tmoeckli
@tmoeckli.bsky.social
#Heidelberg based PhD student working with #protein mass spectrometry to power mathematical models related to #interferon signaling
Klingmüller lab - https://www.dkfz.de/en/systems-biology-of-signal-transduction
Klingmüller lab - https://www.dkfz.de/en/systems-biology-of-signal-transduction
New paper from the @klingmuelab.bsky.social & Timmer labs out in @cp-cellsystems.bsky.social: #Diclofenac & #acetaminophen unexpectedly shape #IL-6 and #hepcidin signaling in #liver cells.
🔗 doi.org/10.1016/j.ce...
👇 Thread with key findings
🔗 doi.org/10.1016/j.ce...
👇 Thread with key findings
November 11, 2025 at 7:16 PM
New paper from the @klingmuelab.bsky.social & Timmer labs out in @cp-cellsystems.bsky.social: #Diclofenac & #acetaminophen unexpectedly shape #IL-6 and #hepcidin signaling in #liver cells.
🔗 doi.org/10.1016/j.ce...
👇 Thread with key findings
🔗 doi.org/10.1016/j.ce...
👇 Thread with key findings
Reposted by tmoeckli
msBayesImpute: A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
October 7, 2025 at 9:40 AM
msBayesImpute: A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
Reposted by tmoeckli
My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
Mathematical modelling for biologists - Modelling concepts in biological research
Mathematical modelling for biologists - Modelling concepts in biological research
www.ebi.ac.uk
August 15, 2025 at 10:39 AM
My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
Reposted by tmoeckli
1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by @walterwchen.bsky.social and a dream team of collaborators, as explained below. www.nature.com/articles/s41...
PEX39 facilitates the peroxisomal import of PTS2-containing proteins - Nature Cell Biology
Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...
www.nature.com
July 30, 2025 at 2:04 PM
1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by @walterwchen.bsky.social and a dream team of collaborators, as explained below. www.nature.com/articles/s41...
Reposted by tmoeckli
SynchroSep-MS: Parallel LC Separations for Multiplexed Proteomics pubs.acs.org/doi/10....
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#proteomics #prot-paper
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#proteomics #prot-paper
July 31, 2025 at 4:00 PM
SynchroSep-MS: Parallel LC Separations for Multiplexed Proteomics pubs.acs.org/doi/10....
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#proteomics #prot-paper
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#proteomics #prot-paper
Reposted by tmoeckli
Our work on new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr) is out in @natcellbio.nature.com! Equal collab w/Tony Rodrigues (Jorge Azevedo lab), @dwendscheck.bsky.social (Bettina Warscheid lab)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PEX39 facilitates the peroxisomal import of PTS2-containing proteins - Nature Cell Biology
Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...
www.nature.com
July 30, 2025 at 12:16 PM
Our work on new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr) is out in @natcellbio.nature.com! Equal collab w/Tony Rodrigues (Jorge Azevedo lab), @dwendscheck.bsky.social (Bettina Warscheid lab)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🥳🥳🥳 Congratulations to everyone involved and in particular to @dwendscheck.bsky.social!
I am soooo happy to see that this story is online now and that I could contribute to it ❤️
I am soooo happy to see that this story is online now and that I could contribute to it ❤️
Major part of my PhD thesis is finally online! Thanks to everyone involved 🙏 @walterwchen.bsky.social @rjdlab.bsky.social @tmoeckli.bsky.social @hirakdas.bsky.social and the entire @warscheidlab.bsky.social #peroxisomes #Massspec #proteomics
#Biochemistry: #PEX39, a newly discovered #peroxin protein, transports enzymes into #peroxisomes like a relay racer. New paper @natcellbio.nature.com – congratulations to @dwendscheck.bsky.social @warscheidlab.bsky.social et al!
➡️ www.uni-wuerzburg.de/en/news-and-...
➡️ www.uni-wuerzburg.de/en/news-and-...
July 30, 2025 at 10:46 AM
🥳🥳🥳 Congratulations to everyone involved and in particular to @dwendscheck.bsky.social!
I am soooo happy to see that this story is online now and that I could contribute to it ❤️
I am soooo happy to see that this story is online now and that I could contribute to it ❤️
📈 Last week I had the chance to present my project on the influence of #interferon on antigen processing by the proteasome at the 2nd #Heidelberg Interferon Symposium! 🦠🧬🧫 1/3
July 13, 2025 at 10:13 AM
📈 Last week I had the chance to present my project on the influence of #interferon on antigen processing by the proteasome at the 2nd #Heidelberg Interferon Symposium! 🦠🧬🧫 1/3
Reposted by tmoeckli
Great first day at the #IFNSymposiumHD, with BBQ dinner, drinks and especially: great people and discussions 😊
Now looking forward to the second day, which will be kicked off by @meganstanifer.bsky.social shortly!
Now looking forward to the second day, which will be kicked off by @meganstanifer.bsky.social shortly!
July 11, 2025 at 6:04 AM
Great first day at the #IFNSymposiumHD, with BBQ dinner, drinks and especially: great people and discussions 😊
Now looking forward to the second day, which will be kicked off by @meganstanifer.bsky.social shortly!
Now looking forward to the second day, which will be kicked off by @meganstanifer.bsky.social shortly!
Reposted by tmoeckli
Let's leave behind simplistic & naive notions.
.
.
June 30, 2025 at 11:16 AM
Let's leave behind simplistic & naive notions.
.
.
📣Attention please!
🦠🧫🧬Interferon researcher in and around Heidelberg are kindly welcome to register for the 2nd Interferon at DKFZ symposium in July!
📜Submit your abstract until tomorrow here: indico.dkfz.de/event/1320/
🦠🧫🧬Interferon researcher in and around Heidelberg are kindly welcome to register for the 2nd Interferon at DKFZ symposium in July!
📜Submit your abstract until tomorrow here: indico.dkfz.de/event/1320/
June 25, 2025 at 9:08 AM
📣Attention please!
🦠🧫🧬Interferon researcher in and around Heidelberg are kindly welcome to register for the 2nd Interferon at DKFZ symposium in July!
📜Submit your abstract until tomorrow here: indico.dkfz.de/event/1320/
🦠🧫🧬Interferon researcher in and around Heidelberg are kindly welcome to register for the 2nd Interferon at DKFZ symposium in July!
📜Submit your abstract until tomorrow here: indico.dkfz.de/event/1320/
Reposted by tmoeckli
June 18, 2025 at 8:00 PM
Reposted by tmoeckli
@miquai.bsky.social and Robert Hazen explore a bold new law of nature: complexity steadily rises - not just in biology, but in everything from rocks to life. A fascinating weekend read. Thoughts welcome. #Science #Biology #Evolution #LawsOfNature #FunctionalInformation #ResearchSky #WeekendReads
A New Law of Nature Attempts to Explain the Complexity of the Universe
A novel suggestion that complexity increases over time, not just in living organisms but in the nonliving world, promises to rewrite notions of time and evolution.
www.wired.com
June 8, 2025 at 1:32 PM
@miquai.bsky.social and Robert Hazen explore a bold new law of nature: complexity steadily rises - not just in biology, but in everything from rocks to life. A fascinating weekend read. Thoughts welcome. #Science #Biology #Evolution #LawsOfNature #FunctionalInformation #ResearchSky #WeekendReads
Start your day right with 1,184,046 error messages 😂
June 6, 2025 at 10:05 AM
Start your day right with 1,184,046 error messages 😂
Reposted by tmoeckli
More evidence for the role of protein degradation in significantly shaping the proteome of brain tissue!
Alzheimer's disease (AD) is associated with numerous proteome changes.
We find large & consistent decrease in the abundance and stoichiometry of 20S proteasome subunits.
⬛️ It leads to abnormal accumulation of 20S substrate proteins.
🧵
biorxiv.org/content/10.1...
We find large & consistent decrease in the abundance and stoichiometry of 20S proteasome subunits.
⬛️ It leads to abnormal accumulation of 20S substrate proteins.
🧵
biorxiv.org/content/10.1...
May 30, 2025 at 2:51 PM
More evidence for the role of protein degradation in significantly shaping the proteome of brain tissue!
Reposted by tmoeckli
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.
It's not just budgets but research, institutions, expertise, and training the next generation.
May 31, 2025 at 4:43 AM
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.
It's not just budgets but research, institutions, expertise, and training the next generation.
Reposted by tmoeckli
May 27, 2025 at 5:54 AM
Reposted by tmoeckli
The antiviral cytokine interferon is thought to act through the induction of hundreds of genes. In this #PLOSBiology Perspective, @jschoggins.bsky.social highlights recent findings that instead suggest distinct viruses are targeted by small subsets of the induced gene repertoire. 🧪
plos.io/4m7hOYi
plos.io/4m7hOYi
Old cytokine, new tricks: A refined model of interferon’s antiviral activity
Interferon is a central component of the vertebrate antiviral immune response, thought to act through induction of hundreds of interferon-stimulated genes, with some redundancy. This Perspective highl...
plos.io
May 8, 2025 at 1:33 PM
The antiviral cytokine interferon is thought to act through the induction of hundreds of genes. In this #PLOSBiology Perspective, @jschoggins.bsky.social highlights recent findings that instead suggest distinct viruses are targeted by small subsets of the induced gene repertoire. 🧪
plos.io/4m7hOYi
plos.io/4m7hOYi
Reposted by tmoeckli
Second Heidelberg Interferons Symposium coming up!! If you are based in HD or Mannheim (@dkfz.bsky.social, @uniheidelberg.bsky.social, @hlsalliance.bsky.social, @embl.org,...) and interested in any facet of these incredible #cytokines, join us on
🗓️ July 10/11
🏫 Marsilius Kolleg
✍🏻 bit.ly/IFN2025
🗓️ July 10/11
🏫 Marsilius Kolleg
✍🏻 bit.ly/IFN2025
May 9, 2025 at 9:10 AM
Second Heidelberg Interferons Symposium coming up!! If you are based in HD or Mannheim (@dkfz.bsky.social, @uniheidelberg.bsky.social, @hlsalliance.bsky.social, @embl.org,...) and interested in any facet of these incredible #cytokines, join us on
🗓️ July 10/11
🏫 Marsilius Kolleg
✍🏻 bit.ly/IFN2025
🗓️ July 10/11
🏫 Marsilius Kolleg
✍🏻 bit.ly/IFN2025
Reposted by tmoeckli
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
May 13, 2025 at 7:55 PM
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
💫 Great Symposium ahead! If you are interested in Interferons, come and join 🥳
Second Heidelberg Interferons Symposium coming up!! If you are based in HD or Mannheim (@dkfz.bsky.social, @uniheidelberg.bsky.social, @hlsalliance.bsky.social, @embl.org,...) and interested in any facet of these incredible #cytokines, join us on
🗓️ July 10/11
🏫 Marsilius Kolleg
✍🏻 bit.ly/IFN2025
🗓️ July 10/11
🏫 Marsilius Kolleg
✍🏻 bit.ly/IFN2025
May 9, 2025 at 9:40 AM
💫 Great Symposium ahead! If you are interested in Interferons, come and join 🥳
Reposted by tmoeckli
Applications with short and medium term payoff are fruitful and needed. They are easier to understand, especially by non experts.
The benefits of basic research are harder to understand. Understanding & appreciation require more expertise and longer term perspective.
The benefits of basic research are harder to understand. Understanding & appreciation require more expertise and longer term perspective.
Today’s most transformative medicines exist because of fundamental discoveries that were made without regard to practical outcome.
Their relevance to therapeutics only appeared decades later.
This article provides some compelling examples.
🔽
Their relevance to therapeutics only appeared decades later.
This article provides some compelling examples.
🔽
April 28, 2025 at 9:56 AM
Applications with short and medium term payoff are fruitful and needed. They are easier to understand, especially by non experts.
The benefits of basic research are harder to understand. Understanding & appreciation require more expertise and longer term perspective.
The benefits of basic research are harder to understand. Understanding & appreciation require more expertise and longer term perspective.
Reposted by tmoeckli
ibaqpy: A scalable #Python package for baseline quantification in proteomics leveraging #SDRF metadata www.sciencedirect.com/science/arti.... We continue our effort to provide tools and algorithms that leverage SDRF metadata to perform quantitative proteomics analysis.
Ibaqpy: A scalable Python package for baseline quantification in proteomics leveraging SDRF metadata
Intensity-based absolute quantification (iBAQ) is essential in proteomics as it allows for the assessment of a protein's absolute abundance in various…
www.sciencedirect.com
April 25, 2025 at 12:22 PM
ibaqpy: A scalable #Python package for baseline quantification in proteomics leveraging #SDRF metadata www.sciencedirect.com/science/arti.... We continue our effort to provide tools and algorithms that leverage SDRF metadata to perform quantitative proteomics analysis.
Reposted by tmoeckli
DDM (n-dodecyl β-D-maltoside). This seems too good to be true?! It's giving us a huge boost in hydrophobic peptide signal.
March 7, 2025 at 6:15 PM
DDM (n-dodecyl β-D-maltoside). This seems too good to be true?! It's giving us a huge boost in hydrophobic peptide signal.