Arjun Bhattacharya
@arjunbhattac.bsky.social
Assistant Professor, Epidemiology at MD Anderson. Molecular epi and statistical genomics to understand cancer and human development
https://bhattacharya-lab.com/
https://bhattacharya-lab.com/
Pinned
A few programming notes for #ashg25 from trainees in my group @mdanderson.bsky.social + a thread of me being a proud PI. Please drop by these sessions and talk to @taylorhead.bsky.social, @seantbres.bsky.social , @ytchang11.bsky.social, and me in Boston @geneticssociety.bsky.social next week!
Excited to see everyone in Boston at #ashg25! 🧵on my group’s presentations.
A few programming notes for #ashg25 from trainees in my group @mdanderson.bsky.social + a thread of me being a proud PI. Please drop by these sessions and talk to @taylorhead.bsky.social, @seantbres.bsky.social , @ytchang11.bsky.social, and me in Boston @geneticssociety.bsky.social next week!
October 14, 2025 at 11:51 AM
Excited to see everyone in Boston at #ashg25! 🧵on my group’s presentations.
A few programming notes for #ashg25 from trainees in my group @mdanderson.bsky.social + a thread of me being a proud PI. Please drop by these sessions and talk to @taylorhead.bsky.social, @seantbres.bsky.social , @ytchang11.bsky.social, and me in Boston @geneticssociety.bsky.social next week!
October 8, 2025 at 11:31 PM
A few programming notes for #ashg25 from trainees in my group @mdanderson.bsky.social + a thread of me being a proud PI. Please drop by these sessions and talk to @taylorhead.bsky.social, @seantbres.bsky.social , @ytchang11.bsky.social, and me in Boston @geneticssociety.bsky.social next week!
Reposted by Arjun Bhattacharya
Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we:
1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs
bsky.app/profile/bior...
1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs
bsky.app/profile/bior...
Cell villages and Dirichlet modeling map human cell fitness genetics https://www.biorxiv.org/content/10.1101/2025.09.26.678880v1
September 29, 2025 at 4:47 PM
Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we:
1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs
bsky.app/profile/bior...
1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs
bsky.app/profile/bior...
Reposted by Arjun Bhattacharya
When testing a computational data analysis method: simulated data are good for checking whether the method is doing what you think it should be doing, real data for checking whether what you think it should be doing is any good.
August 30, 2025 at 9:37 AM
When testing a computational data analysis method: simulated data are good for checking whether the method is doing what you think it should be doing, real data for checking whether what you think it should be doing is any good.
Very proud of @ytchang11.bsky.social for her first publication from her doctoral research! She conducted very meticulous genomic analyses that uncovered novel isoform-specific mechanistic hypotheses underlying genetic loci associated with multiple cancers.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level - British Journal of Cancer
British Journal of Cancer - Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level
www.nature.com
August 20, 2025 at 9:09 PM
Very proud of @ytchang11.bsky.social for her first publication from her doctoral research! She conducted very meticulous genomic analyses that uncovered novel isoform-specific mechanistic hypotheses underlying genetic loci associated with multiple cancers.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Arjun Bhattacharya
Excited to share this preprint from first author Jon Rosen, a postdoctoral fellow in the @klmohlke.bsky.social lab and my lab. We examine eQTL study sample size and how this affects signal discovery and rates of colocalization with GWAS.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Higher eQTL power reveals signals that boost GWAS colocalization
Expression quantitative trait locus (eQTL) studies in human cohorts typically detect at least one regulatory signal per gene, and have been proposed as a way to explain mechanisms of genetic liability...
www.biorxiv.org
August 18, 2025 at 12:18 PM
Excited to share this preprint from first author Jon Rosen, a postdoctoral fellow in the @klmohlke.bsky.social lab and my lab. We examine eQTL study sample size and how this affects signal discovery and rates of colocalization with GWAS.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Arjun Bhattacharya
⚡🦠I'm very excited to share our latest work on the gut microbiome and metabolic dysfunction-associated steatotic liver disease (MASLD) is published in @natmetabolism.nature.com, with @hutlab.bsky.social & @longnguyen.bsky.social!
🔗Check out the paper here:
www.nature.com/articles/s42...
🔗Check out the paper here:
www.nature.com/articles/s42...
July 3, 2025 at 12:59 PM
⚡🦠I'm very excited to share our latest work on the gut microbiome and metabolic dysfunction-associated steatotic liver disease (MASLD) is published in @natmetabolism.nature.com, with @hutlab.bsky.social & @longnguyen.bsky.social!
🔗Check out the paper here:
www.nature.com/articles/s42...
🔗Check out the paper here:
www.nature.com/articles/s42...
Reposted by Arjun Bhattacharya
New work from the lab trying to wrap our heads around the massive complexity of the human transcriptome revealed by long-read RNA-seq! Fun collab with Gloria Sheynkman. www.biorxiv.org/content/10.1...
Perplexity as a Metric for Isoform Diversity in the Human Transcriptome
Long-read sequencing (LRS) has revealed a far greater diversity of RNA isoforms than earlier technologies, increasing the critical need to determine which, and how many, isoforms per gene are biologic...
www.biorxiv.org
July 2, 2025 at 11:46 PM
New work from the lab trying to wrap our heads around the massive complexity of the human transcriptome revealed by long-read RNA-seq! Fun collab with Gloria Sheynkman. www.biorxiv.org/content/10.1...
Excited to share new work investigating transcriptional diversity in the placenta from our group led by talented postdoc @seantbres.bsky.social! Thread below describing the salient results. Welcoming any feedback and comments.
🧬🚨PREPRINT🚨- The first placental isoform reference from long-read seq & supporting data! We demonstrate how tissue-specific assembly improves transcript quantification with short-read data from multi-ancestry birth studies & reveals placenta-mediated effects of gestational diabetes on birth weight🫄
Long-read transcriptome assembly reveals vast isoform diversity in the placenta associated with metabolic and endocrine function
The placenta plays a critical role in fetal development and mediates maternal metabolic effects on offspring health outcomes. Despite its importance, the placenta remains understudied in large-scale g...
doi.org
July 2, 2025 at 1:16 PM
Excited to share new work investigating transcriptional diversity in the placenta from our group led by talented postdoc @seantbres.bsky.social! Thread below describing the salient results. Welcoming any feedback and comments.
Reposted by Arjun Bhattacharya
Much more important things going on in the world, but wanted to share this new work on parent-of-origin effects & “non-canonical” genomic imprinting in developmental plasticity of honey bees, out now in Genome Biology 🧪🧬🔄 link.springer.com/article/10.1...
Intragenomic conflict associated with extreme phenotypic plasticity in queen-worker caste determination in honey bees (Apis mellifera) - Genome Biology
Background Caste determination of honey bees (Apis mellifera) exemplifies developmental plasticity, where differences in larval diet result in identical genotypes yielding either long-lived, reproduct...
link.springer.com
June 18, 2025 at 3:30 PM
Much more important things going on in the world, but wanted to share this new work on parent-of-origin effects & “non-canonical” genomic imprinting in developmental plasticity of honey bees, out now in Genome Biology 🧪🧬🔄 link.springer.com/article/10.1...
Drop by and say hi to @mdanderson.bsky.social Postdoctoral Data Scientist @seantbres.bsky.social if you’re at Biology of Genomes. He’ll be presenting some new work from our group that he’s championed. You’ll have an interesting science and/or science policy discussion!
In NY for Biology of Genomes @cshlnews.bsky.social this week. During a layover on the way here, I tried to write a bit to communicate some of the work our group is doing, and why federal research funding for basic science matters substack.com/home/post/p-...
From Code to Complexity
How Our Cells Read Between the Lines (and Why Federally-Funded Research Matters)
substack.com
May 7, 2025 at 8:05 PM
Drop by and say hi to @mdanderson.bsky.social Postdoctoral Data Scientist @seantbres.bsky.social if you’re at Biology of Genomes. He’ll be presenting some new work from our group that he’s championed. You’ll have an interesting science and/or science policy discussion!
Reposted by Arjun Bhattacharya
Neglected to share this good news this morning :)
January 10, 2025 at 10:27 PM
Neglected to share this good news this morning :)
Reposted by Arjun Bhattacharya
Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students and those planning genomics experiments will find it useful! I’ll share updates soon
January 10, 2025 at 3:40 AM
Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students and those planning genomics experiments will find it useful! I’ll share updates soon
Reposted by Arjun Bhattacharya
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
Ewald Lab
@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
ewaldlab.org
December 13, 2024 at 2:12 PM
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
DEADLINE EXTENDED to Jan. 21! Open to grads & undergrads, join the world of cancer prevention this summer Jun 3 to Aug 9 at MD Anderson with an NCI funded internship working with too cancer researchers & clinicians! Apply at bit.ly/CPRTP-Summer
CPRTP Summer Research Experience
bit.ly
January 17, 2024 at 3:13 AM
DEADLINE EXTENDED to Jan. 21! Open to grads & undergrads, join the world of cancer prevention this summer Jun 3 to Aug 9 at MD Anderson with an NCI funded internship working with too cancer researchers & clinicians! Apply at bit.ly/CPRTP-Summer
Our isoTWAS work with the Pasaniuc and Gandal labs is out at Nature Genetics! Great team effort, especially from Daniel Vo and Connor Jops. Appreciate the helpful and thoughtful comments from reviewers that improved our work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric d...
A multivariate framework for isoform-resolution transcriptome-wide association studies enables modeling of a greater number of genes, with the benefit of identifying isoform-specific associations with...
www.nature.com
November 30, 2023 at 4:19 PM
Our isoTWAS work with the Pasaniuc and Gandal labs is out at Nature Genetics! Great team effort, especially from Daniel Vo and Connor Jops. Appreciate the helpful and thoughtful comments from reviewers that improved our work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
If you’re a trainee or know one looking for a postdoctoral position, let’s chat during ASHG this week!
Come join me at MD Anderson Cancer Center in Houston and the Texas Medical Center! I'm hiring a Postdoctoral Scholar to lead genetic and molecular epidemiology projects to study breast cancer or pregnancy/childhood outcomes.
More details here: bit.ly/pd_blgc2023
More details here: bit.ly/pd_blgc2023
October 30, 2023 at 2:57 PM
If you’re a trainee or know one looking for a postdoctoral position, let’s chat during ASHG this week!
Reposted by Arjun Bhattacharya
This is a Bluesky feed that tracks #WCPG2023 posts for the world congres of psychiatric genetics 2023, SUBSCRIBE!: bsky.app/profile/did:...
October 6, 2023 at 11:17 AM
This is a Bluesky feed that tracks #WCPG2023 posts for the world congres of psychiatric genetics 2023, SUBSCRIBE!: bsky.app/profile/did:...
Come join me at MD Anderson Cancer Center in Houston and the Texas Medical Center! I'm hiring a Postdoctoral Scholar to lead genetic and molecular epidemiology projects to study breast cancer or pregnancy/childhood outcomes.
More details here: bit.ly/pd_blgc2023
More details here: bit.ly/pd_blgc2023
October 9, 2023 at 6:17 PM
Come join me at MD Anderson Cancer Center in Houston and the Texas Medical Center! I'm hiring a Postdoctoral Scholar to lead genetic and molecular epidemiology projects to study breast cancer or pregnancy/childhood outcomes.
More details here: bit.ly/pd_blgc2023
More details here: bit.ly/pd_blgc2023