Tom Ambrosi
@drambrosi.bsky.social
Assistant Prof. @UCDavisOrtho | Former Postdoc @Stanford | Start up Co-Founder 🚀 | Skeletal Stem Cells, Aging & Beyond 🥼🦴🔬 | Family 🇺🇸 🇩🇪 | 🎣🍺🌳
Some good lab news among all the turmoil! Excited about this new publication in collab with Dr. Nancy Lane. Great effort by graduate student Dave & postdoc Kun! Looking forward to presenting this & more at @asbmr.bsky.social meet next month! @ucdavishealth.bsky.social www.nature.com/articles/s41...
Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis - Nature Communications
Glucocorticoid (GC) induced osteoporosis (GIOP) remains a significant clinical problem. Here, the authors find that GCs disrupt skeletal stem cell–endothelial crosstalk via Basigin that can be targete...
www.nature.com
August 15, 2025 at 4:27 PM
Some good lab news among all the turmoil! Excited about this new publication in collab with Dr. Nancy Lane. Great effort by graduate student Dave & postdoc Kun! Looking forward to presenting this & more at @asbmr.bsky.social meet next month! @ucdavishealth.bsky.social www.nature.com/articles/s41...
Reposted by Tom Ambrosi
Stronger bones? A @cp-cellstemcell.bsky.social study by @drambrosi.bsky.social of @ucdavis.bsky.social, funded in part by @wutsaialliance.bsky.social, shed light on how skeletal stem cells change with age and how to boost their fracture-healing abilities. humanperformancealliance.org/news/skeleta...
Skeletal stem cells key to stronger bones, better healing - Wu Tsai Human Performance Alliance
humanperformancealliance.org
May 23, 2025 at 8:22 PM
Stronger bones? A @cp-cellstemcell.bsky.social study by @drambrosi.bsky.social of @ucdavis.bsky.social, funded in part by @wutsaialliance.bsky.social, shed light on how skeletal stem cells change with age and how to boost their fracture-healing abilities. humanperformancealliance.org/news/skeleta...
Reposted by Tom Ambrosi
I feel extremely fortunate to have had the chance to learn from & work with Chuck Chan, building on some of his seminal discoveries and scientific vision. A truly 'chuckesque' manuscript by a wonderful collaborative & interdisciplinary team @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites
Ambrosi and colleagues profile human skeletal stem cells (hSSCs) across ten fetal
skeletal sites and from patients throughout adulthood, identifying, mapping, and functionally
testing four distinct hS...
www.cell.com
March 20, 2025 at 4:30 PM
I feel extremely fortunate to have had the chance to learn from & work with Chuck Chan, building on some of his seminal discoveries and scientific vision. A truly 'chuckesque' manuscript by a wonderful collaborative & interdisciplinary team @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...
Reposted by Tom Ambrosi
Congratulations to Dr. Ambrosi and grad student Kelly Weldon of @UCDavisHealth for this important manuscript! 👏🏻👏🏻👏🏻
Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration academic.oup.com/stmcls/artic...
Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration academic.oup.com/stmcls/artic...
Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration
Abstract. In our aging society, the degeneration of the musculoskeletal system and adjacent tissues is a growing orthopedic concern. As bones age, they bec
academic.oup.com
March 11, 2025 at 8:25 AM
Congratulations to Dr. Ambrosi and grad student Kelly Weldon of @UCDavisHealth for this important manuscript! 👏🏻👏🏻👏🏻
Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration academic.oup.com/stmcls/artic...
Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration academic.oup.com/stmcls/artic...
Reposted by Tom Ambrosi
Just a reminder that Germany was the center of scientific progress until the Nazis suppressed, drove away, or killed all the non-Nazi scientists.
February 13, 2025 at 6:54 PM
Just a reminder that Germany was the center of scientific progress until the Nazis suppressed, drove away, or killed all the non-Nazi scientists.
Reposted by Tom Ambrosi
8/ BOTTOM LINE: NIH BUDGET CUTS WILL MARKEDLY HURT EVERY STATE IN THIS UNION. AND RED ONES RELATIVELY MORE. REPUBLICAN & DEMOCRATIC REPS IN EACH STATE SHOULD BE LASER FOCUSED ON NOT PASSING REFORMS OR ALLOWING EXECUTIVE ORDERS TO FLY THAT HURT REVENUE GENERATION & JOB PROSPECTS. THIS HURTS PEOPLE!
February 13, 2025 at 6:48 PM
8/ BOTTOM LINE: NIH BUDGET CUTS WILL MARKEDLY HURT EVERY STATE IN THIS UNION. AND RED ONES RELATIVELY MORE. REPUBLICAN & DEMOCRATIC REPS IN EACH STATE SHOULD BE LASER FOCUSED ON NOT PASSING REFORMS OR ALLOWING EXECUTIVE ORDERS TO FLY THAT HURT REVENUE GENERATION & JOB PROSPECTS. THIS HURTS PEOPLE!
Reposted by Tom Ambrosi
Check the comments for links to opportunities!
Made some slides for scientists to talk about what's been happening & what we should do next. There are probably many people better qualified than me to talk about these issues. If that's you, please, please, please consider holding some virtual advocacy training sessions for researchers this week.
The War on Science (Feb 2025 teach-in draft)
The War on Science What’s happening? What can we do about it? An interactive teach-in for biomedical researchers Please share, modify, and repurpose this template presentation (with credit). Good luck...
docs.google.com
February 10, 2025 at 5:17 PM
Check the comments for links to opportunities!
New and first pre-print of the lab. Fun project with Nancy Lane @ucdavis.bsky.social. Feedback welcome. www.biorxiv.org/content/10.1...
Basigin Links Altered Skeletal Stem Cell Lineage Dynamics with Glucocorticoid-induced Bone Loss and Impaired Angiogenesis
Glucocorticoid (GC) induced osteoporosis (GIOP) and osteonecrosis remain a significant health issue with few approved therapies that can treat the bone loss and dysfunction of skeletal vasculature. Th...
www.biorxiv.org
January 27, 2025 at 5:19 PM
New and first pre-print of the lab. Fun project with Nancy Lane @ucdavis.bsky.social. Feedback welcome. www.biorxiv.org/content/10.1...
Getting started on this platform by sharing this small year in review I wrote.
rdcu.be/d2U69
rdcu.be/d2U69
Surveying the landscape of emerging osteoanabolic therapies
Nature Reviews Endocrinology - Established antiresorptive treatments for osteoporosis only slow down bone loss, and available osteoanabolic therapies — although more effective — have...
rdcu.be
December 9, 2024 at 5:04 PM
Getting started on this platform by sharing this small year in review I wrote.
rdcu.be/d2U69
rdcu.be/d2U69
Reposted by Tom Ambrosi
Here is an excellent publication with some of the important work in brain-bone signaling from @drambrosi.bsky.social and team.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A maternal brain hormone that builds bone - Nature
A brain-derived hormone, CCN3, is newly identified to have a role as an osteoanabolic factor to build bone in lactating females and in the viability of offspring.
www.nature.com
November 25, 2024 at 5:45 PM
Here is an excellent publication with some of the important work in brain-bone signaling from @drambrosi.bsky.social and team.
www.nature.com/articles/s41...
www.nature.com/articles/s41...