Lendert Gelens
@lendertgelens.bsky.social
Part-time physicist-turned-biologist studying early embryos and the cell cycle @KU Leuven, full-time dad to two active boys. Visualizing academic data trends in Flanders.
www.gelenslab.org | https://academic-compass.be/en/
www.gelenslab.org | https://academic-compass.be/en/
Reposted by Lendert Gelens
🚨 Late preprint alert!
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
October 22, 2025 at 10:29 AM
🚨 Late preprint alert!
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
Reposted by Lendert Gelens
Please allow me to introduce... our new preprint 🎉 Together with Michael Zhao, Anna Erzberger and Alexander Aulehla, we investigate pattern formation due to aggregation in confined systems.
You can find it at arxiv.org/abs/2509.08533
@michaelzhao.bsky.social @erzbergerlab.bsky.social
You can find it at arxiv.org/abs/2509.08533
@michaelzhao.bsky.social @erzbergerlab.bsky.social
September 18, 2025 at 6:48 PM
Please allow me to introduce... our new preprint 🎉 Together with Michael Zhao, Anna Erzberger and Alexander Aulehla, we investigate pattern formation due to aggregation in confined systems.
You can find it at arxiv.org/abs/2509.08533
@michaelzhao.bsky.social @erzbergerlab.bsky.social
You can find it at arxiv.org/abs/2509.08533
@michaelzhao.bsky.social @erzbergerlab.bsky.social
Looking forward to it!!
On Thursday, Sept 25, we host Lendert Gelens (KU Leuven) for a seminar: "Beyond Arrhenius: How temperature scales biological time". He will show how biological timing changes across temperatures.
barcelonacollaboratorium.com
#seminar #KULeuven #EMBL #BCNCollaboratorium
barcelonacollaboratorium.com
#seminar #KULeuven #EMBL #BCNCollaboratorium
September 18, 2025 at 1:34 PM
Looking forward to it!!
Reposted by Lendert Gelens
Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...
Gene Network Organization, Mutation, and Selection Collectively Drive Developmental Pattern Evolvability and Predictability
The historical order in which mutations appear during evolution determine the evolutionary trajectory of gene regulatory networks and influence how developmental patterns change and diversify over tim...
journals.aps.org
September 16, 2025 at 7:46 PM
Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...
Reposted by Lendert Gelens
Drs. Borzo Gharibi, Silvia Santos, and a team at @crick.ac.uk generated an ESC-derived 3D model of the post-gastrulation #amnion.
📄 @cellpress.bsky.social - bit.ly/45bJs0c
🎤 bit.ly/4kE4eKf
📄 @cellpress.bsky.social - bit.ly/45bJs0c
🎤 bit.ly/4kE4eKf
June 4, 2025 at 5:03 PM
Drs. Borzo Gharibi, Silvia Santos, and a team at @crick.ac.uk generated an ESC-derived 3D model of the post-gastrulation #amnion.
📄 @cellpress.bsky.social - bit.ly/45bJs0c
🎤 bit.ly/4kE4eKf
📄 @cellpress.bsky.social - bit.ly/45bJs0c
🎤 bit.ly/4kE4eKf
🧵Why do early embryonic cell cycles speed up with temperature almost like simple chemical reactions, but not quite? 🌡️
Across frogs, fish, worms, and flies we found a shared scaling law, and uncovered why deviations from Arrhenius behavior emerge.
👉 doi.org/10.1038/s41467-025-62918-0
Across frogs, fish, worms, and flies we found a shared scaling law, and uncovered why deviations from Arrhenius behavior emerge.
👉 doi.org/10.1038/s41467-025-62918-0
September 3, 2025 at 3:26 PM
🧵Why do early embryonic cell cycles speed up with temperature almost like simple chemical reactions, but not quite? 🌡️
Across frogs, fish, worms, and flies we found a shared scaling law, and uncovered why deviations from Arrhenius behavior emerge.
👉 doi.org/10.1038/s41467-025-62918-0
Across frogs, fish, worms, and flies we found a shared scaling law, and uncovered why deviations from Arrhenius behavior emerge.
👉 doi.org/10.1038/s41467-025-62918-0
🧵Does the nucleus set the cell cycle clock? 🕒
In frog egg extract “mini-cells” we see that as nuclei grow, cycles slow down. The period scales with the nuclear-to-cytoplasmic ratio, across Xenopus species, and even when DNA replication or transcription are blocked.
👉 doi.org/10.1016/j.cu...
In frog egg extract “mini-cells” we see that as nuclei grow, cycles slow down. The period scales with the nuclear-to-cytoplasmic ratio, across Xenopus species, and even when DNA replication or transcription are blocked.
👉 doi.org/10.1016/j.cu...
September 2, 2025 at 8:43 PM
🧵Does the nucleus set the cell cycle clock? 🕒
In frog egg extract “mini-cells” we see that as nuclei grow, cycles slow down. The period scales with the nuclear-to-cytoplasmic ratio, across Xenopus species, and even when DNA replication or transcription are blocked.
👉 doi.org/10.1016/j.cu...
In frog egg extract “mini-cells” we see that as nuclei grow, cycles slow down. The period scales with the nuclear-to-cytoplasmic ratio, across Xenopus species, and even when DNA replication or transcription are blocked.
👉 doi.org/10.1016/j.cu...
Reposted by Lendert Gelens
Many years in the making but now finally online! What determines the temperature scaling and thermal limits of cell cycle duration in embryos? We tackled the question using a combination of dynamical systems analysis and experimental measurements in embryos and in cycling Xenopus extracts.
August 29, 2025 at 2:06 PM
Many years in the making but now finally online! What determines the temperature scaling and thermal limits of cell cycle duration in embryos? We tackled the question using a combination of dynamical systems analysis and experimental measurements in embryos and in cycling Xenopus extracts.
BOOM💥Martina was on fire at the recent #Biologists100 meeting on Liverpool, sharing her research on cell cycle oscillations. #proudPI
June 3, 2025 at 1:32 PM
BOOM💥Martina was on fire at the recent #Biologists100 meeting on Liverpool, sharing her research on cell cycle oscillations. #proudPI
Reposted by Lendert Gelens
✨We are looking for a PhD student interested in physical cell bio, imaging 🔬, biochemistry, #Xenopus 🐸 & #microtubules ✨
Join us @mpiib-berlin.mpg.de!
Join us @mpiib-berlin.mpg.de!
May 19, 2025 at 8:21 PM
✨We are looking for a PhD student interested in physical cell bio, imaging 🔬, biochemistry, #Xenopus 🐸 & #microtubules ✨
Join us @mpiib-berlin.mpg.de!
Join us @mpiib-berlin.mpg.de!
Reposted by Lendert Gelens
Beautiful work from @santoslab.bsky.social
A 3D model of human amnion from hESCs
These recapitulate amniotic sac development, revealing GATA3 as key amniogenesis driver & autoregulatory BMP/Wnt feedback loops
And check out the size of them in the video
www.cell.com/cell/fulltex...
A 3D model of human amnion from hESCs
These recapitulate amniotic sac development, revealing GATA3 as key amniogenesis driver & autoregulatory BMP/Wnt feedback loops
And check out the size of them in the video
www.cell.com/cell/fulltex...
Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
An embryonic stem cell-based 3D model that accurately recapitulates the size, morphology,
and functional features of the human amnion at 4 weeks, termed the post-gastrulation
amnioid (PGA), is develop...
www.cell.com
May 15, 2025 at 4:17 PM
Beautiful work from @santoslab.bsky.social
A 3D model of human amnion from hESCs
These recapitulate amniotic sac development, revealing GATA3 as key amniogenesis driver & autoregulatory BMP/Wnt feedback loops
And check out the size of them in the video
www.cell.com/cell/fulltex...
A 3D model of human amnion from hESCs
These recapitulate amniotic sac development, revealing GATA3 as key amniogenesis driver & autoregulatory BMP/Wnt feedback loops
And check out the size of them in the video
www.cell.com/cell/fulltex...
Reposted by Lendert Gelens
We can't believe #EESTCBio is over! 😱
Thank you to the organisers, speakers, and participants for creating such a vibrant space for critical thinking. It was a joy to see you exchange ideas, challenge assumptions, and explore new perspectives 💡
We hope to see you again at the next edition! 👋
Thank you to the organisers, speakers, and participants for creating such a vibrant space for critical thinking. It was a joy to see you exchange ideas, challenge assumptions, and explore new perspectives 💡
We hope to see you again at the next edition! 👋
May 9, 2025 at 11:45 AM
We can't believe #EESTCBio is over! 😱
Thank you to the organisers, speakers, and participants for creating such a vibrant space for critical thinking. It was a joy to see you exchange ideas, challenge assumptions, and explore new perspectives 💡
We hope to see you again at the next edition! 👋
Thank you to the organisers, speakers, and participants for creating such a vibrant space for critical thinking. It was a joy to see you exchange ideas, challenge assumptions, and explore new perspectives 💡
We hope to see you again at the next edition! 👋
Reposted by Lendert Gelens
3️⃣"Physics of the Early Embryonic Divisions Workshop – Microtubules, energy and cell fate decisions in early embryogenesis" by @olgaafonso.bsky.social, @shuzokato.bsky.social & Helena Cantwell
thenode.biologists.com/physics-of-t...
Thank you to everyone who wrote these reports!
(3/3🧵)
thenode.biologists.com/physics-of-t...
Thank you to everyone who wrote these reports!
(3/3🧵)
Physics of the Early Embryonic Divisions Workshop – Microtubules, energy and cell fate decisions in early embryogenesis - the Node
Text written by Olga Afonso, Helena Cantwell, and Shuzo Kato This is one of three reports about the "Physics of the Early Embryonic Divisions" Workshop,
thenode.biologists.com
February 20, 2025 at 3:00 PM
3️⃣"Physics of the Early Embryonic Divisions Workshop – Microtubules, energy and cell fate decisions in early embryogenesis" by @olgaafonso.bsky.social, @shuzokato.bsky.social & Helena Cantwell
thenode.biologists.com/physics-of-t...
Thank you to everyone who wrote these reports!
(3/3🧵)
thenode.biologists.com/physics-of-t...
Thank you to everyone who wrote these reports!
(3/3🧵)
Reposted by Lendert Gelens
2️⃣ "Physics of the Early Embryonic Cell Divisions: Feedbacks, Flows and Information" by Claudio Hernández-López and @singh29aditya.bsky.social
thenode.biologists.com/physics-of-t...
(2/3🧵)
thenode.biologists.com/physics-of-t...
(2/3🧵)
Physics of the Early Embryonic Cell Divisions: Feedbacks, Flows and Information - the Node
By Claudio Hernández-López and Aditya Singh Rajput This is one of three reports about the "Physics of the Early Embryonic Divisions" Workshop, organised
thenode.biologists.com
February 20, 2025 at 3:00 PM
2️⃣ "Physics of the Early Embryonic Cell Divisions: Feedbacks, Flows and Information" by Claudio Hernández-López and @singh29aditya.bsky.social
thenode.biologists.com/physics-of-t...
(2/3🧵)
thenode.biologists.com/physics-of-t...
(2/3🧵)
Reposted by Lendert Gelens
Last year, 30 developmental biologists and biophysicists got together for the 'Physics of the Early Embryonic Cell Divisions' Workshop. Find out what happened (1/3🧵)
1️⃣Building Bridges Between Biology and Physics by @irene-yuting-li.bsky.social @isaacsiuwong.bsky.social & @lena-schindler.bsky.social
1️⃣Building Bridges Between Biology and Physics by @irene-yuting-li.bsky.social @isaacsiuwong.bsky.social & @lena-schindler.bsky.social
Building Bridges Between Biology and Physics: Insights from a Workshop on Early Embryonic Cell Divisions - the Node
Written by Irene Li, Magdalena Schindler and Isaac Wong This is one of three reports about the "Physics of the Early Embryonic Divisions" Workshop,
thenode.biologists.com
February 20, 2025 at 3:00 PM
Last year, 30 developmental biologists and biophysicists got together for the 'Physics of the Early Embryonic Cell Divisions' Workshop. Find out what happened (1/3🧵)
1️⃣Building Bridges Between Biology and Physics by @irene-yuting-li.bsky.social @isaacsiuwong.bsky.social & @lena-schindler.bsky.social
1️⃣Building Bridges Between Biology and Physics by @irene-yuting-li.bsky.social @isaacsiuwong.bsky.social & @lena-schindler.bsky.social
Reposted by Lendert Gelens
I am recruiting an #ERC funded PostDoc to work on the evolution of vertebral counts in cichlids. This is an experimental project & will be looking for candidates with experience generating reporter lines, live-imaging and experimental embryology.
Application deadline: 25th Feb.
tinyurl.com/33jbu8fa
Application deadline: 25th Feb.
tinyurl.com/33jbu8fa
February 5, 2025 at 4:50 PM
I am recruiting an #ERC funded PostDoc to work on the evolution of vertebral counts in cichlids. This is an experimental project & will be looking for candidates with experience generating reporter lines, live-imaging and experimental embryology.
Application deadline: 25th Feb.
tinyurl.com/33jbu8fa
Application deadline: 25th Feb.
tinyurl.com/33jbu8fa
Reposted by Lendert Gelens
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
January 3, 2025 at 3:33 PM
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
🐸 are 🆒! ❄️☀️
Double feature on 🐸 #Xenopus & ☀️ temperature ❄️
Tomorrow, Feb 4th
@ 8:00 PT, 11:00 ET, 16:00 GMT, 17:00 CET
@lendertgelens.bsky.social @KU Leuven & our lab @mpiib-berlin.mpg.de Cell Size and Growth Seminars
swafferlab.co.uk/size-and-gro...
Tomorrow, Feb 4th
@ 8:00 PT, 11:00 ET, 16:00 GMT, 17:00 CET
@lendertgelens.bsky.social @KU Leuven & our lab @mpiib-berlin.mpg.de Cell Size and Growth Seminars
swafferlab.co.uk/size-and-gro...
February 3, 2025 at 3:43 PM
🐸 are 🆒! ❄️☀️
Really looking forward to this visit, great way to start the year! Thank you @meiosis-mom.bsky.social for inviting me!
📢 Institut Jacques Monod Seminar
📅 January 10th
📍 Institut Jacques Monod
Invited by the Wassmann Lab, Lendert Gelens, will give an Institut Jacques Monod Seminars on the theme "Nuclei coordinate the cell cycle in space and time"
➡️ https://buff.ly/3ZM7Ykl
📅 January 10th
📍 Institut Jacques Monod
Invited by the Wassmann Lab, Lendert Gelens, will give an Institut Jacques Monod Seminars on the theme "Nuclei coordinate the cell cycle in space and time"
➡️ https://buff.ly/3ZM7Ykl
January 3, 2025 at 11:14 AM
Really looking forward to this visit, great way to start the year! Thank you @meiosis-mom.bsky.social for inviting me!
Cell cycles at double speed? Looks like those frogs are spiraling into party mode, happy xmas!
[1/2] Preprint alert ‼️
When I joined @lendertgelens.bsky.social Lab, they experimentally observed atypical spiral waves in the frog egg cytoplasm, which resulted in almost twice faster cell cycle oscillations.
When I joined @lendertgelens.bsky.social Lab, they experimentally observed atypical spiral waves in the frog egg cytoplasm, which resulted in almost twice faster cell cycle oscillations.
December 24, 2024 at 5:24 PM
Cell cycles at double speed? Looks like those frogs are spiraling into party mode, happy xmas!
Had a great time this week with a wonderful group of researchers at our workshop on the physics of early embryonic cell divisions! Big thanks to everyone there, i.e. Johanna, Frank, Laura and Adam from @biologists.bsky.social, and to my co-organizer @kamenzlab.bsky.social! Let’s do this again!
November 15, 2024 at 12:19 PM
Had a great time this week with a wonderful group of researchers at our workshop on the physics of early embryonic cell divisions! Big thanks to everyone there, i.e. Johanna, Frank, Laura and Adam from @biologists.bsky.social, and to my co-organizer @kamenzlab.bsky.social! Let’s do this again!
Hi #SciSky! I’ve been hearing great things about you, happy to have this alternative to X/Twitter. Looking forward to seeing lots of fascinating science!
November 14, 2024 at 12:55 AM
Hi #SciSky! I’ve been hearing great things about you, happy to have this alternative to X/Twitter. Looking forward to seeing lots of fascinating science!