christakos, Ph.D.!
Congratulations Sylvia Christakos, Ph.D.!
Interesting findings Nick!!
New preprint from our lab! Given the importance of nucleotide synthesis for AML cells, and the fact that aspartate is essential for nucleotide synthesis, we wondered if exogenous aspartate uptake through EAAT transporters plays a role in this cancer.
July 22, 2025 at 6:44 PM
Interesting findings Nick!!
Reposted by Geert Carmeliet
🚨 Where does lipid peroxidation kick off in ferroptosis? 🔥Excited to reveal ER-mitochondria contacts as hotspots of the lipid peroxidation cascade! Kudos to our Maria Livia Sassano @mariamls.bsky.social 🙏 to our amazing collaborators #Ferroptosis#contactsites#ER#mitochondria# doi.org/10.1038/s415...
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
doi.org
June 13, 2025 at 10:24 AM
🚨 Where does lipid peroxidation kick off in ferroptosis? 🔥Excited to reveal ER-mitochondria contacts as hotspots of the lipid peroxidation cascade! Kudos to our Maria Livia Sassano @mariamls.bsky.social 🙏 to our amazing collaborators #Ferroptosis#contactsites#ER#mitochondria# doi.org/10.1038/s415...
Reposted by Geert Carmeliet
Reposted by Geert Carmeliet
New paper from our lab! In this study, we show that AML cells critically depend on LDHA to maintain their NAD+/NADH balance. Congrats to first author Ayşegül Erdem and all co-authors! cancerandmetabolism.biomedcentral.com/articles/10....
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival - Cancer & Metabolism
Background Enhanced glycolysis plays a pivotal role in fueling the aberrant proliferation, survival and therapy resistance of acute myeloid leukemia (AML) cells. Here, we aimed to elucidate the extent...
cancerandmetabolism.biomedcentral.com
May 19, 2025 at 9:27 PM
New paper from our lab! In this study, we show that AML cells critically depend on LDHA to maintain their NAD+/NADH balance. Congrats to first author Ayşegül Erdem and all co-authors! cancerandmetabolism.biomedcentral.com/articles/10....
Reposted by Geert Carmeliet
We have re-openend this position for a post-doctoral fellow in our lab! Reach out if you have an interest in studying metabolism in cancer/stem cells and ideally have some mass spec experience. Please share!
We are hiring! There is still time to apply for an open postdoc position in stem cell metabolomics (mass spec experience required) in our lab, and we’ll soon open applications for a PhD student interested in studying metabolic crosstalk in the bone marrow (but feel free to already send me your CV)!
May 5, 2025 at 5:01 PM
We have re-openend this position for a post-doctoral fellow in our lab! Reach out if you have an interest in studying metabolism in cancer/stem cells and ideally have some mass spec experience. Please share!
Reposted by Geert Carmeliet
I'm excited to share our latest story from the
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/
Intracellular metabolic gradients dictate dependence on exogenous pyruvate
Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...
rdcu.be
April 28, 2025 at 2:28 PM
I'm excited to share our latest story from the
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/
Reposted by Geert Carmeliet
Reposted by Geert Carmeliet
Early Registration Deadline for the congress in Innsbruck!
REGISTER TO NOT MISS OUT
Register until the 23 March to get the early registration fee and seize the opportunity to share science with colleagues from all around the world.
www.ects2025.org/registration/
REGISTER TO NOT MISS OUT
Register until the 23 March to get the early registration fee and seize the opportunity to share science with colleagues from all around the world.
www.ects2025.org/registration/
March 20, 2025 at 12:49 PM
Early Registration Deadline for the congress in Innsbruck!
REGISTER TO NOT MISS OUT
Register until the 23 March to get the early registration fee and seize the opportunity to share science with colleagues from all around the world.
www.ects2025.org/registration/
REGISTER TO NOT MISS OUT
Register until the 23 March to get the early registration fee and seize the opportunity to share science with colleagues from all around the world.
www.ects2025.org/registration/
Reposted by Geert Carmeliet
I feel extremely fortunate to have had the chance to learn from & work with Chuck Chan, building on some of his seminal discoveries and scientific vision. A truly 'chuckesque' manuscript by a wonderful collaborative & interdisciplinary team @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites
Ambrosi and colleagues profile human skeletal stem cells (hSSCs) across ten fetal
skeletal sites and from patients throughout adulthood, identifying, mapping, and functionally
testing four distinct hS...
www.cell.com
March 20, 2025 at 4:30 PM
I feel extremely fortunate to have had the chance to learn from & work with Chuck Chan, building on some of his seminal discoveries and scientific vision. A truly 'chuckesque' manuscript by a wonderful collaborative & interdisciplinary team @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...
Thanks to all co-authors for excellent collaboration and thanks to @kuleuven.bsky.social and FWO for funding.
RESEARCH | S Loopmans, @geertlab.bsky.social et al. (KU Leuven):
The pentose phosphate pathway in #chondrocytes provides reducing power to ensure proteostasis necessary for #bone lengthening 🦴 🐁
https://bit.ly/3X1RuDS
The pentose phosphate pathway in #chondrocytes provides reducing power to ensure proteostasis necessary for #bone lengthening 🦴 🐁
https://bit.ly/3X1RuDS
The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes - Nature Metabolism
Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.
bit.ly
February 16, 2025 at 7:30 PM
Thanks to all co-authors for excellent collaboration and thanks to @kuleuven.bsky.social and FWO for funding.
Reposted by Geert Carmeliet
Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Rhodoquinone carries electrons in the mammalian electron transport chain
Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian
mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal
electron acceptor. The authors de...
www.cell.com
February 4, 2025 at 9:40 PM
Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Geert Carmeliet
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis: Cell Metabolism www.cell.com/cell-metabol...
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
Lactate elevations are a hallmark of human disease, but the mechanisms regulating
lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms
of lactate homeostasis. These invol...
www.cell.com
February 1, 2025 at 4:13 PM
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis: Cell Metabolism www.cell.com/cell-metabol...
very interesting research and great mentor!!
We are hiring at different levels!
- Lab technician for mouse experiments
- Postdoctoral fellow with experience in mass spectrometry-based metabolomics
For more information:
www.deduveinstitute.be/jobs
&
www.deduveinstitute.be/research-gro...
Come join our team and contribute to exciting science!
- Lab technician for mouse experiments
- Postdoctoral fellow with experience in mass spectrometry-based metabolomics
For more information:
www.deduveinstitute.be/jobs
&
www.deduveinstitute.be/research-gro...
Come join our team and contribute to exciting science!
www.deduveinstitute.be
January 29, 2025 at 2:34 PM
very interesting research and great mentor!!
Reposted by Geert Carmeliet
Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert).
Looking forward to working with you!
Looking forward to working with you!
January 23, 2025 at 8:37 AM
Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert).
Looking forward to working with you!
Looking forward to working with you!
Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)
The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes
Nature Metabolism - Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.
rdcu.be
January 13, 2025 at 11:00 AM
Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)
Reposted by Geert Carmeliet
⏰ Deadline is approaching (Feb 6!) to apply for scholarships + short talks for the Keystone meeting on metabolism in development!
keysym.us/KSMetabDev25
The meeting is May 7-9 in Beverly, MA and will be a unique forum for discussing the role of metabolites in development. Hope to see you there!
keysym.us/KSMetabDev25
The meeting is May 7-9 in Beverly, MA and will be a unique forum for discussing the role of metabolites in development. Hope to see you there!
January 6, 2025 at 5:21 PM
⏰ Deadline is approaching (Feb 6!) to apply for scholarships + short talks for the Keystone meeting on metabolism in development!
keysym.us/KSMetabDev25
The meeting is May 7-9 in Beverly, MA and will be a unique forum for discussing the role of metabolites in development. Hope to see you there!
keysym.us/KSMetabDev25
The meeting is May 7-9 in Beverly, MA and will be a unique forum for discussing the role of metabolites in development. Hope to see you there!
Congratulations Ginevra with these very exciting findings!! and congratulations to the whole @fendtlab.bsky.social team!!
Beyond excited to share that the main work of my PhD on how aspartate signaling drives metastasis is finally out in @nature.com ✨
-> go.nature.com/4gCYtuL
A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏
A brief 🧵
-> go.nature.com/4gCYtuL
A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏
A brief 🧵
Aspartate signalling drives lung metastasis via alternative translation - Nature
Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.
go.nature.com
January 1, 2025 at 8:19 PM
Congratulations Ginevra with these very exciting findings!! and congratulations to the whole @fendtlab.bsky.social team!!