Dr Satoshi Akima, FRACP
@toshiakima.bsky.social
Nephrology & Internal Medicine. Immunothrombosis incl DIC. ISTH Member. No Conflicts of Interest. Views my own etc
Pinned
The Central Error of the Pandemic…
Is that of running pandemic management by laissez-faire socioeconomic principles.
If you grasp this, all the other errors fall into place as the inevitable consequence of following that line of thought. 🧵 1/x
Is that of running pandemic management by laissez-faire socioeconomic principles.
If you grasp this, all the other errors fall into place as the inevitable consequence of following that line of thought. 🧵 1/x
Reposted by Dr Satoshi Akima, FRACP
Epstein-Barr virus is linked to development of the autoimmune disease lupus in new research
www.scientificamerican.com/article/the-...
www.scientificamerican.com/article/the-...
The Virus That Causes Mono May Also Cause Lupus
Early findings indicate that Epstein-Barr Virus may also cause the autoimmune disease lupus
www.scientificamerican.com
November 13, 2025 at 2:22 PM
Epstein-Barr virus is linked to development of the autoimmune disease lupus in new research
www.scientificamerican.com/article/the-...
www.scientificamerican.com/article/the-...
Reposted by Dr Satoshi Akima, FRACP
It is "unconscionable’ that the Government [in the UK] has not recognised Long COVID as an occupational disease, warns BMA and RCN [Royal College of Nursing]"
www.bma.org.uk/bma-media-ce...
www.bma.org.uk/bma-media-ce...
‘Unconscionable’ that the Government has not recognised Long COVID as an occupational disease, warns BMA and RCN - BMA media centre - BMA
Press release from the BMA.
www.bma.org.uk
November 13, 2025 at 2:21 PM
It is "unconscionable’ that the Government [in the UK] has not recognised Long COVID as an occupational disease, warns BMA and RCN [Royal College of Nursing]"
www.bma.org.uk/bma-media-ce...
www.bma.org.uk/bma-media-ce...
Reposted by Dr Satoshi Akima, FRACP
The blueprints for a brand new hospital in NSW Australia are open for public review.
A great time to let the government know that air handling upgrades are needed.
www.haveyoursay.nsw.gov.au/rouse-hill-h...
A great time to let the government know that air handling upgrades are needed.
www.haveyoursay.nsw.gov.au/rouse-hill-h...
Rouse Hill Hospital
The NSW and Australian Governments have committed $910 million to deliver a new Rouse Hill Hospital.
www.haveyoursay.nsw.gov.au
November 13, 2025 at 2:29 PM
The blueprints for a brand new hospital in NSW Australia are open for public review.
A great time to let the government know that air handling upgrades are needed.
www.haveyoursay.nsw.gov.au/rouse-hill-h...
A great time to let the government know that air handling upgrades are needed.
www.haveyoursay.nsw.gov.au/rouse-hill-h...
Reposted by Dr Satoshi Akima, FRACP
Despite their frequent use, opioids have limited benefits in managing noncancer pain. Avoiding long-term opioid use, reducing the opioid dose, or replacing opioids with nonopioid alternatives may reduce the risk of opioid-related harm. Learn more: nej.md/4oL3fu2
#MedSky #NeuroSky
#MedSky #NeuroSky
November 11, 2025 at 8:03 PM
Despite their frequent use, opioids have limited benefits in managing noncancer pain. Avoiding long-term opioid use, reducing the opioid dose, or replacing opioids with nonopioid alternatives may reduce the risk of opioid-related harm. Learn more: nej.md/4oL3fu2
#MedSky #NeuroSky
#MedSky #NeuroSky
Reposted by Dr Satoshi Akima, FRACP
New systematic review & meta-analysis compares wearable cuffless devices for continuous blood pressure monitoring against standard 24-hour ambulatory BP monitoring.
🔗 https://ow.ly/MuPs50XpIOU
#Hypertension #Innovation #PreventiveCardiology #CardioTech #CardioSky #MedSky
🔗 https://ow.ly/MuPs50XpIOU
#Hypertension #Innovation #PreventiveCardiology #CardioTech #CardioSky #MedSky
November 10, 2025 at 11:30 PM
New systematic review & meta-analysis compares wearable cuffless devices for continuous blood pressure monitoring against standard 24-hour ambulatory BP monitoring.
🔗 https://ow.ly/MuPs50XpIOU
#Hypertension #Innovation #PreventiveCardiology #CardioTech #CardioSky #MedSky
🔗 https://ow.ly/MuPs50XpIOU
#Hypertension #Innovation #PreventiveCardiology #CardioTech #CardioSky #MedSky
NETosis is an integral part of the inflammasome youtu.be/-etkTCbnB1w?...
November 11, 2025 at 1:22 AM
NETosis is an integral part of the inflammasome youtu.be/-etkTCbnB1w?...
Reposted by Dr Satoshi Akima, FRACP
Study: Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients.
Published: 02 October 2025
onlinelibrary.wiley.com/doi/10.1002/...
Published: 02 October 2025
onlinelibrary.wiley.com/doi/10.1002/...
Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients
The persistence of vasculo-thrombotic complications has been put forward as a possible contributing factor in the Long COVID (LC) syndrome. Given the recently reported separate demonstration of the a...
onlinelibrary.wiley.com
November 11, 2025 at 1:04 AM
Study: Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients.
Published: 02 October 2025
onlinelibrary.wiley.com/doi/10.1002/...
Published: 02 October 2025
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Dr Satoshi Akima, FRACP
Scientists reveal another piece in Long COVID puzzle.
"New study reveals a structural association between circulating microclots and neutrophil extracellular traps (NETs) in patients with Long COVID. When dysregulated, this interaction may become pathogenic"
Source: archive.li/GJl3l
"New study reveals a structural association between circulating microclots and neutrophil extracellular traps (NETs) in patients with Long COVID. When dysregulated, this interaction may become pathogenic"
Source: archive.li/GJl3l
November 11, 2025 at 1:04 AM
Scientists reveal another piece in Long COVID puzzle.
"New study reveals a structural association between circulating microclots and neutrophil extracellular traps (NETs) in patients with Long COVID. When dysregulated, this interaction may become pathogenic"
Source: archive.li/GJl3l
"New study reveals a structural association between circulating microclots and neutrophil extracellular traps (NETs) in patients with Long COVID. When dysregulated, this interaction may become pathogenic"
Source: archive.li/GJl3l
Reposted by Dr Satoshi Akima, FRACP
A randomized clinical trial published in JAMA found that patients with AF who consumed caffeinated coffee had a lower risk of recurrent AF or atrial flutter compared with those who abstained.
#AHA25 #AFib @ahascience.bsky.social
ja.ma/47vUbDB
#AHA25 #AFib @ahascience.bsky.social
ja.ma/47vUbDB
November 9, 2025 at 5:00 PM
A randomized clinical trial published in JAMA found that patients with AF who consumed caffeinated coffee had a lower risk of recurrent AF or atrial flutter compared with those who abstained.
#AHA25 #AFib @ahascience.bsky.social
ja.ma/47vUbDB
#AHA25 #AFib @ahascience.bsky.social
ja.ma/47vUbDB
Reposted by Dr Satoshi Akima, FRACP
📊 Research Summary: Adults with #AFib who drank at least one cup of caffeinated coffee daily after successful cardioversion had a lower risk of recurrence than those who abstained from coffee and caffeine.
#AHA25 @ahascience.bsky.social
ja.ma/4nLL5r0
#AHA25 @ahascience.bsky.social
ja.ma/4nLL5r0
November 9, 2025 at 3:15 PM
📊 Research Summary: Adults with #AFib who drank at least one cup of caffeinated coffee daily after successful cardioversion had a lower risk of recurrence than those who abstained from coffee and caffeine.
#AHA25 @ahascience.bsky.social
ja.ma/4nLL5r0
#AHA25 @ahascience.bsky.social
ja.ma/4nLL5r0
Reposted by Dr Satoshi Akima, FRACP
Fascinating paper suggesting the assumption that there is a sigmoid dose response relationship and threshold effect ( "all-or-nothing") for loop diuretics rests on repeated misinterpretation of original studies from the 70s and 80s. #nephsky #cardiosky #emimcc academic.oup.com/ehjcvp/artic...
What are the pharmacodynamics of loop diuretics?
A recent editorial was entitled ‘Loop diuretics in heart failure: few facts and lots of prejudice’.1 I would argue that we have forgotten or distorted some
academic.oup.com
November 9, 2025 at 6:40 PM
Fascinating paper suggesting the assumption that there is a sigmoid dose response relationship and threshold effect ( "all-or-nothing") for loop diuretics rests on repeated misinterpretation of original studies from the 70s and 80s. #nephsky #cardiosky #emimcc academic.oup.com/ehjcvp/artic...
Reposted by Dr Satoshi Akima, FRACP
Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis
"Even at low levels, drinking was associated with higher BP, and cessation was associated with lower BP in both sexes."
www.jacc.org/doi/10.1016/...
"Even at low levels, drinking was associated with higher BP, and cessation was associated with lower BP in both sexes."
www.jacc.org/doi/10.1016/...
November 10, 2025 at 12:53 AM
Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis
"Even at low levels, drinking was associated with higher BP, and cessation was associated with lower BP in both sexes."
www.jacc.org/doi/10.1016/...
"Even at low levels, drinking was associated with higher BP, and cessation was associated with lower BP in both sexes."
www.jacc.org/doi/10.1016/...
Reposted by Dr Satoshi Akima, FRACP
Among patients with atherosclerosis or diabetes but no previous myocardial infarction or stroke, evolocumab led to a lower risk of major adverse cardiovascular events than placebo. Full VESALIUS-CV trial results: nej.md/4oWrIN6
#AHA25
#AHA25
November 8, 2025 at 3:36 PM
Among patients with atherosclerosis or diabetes but no previous myocardial infarction or stroke, evolocumab led to a lower risk of major adverse cardiovascular events than placebo. Full VESALIUS-CV trial results: nej.md/4oWrIN6
#AHA25
#AHA25
Reposted by Dr Satoshi Akima, FRACP
In an interim analysis, sibeprenlimab, a humanized IgG2 monoclonal antibody that inhibits the proliferation-inducing ligand APRIL (a key driver of IgA nephropathy), reduced proteinuria as compared with placebo. nej.md/493Xtza
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
November 8, 2025 at 4:35 PM
In an interim analysis, sibeprenlimab, a humanized IgG2 monoclonal antibody that inhibits the proliferation-inducing ligand APRIL (a key driver of IgA nephropathy), reduced proteinuria as compared with placebo. nej.md/493Xtza
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
Reposted by Dr Satoshi Akima, FRACP
The second sibeprenlimab paper in @nejm.org
(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial | NEJM
The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of
the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody,
selectively binds to and...
www.nejm.org
November 8, 2025 at 5:03 PM
The second sibeprenlimab paper in @nejm.org
(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
Reposted by Dr Satoshi Akima, FRACP
And another ns-MRA
Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinica...
In participants with chronic kidney disease at increased risk of disease progression,
a fixed dose combination of balcinrenone and dapagliflozin was superior to dapagliflozin
alone in reducing albumin...
www.thelancet.com
November 8, 2025 at 6:18 PM
And another ns-MRA
Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
Reposted by Dr Satoshi Akima, FRACP
Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
November 7, 2025 at 4:45 PM
Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Reposted by Dr Satoshi Akima, FRACP
Got #KidneyWk FOMO like @nephroseeker.medsky.social ?
We got you covered with daily coverage of the simultaneous publications!
www.nephjc.com/news/kidneyw...
We got you covered with daily coverage of the simultaneous publications!
www.nephjc.com/news/kidneyw...
Kidney Week in Houston: Day 1 — NephJC
in this edition: Atacicept in IgAN; Albuminuria as a surrogate outcome, Renal Remission and additional CONFIDENCE analysis
www.nephjc.com
November 7, 2025 at 5:58 PM
Got #KidneyWk FOMO like @nephroseeker.medsky.social ?
We got you covered with daily coverage of the simultaneous publications!
www.nephjc.com/news/kidneyw...
We got you covered with daily coverage of the simultaneous publications!
www.nephjc.com/news/kidneyw...
Reposted by Dr Satoshi Akima, FRACP
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
November 6, 2025 at 6:39 PM
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Reposted by Dr Satoshi Akima, FRACP
And @brendonneuen.bsky.social with another simultaneous pub in @jama.com
jamanetwork.com/journals/jam...
Flozination by GFR/albuminuria
#KidneyWk
jamanetwork.com/journals/jam...
Flozination by GFR/albuminuria
#KidneyWk
SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria
This meta-analysis examines whether estimated glomerular filtration rate or degree of albuminuria, as measured by urinary albumin to creatinine ratio, modifies the effects of sodium-glucose cotranspor...
jamanetwork.com
November 8, 2025 at 12:05 AM
And @brendonneuen.bsky.social with another simultaneous pub in @jama.com
jamanetwork.com/journals/jam...
Flozination by GFR/albuminuria
#KidneyWk
jamanetwork.com/journals/jam...
Flozination by GFR/albuminuria
#KidneyWk
Reposted by Dr Satoshi Akima, FRACP
In PISCES, daily n–3 fatty acids cut serious cardiovascular events in dialysis patients by nearly half (HR 0.57). Fish oil clearly had bigger fish to fry than placebo: fewer MIs, strokes, cardiac deaths without extra adverse catches
@nejm.org #kidneywk sim publication
www.nejm.org/doi/full/10....
@nejm.org #kidneywk sim publication
www.nejm.org/doi/full/10....
Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis | NEJM
Cardiovascular disease is the leading cause of death in patients receiving hemodialysis,
yet effective preventive therapies remain limited. Supplementation with n−3 polyunsaturated
fatty acids, esp...
www.nejm.org
November 7, 2025 at 4:40 PM
In PISCES, daily n–3 fatty acids cut serious cardiovascular events in dialysis patients by nearly half (HR 0.57). Fish oil clearly had bigger fish to fry than placebo: fewer MIs, strokes, cardiac deaths without extra adverse catches
@nejm.org #kidneywk sim publication
www.nejm.org/doi/full/10....
@nejm.org #kidneywk sim publication
www.nejm.org/doi/full/10....
Reposted by Dr Satoshi Akima, FRACP
We are looking for teachers willing to test Jasper, a CO2 monitor in their classrooms. Jasper is a prototype and we would like to receive user feedback as soon as possible from several countries. If you are interested, please fill out the form: letsair.org/jasper
November 7, 2025 at 11:28 AM
We are looking for teachers willing to test Jasper, a CO2 monitor in their classrooms. Jasper is a prototype and we would like to receive user feedback as soon as possible from several countries. If you are interested, please fill out the form: letsair.org/jasper
Reposted by Dr Satoshi Akima, FRACP
Clean the Air: Prenatal Exposure to Air Pollutants Tied to Increased Autism Risk
Prenatal Exposure to Air Pollutants Tied to Autism Risk
Exposure to sulfate and ammonium particles in air in late pregnancy, and ozone soon after birth, may raise the likelihood of autism in children, a large study shows.
www.medscape.com
November 5, 2025 at 9:11 AM
Clean the Air: Prenatal Exposure to Air Pollutants Tied to Increased Autism Risk
Clean the Air: Prenatal Exposure to Air Pollutants Tied to Increased Autism Risk
Prenatal Exposure to Air Pollutants Tied to Autism Risk
Exposure to sulfate and ammonium particles in air in late pregnancy, and ozone soon after birth, may raise the likelihood of autism in children, a large study shows.
www.medscape.com
November 5, 2025 at 9:11 AM
Clean the Air: Prenatal Exposure to Air Pollutants Tied to Increased Autism Risk
Reposted by Dr Satoshi Akima, FRACP
Taiwan is rolling out Novavax JN.1 for ages 12+ from Nov 12.
Australia needs options too.
Hey @markbutlermp.bsky.social — when will Australians be able to access Novavax?
Australia needs options too.
Hey @markbutlermp.bsky.social — when will Australians be able to access Novavax?
November 5, 2025 at 8:09 AM
Taiwan is rolling out Novavax JN.1 for ages 12+ from Nov 12.
Australia needs options too.
Hey @markbutlermp.bsky.social — when will Australians be able to access Novavax?
Australia needs options too.
Hey @markbutlermp.bsky.social — when will Australians be able to access Novavax?