PyrexCorex
@pyrexcorex.bsky.social
Following advances in cellular, molecular & structural biology in a mercifully bot-free space.
Reposted by PyrexCorex
Here is a video that explains the chemistry behind our recent paper in Nature Nanotechnology
video
www.youtube.com/watch?v=WnZN...
publication
www.nature.com/articles/s41...
news & views (Ouldridge & Mukherjee - thanks !)
www.nature.com/articles/s41...
video
www.youtube.com/watch?v=WnZN...
publication
www.nature.com/articles/s41...
news & views (Ouldridge & Mukherjee - thanks !)
www.nature.com/articles/s41...
An information ratchet improves selectivity in molecular recognition… | Nature Nanotechnology
YouTube video by SanGiacomoSpazioArte
www.youtube.com
November 7, 2025 at 2:19 PM
Here is a video that explains the chemistry behind our recent paper in Nature Nanotechnology
video
www.youtube.com/watch?v=WnZN...
publication
www.nature.com/articles/s41...
news & views (Ouldridge & Mukherjee - thanks !)
www.nature.com/articles/s41...
video
www.youtube.com/watch?v=WnZN...
publication
www.nature.com/articles/s41...
news & views (Ouldridge & Mukherjee - thanks !)
www.nature.com/articles/s41...
Reposted by PyrexCorex
Great work from the lab of @jojdavies.bsky.social
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts
between individual motifs within cis-regulatory elements and reveal a unified model
of biophysically mediated enhan...
www.cell.com
November 17, 2025 at 6:55 AM
Great work from the lab of @jojdavies.bsky.social
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Reposted by PyrexCorex
A new approach to pandemic preparedness:
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
NIH Directors: The World Needs a New Pandemic Playbook
The old one failed to cope with Covid and may even have caused it.
www.city-journal.org
November 14, 2025 at 3:21 PM
A new approach to pandemic preparedness:
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
Reposted by PyrexCorex
I hope someone is making plans to rebuild all our national science institutions when this nightmare is finally over
November 16, 2025 at 2:40 PM
I hope someone is making plans to rebuild all our national science institutions when this nightmare is finally over
Reposted by PyrexCorex
Holy shit.
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 15, 2025 at 1:41 PM
Holy shit.
DNA ‘top strand’ degrading.
James Watson, co-discoverer of the double-helix shape of DNA, has died at age 97
Scientist James Watson, who shared a Nobel prize for helping discover the double-helix shape of the DNA molecule, has died. He was 97.
apnews.com
November 7, 2025 at 9:12 PM
DNA ‘top strand’ degrading.
Reposted by PyrexCorex
Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the USA is losing
go.nature.com/3WB8bFS
go.nature.com/3WB8bFS
Dismantling of US federal agencies will ‘destroy science’
From NASA to the National Institutes of Health, federal agencies conduct research that universities cannot. Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the country is losing.
go.nature.com
November 3, 2025 at 12:24 PM
Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the USA is losing
go.nature.com/3WB8bFS
go.nature.com/3WB8bFS
Reposted by PyrexCorex
When people learn with ChatGPT instead of following their own searches, they end up knowing less, caring less, and producing worse advice, even when the facts are the same.
Friction is an essential ingredient for learning! Convenience makes us shallow.
academic.oup.com/pnasnexus/ar...
Friction is an essential ingredient for learning! Convenience makes us shallow.
academic.oup.com/pnasnexus/ar...
Experimental evidence of the effects of large language models versus web search on depth of learning
Abstract. The effects of using large language models (LLMs) versus traditional web search on depth of learning are explored. A theory is proposed that when
academic.oup.com
October 28, 2025 at 3:14 PM
When people learn with ChatGPT instead of following their own searches, they end up knowing less, caring less, and producing worse advice, even when the facts are the same.
Friction is an essential ingredient for learning! Convenience makes us shallow.
academic.oup.com/pnasnexus/ar...
Friction is an essential ingredient for learning! Convenience makes us shallow.
academic.oup.com/pnasnexus/ar...
Reposted by PyrexCorex
A reminder that @science.org is a learned society journal, owned & published by the non-profit @aaas.org. It's green open access, with no article processing fees for authors - compatible with all major funder mandates. All subscription revenue is reinvested in science, not paid to shareholders.
🔭⚛️🧪
🔭⚛️🧪
October 17, 2025 at 11:27 AM
A reminder that @science.org is a learned society journal, owned & published by the non-profit @aaas.org. It's green open access, with no article processing fees for authors - compatible with all major funder mandates. All subscription revenue is reinvested in science, not paid to shareholders.
🔭⚛️🧪
🔭⚛️🧪
Reposted by PyrexCorex
The #MBioSys25 keynote lectures by Prof Caroline Dean (@johninnescentre.bsky.social) and Prof @elowitzlab.bsky.social (Caltech) are now online!
Watch (or revisit!) these two inspiring talks on gene regulation & functional genomics, available for free on our channel
www.youtube.com/@MolecularBi...
Watch (or revisit!) these two inspiring talks on gene regulation & functional genomics, available for free on our channel
www.youtube.com/@MolecularBi...
Molecular Biosystems Conference
Youtube Home Page for the Molecular Biosystems Conference (molbiosystems.com), the premier Latin American meeting on gene regulation.
www.youtube.com
October 27, 2025 at 6:35 PM
The #MBioSys25 keynote lectures by Prof Caroline Dean (@johninnescentre.bsky.social) and Prof @elowitzlab.bsky.social (Caltech) are now online!
Watch (or revisit!) these two inspiring talks on gene regulation & functional genomics, available for free on our channel
www.youtube.com/@MolecularBi...
Watch (or revisit!) these two inspiring talks on gene regulation & functional genomics, available for free on our channel
www.youtube.com/@MolecularBi...
Reposted by PyrexCorex
Holy shit, the NOAA hurricane hunters flying over Jamaica in Kermit are working without pay
God, I love scientists
#noaa #hurricane #melissa
God, I love scientists
#noaa #hurricane #melissa
October 27, 2025 at 12:09 PM
Holy shit, the NOAA hurricane hunters flying over Jamaica in Kermit are working without pay
God, I love scientists
#noaa #hurricane #melissa
God, I love scientists
#noaa #hurricane #melissa
Reposted by PyrexCorex
The body of evidence for persistent activation of the immune system in #LongCovid and related post-infective syndromes
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Immunological associations in post-infective fatigue syndromes including Long COVID—a systematic review and meta-analysis
These findings provide cautious support for persistent immune activation in PIFS,
but warrant further replication. Future studies should include better documentation
of acute infection and PIFS case c...
www.thelancet.com
October 28, 2025 at 7:46 AM
The body of evidence for persistent activation of the immune system in #LongCovid and related post-infective syndromes
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Reposted by PyrexCorex
Ascidians (Ciona intestinalis)🪸Our distant chordate cousins! 🌊 Simple sea squirts that reveal how vertebrate body plans evolved 🧬 A key model for notochord formation, neural induction, and cell lineage mapping 📸 Video by MBL Embryology 2019 #ModelMonday #DevBio #EvoDevo
October 28, 2025 at 12:46 AM
Ascidians (Ciona intestinalis)🪸Our distant chordate cousins! 🌊 Simple sea squirts that reveal how vertebrate body plans evolved 🧬 A key model for notochord formation, neural induction, and cell lineage mapping 📸 Video by MBL Embryology 2019 #ModelMonday #DevBio #EvoDevo
Reposted by PyrexCorex
Fan with a sign, “Best Editing of a Sound Recording.” The Academy Awards, 1974
October 28, 2025 at 8:39 AM
Fan with a sign, “Best Editing of a Sound Recording.” The Academy Awards, 1974
“AI researchers and public health advocates have long been wary of chatbots’ propensity to affirm users’ decisions or delusions regardless of whether they may be harmful, an issue known as sycophancy.”
More than a million people every week show suicidal intent when chatting with ChatGPT, OpenAI estimates
Finding is one of most direct statements from the tech company on how AI can exacerbate mental health issues
www.theguardian.com
October 28, 2025 at 9:17 AM
“AI researchers and public health advocates have long been wary of chatbots’ propensity to affirm users’ decisions or delusions regardless of whether they may be harmful, an issue known as sycophancy.”
Reposted by PyrexCorex
A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
October 27, 2025 at 9:43 PM
A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...
Reposted by PyrexCorex
R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).
October 26, 2025 at 6:54 PM
R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).
Reposted by PyrexCorex
'Here, we show that dysfunctional T cells in cancer did not harbor short telomeres indicative of replicative senescence but rather harbored damaged telomeres, which we hypothesized arose from oxidative stress.'
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer
The functional state of tumor-infiltrating lymphocytes is a critical determinant of
antitumor immunity and response to immunotherapy. Rivadeneira et al. demonstrate that
mitochondrial ROS accumulation...
www.cell.com
October 26, 2025 at 6:08 PM
'Here, we show that dysfunctional T cells in cancer did not harbor short telomeres indicative of replicative senescence but rather harbored damaged telomeres, which we hypothesized arose from oxidative stress.'
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Crimes of omission:
The Treasury Department instructed employees not to share to share photos of the demolition of parts of the White House’s East Wing
Exclusive | Treasury Tells Employees Not to Share Photos of White House Ballroom Construction
Images of the demolition of parts of the East Wing went viral on Monday, and Treasury’s headquarters next door to the White House has a front-row seat.
www.wsj.com
October 21, 2025 at 7:56 AM
Crimes of omission:
Reposted by PyrexCorex
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
October 10, 2025 at 4:47 PM
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
Reposted by PyrexCorex
Type IV secretion systems: from structures to mechanisms
Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems
www.embopress.org/doi/full/10....
Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems
www.embopress.org/doi/full/10....
October 9, 2025 at 10:44 AM
Type IV secretion systems: from structures to mechanisms
Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems
www.embopress.org/doi/full/10....
Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems
www.embopress.org/doi/full/10....
Reposted by PyrexCorex
NEW: Venezuelan opposition leader Maria Corina Machado awarded Nobel Peace Prize.
October 10, 2025 at 9:06 AM
NEW: Venezuelan opposition leader Maria Corina Machado awarded Nobel Peace Prize.
Reposted by PyrexCorex
This year’s #NobelPrize in Chemistry has gone to the architects of molecular “cages” that could be used for everything from carbon capture to drug delivery. https://scim.ag/4mTE1Z6
October 8, 2025 at 2:00 PM
This year’s #NobelPrize in Chemistry has gone to the architects of molecular “cages” that could be used for everything from carbon capture to drug delivery. https://scim.ag/4mTE1Z6