Aditya Singh Rajput
@singh29aditya.bsky.social
Biophysics and Developmental Biology. Graduate student at ICTS-TIFR, Bengaluru
Reposted by Aditya Singh Rajput
#DBfeature
Fritz Müller’s "Für Darwin" (1864) bridged evolution and development, anticipating evo-devo and warning to the dangers of scientific dogma
By Scott Gilbert and Beatrice Steinert
tinyurl.com/3sccvcr5
#SpecialIssue on Research that transformed #DevBio
Fritz Müller’s "Für Darwin" (1864) bridged evolution and development, anticipating evo-devo and warning to the dangers of scientific dogma
By Scott Gilbert and Beatrice Steinert
tinyurl.com/3sccvcr5
#SpecialIssue on Research that transformed #DevBio
November 10, 2025 at 12:35 PM
#DBfeature
Fritz Müller’s "Für Darwin" (1864) bridged evolution and development, anticipating evo-devo and warning to the dangers of scientific dogma
By Scott Gilbert and Beatrice Steinert
tinyurl.com/3sccvcr5
#SpecialIssue on Research that transformed #DevBio
Fritz Müller’s "Für Darwin" (1864) bridged evolution and development, anticipating evo-devo and warning to the dangers of scientific dogma
By Scott Gilbert and Beatrice Steinert
tinyurl.com/3sccvcr5
#SpecialIssue on Research that transformed #DevBio
Reposted by Aditya Singh Rajput
Active geometrodynamics predicts the emergence of cytokinesis https://www.biorxiv.org/content/10.1101/2025.11.07.683232v1
November 8, 2025 at 3:48 AM
Active geometrodynamics predicts the emergence of cytokinesis https://www.biorxiv.org/content/10.1101/2025.11.07.683232v1
Reposted by Aditya Singh Rajput
The United States was the leading destination for top scientists from all over the world.
That is ending. Politicians ended it. It will cripple our future competitiveness.
And it’s such a bitter tragedy. Almost no Americans, Conservative or Liberal, grasp what is now being stolen from them.
That is ending. Politicians ended it. It will cripple our future competitiveness.
And it’s such a bitter tragedy. Almost no Americans, Conservative or Liberal, grasp what is now being stolen from them.
Top researchers consider leaving U.S. amid funding cuts: 'The science world is ending'
YouTube video by PBS NewsHour
youtu.be
November 1, 2025 at 3:44 AM
The United States was the leading destination for top scientists from all over the world.
That is ending. Politicians ended it. It will cripple our future competitiveness.
And it’s such a bitter tragedy. Almost no Americans, Conservative or Liberal, grasp what is now being stolen from them.
That is ending. Politicians ended it. It will cripple our future competitiveness.
And it’s such a bitter tragedy. Almost no Americans, Conservative or Liberal, grasp what is now being stolen from them.
Reposted by Aditya Singh Rajput
Despite higher cell numbers and longer lifespans, large animals don’t have a higher cancer rate: Peto’s paradox. Elephants carry extra copies of tumor suppressor genes, while whales rely on enhanced DNA repair mechanisms! It’s fascinating that nature found different solutions to the same problem
Nature research paper: Evidence for improved DNA repair in long-lived bowhead whale
go.nature.com/4oNJSAG
go.nature.com/4oNJSAG
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.
go.nature.com
October 30, 2025 at 12:26 PM
Despite higher cell numbers and longer lifespans, large animals don’t have a higher cancer rate: Peto’s paradox. Elephants carry extra copies of tumor suppressor genes, while whales rely on enhanced DNA repair mechanisms! It’s fascinating that nature found different solutions to the same problem
Reposted by Aditya Singh Rajput
This article is a homecoming for me.
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
Principles of protein abundance regulation across single cells in a mammalian tissue
Protein synthesis and clearance are major regulatory steps of gene expression, but their in vivo regulatory roles across the cells comprising complex tissues remains unexplored. Here, we systematicall...
www.biorxiv.org
October 18, 2025 at 11:56 AM
This article is a homecoming for me.
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
Reposted by Aditya Singh Rajput
🤔 Can tissue patterning & tumor heterogeneity emerge in a self-organized way?
We show that self-organized mechanical stress & density gradients pattern tumors in vitro & in vivo, and this behavior is quantitatively predicted by a mechano-chemical active fluid model!
Check out Carlos' thread ⬇️
We show that self-organized mechanical stress & density gradients pattern tumors in vitro & in vivo, and this behavior is quantitatively predicted by a mechano-chemical active fluid model!
Check out Carlos' thread ⬇️
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
October 16, 2025 at 10:40 PM
🤔 Can tissue patterning & tumor heterogeneity emerge in a self-organized way?
We show that self-organized mechanical stress & density gradients pattern tumors in vitro & in vivo, and this behavior is quantitatively predicted by a mechano-chemical active fluid model!
Check out Carlos' thread ⬇️
We show that self-organized mechanical stress & density gradients pattern tumors in vitro & in vivo, and this behavior is quantitatively predicted by a mechano-chemical active fluid model!
Check out Carlos' thread ⬇️
Reposted by Aditya Singh Rajput
Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.
More here: elifesciences.org/reviewed-pre...
More here: elifesciences.org/reviewed-pre...
elifesciences.org
September 29, 2025 at 8:45 AM
Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.
More here: elifesciences.org/reviewed-pre...
More here: elifesciences.org/reviewed-pre...
Reposted by Aditya Singh Rajput
Very proud of this extremely collaborative piece: academic.oup.com/mbe/article/...
Here, we show that divergence in visual systems - in response to differences in the light environment - leads to rapid divergence in sexually selected colour traits. Work brilliantly led by Madeleine Carruthers. 🐟👀🎨
Here, we show that divergence in visual systems - in response to differences in the light environment - leads to rapid divergence in sexually selected colour traits. Work brilliantly led by Madeleine Carruthers. 🐟👀🎨
Rapid Divergence of Visual Systems and Signaling Traits to Contrasting Light Regimes During Early Speciation of African Crater Lake Cichlid Fish
Abstract. Sensory adaptation is widely hypothesized to drive ecological speciation, yet empirical evidence from natural populations undergoing early stage
academic.oup.com
September 16, 2025 at 4:23 PM
Very proud of this extremely collaborative piece: academic.oup.com/mbe/article/...
Here, we show that divergence in visual systems - in response to differences in the light environment - leads to rapid divergence in sexually selected colour traits. Work brilliantly led by Madeleine Carruthers. 🐟👀🎨
Here, we show that divergence in visual systems - in response to differences in the light environment - leads to rapid divergence in sexually selected colour traits. Work brilliantly led by Madeleine Carruthers. 🐟👀🎨
Reposted by Aditya Singh Rajput
📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome!
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
September 11, 2025 at 9:36 AM
📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome!
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
Reposted by Aditya Singh Rajput
The final version of our review on biological filaments is out in Philtrans A (w/@jcammann.bsky.social Hannah Laeverenz-Schlogelhofer & Marco Mazza) - we have 417 references!
Enjoy :)
doi.org/10.1098/rsta...
(see also other articles in this special issue on biological fluid dynamics) #biophysics
Enjoy :)
doi.org/10.1098/rsta...
(see also other articles in this special issue on biological fluid dynamics) #biophysics
September 11, 2025 at 8:40 AM
The final version of our review on biological filaments is out in Philtrans A (w/@jcammann.bsky.social Hannah Laeverenz-Schlogelhofer & Marco Mazza) - we have 417 references!
Enjoy :)
doi.org/10.1098/rsta...
(see also other articles in this special issue on biological fluid dynamics) #biophysics
Enjoy :)
doi.org/10.1098/rsta...
(see also other articles in this special issue on biological fluid dynamics) #biophysics
Reposted by Aditya Singh Rajput
@natalieadye.bsky.social @mbisg.bsky.social opened the session discussing the importance of 3D imaging to understand how tissues grow in the correct direction – Full 3D imaging of Drosophila wing disc revealed new dynamics, pouches and folds in the apical surface. #MBIMPG2025
September 11, 2025 at 2:44 AM
@natalieadye.bsky.social @mbisg.bsky.social opened the session discussing the importance of 3D imaging to understand how tissues grow in the correct direction – Full 3D imaging of Drosophila wing disc revealed new dynamics, pouches and folds in the apical surface. #MBIMPG2025
Reposted by Aditya Singh Rajput
Out now in Seminars in Cell & Dev Biol!
doi.org/10.1016/j.se...
With thanks to co-authors @callumbucklow.bsky.social and @bertaverd.bsky.social
doi.org/10.1016/j.se...
With thanks to co-authors @callumbucklow.bsky.social and @bertaverd.bsky.social
September 8, 2025 at 11:59 AM
Out now in Seminars in Cell & Dev Biol!
doi.org/10.1016/j.se...
With thanks to co-authors @callumbucklow.bsky.social and @bertaverd.bsky.social
doi.org/10.1016/j.se...
With thanks to co-authors @callumbucklow.bsky.social and @bertaverd.bsky.social
Reposted by Aditya Singh Rajput
Please re-post:
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
EvoChromo: Evolutionary approaches to research in chromatin
Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…
meetings.embo.org
September 8, 2025 at 11:14 AM
Please re-post:
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
Reposted by Aditya Singh Rajput
The papers have been improved by reviewers @amartinezarias.bsky.social, @thibautbrunet.bsky.social & Cassandra Extavour. Thibaut synthesized the work beautifully in the #News_and_Views. None of that can happen without The Editor: @endofthepier.bsky.social (11/12)
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Flies evolved a shock-absorber tissue used during embryonic development
The role of tissue that forms between the head and trunk of a fly embryo has been unclear. It turns out that it absorbs forces when nearby cells move and divide.
www.nature.com
September 4, 2025 at 8:22 AM
The papers have been improved by reviewers @amartinezarias.bsky.social, @thibautbrunet.bsky.social & Cassandra Extavour. Thibaut synthesized the work beautifully in the #News_and_Views. None of that can happen without The Editor: @endofthepier.bsky.social (11/12)
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Aditya Singh Rajput
Super excited that our group will be supported by an ERC Starting Grant!
In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.
We'll have PhD and Postdoc positions available, please get in touch if interested!
In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.
We'll have PhD and Postdoc positions available, please get in touch if interested!
Why do some cells become neurons and others muscle?
Physicist Prof. David Brückner @davidbrueckner.bsky.social @biozentrum.unibas.ch @unibas.ch receives a prestigious #ERCStartingGrant to uncover how cells make life-shaping decisions. @erc.europa.eu
www.biozentrum.unibas.ch/news/detail/...
Physicist Prof. David Brückner @davidbrueckner.bsky.social @biozentrum.unibas.ch @unibas.ch receives a prestigious #ERCStartingGrant to uncover how cells make life-shaping decisions. @erc.europa.eu
www.biozentrum.unibas.ch/news/detail/...
ERC Starting Grant for Physicist David Brückner
How do cells decide which role to take on in the body? Prof. David Brückner from the Biozentrum of the University of Basel is investigating this and similar questions. Over the next five years, a Star...
www.biozentrum.unibas.ch
September 4, 2025 at 11:27 AM
Super excited that our group will be supported by an ERC Starting Grant!
In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.
We'll have PhD and Postdoc positions available, please get in touch if interested!
In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.
We'll have PhD and Postdoc positions available, please get in touch if interested!
Reposted by Aditya Singh Rajput
Are you a biologist with a research interest in embryogenesis or synthetic biology?
Join our upcoming residential scientific meeting in Brighton on 20-21 October on the topic of generative biology: royalsociety.org/science-even...
Join our upcoming residential scientific meeting in Brighton on 20-21 October on the topic of generative biology: royalsociety.org/science-even...
September 4, 2025 at 11:03 AM
Are you a biologist with a research interest in embryogenesis or synthetic biology?
Join our upcoming residential scientific meeting in Brighton on 20-21 October on the topic of generative biology: royalsociety.org/science-even...
Join our upcoming residential scientific meeting in Brighton on 20-21 October on the topic of generative biology: royalsociety.org/science-even...
Reposted by Aditya Singh Rajput
🧵Why do early embryonic cell cycles speed up with temperature almost like simple chemical reactions, but not quite? 🌡️
Across frogs, fish, worms, and flies we found a shared scaling law, and uncovered why deviations from Arrhenius behavior emerge.
👉 doi.org/10.1038/s41467-025-62918-0
Across frogs, fish, worms, and flies we found a shared scaling law, and uncovered why deviations from Arrhenius behavior emerge.
👉 doi.org/10.1038/s41467-025-62918-0
September 3, 2025 at 3:26 PM
🧵Why do early embryonic cell cycles speed up with temperature almost like simple chemical reactions, but not quite? 🌡️
Across frogs, fish, worms, and flies we found a shared scaling law, and uncovered why deviations from Arrhenius behavior emerge.
👉 doi.org/10.1038/s41467-025-62918-0
Across frogs, fish, worms, and flies we found a shared scaling law, and uncovered why deviations from Arrhenius behavior emerge.
👉 doi.org/10.1038/s41467-025-62918-0
Reposted by Aditya Singh Rajput
For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began
go.nature.com/4lPmznS
go.nature.com/4lPmznS
How did life get multicellular? Five simple organisms could have the answer
Nature - Single-celled species that often stick together in colonies have researchers rethinking the origin of animals.
go.nature.com
August 30, 2025 at 10:21 AM
For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began
go.nature.com/4lPmznS
go.nature.com/4lPmznS
Reposted by Aditya Singh Rajput
Lee, L. W., Lee, G. H., Su, I. H., Lu, C. H., Lin, K. H., Wen, F. L., & Tang, M. J. (2025). Mechanobiological mechanism of cyclic stretch-induced cell columnarization. Cell reports, 44(5), 115662. #EpithelialMechanics
buff.ly/j67xoTn
buff.ly/j67xoTn
August 8, 2025 at 7:01 AM
Lee, L. W., Lee, G. H., Su, I. H., Lu, C. H., Lin, K. H., Wen, F. L., & Tang, M. J. (2025). Mechanobiological mechanism of cyclic stretch-induced cell columnarization. Cell reports, 44(5), 115662. #EpithelialMechanics
buff.ly/j67xoTn
buff.ly/j67xoTn
Reposted by Aditya Singh Rajput
Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut https://www.biorxiv.org/content/10.1101/2025.08.27.672561v1
August 27, 2025 at 3:30 PM
Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut https://www.biorxiv.org/content/10.1101/2025.08.27.672561v1
Reposted by Aditya Singh Rajput
We are excited to announce our new #partnership with the Mechanobiology Institute (MBI) in Singapore! 🇸🇬
This collaboration will combine MBI’s expertise on molecular, cell, and tissue mechanobiology with our research on spatiotemporal organization of living matter to understand how organisms form 🔬
This collaboration will combine MBI’s expertise on molecular, cell, and tissue mechanobiology with our research on spatiotemporal organization of living matter to understand how organisms form 🔬
August 27, 2025 at 8:55 AM
We are excited to announce our new #partnership with the Mechanobiology Institute (MBI) in Singapore! 🇸🇬
This collaboration will combine MBI’s expertise on molecular, cell, and tissue mechanobiology with our research on spatiotemporal organization of living matter to understand how organisms form 🔬
This collaboration will combine MBI’s expertise on molecular, cell, and tissue mechanobiology with our research on spatiotemporal organization of living matter to understand how organisms form 🔬
Reposted by Aditya Singh Rajput
🤔 How do protrusion & polarity interactions govern the collision behavior of migrating cells?
Check out our paper, just out in @prxlife.bsky.social
👉 journals.aps.org/prxlife/abst...
Great work by Tom Brandstätter, in collab. w/ Chase Broedersz & Joachim Rädler @cens-lmu.bsky.social
Check out our paper, just out in @prxlife.bsky.social
👉 journals.aps.org/prxlife/abst...
Great work by Tom Brandstätter, in collab. w/ Chase Broedersz & Joachim Rädler @cens-lmu.bsky.social
August 27, 2025 at 7:03 AM
🤔 How do protrusion & polarity interactions govern the collision behavior of migrating cells?
Check out our paper, just out in @prxlife.bsky.social
👉 journals.aps.org/prxlife/abst...
Great work by Tom Brandstätter, in collab. w/ Chase Broedersz & Joachim Rädler @cens-lmu.bsky.social
Check out our paper, just out in @prxlife.bsky.social
👉 journals.aps.org/prxlife/abst...
Great work by Tom Brandstätter, in collab. w/ Chase Broedersz & Joachim Rädler @cens-lmu.bsky.social
Reposted by Aditya Singh Rajput
📣 Now out in @physreve.bsky.social as editors' suggestion: our theory on the role of different myosin II isoforms during cell migration. For standard parameters, A and B segregate to the front and the back, respectively. Yet for other parameter values, also oscillations are possible.
August 26, 2025 at 7:35 PM
📣 Now out in @physreve.bsky.social as editors' suggestion: our theory on the role of different myosin II isoforms during cell migration. For standard parameters, A and B segregate to the front and the back, respectively. Yet for other parameter values, also oscillations are possible.
Reposted by Aditya Singh Rajput
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…
www.sciencedirect.com
August 26, 2025 at 8:28 AM
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Reposted by Aditya Singh Rajput
A cell's internal spin direction results from myosin chirality – insight into how left-right symmetry is broken in certain tissues & organs
📷 Takaki Yamamoto et al @riken-bdr.bsky.social
in @elife.bsky.social
➡️ bpod.org.uk/archive/2025... with Lux Fatimathas
📷 Takaki Yamamoto et al @riken-bdr.bsky.social
in @elife.bsky.social
➡️ bpod.org.uk/archive/2025... with Lux Fatimathas
August 25, 2025 at 12:56 PM
A cell's internal spin direction results from myosin chirality – insight into how left-right symmetry is broken in certain tissues & organs
📷 Takaki Yamamoto et al @riken-bdr.bsky.social
in @elife.bsky.social
➡️ bpod.org.uk/archive/2025... with Lux Fatimathas
📷 Takaki Yamamoto et al @riken-bdr.bsky.social
in @elife.bsky.social
➡️ bpod.org.uk/archive/2025... with Lux Fatimathas