Sean Bresnahan 🧊🚫
@seantbres.bsky.social
Postdoc. Omics of reproduction, development, cancer, and conflict.
Opinions are my own.
https://seantbresnahan.com/assets/docs/CV_STB_122925.pdf
https://bhattacharya-lab.com
Opinions are my own.
https://seantbresnahan.com/assets/docs/CV_STB_122925.pdf
https://bhattacharya-lab.com
Pinned
Happy new year! Sharing a 🧬🚨REVISED PREPRINT🚨 with major updates to our placental long-read transcriptome paper! Thanks to thorough reviewer feedback, we've strengthened the manuscript with new analyses & clarifications. Key figures in this thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tulsa stands with you, Minneapolis.
More than 100 people showed up to a vigil Tuesday evening at LaFortune Park in Tulsa, OK to remember people murdered by federal officers of the Trump regime.
Photos by Mike Simmons, Tulsa World.
More than 100 people showed up to a vigil Tuesday evening at LaFortune Park in Tulsa, OK to remember people murdered by federal officers of the Trump regime.
Photos by Mike Simmons, Tulsa World.
January 28, 2026 at 3:07 AM
Tulsa stands with you, Minneapolis.
More than 100 people showed up to a vigil Tuesday evening at LaFortune Park in Tulsa, OK to remember people murdered by federal officers of the Trump regime.
Photos by Mike Simmons, Tulsa World.
More than 100 people showed up to a vigil Tuesday evening at LaFortune Park in Tulsa, OK to remember people murdered by federal officers of the Trump regime.
Photos by Mike Simmons, Tulsa World.
Reposted by Sean Bresnahan 🧊🚫
This administration is cooked. Literally no one is scared of them.
January 25, 2026 at 5:20 PM
This administration is cooked. Literally no one is scared of them.
As we prepare for the coming weeks and think about how we will choose to face this moment, remember that in his last few minutes alive, Alex Pretti was rendering aid.
January 25, 2026 at 4:51 AM
As we prepare for the coming weeks and think about how we will choose to face this moment, remember that in his last few minutes alive, Alex Pretti was rendering aid.
Reposted by Sean Bresnahan 🧊🚫
This is Alex Pretti.
This morning he was murdered by ICE. Six ICE agents held him down and shot him at point blank range. Alex was a nurse and researcher at the VA.
Our thoughts are with his loved ones and we stand united in action calling for the abolishment of ICE.
#ScientistsAgainstICE
This morning he was murdered by ICE. Six ICE agents held him down and shot him at point blank range. Alex was a nurse and researcher at the VA.
Our thoughts are with his loved ones and we stand united in action calling for the abolishment of ICE.
#ScientistsAgainstICE
January 24, 2026 at 8:03 PM
This is Alex Pretti.
This morning he was murdered by ICE. Six ICE agents held him down and shot him at point blank range. Alex was a nurse and researcher at the VA.
Our thoughts are with his loved ones and we stand united in action calling for the abolishment of ICE.
#ScientistsAgainstICE
This morning he was murdered by ICE. Six ICE agents held him down and shot him at point blank range. Alex was a nurse and researcher at the VA.
Our thoughts are with his loved ones and we stand united in action calling for the abolishment of ICE.
#ScientistsAgainstICE
We should be doing this in every state.
January 23, 2026 at 11:57 AM
We should be doing this in every state.
Reposted by Sean Bresnahan 🧊🚫
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
January 20, 2026 at 10:53 PM
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
“heroism is neither being perfect, nor doing something spectacular. In fact, it’s just the opposite: it’s regular, flawed human beings choosing to put others before themselves, even at great cost, even if no one will ever know, even as they realize the walls might be closing in around them.”
January 19, 2026 at 1:37 PM
“heroism is neither being perfect, nor doing something spectacular. In fact, it’s just the opposite: it’s regular, flawed human beings choosing to put others before themselves, even at great cost, even if no one will ever know, even as they realize the walls might be closing in around them.”
“Somewhere I read of the freedom of speech.
Somewhere I read of the freedom of the press.
Somewhere I read that the greatness of America is the right to protest for rights.”
Somewhere I read of the freedom of the press.
Somewhere I read that the greatness of America is the right to protest for rights.”
January 19, 2026 at 1:26 PM
“Somewhere I read of the freedom of speech.
Somewhere I read of the freedom of the press.
Somewhere I read that the greatness of America is the right to protest for rights.”
Somewhere I read of the freedom of the press.
Somewhere I read that the greatness of America is the right to protest for rights.”
Reposted by Sean Bresnahan 🧊🚫
I’m seeing posts from people (outside of MN) about how US citizens should carry their passports.
And let me say that *inside* MN, we are calmly responding to requests with: “No, I don’t have to show you any documentation.”
Because that’s how you protect everyone, regardless of immigration status.
And let me say that *inside* MN, we are calmly responding to requests with: “No, I don’t have to show you any documentation.”
Because that’s how you protect everyone, regardless of immigration status.
January 16, 2026 at 12:17 AM
I’m seeing posts from people (outside of MN) about how US citizens should carry their passports.
And let me say that *inside* MN, we are calmly responding to requests with: “No, I don’t have to show you any documentation.”
Because that’s how you protect everyone, regardless of immigration status.
And let me say that *inside* MN, we are calmly responding to requests with: “No, I don’t have to show you any documentation.”
Because that’s how you protect everyone, regardless of immigration status.
Reposted by Sean Bresnahan 🧊🚫
I'm delighted to release the first half of my new textbook in human genetics:
web.stanford.edu/group/pritch...
"An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
web.stanford.edu/group/pritch...
"An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
An Owner's Guide to the Human Genome
An Owner's Guide to the Human Genome
web.stanford.edu
October 1, 2023 at 10:53 PM
I'm delighted to release the first half of my new textbook in human genetics:
web.stanford.edu/group/pritch...
"An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
web.stanford.edu/group/pritch...
"An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
Reposted by Sean Bresnahan 🧊🚫
To be clear, they're play-fighting and also: this video improved my day measurably and I wish I'd've watched it earlier. If you haven't, fix that now.
January 10, 2026 at 12:14 AM
To be clear, they're play-fighting and also: this video improved my day measurably and I wish I'd've watched it earlier. If you haven't, fix that now.
can i let them both be? this fickle faith and this college science that heckles from the back of the
classroom
now i can’t believe—
that the bible and qur’an and bhagavad gita are sliding long hairs behind my ear like mom
used to & exhaling from their mouths “make room for wonder”
classroom
now i can’t believe—
that the bible and qur’an and bhagavad gita are sliding long hairs behind my ear like mom
used to & exhaling from their mouths “make room for wonder”
“i want back my rocking chairs, / solipsist sunsets, / & coastal jungle sounds...”
A poem by Renee Nicole Good, who was murdered by ICE earlier today.
lithub.com/renee-nicole...
A poem by Renee Nicole Good, who was murdered by ICE earlier today.
lithub.com/renee-nicole...
Renee Nicole Good, murdered by ICE, was a prize-winning poet. Here’s that poem.
Renee Nicole Good, 37, mother to a six-year-old boy, was murdered earlier today by an ICE agent in Minneapolis, a few blocks from her home. According to the Minnesota Star Tribune: [An ICE agent] s…
lithub.com
January 8, 2026 at 11:37 AM
can i let them both be? this fickle faith and this college science that heckles from the back of the
classroom
now i can’t believe—
that the bible and qur’an and bhagavad gita are sliding long hairs behind my ear like mom
used to & exhaling from their mouths “make room for wonder”
classroom
now i can’t believe—
that the bible and qur’an and bhagavad gita are sliding long hairs behind my ear like mom
used to & exhaling from their mouths “make room for wonder”
Having a 🍺 with Mr PEG tomorrow who wants to join
Happy to share our new preprint from @sashagusevposts.bsky.social and @nmancuso.bsky.social labs! We introduce Mr. PEG, a framework integrating perturbational screens, eQTL, and GWAS data to identify mediating genes for complex traits. (1/n) www.medrxiv.org/content/10.6...
Integrating perturbational screens, eQTL, and GWAS data identifies mediating genes for complex traits
Most current GWAS-eQTL approaches prioritize genes whose mediating effects on complex traits act through cis-regulation, while trans-acting genes remain largely underexplored. Recent perturbational sc...
www.medrxiv.org
January 6, 2026 at 1:47 AM
Having a 🍺 with Mr PEG tomorrow who wants to join
In 2025, I learned a lot about chronic illness as my spouse and I navigated the US healthcare system to get diagnoses and options for managing symptoms. 1/
January 1, 2026 at 7:12 AM
In 2025, I learned a lot about chronic illness as my spouse and I navigated the US healthcare system to get diagnoses and options for managing symptoms. 1/
Happy new year! Sharing a 🧬🚨REVISED PREPRINT🚨 with major updates to our placental long-read transcriptome paper! Thanks to thorough reviewer feedback, we've strengthened the manuscript with new analyses & clarifications. Key figures in this thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 31, 2025 at 7:04 PM
Happy new year! Sharing a 🧬🚨REVISED PREPRINT🚨 with major updates to our placental long-read transcriptome paper! Thanks to thorough reviewer feedback, we've strengthened the manuscript with new analyses & clarifications. Key figures in this thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Looking into industry bioinformatics / comp bio / data science careers. If you have any leads, message me! CV is in bio. Currently a postdoc data scientist at @mdanderson.bsky.social, have published work in both wet + dry lab multi-omics of non-model organisms & humans. 🧪🧬🖥️
December 27, 2025 at 6:30 PM
Looking into industry bioinformatics / comp bio / data science careers. If you have any leads, message me! CV is in bio. Currently a postdoc data scientist at @mdanderson.bsky.social, have published work in both wet + dry lab multi-omics of non-model organisms & humans. 🧪🧬🖥️
Reposted by Sean Bresnahan 🧊🚫
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...
www.biorxiv.org
December 13, 2025 at 10:08 PM
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Reposted by Sean Bresnahan 🧊🚫
delighted to share our review, out today in
@cp-trendsgenetics.bsky.social! check it out if you're curious about how recent advances in technology & biology have contributed to our understanding of how alternative isoforms diversify the proteome.
@cp-trendsgenetics.bsky.social! check it out if you're curious about how recent advances in technology & biology have contributed to our understanding of how alternative isoforms diversify the proteome.
"Beyond the Gene: Decoding Alternative Isoforms"
by Kaia Mattioli (@kaiamattioli.bsky.social) & Martha Bulyk
"The degree to which alternative isoforms actually contribute to the complexity of the human proteome in their endogenous contexts has been the subject of much debate..."
shorturl.at/YbNoB
by Kaia Mattioli (@kaiamattioli.bsky.social) & Martha Bulyk
"The degree to which alternative isoforms actually contribute to the complexity of the human proteome in their endogenous contexts has been the subject of much debate..."
shorturl.at/YbNoB
December 11, 2025 at 3:47 PM
delighted to share our review, out today in
@cp-trendsgenetics.bsky.social! check it out if you're curious about how recent advances in technology & biology have contributed to our understanding of how alternative isoforms diversify the proteome.
@cp-trendsgenetics.bsky.social! check it out if you're curious about how recent advances in technology & biology have contributed to our understanding of how alternative isoforms diversify the proteome.
Reposted by Sean Bresnahan 🧊🚫
Another day, another day dragging NIH into areas where it doesn't belong and demeaning himself and the agency...
Turning Point USA’s conference starts in 8 days
Of course, the NIH Director and his MAHA ally Russell Brand are speakers….along with Don Trump Jr, JD Vance, Megyn Kelly, Roger Stone….
Of course, the NIH Director and his MAHA ally Russell Brand are speakers….along with Don Trump Jr, JD Vance, Megyn Kelly, Roger Stone….
December 10, 2025 at 6:58 PM
Another day, another day dragging NIH into areas where it doesn't belong and demeaning himself and the agency...
Reposted by Sean Bresnahan 🧊🚫
Lovely new review on H3K27me3 dynamics and potential functions in #plantscience by @drosborneplantsci.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...
nph.onlinelibrary.wiley.com/doi/10.1111/...
Finding balance: the dynamic interplay between H3K27me3 writers and erasers in regulating environmental plasticity and memory
Subject to an ever-changing world, plants must respond to harmful conditions and environmental fluctuations. Their evolutionary success can be attributed to their plasticity in both perceiving and in...
nph.onlinelibrary.wiley.com
December 4, 2025 at 7:54 AM
Lovely new review on H3K27me3 dynamics and potential functions in #plantscience by @drosborneplantsci.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...
nph.onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Sean Bresnahan 🧊🚫
I'm increasingly interested in race science as a form of cultivated, weaponized statistical illiteracy. Take this figure, one of the most common propaganda plots, plotting national IQ data against education polygenic scores. "The correlation is so high! Clearly IQ differences are genetic!"
Oops!
Oops!
November 28, 2025 at 11:31 PM
I'm increasingly interested in race science as a form of cultivated, weaponized statistical illiteracy. Take this figure, one of the most common propaganda plots, plotting national IQ data against education polygenic scores. "The correlation is so high! Clearly IQ differences are genetic!"
Oops!
Oops!
Reposted by Sean Bresnahan 🧊🚫
Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis - Nature Ecology & Evolution
In Caenorhabditis tropicalis, three toxin–antidote elements arose via gene duplication from the essential tRNA-synthetase subunit FARS-3. The ancestral antidote probably acquired affinity for FARS-3, ...
www.nature.com
November 24, 2025 at 9:10 PM
Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Reposted by Sean Bresnahan 🧊🚫
I am procrastinating on writing by reading this interview of one of the true pioneers in evolutionary biology (and one of the nicest people I have ever met in my life)
Why we should be thinking of Welwitschia. What is Welwitschia you might ask (I did!)? Read on.
www.edge.org/conversation...
Why we should be thinking of Welwitschia. What is Welwitschia you might ask (I did!)? Read on.
www.edge.org/conversation...
GENOMIC IMPRINTING | Edge.org
www.edge.org
November 25, 2025 at 2:20 AM
I am procrastinating on writing by reading this interview of one of the true pioneers in evolutionary biology (and one of the nicest people I have ever met in my life)
Why we should be thinking of Welwitschia. What is Welwitschia you might ask (I did!)? Read on.
www.edge.org/conversation...
Why we should be thinking of Welwitschia. What is Welwitschia you might ask (I did!)? Read on.
www.edge.org/conversation...
Reposted by Sean Bresnahan 🧊🚫
The Zohran press conference is your regular reminder that the entire administration folds like tissue paper at the slightest hint of confidence and conviction, and thus the fact that national democrats are playing a game of capitulation and weakness is exactly why they're all getting away with it
November 21, 2025 at 9:54 PM
The Zohran press conference is your regular reminder that the entire administration folds like tissue paper at the slightest hint of confidence and conviction, and thus the fact that national democrats are playing a game of capitulation and weakness is exactly why they're all getting away with it