Sander Houten
@sanderhouten.bsky.social
Scientist working on inborn errors of metabolism. Associate Professor at the Icahn School of Medicine at Mount Sinai. New York.
Pinned
Sander Houten
@sanderhouten.bsky.social
· Feb 24
I haven't been posting often on Bluesky. And the skies are not so blue these days in the US science world. One thing we can certainly do is to show that our work is important and contributes to progress in science. Two studies that my lab contributed to were posted on bioRxiv over the last 2 weeks.
Reposted by Sander Houten
Loss of MFE-2 impairs microglial lipid homeostasis and drives neuroinflammation in Alzheimer’s pathogenesis @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Loss of MFE-2 impairs microglial lipid homeostasis and drives neuroinflammation in Alzheimer’s pathogenesis - Nature Aging
Gao, Bai and colleagues identify peroxisomal MFE-2 as an essential regulator for microglial homeostasis in Alzheimer’s disease, showing that maintaining MFE-2 reduces neuroinflammation and slows Alzhe...
www.nature.com
October 29, 2025 at 6:59 PM
Loss of MFE-2 impairs microglial lipid homeostasis and drives neuroinflammation in Alzheimer’s pathogenesis @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Sander Houten
Hi friends and colleagues. In these dark times for scientists and experts, I am trying to make a difference by running the NYC marathon for the propionic acidemia foundation. Please click on the link if you’re interested. fundraisers.nyrr.org/sander-houten
Thanks for considering.
Thanks for considering.
August 30, 2025 at 4:27 PM
Hi friends and colleagues. In these dark times for scientists and experts, I am trying to make a difference by running the NYC marathon for the propionic acidemia foundation. Please click on the link if you’re interested. fundraisers.nyrr.org/sander-houten
Thanks for considering.
Thanks for considering.
Reposted by Sander Houten
When 2 life science discoveries converge: solving a ~3 decade mystery of extraordinary longevity and healthspan + an essential cell danger sensor
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
A Long-Awaited Longevity Mystery Solved
Spotlighting an essential human biologic pathway targeted by drugs in clinical trials
erictopol.substack.com
October 12, 2025 at 12:32 PM
When 2 life science discoveries converge: solving a ~3 decade mystery of extraordinary longevity and healthspan + an essential cell danger sensor
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
Reposted by Sander Houten
Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...
www.science.org
October 2, 2025 at 11:27 PM
Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...
Reposted by Sander Houten
Are #InheritedMetabolicDisorders more common than we think?
New review argues genotype-first data reveal IMDs in many “healthy” individuals — challenging assumptions about prevalence, penetrance & screening.
What should this mean for clinical care?
#ThinkMetabolic #Genomics
New review argues genotype-first data reveal IMDs in many “healthy” individuals — challenging assumptions about prevalence, penetrance & screening.
What should this mean for clinical care?
#ThinkMetabolic #Genomics
October 1, 2025 at 10:18 AM
Are #InheritedMetabolicDisorders more common than we think?
New review argues genotype-first data reveal IMDs in many “healthy” individuals — challenging assumptions about prevalence, penetrance & screening.
What should this mean for clinical care?
#ThinkMetabolic #Genomics
New review argues genotype-first data reveal IMDs in many “healthy” individuals — challenging assumptions about prevalence, penetrance & screening.
What should this mean for clinical care?
#ThinkMetabolic #Genomics
Reposted by Sander Houten
Reposted by Sander Houten
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target | Nature
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target - Nature
The enzyme ABHD18 is shown to have a key role in cardiolipin metabolism in mitochondria, offering a potential route for a small-molecule treatment of the rare genetic disease Barth syndrome.
www.nature.com
September 7, 2025 at 11:03 AM
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target | Nature
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hi friends and colleagues. In these dark times for scientists and experts, I am trying to make a difference by running the NYC marathon for the propionic acidemia foundation. Please click on the link if you’re interested. fundraisers.nyrr.org/sander-houten
Thanks for considering.
Thanks for considering.
August 30, 2025 at 4:27 PM
Hi friends and colleagues. In these dark times for scientists and experts, I am trying to make a difference by running the NYC marathon for the propionic acidemia foundation. Please click on the link if you’re interested. fundraisers.nyrr.org/sander-houten
Thanks for considering.
Thanks for considering.
Reposted by Sander Houten
Belangrijk initiatief!! www.volkskrant.nl/politiek/d66...
D66 en GL-PvdA dienen wetsvoorstel in om Nederlanders het recht op een dubbele nationaliteit te geven
Nederlanders moeten het recht krijgen om hun Nederlanderschap te behouden als zij vrijwillig een andere nationaliteit aannemen. D66 en GroenLinks-PvdA dienen woensdag een initiatiefwet in om dat recht...
www.volkskrant.nl
August 20, 2025 at 4:32 AM
Belangrijk initiatief!! www.volkskrant.nl/politiek/d66...
Reposted by Sander Houten
My lab at ETHZ has an opening for a postdoc in spatial risk stratification: www.jobs.ethz.ch/job/view/JOP.... Please apply if suitable, or RT, thanks!
Postdoctoral Researcher - Spatial Omics for Colorectal Cancer Risk Stratification
www.jobs.ethz.ch
August 19, 2025 at 3:28 PM
My lab at ETHZ has an opening for a postdoc in spatial risk stratification: www.jobs.ethz.ch/job/view/JOP.... Please apply if suitable, or RT, thanks!
Apparently I have been checking my Google Scholar profile too often 🙃 Anybody any idea why google think I am sending automated queries?
August 19, 2025 at 3:30 PM
Apparently I have been checking my Google Scholar profile too often 🙃 Anybody any idea why google think I am sending automated queries?
Reposted by Sander Houten
#Throwback 🧪
COMMENT | A safety guide for transgenic Cre drivers in metabolism
C Horvath, C Wolfrum & P Pelczar
COMMENT | A safety guide for transgenic Cre drivers in metabolism
C Horvath, C Wolfrum & P Pelczar
A safety guide for transgenic Cre drivers in metabolism - Nature Metabolism
Despite the high utility and widespread use of Cre driver lines, lack of Cre specificity, Cre-induced toxicity or poor experimental design can affect experimental results and conclusions. Such pitfalls must be considered before embarking on any Cre-based studies in metabolic research.
bit.ly
August 18, 2025 at 3:25 PM
#Throwback 🧪
COMMENT | A safety guide for transgenic Cre drivers in metabolism
C Horvath, C Wolfrum & P Pelczar
COMMENT | A safety guide for transgenic Cre drivers in metabolism
C Horvath, C Wolfrum & P Pelczar
Interesting, but puzzling www.nature.com/articles/s41...
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism - Nature Chemical Biology
Glutarate rewires cell metabolism through conjugation to proteins or fatty acids, but how glutarylation is regulated is unclear. ABHD11 was identified as a lipoyl-deglutarylase to maintain the TCA cyc...
www.nature.com
July 22, 2025 at 10:12 PM
Interesting, but puzzling www.nature.com/articles/s41...
Reposted by Sander Houten
🧪 Can cholic acid be personalised for bile acid synthesis defects?
New open-label study explores long-term CA therapy in AMACR & 3β-HSD deficiency.
👶 Good response in children
🧓 More side effects, less benefit in adults
⚠️ Toxic intermediates persist
Read: doi.org/10.1002/jimd...
New open-label study explores long-term CA therapy in AMACR & 3β-HSD deficiency.
👶 Good response in children
🧓 More side effects, less benefit in adults
⚠️ Toxic intermediates persist
Read: doi.org/10.1002/jimd...
July 18, 2025 at 8:17 PM
🧪 Can cholic acid be personalised for bile acid synthesis defects?
New open-label study explores long-term CA therapy in AMACR & 3β-HSD deficiency.
👶 Good response in children
🧓 More side effects, less benefit in adults
⚠️ Toxic intermediates persist
Read: doi.org/10.1002/jimd...
New open-label study explores long-term CA therapy in AMACR & 3β-HSD deficiency.
👶 Good response in children
🧓 More side effects, less benefit in adults
⚠️ Toxic intermediates persist
Read: doi.org/10.1002/jimd...
Reposted by Sander Houten
Excited to share Chapter #1 of our LPCAT3 journey in adipose biology and membrane dynamics—born of a rewarding, years-long, espresso-fueled partnership with Prof. Yuta Shimanaka @shimachu64.bsky.social. www.nature.com/articles/s42...
Dietary control of peripheral adipose storage capacity through membrane lipid remodelling - Nature Metabolism
Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.
www.nature.com
July 2, 2025 at 9:22 AM
Excited to share Chapter #1 of our LPCAT3 journey in adipose biology and membrane dynamics—born of a rewarding, years-long, espresso-fueled partnership with Prof. Yuta Shimanaka @shimachu64.bsky.social. www.nature.com/articles/s42...
Reposted by Sander Houten
Reposted by Sander Houten
🎉 5 years of the JIMD Podcast! 🎉
Since June 2020:
🎙️ 133 interviews
📚 51+ hours of IMD content
🌍 Listeners in 100+ countries
Plus spin-offs:
Shortcast
Metabolic Mysteries
Footprints of IMD
Research Round-Up
Thanks to every guest & listener. Here’s to 5 more years!
🔗 soundcloud.com/user-109006120
Since June 2020:
🎙️ 133 interviews
📚 51+ hours of IMD content
🌍 Listeners in 100+ countries
Plus spin-offs:
Shortcast
Metabolic Mysteries
Footprints of IMD
Research Round-Up
Thanks to every guest & listener. Here’s to 5 more years!
🔗 soundcloud.com/user-109006120
June 24, 2025 at 3:44 PM
🎉 5 years of the JIMD Podcast! 🎉
Since June 2020:
🎙️ 133 interviews
📚 51+ hours of IMD content
🌍 Listeners in 100+ countries
Plus spin-offs:
Shortcast
Metabolic Mysteries
Footprints of IMD
Research Round-Up
Thanks to every guest & listener. Here’s to 5 more years!
🔗 soundcloud.com/user-109006120
Since June 2020:
🎙️ 133 interviews
📚 51+ hours of IMD content
🌍 Listeners in 100+ countries
Plus spin-offs:
Shortcast
Metabolic Mysteries
Footprints of IMD
Research Round-Up
Thanks to every guest & listener. Here’s to 5 more years!
🔗 soundcloud.com/user-109006120
Reposted by Sander Houten
La ECI1 mitocondrial y la ECI2 peroxisómica tras llevar a cabo la isomerización del Δ³‑cis‑enoil‑CoA:
June 13, 2025 at 10:40 AM
La ECI1 mitocondrial y la ECI2 peroxisómica tras llevar a cabo la isomerización del Δ³‑cis‑enoil‑CoA:
Reposted by Sander Houten
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
May 13, 2025 at 7:55 PM
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
Reposted by Sander Houten
RESEARCH| J Okada, A Landgraf, S Sidoli, J Pessin et. al. (@einsteinmededu.bsky.social)
Single-cell analyses demonstrate the spatiotemporal plasticity of hepatocyte gluconeogenesis
Single-cell analyses demonstrate the spatiotemporal plasticity of hepatocyte gluconeogenesis
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states - Nature Metabolism
The authors use single-cell analyses to demonstrate the spatiotemporal plasticity of hepatocyte gluconeogenesis, highlighting the complexity of hepatic glucose homeostasis across states of feeding, fasting and starvation.
bit.ly
June 3, 2025 at 3:33 PM
RESEARCH| J Okada, A Landgraf, S Sidoli, J Pessin et. al. (@einsteinmededu.bsky.social)
Single-cell analyses demonstrate the spatiotemporal plasticity of hepatocyte gluconeogenesis
Single-cell analyses demonstrate the spatiotemporal plasticity of hepatocyte gluconeogenesis
Reposted by Sander Houten
🔬 A novel multiomic network strategy to uncover disease-modifying mechanisms in inborn errors of metabolism!
🧬 Glucocorticoid & complement signaling revealed as modifiers of FAO disorders and Gaucher disease.
📄 Read in @JIMDjournal: doi.org/10.1002/jimd...
#RareDisease #SystemsBiology #IEM
🧬 Glucocorticoid & complement signaling revealed as modifiers of FAO disorders and Gaucher disease.
📄 Read in @JIMDjournal: doi.org/10.1002/jimd...
#RareDisease #SystemsBiology #IEM
June 1, 2025 at 6:48 PM
🔬 A novel multiomic network strategy to uncover disease-modifying mechanisms in inborn errors of metabolism!
🧬 Glucocorticoid & complement signaling revealed as modifiers of FAO disorders and Gaucher disease.
📄 Read in @JIMDjournal: doi.org/10.1002/jimd...
#RareDisease #SystemsBiology #IEM
🧬 Glucocorticoid & complement signaling revealed as modifiers of FAO disorders and Gaucher disease.
📄 Read in @JIMDjournal: doi.org/10.1002/jimd...
#RareDisease #SystemsBiology #IEM
Reposted by Sander Houten
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mitochondrial presequences harbor variable strengths to maintain organellar function
Hundreds of mitochondrial-destined proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphipathic helices, presequences lack ...
www.biorxiv.org
May 29, 2025 at 9:18 PM
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sander Houten
Fascinating new publication in JIMD Reports, detailing the use of modified cornstarch and pancreatic enzyme to achieve metabolic stability in an infant affected by a previously unreported, severe OXCT1 gene deletion leading to SCOT deficiency.
Read it here 👉 doi.org/10.1002/jmd2...
Read it here 👉 doi.org/10.1002/jmd2...
May 23, 2025 at 5:33 PM
Fascinating new publication in JIMD Reports, detailing the use of modified cornstarch and pancreatic enzyme to achieve metabolic stability in an infant affected by a previously unreported, severe OXCT1 gene deletion leading to SCOT deficiency.
Read it here 👉 doi.org/10.1002/jmd2...
Read it here 👉 doi.org/10.1002/jmd2...
Reposted by Sander Houten
Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is:
“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
In our Special Issue: Cell Biology of Mitochondria we interview Guest Editor Heidi McBride @mitodynamics.bsky.social Heidi discusses her career path, the past, present & future of #mitochondria research & her role as guest editor at JCS.
journals.biologists.com/jcs/article/...
#JCSMitoSI
journals.biologists.com/jcs/article/...
#JCSMitoSI
May 22, 2025 at 2:28 PM
Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is:
“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
Reposted by Sander Houten
Non-profit journals are on the critical list.
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is:
“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
In our Special Issue: Cell Biology of Mitochondria we interview Guest Editor Heidi McBride @mitodynamics.bsky.social Heidi discusses her career path, the past, present & future of #mitochondria research & her role as guest editor at JCS.
journals.biologists.com/jcs/article/...
#JCSMitoSI
journals.biologists.com/jcs/article/...
#JCSMitoSI
May 23, 2025 at 11:54 AM
Non-profit journals are on the critical list.
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..