Thomas Gregor
@thomasgregor.bsky.social
Scientist — Biophysicist
https://tglab.princeton.edu/
https://research.pasteur.fr/en/team/physics-of-biological-functions/
https://tglab.princeton.edu/
https://research.pasteur.fr/en/team/physics-of-biological-functions/
Reposted by Thomas Gregor
An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning https://www.biorxiv.org/content/10.1101/2025.06.17.660116v1
June 22, 2025 at 10:30 AM
An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning https://www.biorxiv.org/content/10.1101/2025.06.17.660116v1
Reposted by Thomas Gregor
Catch up on our recent Community Lecture with Blaise Agüera y Arcas! The lecture, Computing, Life, and Intelligence, is available on SFI’s YouTube channel: www.youtube.com/live/75PAyV8...
@blaiseaguera.bsky.social
@blaiseaguera.bsky.social
May 23, 2025 at 1:30 PM
Catch up on our recent Community Lecture with Blaise Agüera y Arcas! The lecture, Computing, Life, and Intelligence, is available on SFI’s YouTube channel: www.youtube.com/live/75PAyV8...
@blaiseaguera.bsky.social
@blaiseaguera.bsky.social
Reposted by Thomas Gregor
In which we discuss the homologies between amphibian and mammalian organizers from the perspective of #gastruloids with special relevance to recently described A and C gastruloids as containing Spemann/Mangold and Trunk/Tail organizers www.sciencedirect.com/science/arti...
May 23, 2025 at 10:35 AM
In which we discuss the homologies between amphibian and mammalian organizers from the perspective of #gastruloids with special relevance to recently described A and C gastruloids as containing Spemann/Mangold and Trunk/Tail organizers www.sciencedirect.com/science/arti...
Reposted by Thomas Gregor
Check out our "In Preprints" @dev-journal.bsky.social w/ Yonit Maroudas-Sacks & Marc Trani Bustos @mpi-cbg.de @poldresden.bsky.social, putting recent #gastruloid work from @viktri08.bsky.social @thomasgregor.bsky.social @amartinezarias.bsky.social labs in broader perspective: doi.org/10.1242/dev....
In preprints: exploring developmental robustness and timing with gastruloids
How developmental processes are coordinated in time and space to ensure the robust formation of complex, functional patterns during embryogenesis remains an outstanding question. Investigating this in...
doi.org
May 19, 2025 at 11:42 AM
Check out our "In Preprints" @dev-journal.bsky.social w/ Yonit Maroudas-Sacks & Marc Trani Bustos @mpi-cbg.de @poldresden.bsky.social, putting recent #gastruloid work from @viktri08.bsky.social @thomasgregor.bsky.social @amartinezarias.bsky.social labs in broader perspective: doi.org/10.1242/dev....
Reposted by Thomas Gregor
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...
May 6, 2025 at 9:01 AM
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...
Reposted by Thomas Gregor
It is also good to get some perspective, such as given by ballpark numbers and recent policies, since announcements were made. With the help of Perplexity. (1) The two systems start on different scales:
May 5, 2025 at 6:48 PM
It is also good to get some perspective, such as given by ballpark numbers and recent policies, since announcements were made. With the help of Perplexity. (1) The two systems start on different scales:
Reposted by Thomas Gregor
😱 A very hungry #PacManoid ate the original post 🍬🍬🍬
Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!
Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...
Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!
Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...
Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
April 19, 2025 at 8:49 AM
😱 A very hungry #PacManoid ate the original post 🍬🍬🍬
Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!
Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...
Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!
Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...
Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
Reposted by Thomas Gregor
Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 9, 2025 at 4:52 PM
Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Thomas Gregor
A methodology to reduce the localization error in multi-loci microscopy provides new insights into enhancer biology https://www.biorxiv.org/content/10.1101/2025.04.05.647393v1
April 9, 2025 at 11:48 PM
A methodology to reduce the localization error in multi-loci microscopy provides new insights into enhancer biology https://www.biorxiv.org/content/10.1101/2025.04.05.647393v1
Reposted by Thomas Gregor
The Dark Energy Spectroscopic Instrument (DESI) has determined the distances to enough galaxies by now to conclude that the cosmological constant is not in fact constant.
The Standard Cosmology Model May Be Breaking
Measurements of millions of galaxies suggest that dark energy changes over time and is more complicated than previously thought.
physics.aps.org
March 28, 2025 at 7:20 PM
The Dark Energy Spectroscopic Instrument (DESI) has determined the distances to enough galaxies by now to conclude that the cosmological constant is not in fact constant.
Reposted by Thomas Gregor
Martino Ugolini and I wrote a review on how useful embryos are to understand the role of transcription bodies in gene expression. I am sure
@mirlab.bsky.social, @harrisonflylab.bsky.social, @lennarthilbert.bsky.social and others would agree. Enjoy the read! portlandpress.com/biochemsoctr....
@mirlab.bsky.social, @harrisonflylab.bsky.social, @lennarthilbert.bsky.social and others would agree. Enjoy the read! portlandpress.com/biochemsoctr....
The role of transcription bodies in gene expression: what embryos teach us
Transcription does not occur diffusely throughout the nucleus but is concentrated in specific areas. Areas of accumulated transcriptional machinery have been called clusters, hubs, or condensates, whi...
portlandpress.com
March 28, 2025 at 3:09 PM
Martino Ugolini and I wrote a review on how useful embryos are to understand the role of transcription bodies in gene expression. I am sure
@mirlab.bsky.social, @harrisonflylab.bsky.social, @lennarthilbert.bsky.social and others would agree. Enjoy the read! portlandpress.com/biochemsoctr....
@mirlab.bsky.social, @harrisonflylab.bsky.social, @lennarthilbert.bsky.social and others would agree. Enjoy the read! portlandpress.com/biochemsoctr....
Reposted by Thomas Gregor
We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview
Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
March 25, 2025 at 11:21 AM
We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview
Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
Reposted by Thomas Gregor
I'm so happy to report that our preprint on light-induced collective cell migration has now been published in Cell Systems! This project was a lot of fun and will be the basis for a lot of our ongoing & future work.
Large-scale control over collective cell migration using light-activated epidermal growth factor receptors
Programmable control over tissue movement is a fundamental challenge for tissue engineering
and wound healing. Suh, Thornton, et al. discovered that a light-controlled EGF receptor
controls long-range...
www.cell.com
March 25, 2025 at 6:29 PM
I'm so happy to report that our preprint on light-induced collective cell migration has now been published in Cell Systems! This project was a lot of fun and will be the basis for a lot of our ongoing & future work.
Reposted by Thomas Gregor
How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...
Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous
For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...
www.science.org
March 22, 2025 at 1:47 AM
How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...
Reposted by Thomas Gregor
The Barcelona #gastruloid meeting has been a blast. A witness to a field that is maturing and a statement of a promise that lurks in its horizon. Thank you @joshifrenster.bsky.social @dias-andre.bsky.social and Ulla Fiuza for the organization, @EMBO, @ERC and the community for support.
March 21, 2025 at 10:03 PM
The Barcelona #gastruloid meeting has been a blast. A witness to a field that is maturing and a statement of a promise that lurks in its horizon. Thank you @joshifrenster.bsky.social @dias-andre.bsky.social and Ulla Fiuza for the organization, @EMBO, @ERC and the community for support.
Reposted by Thomas Gregor
still possible to apply:
phygenome.sciencesconf.org
phygenome.sciencesconf.org
March 20, 2025 at 8:40 AM
still possible to apply:
phygenome.sciencesconf.org
phygenome.sciencesconf.org
Reposted by Thomas Gregor
⭐️ Please Fwd. Are you in Paris on 16th May? See👇 poster of symposium on « Information processing in biological systems » @collegedefrance.bsky.social Fantastic line of speakers 🤩.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.
March 20, 2025 at 8:03 AM
⭐️ Please Fwd. Are you in Paris on 16th May? See👇 poster of symposium on « Information processing in biological systems » @collegedefrance.bsky.social Fantastic line of speakers 🤩.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.
Reposted by Thomas Gregor
N2B27 media formulations influence gastruloid development https://www.biorxiv.org/content/10.1101/2025.03.15.643474v1
March 17, 2025 at 4:30 AM
N2B27 media formulations influence gastruloid development https://www.biorxiv.org/content/10.1101/2025.03.15.643474v1
Reposted by Thomas Gregor
There's increasing evidence that in organoid/embryoids conditions of cells at start of experiments is crucial/ determines outcome. Much to be learnt still. Taking advantage of mouse #gastruloids, two groups explore this here. Important work to calibrate the field www.biorxiv.org/content/10.1...
March 19, 2025 at 12:01 PM
There's increasing evidence that in organoid/embryoids conditions of cells at start of experiments is crucial/ determines outcome. Much to be learnt still. Taking advantage of mouse #gastruloids, two groups explore this here. Important work to calibrate the field www.biorxiv.org/content/10.1...
Reposted by Thomas Gregor
We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com
Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable
Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable
March 11, 2025 at 11:50 PM
We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com
Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable
Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable
Reposted by Thomas Gregor
Excited to share our new work with Frank Jülicher on noise control & concentration buffering in intracellular condensates! There has been confusion about these concepts, which we aim to address in this paper.
www.cell.com/cell-systems...
www.cell.com/cell-systems...
February 12, 2025 at 8:47 AM
Excited to share our new work with Frank Jülicher on noise control & concentration buffering in intracellular condensates! There has been confusion about these concepts, which we aim to address in this paper.
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Shocking: a pioneer in quantitative developmental biology passed... one of my all-time heroes! He had a dominant influence on many in the early 2000s when this field started to take off. What a loss!
Obituary written by two of his former students:
biologicalsciences.uchicago.edu/news/john-re...
Obituary written by two of his former students:
biologicalsciences.uchicago.edu/news/john-re...
John Reinitz, systems biologist, 1958-2025
Reinitz helped pioneer a data-driven, systems approach to developmental biology that is now widely used in the field today.
biologicalsciences.uchicago.edu
February 6, 2025 at 2:13 PM
Shocking: a pioneer in quantitative developmental biology passed... one of my all-time heroes! He had a dominant influence on many in the early 2000s when this field started to take off. What a loss!
Obituary written by two of his former students:
biologicalsciences.uchicago.edu/news/john-re...
Obituary written by two of his former students:
biologicalsciences.uchicago.edu/news/john-re...
Reposted by Thomas Gregor
January has been a plentiful month for #gastruloid #preprints. Here @thomasgregor.bsky.social @denisduboule.bsky.social & colleagues introduce a new family of #hydrogels and probe the effect of mechanical constrains on morphogenesis www.biorxiv.org/content/10.1...
#NotInTheGenes #InNumbersWeTrust
#NotInTheGenes #InNumbersWeTrust
January 30, 2025 at 6:47 PM
January has been a plentiful month for #gastruloid #preprints. Here @thomasgregor.bsky.social @denisduboule.bsky.social & colleagues introduce a new family of #hydrogels and probe the effect of mechanical constrains on morphogenesis www.biorxiv.org/content/10.1...
#NotInTheGenes #InNumbersWeTrust
#NotInTheGenes #InNumbersWeTrust
Reposted by Thomas Gregor
Check out this new paper from @thomasgregor.bsky.social 's lab on hydrogel embedding of mouse gastruloids to control gene expression and patterning.
January 30, 2025 at 8:05 AM
Check out this new paper from @thomasgregor.bsky.social 's lab on hydrogel embedding of mouse gastruloids to control gene expression and patterning.
Reposted by Thomas Gregor
Does anyone know of a search engine which searches all preprint archives, and only preprint archives (i.e., not Google Scholar)? In @europepmc.bsky.social I find @biorxivpreprint.bsky.social and EcoEvoRxiv , but not arXiv-Qbio.
January 21, 2025 at 1:25 PM
Does anyone know of a search engine which searches all preprint archives, and only preprint archives (i.e., not Google Scholar)? In @europepmc.bsky.social I find @biorxivpreprint.bsky.social and EcoEvoRxiv , but not arXiv-Qbio.