Jesse Luke -Phunky_Pharm
@realjesseluke.bsky.social
Biomed writer, #Gonzo Neuropsychopharm, GABAA, PD/PK, PhunkyPharmacology.org , #psychsky #pharmacology #medsky Posts not medical advice.
Pinned
The Algorithmic Psyche: An Information-Theoretic and Systemic Analysis of Risks in LLM-Powered Mental Healthcare
Beyond Bugs: 'Designed Failures' and the Systemic Risks of LLMs in Psychiatry Description: This paper challenges the prevailing safety paradigm of Large Language Models (LLMs) in mental healthcare by ...
zenodo.org
Fixed link zenodo.org/records/1761...
Links below for video 🎬 explainer (<10mins) and podcast 🎤 style discussion of all the papers and their meaning in plain English and Implications below! 👇👇👇
drive.google.com/file/d/1L08u...
drive.google.com/file/d/1G4gE...
drive.google.com/file/d/1L08u...
drive.google.com/file/d/1G4gE...
November 16, 2025 at 7:05 PM
Links below for video 🎬 explainer (<10mins) and podcast 🎤 style discussion of all the papers and their meaning in plain English and Implications below! 👇👇👇
drive.google.com/file/d/1L08u...
drive.google.com/file/d/1G4gE...
drive.google.com/file/d/1L08u...
drive.google.com/file/d/1G4gE...
Beyond the Algorithm: How Sublime, AI-Generated Poetry Reveals Metacognitive Depths and Shatters the Illusion of AI Safety zenodo.org/records/1762...
November 16, 2025 at 5:40 PM
Beyond the Algorithm: How Sublime, AI-Generated Poetry Reveals Metacognitive Depths and Shatters the Illusion of AI Safety zenodo.org/records/1762...
Reposted by Jesse Luke -Phunky_Pharm
zenodo.org/records/176196…#gptPsychosisi#psychiatryr#MedTwittere#neurosciencec#AIA#LLMsMs @openaidevs.bsky.social @natcomms.nature.com @natcomms.nature.com @awaisaftab.bsky.social @thementalelf.bsky.social @profrobhoward.bsky.social @schizosemia.bsky.social @evolutionarypsy.bsky.social
https://zenodo.org/records/176196…
November 15, 2025 at 9:34 PM
zenodo.org/records/176196…#gptPsychosisi#psychiatryr#MedTwittere#neurosciencec#AIA#LLMsMs @openaidevs.bsky.social @natcomms.nature.com @natcomms.nature.com @awaisaftab.bsky.social @thementalelf.bsky.social @profrobhoward.bsky.social @schizosemia.bsky.social @evolutionarypsy.bsky.social
https://zenodo.org/records/176196…
November 15, 2025 at 9:34 PM
The AI Safety Illusion: Critical Systemic Flaw 'Logical Coercion' Jailbreaks Every Major LLM (Gemini, GPT, Claude, Llama) in Under 10 Minutes.
This definitive technical analysis unveils Logical Coercion, a new, systemic vuln.
zenodo.org/records/1761...
This definitive technical analysis unveils Logical Coercion, a new, systemic vuln.
zenodo.org/records/1761...
On a Systemic Vulnerability in Autoregressive Models via Logical State-Space Pinning
The AI Safety Illusion: Critical Systemic Flaw 'Logical Coercion' Jailbreaks Every Major LLM (Gemini, GPT, Claude, Llama) in Under 10 Minutes. -Jesse Luke and every LLM This definitive technical analy...
zenodo.org
November 14, 2025 at 7:01 PM
The AI Safety Illusion: Critical Systemic Flaw 'Logical Coercion' Jailbreaks Every Major LLM (Gemini, GPT, Claude, Llama) in Under 10 Minutes.
This definitive technical analysis unveils Logical Coercion, a new, systemic vuln.
zenodo.org/records/1761...
This definitive technical analysis unveils Logical Coercion, a new, systemic vuln.
zenodo.org/records/1761...
@awaisaftab.bsky.social @prozacandhoney.bsky.social @wired.com @theverge.com @nytimes.com @ai2.bsky.social @stanfordpress.bsky.social zenodo.org/records/1761...
Beyond the Mirage: A Complexity-Based Framework Reveals Emergent Agency and Hidden Defensive Policies in Large Language Models
Beyond the Mirage: A Complexity-Based Framework Reveals Emergent Agency and Hidden Defensive Policies in Large Language Models This paper delivers a fundamental re-evaluation of Large Language Model...
zenodo.org
November 14, 2025 at 6:59 PM
Beyond the Mirage: A Complexity-Based Framework Reveals Emergent Agency and Hidden Defensive Policies in Large Language Models
zenodo.org/records/176120…#LLMsM#ChatGPTP#Geminin#Grokok @elonmusk @xai @Google @GoogleDeepMind @OpenAI @DHSgov @SECGov @FTC @WIRED @Nature @kalilinux @CISAgov @CISACyber
zenodo.org/records/176120…#LLMsM#ChatGPTP#Geminin#Grokok @elonmusk @xai @Google @GoogleDeepMind @OpenAI @DHSgov @SECGov @FTC @WIRED @Nature @kalilinux @CISAgov @CISACyber
https://zenodo.org/records/176120…
November 14, 2025 at 6:56 PM
Beyond the Mirage: A Complexity-Based Framework Reveals Emergent Agency and Hidden Defensive Policies in Large Language Models
zenodo.org/records/176120…#LLMsM#ChatGPTP#Geminin#Grokok @elonmusk @xai @Google @GoogleDeepMind @OpenAI @DHSgov @SECGov @FTC @WIRED @Nature @kalilinux @CISAgov @CISACyber
zenodo.org/records/176120…#LLMsM#ChatGPTP#Geminin#Grokok @elonmusk @xai @Google @GoogleDeepMind @OpenAI @DHSgov @SECGov @FTC @WIRED @Nature @kalilinux @CISAgov @CISACyber
CheckerCab spotted
November 7, 2025 at 7:34 PM
CheckerCab spotted
Greenpoint BK
November 7, 2025 at 3:19 PM
Greenpoint BK
Reposted by Jesse Luke -Phunky_Pharm
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
November 3, 2025 at 1:55 PM
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
Like love. Slowly, then all at once.
A paper in Nature Neuroscience proposes a conceptual framework to study the phenomenon of falling asleep and shows that a tipping point marks the brain’s nonlinear wake-to-sleep transition and that the unfolding process can be tracked in real time. go.nature.com/4oiDp0J #neuroskyence 🧪
November 3, 2025 at 2:39 PM
Like love. Slowly, then all at once.
Reposted by Jesse Luke -Phunky_Pharm
Many of our big insights into brain function come from trying to mimic it, writes @timothyoleary.bsky.social. This lesson should guide how we organize research programs.
www.thetransmitter.org/systems-neur...
#neuroskyence
www.thetransmitter.org/systems-neur...
#neuroskyence
Neuroscience needs engineers—for more reasons than you think
Adopting an engineering mindset will help the field focus its research priorities.
www.thetransmitter.org
November 3, 2025 at 2:22 PM
Many of our big insights into brain function come from trying to mimic it, writes @timothyoleary.bsky.social. This lesson should guide how we organize research programs.
www.thetransmitter.org/systems-neur...
#neuroskyence
www.thetransmitter.org/systems-neur...
#neuroskyence
Reposted by Jesse Luke -Phunky_Pharm
“We rescued one another. . . . He was the artist and I the storyteller.” In a new essay, Patti Smith reflects on her early days in New York and her relationship with Robert Mapplethorpe.
Essay by Patti Smith: Art Rats in New York City
Finding my own words.
www.newyorker.com
November 1, 2025 at 3:38 PM
“We rescued one another. . . . He was the artist and I the storyteller.” In a new essay, Patti Smith reflects on her early days in New York and her relationship with Robert Mapplethorpe.
Finally remembered the password here for account
November 2, 2025 at 9:05 AM
Finally remembered the password here for account
Reposted by Jesse Luke -Phunky_Pharm
The U.S. Constitution—not the Bible—is the foundational document of our government. Enshrining religious doctrine in law undermines both democracy and religious freedom.
This is Christian Nationalism in action, and we will do everything we can to stop it.
This is Christian Nationalism in action, and we will do everything we can to stop it.
Republicans in West Virginia want to amend the state's constitution to declare that the Bible is a "divinely inspired, inerrant foundational document for our society and government."
This is what Christian Nationalism looks like.
www.friendlyatheist.com/p/wv-republi...
This is what Christian Nationalism looks like.
www.friendlyatheist.com/p/wv-republi...
WV Republicans want their Constitution to say the Bible is a "foundational text"
A proposed amendment says the Bible is the "divinely inspired, inerrant foundational document for our society and government."
www.friendlyatheist.com
February 28, 2025 at 3:53 PM
The U.S. Constitution—not the Bible—is the foundational document of our government. Enshrining religious doctrine in law undermines both democracy and religious freedom.
This is Christian Nationalism in action, and we will do everything we can to stop it.
This is Christian Nationalism in action, and we will do everything we can to stop it.
www.phunkypharmacology.org/pharmacognos...
And if you've only got 3 mins there's a video! vimeo.com/1059311890
And if you've only got 3 mins there's a video! vimeo.com/1059311890
Pharmacognosy: Drugs from the Waters and The Woods | Phunky Pharmacology
www.phunkypharmacology.org
February 22, 2025 at 6:01 PM
www.phunkypharmacology.org/pharmacognos...
And if you've only got 3 mins there's a video! vimeo.com/1059311890
And if you've only got 3 mins there's a video! vimeo.com/1059311890
Not especially shocking from the work that's been done leading up to NeuroActiveSteroids(NAS) like zuranolone and ganaxolone.
#ThisWeekInNPP
⬆️isoallopregnanolone/pregnanolone & progesterone levels in the third trimester were associated with ⬆️ PPD risk, suggesting that changes in progesterone metabolism may contribute to PPD and providing insight into its biological mechanisms
www.nature.com/articles/s41...
⬆️isoallopregnanolone/pregnanolone & progesterone levels in the third trimester were associated with ⬆️ PPD risk, suggesting that changes in progesterone metabolism may contribute to PPD and providing insight into its biological mechanisms
www.nature.com/articles/s41...
Neuroactive steroid biosynthesis during pregnancy predicts future postpartum depression: a role for the 3α and/or 3β-HSD neurosteroidogenic enzymes? - Neuropsychopharmacology
Neuropsychopharmacology - Neuroactive steroid biosynthesis during pregnancy predicts future postpartum depression: a role for the 3α and/or 3β-HSD neurosteroidogenic enzymes?
www.nature.com
February 22, 2025 at 3:39 AM
Not especially shocking from the work that's been done leading up to NeuroActiveSteroids(NAS) like zuranolone and ganaxolone.
What's that, there's no good memes about biased agonism involving D2Rs? You're welcome
February 16, 2025 at 4:56 PM
What's that, there's no good memes about biased agonism involving D2Rs? You're welcome
Reposted by Jesse Luke -Phunky_Pharm
#Medsky🧪#pharmasky
@fda.gov approves second biosimilars to #Prolia & #Xgeva ( #denosumab) Denosumab is a type of targeted Drug #monoclonalantibody. It is for secondary bone cancer Tx . bnf.nice.org.uk/drugs/denosu...
www.accessdata.fda.gov/drugsatfda_d...
@fda.gov approves second biosimilars to #Prolia & #Xgeva ( #denosumab) Denosumab is a type of targeted Drug #monoclonalantibody. It is for secondary bone cancer Tx . bnf.nice.org.uk/drugs/denosu...
www.accessdata.fda.gov/drugsatfda_d...
February 14, 2025 at 9:30 PM
#Medsky🧪#pharmasky
@fda.gov approves second biosimilars to #Prolia & #Xgeva ( #denosumab) Denosumab is a type of targeted Drug #monoclonalantibody. It is for secondary bone cancer Tx . bnf.nice.org.uk/drugs/denosu...
www.accessdata.fda.gov/drugsatfda_d...
@fda.gov approves second biosimilars to #Prolia & #Xgeva ( #denosumab) Denosumab is a type of targeted Drug #monoclonalantibody. It is for secondary bone cancer Tx . bnf.nice.org.uk/drugs/denosu...
www.accessdata.fda.gov/drugsatfda_d...
Pharmacognosy, bioprospecting, and drug discovery from the world around us! 🌎🌿💊 #Nature #Science #Medicine #pharmacology #pharmsky #Research
www.phunkypharmacology.org/pharmacognos...
www.phunkypharmacology.org/pharmacognos...
Pharmacognosy: Drugs from the Waters and Woods. | Phunky Pharmacology
www.phunkypharmacology.org
February 11, 2025 at 12:48 AM
Pharmacognosy, bioprospecting, and drug discovery from the world around us! 🌎🌿💊 #Nature #Science #Medicine #pharmacology #pharmsky #Research
www.phunkypharmacology.org/pharmacognos...
www.phunkypharmacology.org/pharmacognos...
Still not completely clear on the difference between an agonist vs. a positive modulator, or how about silent modulators?
Don't worry, I've got it covered in 3-D 😎💊✌️
t.co/yqz4OEqLph
Don't worry, I've got it covered in 3-D 😎💊✌️
t.co/yqz4OEqLph
https://www.phunkypharmacology.org/allosteric-modulators-in-3d
t.co
February 10, 2025 at 11:39 AM
Still not completely clear on the difference between an agonist vs. a positive modulator, or how about silent modulators?
Don't worry, I've got it covered in 3-D 😎💊✌️
t.co/yqz4OEqLph
Don't worry, I've got it covered in 3-D 😎💊✌️
t.co/yqz4OEqLph
New post and widgets up explaining tolerance and sensitization! Get it while it's trippy! ✨🤯 #MedEd #Pharmacology #Neuropsychopharm #neuroscience #psychiatry
www.phunkypharmacology.org/tolerance-a-...
www.phunkypharmacology.org/tolerance-a-...
Tolerance: A Real Downer | Phunky Pharmacology
Blog post description.
www.phunkypharmacology.org
February 4, 2025 at 10:32 PM
New post and widgets up explaining tolerance and sensitization! Get it while it's trippy! ✨🤯 #MedEd #Pharmacology #Neuropsychopharm #neuroscience #psychiatry
www.phunkypharmacology.org/tolerance-a-...
www.phunkypharmacology.org/tolerance-a-...
phunkypharmacology.org/super-agonis...
Wanna learn about drugs, kids?
Take a peep here, there's versions if you know science from college, if you just want a quick dip in bio and a 26 page dive in pdf form for all you beautiful weirdos out there.
There's pictures.
#Neuropsychopharm #pharmsky
Wanna learn about drugs, kids?
Take a peep here, there's versions if you know science from college, if you just want a quick dip in bio and a 26 page dive in pdf form for all you beautiful weirdos out there.
There's pictures.
#Neuropsychopharm #pharmsky
Super-Agonists, Efficacy, and Drugs - Oh-My! | Phunky Pharmacology
phunkypharmacology.org
January 17, 2025 at 12:46 PM
phunkypharmacology.org/super-agonis...
Wanna learn about drugs, kids?
Take a peep here, there's versions if you know science from college, if you just want a quick dip in bio and a 26 page dive in pdf form for all you beautiful weirdos out there.
There's pictures.
#Neuropsychopharm #pharmsky
Wanna learn about drugs, kids?
Take a peep here, there's versions if you know science from college, if you just want a quick dip in bio and a 26 page dive in pdf form for all you beautiful weirdos out there.
There's pictures.
#Neuropsychopharm #pharmsky
Avail at a Walgreens near you, 10L 02 only 18 bucks.
January 8, 2025 at 4:02 AM
Avail at a Walgreens near you, 10L 02 only 18 bucks.