Sabina Leanti La Rosa
@sabinallarosa.bsky.social
Associate Professor of Microbiology @UniNMBU, Norway. Fond of carb degradation by gut #microbiomes, #multiomics, #CAZymes,#prebiotics. Editorial Board Member @CommsBio. Italian 🇮🇹 via 🇺🇸 to 🇳🇴
Reposted by Sabina Leanti La Rosa
“Bin Chicken” is now published in Nature Methods! It substantially improves genome recovery through rational coassembly 🧬🖥️. Applied to public 🌍 metagenomes, we recovered 24,000 novel species 🦠, including 6 new phyla.
doi.org/10.1038/s415...
@benjwoodcroft.bsky.social @rhysnewell.bsky.social
🧵1/6
doi.org/10.1038/s415...
@benjwoodcroft.bsky.social @rhysnewell.bsky.social
🧵1/6
November 13, 2025 at 10:09 AM
“Bin Chicken” is now published in Nature Methods! It substantially improves genome recovery through rational coassembly 🧬🖥️. Applied to public 🌍 metagenomes, we recovered 24,000 novel species 🦠, including 6 new phyla.
doi.org/10.1038/s415...
@benjwoodcroft.bsky.social @rhysnewell.bsky.social
🧵1/6
doi.org/10.1038/s415...
@benjwoodcroft.bsky.social @rhysnewell.bsky.social
🧵1/6
Reposted by Sabina Leanti La Rosa
Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
Resistance to last-resort antibiotics in enterococci
Abstract. The genus Enterococcus comprises a diverse group of species, many of which are commensal members of the gut microbiota of humans and animals. The
academic.oup.com
November 8, 2025 at 5:41 PM
Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
Reposted by Sabina Leanti La Rosa
#NewResearch
Single-particle genomics uncovers abundant non-canonical marine viruses from nanolitre volumes
@rstepanauskas.bsky.social & co
#microsky
www.nature.com/articles/s41...
Single-particle genomics uncovers abundant non-canonical marine viruses from nanolitre volumes
@rstepanauskas.bsky.social & co
#microsky
www.nature.com/articles/s41...
Single-particle genomics uncovers abundant non-canonical marine viruses from nanolitre volumes - Nature Microbiology
Environmental micro-compartment genomics provides efficient and high-throughput single-particle DNA sequencing that captures overlooked members of microbial communities.
www.nature.com
November 7, 2025 at 11:19 AM
#NewResearch
Single-particle genomics uncovers abundant non-canonical marine viruses from nanolitre volumes
@rstepanauskas.bsky.social & co
#microsky
www.nature.com/articles/s41...
Single-particle genomics uncovers abundant non-canonical marine viruses from nanolitre volumes
@rstepanauskas.bsky.social & co
#microsky
www.nature.com/articles/s41...
Reposted by Sabina Leanti La Rosa
🧬 🦠 🏙️
Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host?
Excited to share our new paper: www.biorxiv.org/content/10.1...
Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host?
Excited to share our new paper: www.biorxiv.org/content/10.1...
November 5, 2025 at 2:04 AM
🧬 🦠 🏙️
Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host?
Excited to share our new paper: www.biorxiv.org/content/10.1...
Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host?
Excited to share our new paper: www.biorxiv.org/content/10.1...
Reposted by Sabina Leanti La Rosa
Ocean-M: an integrated global-scale multi-omics database for marine microbial diversity, function and ecological interactions academic.oup.com/nar/advance-... #jcampubs 🌊
Ocean-M: an integrated global-scale multi-omics database for marine microbial diversity, function and ecological interactions
Abstract. Multi-omics analyses have significantly advanced the understanding of complex marine microbial communities and their interactions. Despite notabl
academic.oup.com
November 1, 2025 at 7:35 AM
Ocean-M: an integrated global-scale multi-omics database for marine microbial diversity, function and ecological interactions academic.oup.com/nar/advance-... #jcampubs 🌊
Reposted by Sabina Leanti La Rosa
We are very happy to share a new preprint 🎉
Congratulations to everyone involved!
@carolinedricot.bsky.social, @denisemselegato.bsky.social, @sarahlebeer.bsky.social and co.
www.biorxiv.org/content/10.1...
Congratulations to everyone involved!
@carolinedricot.bsky.social, @denisemselegato.bsky.social, @sarahlebeer.bsky.social and co.
www.biorxiv.org/content/10.1...
Vitamin B2 Production by Vaginal Lactobacilli Promotes Symbiosis
The human vaginal microbiome, particularly with lactobacilli as the main inhabitants, plays a key role in maintaining women's health. While lactic acid-mediated pathogen exclusion is well known, broad...
www.biorxiv.org
October 29, 2025 at 4:13 PM
We are very happy to share a new preprint 🎉
Congratulations to everyone involved!
@carolinedricot.bsky.social, @denisemselegato.bsky.social, @sarahlebeer.bsky.social and co.
www.biorxiv.org/content/10.1...
Congratulations to everyone involved!
@carolinedricot.bsky.social, @denisemselegato.bsky.social, @sarahlebeer.bsky.social and co.
www.biorxiv.org/content/10.1...
Reposted by Sabina Leanti La Rosa
Want to know how diverse soil really is?
Our ultra deep sequencing is now published in GigaScience: academic.oup.com/gigascience/...
Soil is wild! Thanks for leading the study @canerbagci.bsky.social
#secmet #soil #metagenomics #bacterialdiversity
Our ultra deep sequencing is now published in GigaScience: academic.oup.com/gigascience/...
Soil is wild! Thanks for leading the study @canerbagci.bsky.social
#secmet #soil #metagenomics #bacterialdiversity
Ultra-deep long-read metagenomics captures diverse taxonomic and biosynthetic potential of soil microbes
AbstractBackground. Soil ecosystems have long been recognised as hotspots of microbial diversity, but most estimates of their microbial and functional comp
academic.oup.com
October 28, 2025 at 3:08 PM
Want to know how diverse soil really is?
Our ultra deep sequencing is now published in GigaScience: academic.oup.com/gigascience/...
Soil is wild! Thanks for leading the study @canerbagci.bsky.social
#secmet #soil #metagenomics #bacterialdiversity
Our ultra deep sequencing is now published in GigaScience: academic.oup.com/gigascience/...
Soil is wild! Thanks for leading the study @canerbagci.bsky.social
#secmet #soil #metagenomics #bacterialdiversity
Reposted by Sabina Leanti La Rosa
We selected the laziest mouse at each round to inoculate the next batch of germfree mice: over rounds of selection and passaging, behavior shifted without changes to the mouse genome: rdcu.be/eM3rO
🦠🧫
🦠🧫
Selection and transmission of the gut microbiome alone can shift mammalian behavior
Nature Communications - Here, the authors present evidence that the gut microbiome alone, without changes in the host genome, can shape how animals respond to selection, identifying a bacterium and...
rdcu.be
October 28, 2025 at 7:51 AM
We selected the laziest mouse at each round to inoculate the next batch of germfree mice: over rounds of selection and passaging, behavior shifted without changes to the mouse genome: rdcu.be/eM3rO
🦠🧫
🦠🧫
Reposted by Sabina Leanti La Rosa
The #TMHMS25 has just wrapped up!
It’s been four amazing days of stimulating discussions and sharing our science in a wonderfully relaxed and supportive atmosphere.
There was a truly genuine sense of community among all participants, which I really cherish.
Cheers, to the next one! 🌊
It’s been four amazing days of stimulating discussions and sharing our science in a wonderfully relaxed and supportive atmosphere.
There was a truly genuine sense of community among all participants, which I really cherish.
Cheers, to the next one! 🌊
October 27, 2025 at 2:10 PM
The #TMHMS25 has just wrapped up!
It’s been four amazing days of stimulating discussions and sharing our science in a wonderfully relaxed and supportive atmosphere.
There was a truly genuine sense of community among all participants, which I really cherish.
Cheers, to the next one! 🌊
It’s been four amazing days of stimulating discussions and sharing our science in a wonderfully relaxed and supportive atmosphere.
There was a truly genuine sense of community among all participants, which I really cherish.
Cheers, to the next one! 🌊
Reposted by Sabina Leanti La Rosa
Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs.
@quadraminstitute.bsky.social
rdcu.be/eMmcT
@quadraminstitute.bsky.social
rdcu.be/eMmcT
Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs
Nature Communications - Here, the authors systematically map metaproteomic responses of ex vivo human gut microbiota to common therapeutics, identifying several drug classes inducing strong...
rdcu.be
October 24, 2025 at 4:20 PM
Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs.
@quadraminstitute.bsky.social
rdcu.be/eMmcT
@quadraminstitute.bsky.social
rdcu.be/eMmcT
Reposted by Sabina Leanti La Rosa
Reposted by Sabina Leanti La Rosa
Live from the Italian Dolce Vita at the Trends in Marine Host-Microbe Symbiosis Conference hosted by the illustrious @memartino.bsky.social and @raquelpeixoto.bsky.social with the best scholars/friends @momedinamunoz.bsky.social @sabinallarosa.bsky.social @jcamthrash.bsky.social et al.
October 24, 2025 at 10:37 PM
Live from the Italian Dolce Vita at the Trends in Marine Host-Microbe Symbiosis Conference hosted by the illustrious @memartino.bsky.social and @raquelpeixoto.bsky.social with the best scholars/friends @momedinamunoz.bsky.social @sabinallarosa.bsky.social @jcamthrash.bsky.social et al.
Reposted by Sabina Leanti La Rosa
NEW publication from our lab: One of the first methodologies (FUGAsseM) for gene function prediction from microbial community multi-omics data!
www.nature.com/articles/s41...
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1/8
www.nature.com/articles/s41...
🧵⬇️
1/8
Predicting functions of uncharacterized gene products from microbial communities - Nature Biotechnology
FUGAsseM predicts protein function in microbiomes using coexpression patterns from metatranscriptomes and diverse community-wide data.
www.nature.com
October 23, 2025 at 6:53 PM
NEW publication from our lab: One of the first methodologies (FUGAsseM) for gene function prediction from microbial community multi-omics data!
www.nature.com/articles/s41...
🧵⬇️
1/8
www.nature.com/articles/s41...
🧵⬇️
1/8
Reposted by Sabina Leanti La Rosa
Check out this preprint of the first article for my PhD thesis!
www.biorxiv.org/content/10.1...
We've leveraged methods developed for multi-omics to investigate a holo-omic system (🐷🦠), and predicted host-microbiome interactions between important features for observed cross-omic data patterns 🔍📊
www.biorxiv.org/content/10.1...
We've leveraged methods developed for multi-omics to investigate a holo-omic system (🐷🦠), and predicted host-microbiome interactions between important features for observed cross-omic data patterns 🔍📊
October 23, 2025 at 2:16 PM
Check out this preprint of the first article for my PhD thesis!
www.biorxiv.org/content/10.1...
We've leveraged methods developed for multi-omics to investigate a holo-omic system (🐷🦠), and predicted host-microbiome interactions between important features for observed cross-omic data patterns 🔍📊
www.biorxiv.org/content/10.1...
We've leveraged methods developed for multi-omics to investigate a holo-omic system (🐷🦠), and predicted host-microbiome interactions between important features for observed cross-omic data patterns 🔍📊
Reposted by Sabina Leanti La Rosa
Tree evolution is surprisingly quirky! 🌳 Trees are likely ancestral in many plant groups, often re-evolve on islands, and Arabidopsis can be made tree-like by tweaking a few genes. We revisited what genes really make a tree a tree using comparative genomics. @trhvidsten.bsky.social #trees #evolution
An updated perspective: what genes make a tree a tree? #plantscience
An updated perspective: what genes make a tree a tree?
We learn early on how to tell trees apart from other plants. However, it has proved hard to distinguish trees from other plants at the genetic level, and it is believed that there are no unique ‘tree genes’. With the rapid increase in available tree genomes, we can perform new comparative and evolutionary analyses of plant life histories and growth forms. Here we provide a fresh perspective on the genetic foundation for woodiness and perenniality in angiosperms by analyzing selection pressures and gene family evolution in the rosids using genomic data. We examine genes distinguishing trees from herbs and discuss future directions for uncovering the genetic factors that define a tree in this new era of tree genomics.
dlvr.it
October 24, 2025 at 7:09 AM
Tree evolution is surprisingly quirky! 🌳 Trees are likely ancestral in many plant groups, often re-evolve on islands, and Arabidopsis can be made tree-like by tweaking a few genes. We revisited what genes really make a tree a tree using comparative genomics. @trhvidsten.bsky.social #trees #evolution
Reposted by Sabina Leanti La Rosa
Why can our farts ignite? Time to find out (and quite a bit more) in our new paper in Nature Microbiology led by the amazing Dr Cait Welsh. Integrating atomic-to-ecosystem level insights. www.nature.com/articles/s41...
A widespread hydrogenase supports fermentative growth of gut bacteria in healthy people - Nature Microbiology
A previously uncharacterized microbial enzyme is responsible for the production of molecular hydrogen in the gut, which drives the growth of other bacteria and has implications for human health.
www.nature.com
October 24, 2025 at 10:24 AM
Why can our farts ignite? Time to find out (and quite a bit more) in our new paper in Nature Microbiology led by the amazing Dr Cait Welsh. Integrating atomic-to-ecosystem level insights. www.nature.com/articles/s41...
Reposted by Sabina Leanti La Rosa
OUT NOW - Long-read metagenomics method for strain tracking after FMT #microsky www.nature.com/articles/s41...
Long-read metagenomics for strain tracking after faecal microbiota transplant - Nature Microbiology
A long-read metagenomics method empowers faecal microbiota transplantation studies by precisely tracking bacteria from donors to recipients, distinguishing co-existing strains and revealing genomic ch...
www.nature.com
October 23, 2025 at 12:59 PM
OUT NOW - Long-read metagenomics method for strain tracking after FMT #microsky www.nature.com/articles/s41...
Reposted by Sabina Leanti La Rosa
Our latest Research Briefing is out, on using metaproteomics and stable isotope labelling to uncover rare species involved in carbon turnover www.nature.com/articles/s41...
Identifying rare and active species that drive carbon turnover in complex microbiotas - Nature Microbiology
By combining bioorthogonal non-canonical amino acid tagging, metaproteomics and stable isotope probing, we identified a rare and uncharacterized bacterium with a glycine-mediated metabolism for syntro...
www.nature.com
October 23, 2025 at 1:02 PM
Our latest Research Briefing is out, on using metaproteomics and stable isotope labelling to uncover rare species involved in carbon turnover www.nature.com/articles/s41...
Reposted by Sabina Leanti La Rosa
OUT NOW Activity-targeted metaproteomics uncovers rare syntrophic bacteria central to anaerobic community metabolism by @ryanziels.bsky.social www.nature.com/articles/s41...
Activity-targeted metaproteomics uncovers rare syntrophic bacteria central to anaerobic community metabolism - Nature Microbiology
An approach combining BONCAT, stable isotope probing and metaproteomics showcases the hidden metabolic interconnectivity of microorganisms within an anaerobic digestion community.
www.nature.com
October 21, 2025 at 1:38 PM
OUT NOW Activity-targeted metaproteomics uncovers rare syntrophic bacteria central to anaerobic community metabolism by @ryanziels.bsky.social www.nature.com/articles/s41...
Reposted by Sabina Leanti La Rosa
Finally got my tool published!
CompareM2 is a genomes-to-report pipeline for comparing microbial genomes | Bioinformatics | Oxford Academic https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btaf517/8254279?rss=1&login=true
CompareM2 is a genomes-to-report pipeline for comparing microbial genomes
AbstractSummary. Here, we present CompareM2, a genomes-to-report pipeline for comparative analysis of bacterial and archaeal genomes derived from isolates
dx.doi.org
October 9, 2025 at 6:22 PM
Finally got my tool published!
Reposted by Sabina Leanti La Rosa
Like here our criteria was that >70% of genes in a an enriched pathway had to be present, including the "key" genes required for proper functioning. One enriched gene says little, but we try to make it as unlikely that we're focusing on statistical accidents.
academic.oup.com/ismej/articl...
academic.oup.com/ismej/articl...
A genomic view of the microbiome of coral reef demosponges
AbstractSponges underpin the productivity of coral reefs, yet few of their microbial symbionts have been functionally characterised. Here we present an ana
academic.oup.com
October 7, 2025 at 3:55 PM
Like here our criteria was that >70% of genes in a an enriched pathway had to be present, including the "key" genes required for proper functioning. One enriched gene says little, but we try to make it as unlikely that we're focusing on statistical accidents.
academic.oup.com/ismej/articl...
academic.oup.com/ismej/articl...
Reposted by Sabina Leanti La Rosa
Lecturership in Microbiolgy @uniofgalway.bsky.social. Application submission deadline coming soon - October 9th. universityvacancies.com/university-g...
Lecturer in Microbiology, Permanent, 1 FTE, Contract Type B, 011296 | University Vacancies Ireland
universityvacancies.com
October 3, 2025 at 1:38 PM
Lecturership in Microbiolgy @uniofgalway.bsky.social. Application submission deadline coming soon - October 9th. universityvacancies.com/university-g...
Reposted by Sabina Leanti La Rosa
Reposted by Sabina Leanti La Rosa
The main work from my time in Aachen is now out 🎉 if you have wanted to make a SynCom that captures the functional-landscape of microbiota, MiMiC2 makes that possible based on metagenomic data! 1/7 doi.org/10.1093/isme...
Function-Based Selection of Synthetic Communities Enables Mechanistic Microbiome Studies
Abstract. Understanding the complex interactions between microbes and their environment requires robust model systems such as synthetic communities (SynCom
doi.org
September 24, 2025 at 1:22 PM
The main work from my time in Aachen is now out 🎉 if you have wanted to make a SynCom that captures the functional-landscape of microbiota, MiMiC2 makes that possible based on metagenomic data! 1/7 doi.org/10.1093/isme...
Reposted by Sabina Leanti La Rosa
Polysaccharide-degrading archaea dominate acidic hot springs: genomic and cultivation insights into a novel Thermoproteota lineage
Candidatus Marsarchaeota is now isolated and renamed as Tardisphaerales (phylum Thermoproteota) 🤓
@asm.org
journals.asm.org/doi/10.1128/...
Candidatus Marsarchaeota is now isolated and renamed as Tardisphaerales (phylum Thermoproteota) 🤓
@asm.org
journals.asm.org/doi/10.1128/...
September 28, 2025 at 8:31 AM
Polysaccharide-degrading archaea dominate acidic hot springs: genomic and cultivation insights into a novel Thermoproteota lineage
Candidatus Marsarchaeota is now isolated and renamed as Tardisphaerales (phylum Thermoproteota) 🤓
@asm.org
journals.asm.org/doi/10.1128/...
Candidatus Marsarchaeota is now isolated and renamed as Tardisphaerales (phylum Thermoproteota) 🤓
@asm.org
journals.asm.org/doi/10.1128/...