Giuditta De Lorenzo
@serdelor.bsky.social
Italian virologist, studying viruses and cells at AreaSciencePark and ICGEB (Trieste - IT), previously Research Associate at the Centre for Virus Research (Glasgow - UK)
https://areasciencepark-rit.gitlab.io/virology/giuditta.delorenzo/#about
https://areasciencepark-rit.gitlab.io/virology/giuditta.delorenzo/#about
Pinned
Giuditta De Lorenzo
@serdelor.bsky.social
· Jul 30
AI in Virology: Leveraging AI to Advance Our Understanding of Viruses - Area Science Park
Artificial intelligence is opening new perspectives in virus research, providing advanced tools to analyze viral evolution and to understand protein structure and dynamics on a large scale. To explore...
www.areasciencepark.it
🧬 Excited to share our International Workshop: AI in Virology
📆 Sept 9, 2025 - Trieste, Italy
@AreaSciencePark
We’ll explore how #AI is transforming virology — from protein language models to vaccine design and biosecurity.
🔗 Program & details: www.areasciencepark.it/en/events/ai...
📆 Sept 9, 2025 - Trieste, Italy
@AreaSciencePark
We’ll explore how #AI is transforming virology — from protein language models to vaccine design and biosecurity.
🔗 Program & details: www.areasciencepark.it/en/events/ai...
Reposted by Giuditta De Lorenzo
Reposted by Giuditta De Lorenzo
October 31, 2025 at 4:18 PM
Reposted by Giuditta De Lorenzo
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
August 19, 2025 at 6:24 PM
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
Reposted by Giuditta De Lorenzo
Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...
September 27, 2025 at 3:31 AM
Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...
Reposted by Giuditta De Lorenzo
New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology
imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for
>4,400 viruses, allowing mapping of form and function across the human and animal
virosphere. Viro3D i...
www.embopress.org
September 28, 2025 at 5:39 AM
New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Reposted by Giuditta De Lorenzo
Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...
Understanding the future risk of bat coronavirus spillover into humans: correlating sarbecovirus receptor usage, host range, and antigenicity.
Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understandin...
www.biorxiv.org
September 9, 2025 at 3:02 PM
Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...
Reposted by Giuditta De Lorenzo
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
August 13, 2025 at 10:10 PM
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
🧬 Excited to share our International Workshop: AI in Virology
📆 Sept 9, 2025 - Trieste, Italy
@AreaSciencePark
We’ll explore how #AI is transforming virology — from protein language models to vaccine design and biosecurity.
🔗 Program & details: www.areasciencepark.it/en/events/ai...
📆 Sept 9, 2025 - Trieste, Italy
@AreaSciencePark
We’ll explore how #AI is transforming virology — from protein language models to vaccine design and biosecurity.
🔗 Program & details: www.areasciencepark.it/en/events/ai...
AI in Virology: Leveraging AI to Advance Our Understanding of Viruses - Area Science Park
Artificial intelligence is opening new perspectives in virus research, providing advanced tools to analyze viral evolution and to understand protein structure and dynamics on a large scale. To explore...
www.areasciencepark.it
July 30, 2025 at 7:07 AM
🧬 Excited to share our International Workshop: AI in Virology
📆 Sept 9, 2025 - Trieste, Italy
@AreaSciencePark
We’ll explore how #AI is transforming virology — from protein language models to vaccine design and biosecurity.
🔗 Program & details: www.areasciencepark.it/en/events/ai...
📆 Sept 9, 2025 - Trieste, Italy
@AreaSciencePark
We’ll explore how #AI is transforming virology — from protein language models to vaccine design and biosecurity.
🔗 Program & details: www.areasciencepark.it/en/events/ai...
Proud moment: PhD student Beatrice Pani presented her very first poster at our Summer retreat! 😎 #AcademicLife #PhDJourney #MentorProud
July 30, 2025 at 6:48 AM
Proud moment: PhD student Beatrice Pani presented her very first poster at our Summer retreat! 😎 #AcademicLife #PhDJourney #MentorProud
April 28, 2025 at 9:47 AM
Always enjoyable and informative to listen to @peacockflu.bsky.social #microbio25
April 3, 2025 at 10:36 AM
Always enjoyable and informative to listen to @peacockflu.bsky.social #microbio25
Once again, @wfurnon.bsky.social has very nicely delivered our study about the phenotypic evolution of SARS-CoV-2 spike. Well done mate! #microbio25
April 2, 2025 at 3:46 PM
Once again, @wfurnon.bsky.social has very nicely delivered our study about the phenotypic evolution of SARS-CoV-2 spike. Well done mate! #microbio25
Reposted by Giuditta De Lorenzo
The thing I need people to understand about the lab leak conspiracy is that, aside from the fact that there is no compelling evidence for a laboratory origin for SARS-CoV-2, the constant advancement of this idea is used for nefarious political purposes. In particular,…
March 25, 2025 at 2:30 AM
The thing I need people to understand about the lab leak conspiracy is that, aside from the fact that there is no compelling evidence for a laboratory origin for SARS-CoV-2, the constant advancement of this idea is used for nefarious political purposes. In particular,…
So excited to hear the seminar of old friend and @icgeb.bsky.social alumni, Alessio Guglielmi, who started a career in forensic after his PhD.
January 17, 2025 at 11:15 AM
So excited to hear the seminar of old friend and @icgeb.bsky.social alumni, Alessio Guglielmi, who started a career in forensic after his PhD.
It is finally out, our beautiful work 😍
You have never seen so many Spike at once 😎
But the best thing has been working elbow to elbow with my best pal, @wfurnon.bsky.social
You have never seen so many Spike at once 😎
But the best thing has been working elbow to elbow with my best pal, @wfurnon.bsky.social
🚨🔔 Delighted to see this piece of work from @cvrinfo.bsky.social now out in @naturemicrobiol.bsky.social ! Indeed, it really reflects what multidisciplinary team effort can be. Guess what? Spike of #SARSCoV2 is not just about antigenicity/immune evasion… doi.org/10.1038/s415...
Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic - Nature Microbiology
Systematic comparison of SARS-CoV-2 spike proteins from pre- and post-Omicron variants in cell lines, primary respiratory epithelial cells and Syrian hamsters show distinct phenotypic trajectories in ...
doi.org
January 8, 2025 at 3:07 PM
It is finally out, our beautiful work 😍
You have never seen so many Spike at once 😎
But the best thing has been working elbow to elbow with my best pal, @wfurnon.bsky.social
You have never seen so many Spike at once 😎
But the best thing has been working elbow to elbow with my best pal, @wfurnon.bsky.social
Reposted by Giuditta De Lorenzo
For those interested in how SARS-CoV-2 is evolving, I found this paper to be interesting: Furnon et al, “Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic”, Nature Microbiology, www.nature.com/articles/s41...
Some of my notes about this paper: (1/13)
Some of my notes about this paper: (1/13)
Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic - Nature Microbiology
Systematic comparison of SARS-CoV-2 spike proteins from pre- and post-Omicron variants in cell lines, primary respiratory epithelial cells and Syrian hamsters show distinct phenotypic trajectories in ...
www.nature.com
January 7, 2025 at 12:57 AM
For those interested in how SARS-CoV-2 is evolving, I found this paper to be interesting: Furnon et al, “Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic”, Nature Microbiology, www.nature.com/articles/s41...
Some of my notes about this paper: (1/13)
Some of my notes about this paper: (1/13)
Reposted by Giuditta De Lorenzo
Great article on the growing use of #AI to study virus evolution, including insights from @cvrinfo.bsky.social @davidlrobertson.bsky.social.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
What will viruses do next? AI is helping scientists predict their evolution
Forecasts of viral variation could improve vaccine and antiviral treatments ahead of time.
www.nature.com
January 8, 2025 at 12:36 PM
Great article on the growing use of #AI to study virus evolution, including insights from @cvrinfo.bsky.social @davidlrobertson.bsky.social.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Giuditta De Lorenzo
Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans.
With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.
In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds...
www.biorxiv.org
January 7, 2025 at 7:59 AM
Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans.
With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
Reposted by Giuditta De Lorenzo
I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant.
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
Postdoctoral Researcher in Structural Virology
This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.
tiny.cc
December 27, 2024 at 7:59 AM
I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant.
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
Reposted by Giuditta De Lorenzo
If like me, you love Dickens, the Brontë sisters & care about infectious diseases, this is for you! 👇
Great Read!
theconversation.com/infectious-d...
theconversation.com/infectious-d...
Infectious diseases killed Victorian children at alarming rates — their novels highlight the fragility of public health today
Between 40% and 50% of children didn’t live past 5 in the US during the 19th century. Popular authors like Charles Dickens documented the common but no less gutting grief of losing a child.
theconversation.com
December 18, 2024 at 1:44 PM
If like me, you love Dickens, the Brontë sisters & care about infectious diseases, this is for you! 👇
Reposted by Giuditta De Lorenzo
Currently, Aedes mosquitoes that carry Zika Virus (ZIKV) in Africa (“subspecies”) do not prefer human hosts.
Climate change might change that.
“we predict that approximately three-quarters of the most populous African cities will be suitable for ZIKV outbreaks by the end of the century.”
🧪🛟🌎🦟💉🔬🩺
Climate change might change that.
“we predict that approximately three-quarters of the most populous African cities will be suitable for ZIKV outbreaks by the end of the century.”
🧪🛟🌎🦟💉🔬🩺
The role of vector population variation and climate in Zika virus transmission patterns in Africa: a modelling study
Both population-level genomic variation in mosquitoes and climate contribute to the lack of ZIKV outbreaks in Africa. Given the importance of mosquito genetics in driving this pattern, local genomic surveillance of mosquito populations would help predict outbreaks in vulnerable communities. This will become increasingly important with population growth, urbanisation, and climate change.
www.thelancet.com
December 11, 2024 at 11:41 PM
Currently, Aedes mosquitoes that carry Zika Virus (ZIKV) in Africa (“subspecies”) do not prefer human hosts.
Climate change might change that.
“we predict that approximately three-quarters of the most populous African cities will be suitable for ZIKV outbreaks by the end of the century.”
🧪🛟🌎🦟💉🔬🩺
Climate change might change that.
“we predict that approximately three-quarters of the most populous African cities will be suitable for ZIKV outbreaks by the end of the century.”
🧪🛟🌎🦟💉🔬🩺
Reposted by Giuditta De Lorenzo
Really looking forward to catching up with the influenza research community, from academia and industry across the UK and beyond, at next week's Influenza Update Meeting, which this year we're hosting here at the University of Glasgow. Can't wait!
November 26, 2024 at 11:12 AM
Really looking forward to catching up with the influenza research community, from academia and industry across the UK and beyond, at next week's Influenza Update Meeting, which this year we're hosting here at the University of Glasgow. Can't wait!
Reposted by Giuditta De Lorenzo
🐄 NEW | Research from the CVR reveals how #H5N1 avian influenza has adapted to infect bovine cells, contributing to a major outbreak in dairy cattle in North America.
Multiple internal genomic segments of the virus drive its adaptation to bovine cells.
www.biorxiv.org/content/10.1...
Multiple internal genomic segments of the virus drive its adaptation to bovine cells.
www.biorxiv.org/content/10.1...
POLYGENIC DETERMINANTS OF H5N1 ADAPTATION TO BOVINE CELLS
H5N1 avian influenza virus (lineage 2.3.4.4b, B3.13 genotype) has caused, unexpectedly, a large outbreak in dairy cattle in North America. It is critical to ascertain how this virus has specifically a...
www.biorxiv.org
December 4, 2024 at 12:07 PM
🐄 NEW | Research from the CVR reveals how #H5N1 avian influenza has adapted to infect bovine cells, contributing to a major outbreak in dairy cattle in North America.
Multiple internal genomic segments of the virus drive its adaptation to bovine cells.
www.biorxiv.org/content/10.1...
Multiple internal genomic segments of the virus drive its adaptation to bovine cells.
www.biorxiv.org/content/10.1...
Glasgow is fab, but also @cvrinfo.bsky.social !
Do you want to become a virologist?
The @CVRinfo PhD programme is now recruiting for both UK and international applicants - rotate in two labs then choose a project tailored to your interests.
Also you get to live in Glasgow, which is fab.
Please RT!
www.findaphd.com/phds/program...
The @CVRinfo PhD programme is now recruiting for both UK and international applicants - rotate in two labs then choose a project tailored to your interests.
Also you get to live in Glasgow, which is fab.
Please RT!
www.findaphd.com/phds/program...
November 24, 2024 at 5:48 PM
Glasgow is fab, but also @cvrinfo.bsky.social !