Steve Fletcher
@stephenfletcher.bsky.social
Prof of Chemistry at the University of Oxford. loves Ruben sandwiches and complex chemical systems. Canadian, father, synthesis, chirality
Reposted by Steve Fletcher
Activity-based protein profiling covalent small molecules that potentiate the activity of the METTL5:TRMT112 complex through binding to a complexoform-restricted allosteric pocket absent in other TRMT112:methyltransferase complexes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 12, 2026 at 5:12 PM
Activity-based protein profiling covalent small molecules that potentiate the activity of the METTL5:TRMT112 complex through binding to a complexoform-restricted allosteric pocket absent in other TRMT112:methyltransferase complexes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Steve Fletcher
We're Hiring! If you are interested in a PDRA post with the Mehta group, please apply! @ox.ac.uk @oxfordchemistry.bsky.social
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
Job Details
my.corehr.com
January 12, 2026 at 12:09 PM
We're Hiring! If you are interested in a PDRA post with the Mehta group, please apply! @ox.ac.uk @oxfordchemistry.bsky.social
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
Reposted by Steve Fletcher
In @science.org for chemsky this week, Michael Willis’ group make beta-lactam analogues with S=O in place of C=O, using energy-transfer reactivity of N-silyl sulfinylamine precursors.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Access to four-membered cyclic sulfinamides by energy transfer catalysis
Synthetic transformations that advance through excited states proceed by unconventional mechanistic pathways and deliver products not accessible using ground-state chemistry. The breadth of these synt...
www.science.org
January 8, 2026 at 8:03 PM
In @science.org for chemsky this week, Michael Willis’ group make beta-lactam analogues with S=O in place of C=O, using energy-transfer reactivity of N-silyl sulfinylamine precursors.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Two (2) corkscrews went down trying to open this
January 3, 2026 at 10:35 PM
Two (2) corkscrews went down trying to open this
Reposted by Steve Fletcher
Ok here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.
December 30, 2025 at 12:56 PM
Ok here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.
Reposted by Steve Fletcher
Come be my colleague @ucdchemistry.bsky.social!
We're currently looking for an organic chemist (broadly defined) to start as a permanent (i.e., tenured) assistant professor.
Job reference (www.ucd.ie/workatucd/jo...) is 019237. Due date Feb. 27, 2026
Reach out if you have questions!
We're currently looking for an organic chemist (broadly defined) to start as a permanent (i.e., tenured) assistant professor.
Job reference (www.ucd.ie/workatucd/jo...) is 019237. Due date Feb. 27, 2026
Reach out if you have questions!
December 19, 2025 at 11:36 AM
Come be my colleague @ucdchemistry.bsky.social!
We're currently looking for an organic chemist (broadly defined) to start as a permanent (i.e., tenured) assistant professor.
Job reference (www.ucd.ie/workatucd/jo...) is 019237. Due date Feb. 27, 2026
Reach out if you have questions!
We're currently looking for an organic chemist (broadly defined) to start as a permanent (i.e., tenured) assistant professor.
Job reference (www.ucd.ie/workatucd/jo...) is 019237. Due date Feb. 27, 2026
Reach out if you have questions!
Beep was nasty…
For five decades, Beep Fruit Drink was a lunchbox staple for many.
Created and manufactured in Nova Scotia, the drink was very popular.
Eventually though, sales started to decline leading to its discontinuation (TWICE!).
This is the story of Beep Juice!
🧵 1/5
Created and manufactured in Nova Scotia, the drink was very popular.
Eventually though, sales started to decline leading to its discontinuation (TWICE!).
This is the story of Beep Juice!
🧵 1/5
December 13, 2025 at 2:50 PM
Beep was nasty…
Reposted by Steve Fletcher
On Dec. 6, 1917 at 8:45 a.m., the Imo and Mont-Blanc (which was packed with explosives) collided in Halifax Harbour.
At 9:05 a.m., the Mont-Blanc exploded. The 2.9 kiloton blast levelled most of Halifax, killed 1,700 and injured 9,000.
This is the story.
📸 LAC
🧵 1/12
At 9:05 a.m., the Mont-Blanc exploded. The 2.9 kiloton blast levelled most of Halifax, killed 1,700 and injured 9,000.
This is the story.
📸 LAC
🧵 1/12
December 6, 2025 at 2:00 PM
On Dec. 6, 1917 at 8:45 a.m., the Imo and Mont-Blanc (which was packed with explosives) collided in Halifax Harbour.
At 9:05 a.m., the Mont-Blanc exploded. The 2.9 kiloton blast levelled most of Halifax, killed 1,700 and injured 9,000.
This is the story.
📸 LAC
🧵 1/12
At 9:05 a.m., the Mont-Blanc exploded. The 2.9 kiloton blast levelled most of Halifax, killed 1,700 and injured 9,000.
This is the story.
📸 LAC
🧵 1/12
watching The wire - Omar easily one of the best bad guys ever
November 28, 2025 at 11:33 PM
watching The wire - Omar easily one of the best bad guys ever
A movie that takes place where I’m from
a hockey player wearing a blue jersey with the letter a on the front
ALT: a hockey player wearing a blue jersey with the letter a on the front
media.tenor.com
November 23, 2025 at 6:56 PM
A movie that takes place where I’m from
Reposted by Steve Fletcher
The chemotypes within FDA approvals so far this year are quite diverse. Most of the 2025 small molecule approvals are chiral with four covalent electrophiles.
November 23, 2025 at 12:58 AM
The chemotypes within FDA approvals so far this year are quite diverse. Most of the 2025 small molecule approvals are chiral with four covalent electrophiles.
any suggestions for a equivalent reagent for Na/Hg?
November 21, 2025 at 11:48 AM
any suggestions for a equivalent reagent for Na/Hg?
Reposted by Steve Fletcher
#ICIQJobs
🚀 Join ICIQ as a Junior Group Leader!
We’re seeking talented, innovative scientists ready to push the frontiers of research.
Apply now 👉🏼 careers.iciq.org/jobs/6745027...
@cerca.cat @bist.eu #SOMM_alliance
🚀 Join ICIQ as a Junior Group Leader!
We’re seeking talented, innovative scientists ready to push the frontiers of research.
Apply now 👉🏼 careers.iciq.org/jobs/6745027...
@cerca.cat @bist.eu #SOMM_alliance
November 13, 2025 at 12:14 PM
#ICIQJobs
🚀 Join ICIQ as a Junior Group Leader!
We’re seeking talented, innovative scientists ready to push the frontiers of research.
Apply now 👉🏼 careers.iciq.org/jobs/6745027...
@cerca.cat @bist.eu #SOMM_alliance
🚀 Join ICIQ as a Junior Group Leader!
We’re seeking talented, innovative scientists ready to push the frontiers of research.
Apply now 👉🏼 careers.iciq.org/jobs/6745027...
@cerca.cat @bist.eu #SOMM_alliance
It’s England so I appreciate how not everyone ‘gets it’ - but somehow my kid ended up with a moul piece of garlic and another got a brussel sprout from the same house. I suggested that they might not understand the full implications of ‘trick or treat‘ …
Every Halloween, one of the houses in our neighborhood offers kids the choice of a variety of full-size candies or, as a joke, a piece of fruit.
Naturally, my youngest ended up with an orange in their bag tonight.
Naturally, my youngest ended up with an orange in their bag tonight.
November 1, 2025 at 1:13 AM
It’s England so I appreciate how not everyone ‘gets it’ - but somehow my kid ended up with a moul piece of garlic and another got a brussel sprout from the same house. I suggested that they might not understand the full implications of ‘trick or treat‘ …
J. H. Christ...
How the origin of life was debated at the 1913 BA meeting in Birmingham. Have we progressed on this topic today?
October 24, 2025 at 1:07 PM
J. H. Christ...
Reposted by Steve Fletcher
Pen stealing isn’t a big deal - my Asian food take out uses a pen from my bank
But DON’T EVER touch a hood Sharpie - get your own
But DON’T EVER touch a hood Sharpie - get your own
October 18, 2025 at 2:29 PM
Pen stealing isn’t a big deal - my Asian food take out uses a pen from my bank
But DON’T EVER touch a hood Sharpie - get your own
But DON’T EVER touch a hood Sharpie - get your own
Reposted by Steve Fletcher
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
I guess, in hindsigh, it would make sense to push my own published theory here…https://pubs.rsc.org/en/content/articlelanding/2007/cc/b702882b
making diastereomers is an inevitable consequence of polymerisation - diastereomers have different properties
October 7, 2025 at 9:46 PM
I guess, in hindsigh, it would make sense to push my own published theory here…https://pubs.rsc.org/en/content/articlelanding/2007/cc/b702882b
Reposted by Steve Fletcher
Warning that "all radio stations and most of their DJ's are a part of the intelligence community," the QAnon Shaman has declared himself the first president of the "New Constitutional Republic of the United States," with its capital in Phoenix.
QAnon Shaman says he's rightful president, sues Trump for $40 trillion
In a rambling complaint, Jacob Chansley claims DJs are spies, that the NSA stole his work for a Batman movie and more.
www.phoenixnewtimes.com
September 30, 2025 at 1:10 AM
Warning that "all radio stations and most of their DJ's are a part of the intelligence community," the QAnon Shaman has declared himself the first president of the "New Constitutional Republic of the United States," with its capital in Phoenix.
Reposted by Steve Fletcher
this is how it feels to wear high rise pants
September 30, 2025 at 6:40 PM
this is how it feels to wear high rise pants
Reposted by Steve Fletcher
Reposted by Steve Fletcher
This is a bit of a shock
www.ft.com/content/5ace...
www.ft.com/content/5ace...
Merck slams UK as it scraps £1bn London drug research centre
US company says country is ‘not internationally competitive’ and lays off 125 staff
www.ft.com
September 10, 2025 at 9:35 PM
This is a bit of a shock
www.ft.com/content/5ace...
www.ft.com/content/5ace...
Just maybe!
We might be “experiencing an AI bubble,” Rogé Karma argues. “If that bubble bursts, it could put the dot-com crash to shame—and the tech giants and their Silicon Valley backers won’t be the only ones who suffer.”
Just How Bad Would an AI Bubble Be?
The entire U.S. economy is being propped up by the promise of productivity gains that seem very far from materializing.
bit.ly
September 8, 2025 at 10:19 PM
Just maybe!
not a big fan of the bluesky doomposting in here - but I was just about to post about something with photos and realized I shouldn’t bother and do it on facebook or linked in
September 6, 2025 at 10:57 PM
not a big fan of the bluesky doomposting in here - but I was just about to post about something with photos and realized I shouldn’t bother and do it on facebook or linked in