Scheff Research Lab
@schefflab.bsky.social
The goal of our research is to investigate whether therapy targeted to peripheral neurons in the cancer microenvironment can alleviate pain and slow tumor progression. https://schefflab.pitt.edu/
#cancerneuroscience #research
#cancerneuroscience #research
Reposted by Scheff Research Lab
Abstract deadline approaching quickly (Nov 7, 2025) for the international #cancerneuroscience #symposium happening in Feb 2026!! Check out registration (SO CHEAP for 3 days!), abstract, and award details here:
mdanderson.cloud-cme.com/course/cours...
mdanderson.cloud-cme.com/course/cours...
October 24, 2025 at 6:40 PM
Abstract deadline approaching quickly (Nov 7, 2025) for the international #cancerneuroscience #symposium happening in Feb 2026!! Check out registration (SO CHEAP for 3 days!), abstract, and award details here:
mdanderson.cloud-cme.com/course/cours...
mdanderson.cloud-cme.com/course/cours...
2026 Cancer Neuroscience Symposium
Abstract submission deadline: 11.7.2025
This is one of my favorite meetings of the year where all the science is really great and so much collaboration that starts within those couple days. Even if you're on a cusp of the field, totally worth checking out!
Abstract submission deadline: 11.7.2025
This is one of my favorite meetings of the year where all the science is really great and so much collaboration that starts within those couple days. Even if you're on a cusp of the field, totally worth checking out!
October 22, 2025 at 1:02 PM
2026 Cancer Neuroscience Symposium
Abstract submission deadline: 11.7.2025
This is one of my favorite meetings of the year where all the science is really great and so much collaboration that starts within those couple days. Even if you're on a cusp of the field, totally worth checking out!
Abstract submission deadline: 11.7.2025
This is one of my favorite meetings of the year where all the science is really great and so much collaboration that starts within those couple days. Even if you're on a cusp of the field, totally worth checking out!
Reposted by Scheff Research Lab
Great conversation with Erica Sloan about stress and cancer…https://m.youtube.com/watch?v=5zJzPdzE65g
Episode 1: A Conversation with Dr. Erica Sloan
YouTube video by Advanced Portfolio News
m.youtube.com
August 29, 2025 at 9:23 PM
Great conversation with Erica Sloan about stress and cancer…https://m.youtube.com/watch?v=5zJzPdzE65g
Reposted by Scheff Research Lab
Cancer-induced Nerve Injury Unveils a Sympathetic-to-Sensory Nerve Axis in Head and Neck Cancer https://www.biorxiv.org/content/10.1101/2025.09.19.677339v1
September 20, 2025 at 12:15 AM
Cancer-induced Nerve Injury Unveils a Sympathetic-to-Sensory Nerve Axis in Head and Neck Cancer https://www.biorxiv.org/content/10.1101/2025.09.19.677339v1
The NOA has landed! We have our first 🛏️to 🔬 to🛌translation! In collaboration with Glycyx Therapeutics, we received funding for a multi-institutional clinical trial to test if peripheral acting OPRM1 antagonism can improve response to immune checkpoint blockade in head and neck cancer patients!
September 23, 2025 at 10:26 PM
The NOA has landed! We have our first 🛏️to 🔬 to🛌translation! In collaboration with Glycyx Therapeutics, we received funding for a multi-institutional clinical trial to test if peripheral acting OPRM1 antagonism can improve response to immune checkpoint blockade in head and neck cancer patients!
Congratulations to @andremartel.bsky.social for his first author preprint, now available on bioRxiv: Cancer-induced Nerve Injury Unveils a Sympathetic-to-Sensory Nerve Axis in Head and Neck Cancer! #cancerneuroscience #cancerpain
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Cancer-induced Nerve Injury Unveils a Sympathetic-to-Sensory Nerve Axis in Head and Neck Cancer
Oral squamous cell carcinoma (OSCC) is one of the most painful cancers, with patients frequently reporting spontaneous, neuropathic-like pain. While sympathetic and sensory nerves have been individual...
www.biorxiv.org
September 22, 2025 at 7:49 PM
Congratulations to @andremartel.bsky.social for his first author preprint, now available on bioRxiv: Cancer-induced Nerve Injury Unveils a Sympathetic-to-Sensory Nerve Axis in Head and Neck Cancer! #cancerneuroscience #cancerpain
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
📢Happy to announce the Scheff lab's contribution to this important exploration of #neurobiology of #cancer, out now in @cp-neuron.bsky.social! Thanks to @andremartel.bsky.social!
A Review by Alexander Birbrair and colleagues on the role of sensory neurons within the tumor microenvironment
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Entangled cellular and molecular relationships at the sensory neuron-cancer interface
Beyond acting as a passive route for nociceptive signals, sensory neurons are active
participants in tumor progression. This review examines sensory neuron-tumor bidirectional
interaction and explores...
www.cell.com
September 3, 2025 at 4:42 PM
📢Happy to announce the Scheff lab's contribution to this important exploration of #neurobiology of #cancer, out now in @cp-neuron.bsky.social! Thanks to @andremartel.bsky.social!
The Scheff Lab image was selected to be the background of the @pcpr-pittpain.bsky.social seminar series poster highlighting mammary innervating dorsal root ganglia neurons. This image was taken in a study understanding the impact of sensory neurons on breast cancer progression and (lack of) pain.
August 19, 2025 at 1:11 PM
The Scheff Lab image was selected to be the background of the @pcpr-pittpain.bsky.social seminar series poster highlighting mammary innervating dorsal root ganglia neurons. This image was taken in a study understanding the impact of sensory neurons on breast cancer progression and (lack of) pain.
Cancer #pain isn't just a symptom, it can influence survival. Our new commentary in @cp-cancercell.bsky.social explores the idea that choosing the right analgesic could improve tumor immunity. Thanks to my co-authors for their support with this piece! #cancerneuroscience
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Rethinking relief: Targeting sensory neurons to combat cancer and pain
Cancer pain is a complex problem that, when left unaddressed, can impact overall survival
and decrease patients’ quality of life. Collaboration among medical oncologists, immunologists,
and neurobiolo...
www.cell.com
August 8, 2025 at 2:21 PM
Cancer #pain isn't just a symptom, it can influence survival. Our new commentary in @cp-cancercell.bsky.social explores the idea that choosing the right analgesic could improve tumor immunity. Thanks to my co-authors for their support with this piece! #cancerneuroscience
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Reposted by Scheff Research Lab
www.biorxiv.org/content/10.1... New data from us on Botox-A effects on human DRG neurons, including some really surprising effects on DRG transcriptome. All of this work was led by Katherin Gabriel, and was a great collaboration with our friends at AbbVie.
Botulinum Neurotoxin A1 Signaling in Pain Modulation within Human Sensory Neurons
Botulinum neurotoxin type A1 (BoNT/A1) is an effective treatment for chronic migraine, but its direct mechanism of action on human sensory neurons has not been fully elucidated. While rodent studies o...
www.biorxiv.org
June 25, 2025 at 1:26 PM
www.biorxiv.org/content/10.1... New data from us on Botox-A effects on human DRG neurons, including some really surprising effects on DRG transcriptome. All of this work was led by Katherin Gabriel, and was a great collaboration with our friends at AbbVie.
Reposted by Scheff Research Lab
#REVIEW 🚨
Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.
📖 ⬇️
Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.
📖 ⬇️
Neuro-immune cross-talk in cancer - Nature Reviews Cancer
The nervous and immune systems have co-evolved to respond to threats, including cancer. In this Review, Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.
www.nature.com
June 23, 2025 at 2:19 PM
#REVIEW 🚨
Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.
📖 ⬇️
Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.
📖 ⬇️
May 21, 2025 at 3:26 PM
🎉Congratulations to @andremartel.bsky.social for winning BEST POSTER at yesterday's #painday, held at the University of Pittsburgh @cnup.bsky.social! Thanks to Hannah and @nehamokhasi.bsky.social for their excellent contributions.
May 8, 2025 at 3:41 PM
🎉Congratulations to @andremartel.bsky.social for winning BEST POSTER at yesterday's #painday, held at the University of Pittsburgh @cnup.bsky.social! Thanks to Hannah and @nehamokhasi.bsky.social for their excellent contributions.
Thanks to @usasp.bsky.social for a great conference! Dr Scheff discussed reverse translation in #cancerpain and presented a poster detailing new work on radiation-induced pain and oral mucositis. @andremartel.bsky.social presented updates on his project on sympathetics and cancer pain. #research
May 6, 2025 at 6:53 PM
Thanks to @usasp.bsky.social for a great conference! Dr Scheff discussed reverse translation in #cancerpain and presented a poster detailing new work on radiation-induced pain and oral mucositis. @andremartel.bsky.social presented updates on his project on sympathetics and cancer pain. #research
Reposted by Scheff Research Lab
@andremartel.bsky.social and I had an awesome time teaching at the inaugural Cold Spring Harbor Laboratory 2025 Methods in Cancer Neuroscience course this week! #cshl #cancerneuroscience. Wish we could have stayed but had to be home for the Stand Up For Science Event! @standupforscience.bsky.social
March 7, 2025 at 3:35 PM
@andremartel.bsky.social and I had an awesome time teaching at the inaugural Cold Spring Harbor Laboratory 2025 Methods in Cancer Neuroscience course this week! #cshl #cancerneuroscience. Wish we could have stayed but had to be home for the Stand Up For Science Event! @standupforscience.bsky.social
Reposted by Scheff Research Lab
The Gulf Coast Consortia invites you to register for their Feb. 21, #Pain2025 workshop featuring Rita Allen Scholars, Kara Marshall, Baylor College of Medicine, and Katelyn Sadler, Univ. of Texas, Dallas. The event will occur via Zoom webinar on Feb. 21, from 1-2 pm (CST).
February 10, 2025 at 2:58 PM
The Gulf Coast Consortia invites you to register for their Feb. 21, #Pain2025 workshop featuring Rita Allen Scholars, Kara Marshall, Baylor College of Medicine, and Katelyn Sadler, Univ. of Texas, Dallas. The event will occur via Zoom webinar on Feb. 21, from 1-2 pm (CST).
Reposted by Scheff Research Lab
Elegant paper from the Gereau lab examining intrinsic adaptive plasticity in mouse and human sensory neurons rupress.org/jgp/article/...
Intrinsic adaptive plasticity in mouse and human sensory neurons | Journal of General Physiology | Rockefeller University Press
In this study, McIlvried, Del Rosario, and colleagues show that mechanisms of adaptive plasticity are engaged in mouse and human sensory neurons after sust
rupress.org
December 17, 2024 at 5:44 PM
Elegant paper from the Gereau lab examining intrinsic adaptive plasticity in mouse and human sensory neurons rupress.org/jgp/article/...
📢New publication out: Sensory Neurotransmission and Pain in Solid Tumor Progression! This review article by first author @andremartel.bsky.social details recent work on the bidirectional relationship between sensory neurons and #cancer cells.
authors.elsevier.com/sd/article/S...
#neurobiology
authors.elsevier.com/sd/article/S...
#neurobiology
January 30, 2025 at 2:29 PM
📢New publication out: Sensory Neurotransmission and Pain in Solid Tumor Progression! This review article by first author @andremartel.bsky.social details recent work on the bidirectional relationship between sensory neurons and #cancer cells.
authors.elsevier.com/sd/article/S...
#neurobiology
authors.elsevier.com/sd/article/S...
#neurobiology
🎉Excited to share that our application, “Breast Cancer Control of Neural Invasion Modulates Immunosurveillance” has been funded by The Magee Women’s Cancer Research and Education Funding Committee. We are grateful for the support to explore this new direction!
#breastcancer #neuroscience #immunology
#breastcancer #neuroscience #immunology
January 3, 2025 at 12:41 PM
🎉Excited to share that our application, “Breast Cancer Control of Neural Invasion Modulates Immunosurveillance” has been funded by The Magee Women’s Cancer Research and Education Funding Committee. We are grateful for the support to explore this new direction!
#breastcancer #neuroscience #immunology
#breastcancer #neuroscience #immunology
Reposted by Scheff Research Lab
What is the best time of the month to treat breast cancer? #Nature
"Breast Cancer: Menstrual cycle may affect chemotherapy sensitivity"
Open Access
www.nature.com/articles/s41...
"Breast Cancer: Menstrual cycle may affect chemotherapy sensitivity"
Open Access
www.nature.com/articles/s41...
December 5, 2024 at 11:06 AM
What is the best time of the month to treat breast cancer? #Nature
"Breast Cancer: Menstrual cycle may affect chemotherapy sensitivity"
Open Access
www.nature.com/articles/s41...
"Breast Cancer: Menstrual cycle may affect chemotherapy sensitivity"
Open Access
www.nature.com/articles/s41...
📢Check out our new publication, Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma, out now in the Journal for ImmunoTherapy of Cancer! This article presents urgent work with implications for improving ICI therapy responses. jitc.bmj.com/content/12/1...
November 21, 2024 at 6:33 PM
📢Check out our new publication, Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma, out now in the Journal for ImmunoTherapy of Cancer! This article presents urgent work with implications for improving ICI therapy responses. jitc.bmj.com/content/12/1...
Reposted by Scheff Research Lab
The application deadline is on December 6th: meetings.cshl.edu/courses.aspx...
Whether you're a neuroscientist or a cancer biologist, this is the training you’ve been waiting for!
#cancerneuroscience
Whether you're a neuroscientist or a cancer biologist, this is the training you’ve been waiting for!
#cancerneuroscience
Methods in Cancer Neuroscience
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
November 13, 2024 at 10:58 PM
The application deadline is on December 6th: meetings.cshl.edu/courses.aspx...
Whether you're a neuroscientist or a cancer biologist, this is the training you’ve been waiting for!
#cancerneuroscience
Whether you're a neuroscientist or a cancer biologist, this is the training you’ve been waiting for!
#cancerneuroscience
Reposted by Scheff Research Lab
Don't miss out on the chance to register for Neural Influence on Cancer and snag a $200 discount if you sign up by December 3, 11:59 pm MST. Secure your spot now at hubs.la/Q02YNzHH0. #KSNeuroCancer25 #CancerNeuroscience
November 20, 2024 at 4:05 PM
Don't miss out on the chance to register for Neural Influence on Cancer and snag a $200 discount if you sign up by December 3, 11:59 pm MST. Secure your spot now at hubs.la/Q02YNzHH0. #KSNeuroCancer25 #CancerNeuroscience