Thilani Babuji
@thilanibabuji.bsky.social
Scientist 👩🏾🔬 PhD candidate in Dynamic Molecular Cell Biology in the Dodding lab @BristolBiochem
Part time painter 🎨 Big on protein interactions and proteins in general! 🔬
Part time painter 🎨 Big on protein interactions and proteins in general! 🔬
Reposted by Thilani Babuji
How do the two most abundant glial cell types in the brain "welcome" red blood cells and other things coming through the blood vessels? Check the image below! 🤓 🔬 🧠
Astrocytes 🔵
Microglia 🟡
Red blood cells 🔴
#FluorescenceFriday
Astrocytes 🔵
Microglia 🟡
Red blood cells 🔴
#FluorescenceFriday
June 13, 2025 at 4:18 PM
How do the two most abundant glial cell types in the brain "welcome" red blood cells and other things coming through the blood vessels? Check the image below! 🤓 🔬 🧠
Astrocytes 🔵
Microglia 🟡
Red blood cells 🔴
#FluorescenceFriday
Astrocytes 🔵
Microglia 🟡
Red blood cells 🔴
#FluorescenceFriday
Reposted by Thilani Babuji
Wonder doesn’t flinch. It’s our compass pulling us toward curiosity, creativity It reminds us: #science & #discovery are good. Here’s a moment that stirred mine: a new PI(3,4)P₂ probe illuminating the cell membrane & endosomes. Marvel with me. Captured on #FluorescenceFriday for #MicroscopyMonday
May 26, 2025 at 4:43 PM
Wonder doesn’t flinch. It’s our compass pulling us toward curiosity, creativity It reminds us: #science & #discovery are good. Here’s a moment that stirred mine: a new PI(3,4)P₂ probe illuminating the cell membrane & endosomes. Marvel with me. Captured on #FluorescenceFriday for #MicroscopyMonday
Reposted by Thilani Babuji
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
May 2, 2025 at 2:39 PM
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Reposted by Thilani Babuji
🧪Holy shit. The Covid.gov website directs to the WH website claiming that covid came from a lab leak. And they are blaming Anthony Fauci. And calling the NIH a failure. I am utterly speechless. Anti-science propaganda running its wheels in real time.
Lab Leak: The True Origins of Covid-19
THE ORIGIN “The Proximal Origin of SARS-CoV-2” publication — which was used repeatedly by public health officials and the media to discredit the lab leak
Covid.gov
April 19, 2025 at 12:19 AM
🧪Holy shit. The Covid.gov website directs to the WH website claiming that covid came from a lab leak. And they are blaming Anthony Fauci. And calling the NIH a failure. I am utterly speechless. Anti-science propaganda running its wheels in real time.
Reposted by Thilani Babuji
aside: a stunning comment from David Baker, UW professor who won the Nobel Prize in 2024. Now 15 lab members are looking for positions overseas.
“There’s so many amazing people who want to come in, & we can’t take them. The Nobel Prize was just a little blip. But things have gotten quite bleak.”
“There’s so many amazing people who want to come in, & we can’t take them. The Nobel Prize was just a little blip. But things have gotten quite bleak.”
April 14, 2025 at 12:37 PM
aside: a stunning comment from David Baker, UW professor who won the Nobel Prize in 2024. Now 15 lab members are looking for positions overseas.
“There’s so many amazing people who want to come in, & we can’t take them. The Nobel Prize was just a little blip. But things have gotten quite bleak.”
“There’s so many amazing people who want to come in, & we can’t take them. The Nobel Prize was just a little blip. But things have gotten quite bleak.”
Reposted by Thilani Babuji
I offered to present online but was told that this isn’t possible. We need to change this culture! In a world where scientists cannot travel freely, it should be possible to attend virtually. There are always people who can’t travel who shouldn’t be excluded. Science belongs to everyone, everywhere.
April 11, 2025 at 8:12 PM
I offered to present online but was told that this isn’t possible. We need to change this culture! In a world where scientists cannot travel freely, it should be possible to attend virtually. There are always people who can’t travel who shouldn’t be excluded. Science belongs to everyone, everywhere.
Reposted by Thilani Babuji
And a postdoc position available working between our lab and the Woolfson lab designing proteins and peptides to augment intracellular transport pathways t.co/0WWgylZMbS
https://www.jobs.ac.uk/job/DMN615/research-associate-senior-research-associate-in-de-novo-peptide-and-protein-design
t.co
April 10, 2025 at 1:02 PM
And a postdoc position available working between our lab and the Woolfson lab designing proteins and peptides to augment intracellular transport pathways t.co/0WWgylZMbS
Reposted by Thilani Babuji
New preprint on kinesin inhibition and activation - collaborative effort across Bristol Biochem and Chemistry with Woolfson and Schaffizel labs and JJ Phillips in Exeter 1/2 www.biorxiv.org/content/10.1...
Molecular mechanism for cargo-mediated initiation of kinesin-1 activation
Kinesin-1 is a dynamic heterotetrameric assembly of two heavy and two light chains (KHC and KLC) that mediates microtubule-based intracellular transport of many different cargoes. The complex adopts a...
www.biorxiv.org
April 10, 2025 at 1:02 PM
New preprint on kinesin inhibition and activation - collaborative effort across Bristol Biochem and Chemistry with Woolfson and Schaffizel labs and JJ Phillips in Exeter 1/2 www.biorxiv.org/content/10.1...
Reposted by Thilani Babuji
Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!
April 9, 2025 at 3:42 PM
Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!
Reposted by Thilani Babuji
Today @gogs-k.bsky.social, @tlhr.bsky.social, and I are launching @bindresearch.org, a UK-based not-for-profit research startup to deliver publicly–available tools and datasets to make intrinsically disordered proteins druggable. 🍝 💊🧲 💻 🦠
February 11, 2025 at 9:26 AM
Today @gogs-k.bsky.social, @tlhr.bsky.social, and I are launching @bindresearch.org, a UK-based not-for-profit research startup to deliver publicly–available tools and datasets to make intrinsically disordered proteins druggable. 🍝 💊🧲 💻 🦠
Reposted by Thilani Babuji
Summer #internships in cell, developmental, and systems #biology, #biophysics, #mathematics (and more) @mpicbg.bsky.social @mpipks.bsky.social. Applications are open now:
www.imprs-celldevosys.de/join/interns....
Join us in #Dresden over the summer!
www.imprs-celldevosys.de/join/interns....
Join us in #Dresden over the summer!
IMPRS-CellDevoSys / Join! / Internships / Introduction
www.imprs-celldevosys.de
February 7, 2025 at 2:28 PM
Summer #internships in cell, developmental, and systems #biology, #biophysics, #mathematics (and more) @mpicbg.bsky.social @mpipks.bsky.social. Applications are open now:
www.imprs-celldevosys.de/join/interns....
Join us in #Dresden over the summer!
www.imprs-celldevosys.de/join/interns....
Join us in #Dresden over the summer!
Reposted by Thilani Babuji
When Scientific American endorsed Harris, many scientists and science-friendly people were supportive and grateful, but some said: stick to science, science isn’t political, etc. But reality-denying right-wing fanatics will absolutely come for the scientists www.washingtonpost.com/science/2025...
Trump policies sow chaos, confusion across scientific community
U.S. scientists, unaccustomed to shock-and-awe political assaults, are reeling from President Donald Trump’s executive orders on DEI, gender and other subjects.
www.washingtonpost.com
February 7, 2025 at 7:47 PM
When Scientific American endorsed Harris, many scientists and science-friendly people were supportive and grateful, but some said: stick to science, science isn’t political, etc. But reality-denying right-wing fanatics will absolutely come for the scientists www.washingtonpost.com/science/2025...
Reposted by Thilani Babuji
📢 JOB VACANCY
4-Year Postdoc Position in Protein Design at @bristoluni.bsky.social
Develop new peptides and proteins to manipulate, target and probe the mechanisms that underpin intracellular transport by microtubule motors.
More: www.bristol.ac.uk/jobs/find-in...
Deadline: 6 Feb 2025
4-Year Postdoc Position in Protein Design at @bristoluni.bsky.social
Develop new peptides and proteins to manipulate, target and probe the mechanisms that underpin intracellular transport by microtubule motors.
More: www.bristol.ac.uk/jobs/find-in...
Deadline: 6 Feb 2025
January 10, 2025 at 12:25 PM
📢 JOB VACANCY
4-Year Postdoc Position in Protein Design at @bristoluni.bsky.social
Develop new peptides and proteins to manipulate, target and probe the mechanisms that underpin intracellular transport by microtubule motors.
More: www.bristol.ac.uk/jobs/find-in...
Deadline: 6 Feb 2025
4-Year Postdoc Position in Protein Design at @bristoluni.bsky.social
Develop new peptides and proteins to manipulate, target and probe the mechanisms that underpin intracellular transport by microtubule motors.
More: www.bristol.ac.uk/jobs/find-in...
Deadline: 6 Feb 2025
Reposted by Thilani Babuji
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 5:49 PM
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Thilani Babuji
There’s a lot more to say about it, but it can wait till the new year. There’s a big addgene deposit with a bunch of useful dual CLIP and SNAP tagged things that will hopefully be useful for lots of folks (Merry Christmas!), as well as kinesin stuff.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo
Kinesin-1 is an essential anterograde microtubule motor protein. The core kinesin motor is a homodimer of two heavy chains; N-terminal motor domains hydrolyse ATP and walk along microtubules, whilst...
www.biorxiv.org
December 21, 2024 at 2:55 PM
There’s a lot more to say about it, but it can wait till the new year. There’s a big addgene deposit with a bunch of useful dual CLIP and SNAP tagged things that will hopefully be useful for lots of folks (Merry Christmas!), as well as kinesin stuff.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Thilani Babuji
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion https://www.biorxiv.org/content/10.1101/2024.12.13.628370v1
December 18, 2024 at 6:49 AM
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion https://www.biorxiv.org/content/10.1101/2024.12.13.628370v1
Reposted by Thilani Babuji
I have a funded PhD studentship available to start in my new lab in 2025! If you are interested in Endosomal Biology, Astrocytes and Alzheimer’s Disease have a look:
www.findaphd.com/phds/project...
Please feel free to share.
www.findaphd.com/phds/project...
Please feel free to share.
The Role of the Endosomal System in Alzheimer’s Disease. at University of Liverpool on FindAPhD.com
PhD Project - The Role of the Endosomal System in Alzheimer’s Disease. at University of Liverpool, listed on FindAPhD.com
www.findaphd.com
December 18, 2024 at 4:58 PM
I have a funded PhD studentship available to start in my new lab in 2025! If you are interested in Endosomal Biology, Astrocytes and Alzheimer’s Disease have a look:
www.findaphd.com/phds/project...
Please feel free to share.
www.findaphd.com/phds/project...
Please feel free to share.
Reposted by Thilani Babuji
Read about my amazing PhD student Ryan. Many thanks to CoB for hosting him for 3 months
🧪 Each year, we offer professional internships for PhD students. This year Ryan Harrison, a PhD student between the labs of @timesaunders.bsky.social and @jamesbriscoe.bsky.social lab, completed a 12-week internship with our community sites. Read his story: https://bit.ly/4fihgtX
#SciSky #SciComm
#SciSky #SciComm
Ryan Harrison recounts his professional internship at The Company of Biologists
5 December 2024 Ryan Harrison, a PhD student between the labs of Timothy Saunders and James Briscoe as part of the MRC DTP in Interdisciplinary Biomedical Research, recounts his recent internship…
bit.ly
December 16, 2024 at 5:25 PM
Read about my amazing PhD student Ryan. Many thanks to CoB for hosting him for 3 months
Reposted by Thilani Babuji
@christanny.bsky.social will present her PhD work on #Cytoskeletal- #Golgi crosstalk during cellular #migration through #confined environments, P2586 Tuesday Dec 17, B195, 11:15am - 12:45pm #cytoskeleton #CellBio2024 @ascbiology.bsky.social
December 12, 2024 at 1:26 AM
@christanny.bsky.social will present her PhD work on #Cytoskeletal- #Golgi crosstalk during cellular #migration through #confined environments, P2586 Tuesday Dec 17, B195, 11:15am - 12:45pm #cytoskeleton #CellBio2024 @ascbiology.bsky.social
Reposted by Thilani Babuji
Impressive work by @franknoe.bsky.social and team! A pragmatic tour-de-force combining experimental and predicted protein structures, MD simulations and experimental stability data to sample conformational ensembles of proteins. Think AlphaFold, but capturing multiple free energy minima.
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 8, 2024 at 11:21 AM
Impressive work by @franknoe.bsky.social and team! A pragmatic tour-de-force combining experimental and predicted protein structures, MD simulations and experimental stability data to sample conformational ensembles of proteins. Think AlphaFold, but capturing multiple free energy minima.
Reposted by Thilani Babuji
Reading the paper in Cell about how to close the scissor plots in gender representation at senior academic positions, I feel just a touch of pessimism. Having reached a level of seniority (middle management) I didn’t think I ever would, I read these great ideas wanting more, much more /1.
Closing the scissor-shaped curve: Strategies to promote gender equality in academia
Gender inequality in STEM fields remains pervasive and undermines the ability for
talented individuals to excel. Despite advances, women still encounter obstacles in
pursuing academic careers and reac...
www.cell.com
December 1, 2024 at 4:12 AM
Reading the paper in Cell about how to close the scissor plots in gender representation at senior academic positions, I feel just a touch of pessimism. Having reached a level of seniority (middle management) I didn’t think I ever would, I read these great ideas wanting more, much more /1.
Cool project, great new PI!
Please share this PhD opportunity in my new lab in Bristol, using protein design/ engineering to understand and build molecular motors to control intracellular transport. Working with @markdodding.bsky.social and Prof Dek Woolfson.
www.findaphd.com/phds/project...
www.swbio.ac.uk/biomolecular...
www.findaphd.com/phds/project...
www.swbio.ac.uk/biomolecular...
November 28, 2024 at 6:12 PM
Cool project, great new PI!
Reposted by Thilani Babuji
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
November 27, 2024 at 12:15 PM
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
Reposted by Thilani Babuji
I wish there was an easier way to communicate to early career people what being at the next stage is actually like.
You can describe it, but it’s like an embodied experience that’s very hard to help people really understand. There’s no analog.
You can describe it, but it’s like an embodied experience that’s very hard to help people really understand. There’s no analog.
November 23, 2024 at 8:18 PM
I wish there was an easier way to communicate to early career people what being at the next stage is actually like.
You can describe it, but it’s like an embodied experience that’s very hard to help people really understand. There’s no analog.
You can describe it, but it’s like an embodied experience that’s very hard to help people really understand. There’s no analog.