Raluca Groza
@ralucag.bsky.social
Postdoc in the Kleele lab, ETH Zürich | HFSP and EMBO fellow | Previously PhD in the Ewers lab, FU Berlin | mitochondria, neurons, super-resolution microscopy
Reposted by Raluca Groza
Reposted by Raluca Groza
A team involving @uclqsion.bsky.social scientists has, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease.
Parkinson’s breakthrough could unlock treatments for devastating disease
Scientists have developed a groundbreaking new technique to visualise the brain clusters that may trigger Parkinson’s
www.the-independent.com
November 9, 2025 at 11:08 AM
A team involving @uclqsion.bsky.social scientists has, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease.
Reposted by Raluca Groza
Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com!
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression
Nature Methods - Spotiflow uses deep learning for subpixel-accurate spot detection in diverse 2D and 3D images. The improved accuracy offered by Spotiflow enables improved biological insights in...
rdcu.be
June 6, 2025 at 6:58 PM
Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com!
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Reposted by Raluca Groza
What is RNA velocity in situ? ChatGPT kept getting it wrong...
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
RNA velocity in situ infers gene expression dynamics using spatial transcriptomics data
YouTube video by Prof. Jean Fan
youtu.be
October 13, 2025 at 7:09 PM
What is RNA velocity in situ? ChatGPT kept getting it wrong...
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
Reposted by Raluca Groza
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
October 9, 2025 at 9:01 AM
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
Reposted by Raluca Groza
#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added!
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
November 12, 2024 at 6:35 PM
#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added!
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
Reposted by Raluca Groza
Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5
Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics
Nature Chemical Biology - Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly...
rdcu.be
October 2, 2025 at 2:10 PM
Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5
Reposted by Raluca Groza
🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉
🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
October 1, 2025 at 4:11 AM
🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉
🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
check out Nadja’s beautiful work on cytokinesis, many congratulations 👏👏
Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF
September 30, 2025 at 7:57 AM
check out Nadja’s beautiful work on cytokinesis, many congratulations 👏👏
Reposted by Raluca Groza
Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF
September 28, 2025 at 2:15 PM
Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF
Reposted by Raluca Groza
SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission, say Rachel Shannon, William Trimble and colleagues @sickkidsto.bsky.social @utoronto.ca: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #Mitochondria #septins
#Cytoskeleton #Biochemistry #Mitochondria #septins
September 15, 2025 at 6:15 PM
SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission, say Rachel Shannon, William Trimble and colleagues @sickkidsto.bsky.social @utoronto.ca: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #Mitochondria #septins
#Cytoskeleton #Biochemistry #Mitochondria #septins
Reposted by Raluca Groza
Join us at the LS2 Annual Meeting 2026 in Zürich!
🚨 Save the date!
LS2 Annual Meeting 2026:
📍 Zürich | 🗓 Feb 11–12 (YSS: Feb 10)
Join us for keynotes by Sarah-Maria Fendt, Heidi McBride & Jennifer Lippincott-Schwartz + 11 symposia, poster session, & networking.
🔗 Abstracts due Nov 9
🔗 Register by Jan 11, 2026: annual-meeting.ls2.ch/2026/registr...
LS2 Annual Meeting 2026:
📍 Zürich | 🗓 Feb 11–12 (YSS: Feb 10)
Join us for keynotes by Sarah-Maria Fendt, Heidi McBride & Jennifer Lippincott-Schwartz + 11 symposia, poster session, & networking.
🔗 Abstracts due Nov 9
🔗 Register by Jan 11, 2026: annual-meeting.ls2.ch/2026/registr...
September 1, 2025 at 7:11 PM
Join us at the LS2 Annual Meeting 2026 in Zürich!
many congratulations for such beautiful work André and co👏👏
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 6:16 AM
many congratulations for such beautiful work André and co👏👏
Reposted by Raluca Groza
www.biorxiv.org/content/10.1...
Excellent Jasper van den Ende in Esther's lab @esthernoltethoen.bsky.social. Using Marvin's @marvintanenbaum.bsky.social SUNtag system to monitor EV cargo access to cytoplasm allows real time quantification of the process. #EV #extracellular vesicles
Excellent Jasper van den Ende in Esther's lab @esthernoltethoen.bsky.social. Using Marvin's @marvintanenbaum.bsky.social SUNtag system to monitor EV cargo access to cytoplasm allows real time quantification of the process. #EV #extracellular vesicles
Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells
Cells communicate via extracellular vesicles (EVs) containing functional RNAs, proteins and lipids. Knowledge on the fate of internalized EVs, especially their capacity to fuse with target cell membra...
www.biorxiv.org
August 2, 2025 at 8:34 AM
www.biorxiv.org/content/10.1...
Excellent Jasper van den Ende in Esther's lab @esthernoltethoen.bsky.social. Using Marvin's @marvintanenbaum.bsky.social SUNtag system to monitor EV cargo access to cytoplasm allows real time quantification of the process. #EV #extracellular vesicles
Excellent Jasper van den Ende in Esther's lab @esthernoltethoen.bsky.social. Using Marvin's @marvintanenbaum.bsky.social SUNtag system to monitor EV cargo access to cytoplasm allows real time quantification of the process. #EV #extracellular vesicles
Reposted by Raluca Groza
🍹@mariamls.bsky.social et al. identify ER–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact sites dictates #ferroptosis sensitivity in #BreastCancer. @agostinislab.bsky.social
bit.ly/4l93AUW
bit.ly/4l93AUW
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
bit.ly
August 2, 2025 at 7:04 PM
🍹@mariamls.bsky.social et al. identify ER–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact sites dictates #ferroptosis sensitivity in #BreastCancer. @agostinislab.bsky.social
bit.ly/4l93AUW
bit.ly/4l93AUW
Reposted by Raluca Groza
We demonstrated how to make and dissolve #RNA #condensates through strand displacement using synthetic genes - excited to see this new paper out in @narjournal.bsky.social Collab w/ the Andersen group @esandersen.bsky.social academic.oup.com/nar/article/...
Switchable RNA motifs for dynamic transcriptional control of RNA condensates
Abstract. RNA-driven phase separation is emerging as a promising approach for engineering biomolecular condensates with diverse functionalities. Condensate
academic.oup.com
June 26, 2025 at 2:53 PM
We demonstrated how to make and dissolve #RNA #condensates through strand displacement using synthetic genes - excited to see this new paper out in @narjournal.bsky.social Collab w/ the Andersen group @esandersen.bsky.social academic.oup.com/nar/article/...
Reposted by Raluca Groza
Die Kürzungen sind ein absoluter Skandal, die Wissenschaft ist eine der grossen Stärken Berlins. Wir sidn eine der Besten Unis Deutschlands mit vergleichsweise wenig Mitteln, diese noch zu kürzen ist Wahnsinn. Wie sollen wir kompetitiv bleiben? Eine Abwärtsspirale droht.
Die #FUBerlin finanziert sich v.a. durch Landes- und Drittmittel - viele davon sind langfristig gebunden:
Gehälter, Mieten, Forschung. Die Kürzung um 37 Mio. € trifft die Uni daher schwer. Kurzfristig sparen? Kaum möglich.
🔗: www.fu-berlin.de/sites/hausha... (1/5)
Gehälter, Mieten, Forschung. Die Kürzung um 37 Mio. € trifft die Uni daher schwer. Kurzfristig sparen? Kaum möglich.
🔗: www.fu-berlin.de/sites/hausha... (1/5)
June 23, 2025 at 7:57 AM
Die Kürzungen sind ein absoluter Skandal, die Wissenschaft ist eine der grossen Stärken Berlins. Wir sidn eine der Besten Unis Deutschlands mit vergleichsweise wenig Mitteln, diese noch zu kürzen ist Wahnsinn. Wie sollen wir kompetitiv bleiben? Eine Abwärtsspirale droht.
Reposted by Raluca Groza
Come all next week to the online seminar on "Imaging for Cell Biology" of the @dgz.bsky.social
Tuesday June 24th at 12:00 on zoom, info see below.
Tuesday June 24th at 12:00 on zoom, info see below.
June 18, 2025 at 11:59 AM
Come all next week to the online seminar on "Imaging for Cell Biology" of the @dgz.bsky.social
Tuesday June 24th at 12:00 on zoom, info see below.
Tuesday June 24th at 12:00 on zoom, info see below.
Reposted by Raluca Groza
Thank you @jcellsci.bsky.social, Sara Morais da Silva and Co for highlighting me as “cell scientists to watch”! It means a lot to me and I feel so honored as you guys are such a great community of amazing cell biologists! journals.biologists.com/jcs/article/...
Cell scientist to watch – Francesca Bottanelli
ABSTRACT. Francesca Bottanelli is an Assistant Professor in the Department of Biochemistry at Freie Universität Berlin (Germany). Francesca graduated in Plant Biotechnology from the University of Mila...
journals.biologists.com
May 28, 2025 at 7:26 AM
Thank you @jcellsci.bsky.social, Sara Morais da Silva and Co for highlighting me as “cell scientists to watch”! It means a lot to me and I feel so honored as you guys are such a great community of amazing cell biologists! journals.biologists.com/jcs/article/...
Reposted by Raluca Groza
Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell
great work by Martin Picard
www.scientificamerican.com/article/why-...
great work by Martin Picard
www.scientificamerican.com/article/why-...
The Hidden Social Lives of Mitochondria
When these energy-giving organelles thrive, so do we
www.scientificamerican.com
May 22, 2025 at 4:41 AM
Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell
great work by Martin Picard
www.scientificamerican.com/article/why-...
great work by Martin Picard
www.scientificamerican.com/article/why-...
Reposted by Raluca Groza
The 2025 version of Biomembrane Days is online for registration! Sign up now, it is going to be spectacular as always! Looking forward to an outstanding lineup of speakers both invited and selected. We look forward to having experts in the Cell Biology and Biophysics of membranes!
📢 Registration is open for the Biomembrane Days 2025!
🔗 biomembrane-days-2025.mpikg.mpg.de
A top-notch lineup of speakers, 120 posters, 200 scientists.
📜Submit an abstract by July 14
🏆3 Poster prizes
⚠️Limited spots-previous events were fully booked!
#BiomembraneDays2025 #Biophysics #CellMembranes
🔗 biomembrane-days-2025.mpikg.mpg.de
A top-notch lineup of speakers, 120 posters, 200 scientists.
📜Submit an abstract by July 14
🏆3 Poster prizes
⚠️Limited spots-previous events were fully booked!
#BiomembraneDays2025 #Biophysics #CellMembranes
May 9, 2025 at 10:28 AM
The 2025 version of Biomembrane Days is online for registration! Sign up now, it is going to be spectacular as always! Looking forward to an outstanding lineup of speakers both invited and selected. We look forward to having experts in the Cell Biology and Biophysics of membranes!
Reposted by Raluca Groza
Join us in Engelberg for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys. Great speaker line up and opportunities for short talks from early career scientists!
Submit your abstract until May 30st!
meetings.embo.org/event/25-mit...
Submit your abstract until May 30st!
meetings.embo.org/event/25-mit...
April 14, 2025 at 8:48 AM
Join us in Engelberg for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys. Great speaker line up and opportunities for short talks from early career scientists!
Submit your abstract until May 30st!
meetings.embo.org/event/25-mit...
Submit your abstract until May 30st!
meetings.embo.org/event/25-mit...
Reposted by Raluca Groza
☕Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with #Alzheimers. Studies of endolysosomes and proteostasis suggest a role for lysosomal quality control in Alzheimer’s disease pathology.
bit.ly/4lSORPV
bit.ly/4lSORPV
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease - Nature Cell Biology
Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...
bit.ly
April 27, 2025 at 7:11 AM
☕Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with #Alzheimers. Studies of endolysosomes and proteostasis suggest a role for lysosomal quality control in Alzheimer’s disease pathology.
bit.ly/4lSORPV
bit.ly/4lSORPV
Reposted by Raluca Groza
Check out also our post to see how the @mrcharwell.bsky.social contributed to the work and what we think it will me for #preclinical in vivo studies and better #TranslationalResearch outcomes www.har.mrc.ac.uk/news/new-fra...
April 25, 2025 at 10:35 AM
Check out also our post to see how the @mrcharwell.bsky.social contributed to the work and what we think it will me for #preclinical in vivo studies and better #TranslationalResearch outcomes www.har.mrc.ac.uk/news/new-fra...
Happy #FluorescenceFriday! Here are some (sm)FISHy iNeurons imaged on a spinning disk🐠 magenta: mitochondria, cyan: GAPDH mRNA, yellow: Map2
April 11, 2025 at 9:56 AM
Happy #FluorescenceFriday! Here are some (sm)FISHy iNeurons imaged on a spinning disk🐠 magenta: mitochondria, cyan: GAPDH mRNA, yellow: Map2