@slavofflab.bsky.social
Reposted
LOV-BirA, light regulated biotin ligase, engineered by Song-Yi Lee
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
August 27, 2025 at 3:30 PM
LOV-BirA, light regulated biotin ligase, engineered by Song-Yi Lee
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted
Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr...
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Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling
Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...
chemrxiv.org
August 28, 2025 at 7:04 PM
Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr...
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Reposted
A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-, γ-, or δ-peptide backbone
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Site-selective protein editing by backbone extension acyl rearrangements - Nature Chemical Biology
A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-peptide, γ-peptide or δ-pe...
www.nature.com
August 21, 2025 at 4:34 PM
A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-, γ-, or δ-peptide backbone
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that.
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
July 26, 2025 at 5:35 PM
First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that.
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
Reposted
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells
In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...
www.biorxiv.org
July 23, 2025 at 10:57 AM
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
I don't disagree and I have data (now rather old but I bet still relevant) to support this.
loop.nigms.nih.gov/2011/06/prod...
loop.nigms.nih.gov/2011/06/prod...
July 22, 2025 at 8:55 PM
I don't disagree and I have data (now rather old but I bet still relevant) to support this.
loop.nigms.nih.gov/2011/06/prod...
loop.nigms.nih.gov/2011/06/prod...
Reposted
Exciting new work from Sattely lab with collaborator @pollyfordyce.bsky.social and coworkers @stanford-chemh.bsky.social, solving they biosynthesis of taxol!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature
An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...
www.nature.com
June 19, 2025 at 6:01 AM
Exciting new work from Sattely lab with collaborator @pollyfordyce.bsky.social and coworkers @stanford-chemh.bsky.social, solving they biosynthesis of taxol!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Awesome to hear so much great science today at the New York Academy Chemical Biology Year-End Symposium, and proud of grad student Jessie Mohsen, who gave an awesome talk on an overlapping, stress-response microprotein in E. coli. Thanks to @davidlabmsk.bsky.social and the rest of the organizers!
May 28, 2025 at 11:12 PM
Awesome to hear so much great science today at the New York Academy Chemical Biology Year-End Symposium, and proud of grad student Jessie Mohsen, who gave an awesome talk on an overlapping, stress-response microprotein in E. coli. Thanks to @davidlabmsk.bsky.social and the rest of the organizers!
Reposted
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
www.wsj.com
April 21, 2025 at 6:21 PM
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Reposted
New preprint drop! Check out work from @jimmy-ly.bsky.social et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. "Blue-tutorial" thread below.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 28, 2025 at 10:41 AM
New preprint drop! Check out work from @jimmy-ly.bsky.social et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. "Blue-tutorial" thread below.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
It’s an honor to receive the ACS Chem Biol Young Investigator Award! I’m most grateful for the contributions from all past & present lab members — it is an award for all of you as much as for me. (& also grateful to still be considered young 😅) axial.acs.org/chemical-bio...
@acsbiol.bsky.social 1/2
@acsbiol.bsky.social 1/2
Dr. Jeremy Baskin wins the 2024 ACS Chemical Biology Young Investigator Award | ACS Publications Chemistry Blog
Get to know more about Dr. Baskin's work and career in this exclusive interview.
axial.acs.org
March 22, 2025 at 6:35 PM
It’s an honor to receive the ACS Chem Biol Young Investigator Award! I’m most grateful for the contributions from all past & present lab members — it is an award for all of you as much as for me. (& also grateful to still be considered young 😅) axial.acs.org/chemical-bio...
@acsbiol.bsky.social 1/2
@acsbiol.bsky.social 1/2
Reposted
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Transfer RNA acetylation regulates in vivo mammalian stress signaling
An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.
www.science.org
March 20, 2025 at 1:42 AM
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Congrats to Anna Seminara on her paper out today in @cp-cellchembiol.bsky.social reporting a new approach to metabolite depletion using a bacterial ABC transporter, applied to study the antioxidant ergothioneine in H. pylori!
Online now! An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology by Anna B. Seminara and Stavroula K. Hatzios @hatzioslab.bsky.social at @yale.edu @mcdb-yale.bsky.social http://dlvr.it/TJRWKG
March 10, 2025 at 7:23 PM
Congrats to Anna Seminara on her paper out today in @cp-cellchembiol.bsky.social reporting a new approach to metabolite depletion using a bacterial ABC transporter, applied to study the antioxidant ergothioneine in H. pylori!
Reposted
#Microproteins may be the next frontier in #proteomics. But figuring out the publications can be tough.
If you are looking for some advice about microprotein evidence, check out the latest from our consortium. Lead by @carvunis.bsky.social and Aaron Wacholder!
🧬 💻
#genomics
#RNASky
bit.ly/4bgJSDm
If you are looking for some advice about microprotein evidence, check out the latest from our consortium. Lead by @carvunis.bsky.social and Aaron Wacholder!
🧬 💻
#genomics
#RNASky
bit.ly/4bgJSDm
Detection of human unannotated microproteins by mass spectrometry-based proteomics: a community assessment
Thousands of short open reading frames (sORFs) are translated outside of annotated coding sequences. Recent studies have pioneered searching for sORF-encoded microproteins in mass spectrometry (MS)-ba...
bit.ly
February 24, 2025 at 12:33 PM
#Microproteins may be the next frontier in #proteomics. But figuring out the publications can be tough.
If you are looking for some advice about microprotein evidence, check out the latest from our consortium. Lead by @carvunis.bsky.social and Aaron Wacholder!
🧬 💻
#genomics
#RNASky
bit.ly/4bgJSDm
If you are looking for some advice about microprotein evidence, check out the latest from our consortium. Lead by @carvunis.bsky.social and Aaron Wacholder!
🧬 💻
#genomics
#RNASky
bit.ly/4bgJSDm
Reposted
Graduate admissions being put on hold because of the chaos...
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Graduate Reductions Across Biomedical Sciences (2025)
docs.google.com
February 22, 2025 at 2:29 PM
Graduate admissions being put on hold because of the chaos...
Reposted
I have been trying to find the time to move away from the polical hellscape we find ourselves in to finish and share a bluetorial about science.
This helps me remember what this is all about.
Ironically, it is about the treatment of pain.
This helps me remember what this is all about.
Ironically, it is about the treatment of pain.
the word irony is written on a white background
ALT: the word irony is written on a white background
media.tenor.com
February 22, 2025 at 10:19 AM
I have been trying to find the time to move away from the polical hellscape we find ourselves in to finish and share a bluetorial about science.
This helps me remember what this is all about.
Ironically, it is about the treatment of pain.
This helps me remember what this is all about.
Ironically, it is about the treatment of pain.
Reposted
Excited to share our publication on bacterial microproteome www.cell.com/molecular-ce...
#microproteins
#microproteins
The hidden bacterial microproteome
This study uncovers thousands of microprotein families encoded by intergenic small
open reading frames (smORFs) in bacterial genomes and provides a publicly available
resource featuring structural pre...
www.cell.com
February 19, 2025 at 7:16 PM
Excited to share our publication on bacterial microproteome www.cell.com/molecular-ce...
#microproteins
#microproteins
Reposted
🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start.
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
February 19, 2025 at 7:55 PM
🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start.
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
Reposted
March 7. Stand Up For Science. Rallies in DC and nationwide. 🧪
Please visit the website and spread the word.
www.standupforscience2025.org
Please visit the website and spread the word.
www.standupforscience2025.org
February 11, 2025 at 1:12 PM
March 7. Stand Up For Science. Rallies in DC and nationwide. 🧪
Please visit the website and spread the word.
www.standupforscience2025.org
Please visit the website and spread the word.
www.standupforscience2025.org
Reposted
"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...
February 6, 2025 at 4:02 PM
"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...
Reposted
ONLY 200 days until the GRC on #microproteins launches!
Sign up now for the landmark event in the scientific field.
Don't miss this chance to meet all of the leaders in #RiboSeq, #RNA, #Proteomics, #Translation!
#genomics
#bioinformatics
🧬 💻
🔎 microproteins
#RNAsky
www.grc.org/decoding-mic...
Sign up now for the landmark event in the scientific field.
Don't miss this chance to meet all of the leaders in #RiboSeq, #RNA, #Proteomics, #Translation!
#genomics
#bioinformatics
🧬 💻
🔎 microproteins
#RNAsky
www.grc.org/decoding-mic...
2025 Decoding Microproteins Across Evolution and Disease Conference GRC
The 2025 Gordon Research Conference on Decoding Microproteins Across Evolution and Disease will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
www.grc.org
January 27, 2025 at 12:00 PM
ONLY 200 days until the GRC on #microproteins launches!
Sign up now for the landmark event in the scientific field.
Don't miss this chance to meet all of the leaders in #RiboSeq, #RNA, #Proteomics, #Translation!
#genomics
#bioinformatics
🧬 💻
🔎 microproteins
#RNAsky
www.grc.org/decoding-mic...
Sign up now for the landmark event in the scientific field.
Don't miss this chance to meet all of the leaders in #RiboSeq, #RNA, #Proteomics, #Translation!
#genomics
#bioinformatics
🧬 💻
🔎 microproteins
#RNAsky
www.grc.org/decoding-mic...
Reposted
Back by popular demand, I present PPI Prediction Challenge #2.
My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.
Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...
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My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.
Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...
1/n
PPI Prediction Challenge #2
For this protein-protein interaction prediction challenge, we present three target proteins: KRAS, RAF (the KRAS binding domain), and Mdm2. For each target protein, we are providing you a list of 8 po...
docs.google.com
December 10, 2024 at 9:45 PM
Back by popular demand, I present PPI Prediction Challenge #2.
My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.
Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...
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My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.
Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...
1/n