Philippe Domenech
@philippedomenech.bsky.social
Computational neuroscientist and Full Prof in Psychiatry @ University of Paris, Head of Neuromodulation Institute at GHU Paris, Psychiatry Neurosciences
Pinned
Excited to share our preprint: "Recasting adaptation as strategy inference". This work explores how humans spontaneously adapt to changes by inferring strategies, rather than relying on incremental learning.@philippedomenech.bsky.social @khamascience.bsky.social @computationalbrain.bsky.social 🧠🟦 🧠🤖
Recasting adaptation as strategy inference
Flexible adaptation to uncertain and changing environments requires dynamic adjustments in behavioral strategies. While classical learning theories emphasize incremental strengthening of local stimulu...
tinyurl.com
🚨 !!! New preprint !!! 🚨
Excited to share my student @samibeaumont’s latest work, where we demonstrate that inference over putative strategies is sufficient to fully accounts for human adaptation across diverse statistical contexts, when reinforcement learning cannot. 🧠🟦 🧠🤖
#Neuroscience #Preprint
Excited to share my student @samibeaumont’s latest work, where we demonstrate that inference over putative strategies is sufficient to fully accounts for human adaptation across diverse statistical contexts, when reinforcement learning cannot. 🧠🟦 🧠🤖
#Neuroscience #Preprint
Reposted by Philippe Domenech
Tuberculosis still kills around 1.3 million people every year.
It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it?
Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...
It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it?
Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...
June 9, 2025 at 6:17 AM
Tuberculosis still kills around 1.3 million people every year.
It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it?
Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...
It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it?
Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...
Reposted by Philippe Domenech
Les visas des chercheurs, des universitaires et des étudiants pour les Etats-Unis ne seront pas accordés à celles et ceux qui ont exprimé de l'hostilité au régime autoritaire de Trump. Ces refus de visa se feront par analyse des posts sur les réseaux sociaux.
www.nytimes.com/2025/06/18/u...
www.nytimes.com/2025/06/18/u...
U.S. to Review Social Media Posts of Student and Scholar Visa Applicants
www.nytimes.com
June 19, 2025 at 8:15 AM
Les visas des chercheurs, des universitaires et des étudiants pour les Etats-Unis ne seront pas accordés à celles et ceux qui ont exprimé de l'hostilité au régime autoritaire de Trump. Ces refus de visa se feront par analyse des posts sur les réseaux sociaux.
www.nytimes.com/2025/06/18/u...
www.nytimes.com/2025/06/18/u...
Reposted by Philippe Domenech
This is fantastic, causal work demonstrating the basal ganglia’s role in explore-exploit decision making www.nature.com/articles/s41...
Basal ganglia deep brain stimulation restores cognitive flexibility and exploration-exploitation balance disrupted by NMDA-R antagonism - Nature Communications
Deep brain stimulation of the basal ganglia restores cognitive flexibility and rebalances exploration disrupted by NMDA receptor antagonism in nonhuman primates, offering insights into the neural basi...
www.nature.com
June 6, 2025 at 12:43 PM
This is fantastic, causal work demonstrating the basal ganglia’s role in explore-exploit decision making www.nature.com/articles/s41...
Reposted by Philippe Domenech
Year ago, the prevailing attitude was that deep learning would significantly improve polygenic risk scores (or anything else, to be fair).
A rather important set of negative results indicating that isn't the case (though I imagine many will still try).
nature.com/articles/s41...
A rather important set of negative results indicating that isn't the case (though I imagine many will still try).
nature.com/articles/s41...
June 6, 2025 at 1:36 PM
Year ago, the prevailing attitude was that deep learning would significantly improve polygenic risk scores (or anything else, to be fair).
A rather important set of negative results indicating that isn't the case (though I imagine many will still try).
nature.com/articles/s41...
A rather important set of negative results indicating that isn't the case (though I imagine many will still try).
nature.com/articles/s41...
Reposted by Philippe Domenech
New in Nature MentalHealth! with Vrizzi, Najar, Lemogne, and @mael-lebreton.bsky.social
We tested whether behavioural and RL-based model parameters are test-retest reliable and predict mental health traits.
The result? Not really.
A cautionary tale for comp. psychiatry
doi.org/10.1038/s442...
We tested whether behavioural and RL-based model parameters are test-retest reliable and predict mental health traits.
The result? Not really.
A cautionary tale for comp. psychiatry
doi.org/10.1038/s442...
Behavioral, computational and self-reported measures of reward and punishment sensitivity as predictors of mental health characteristics - Nature Mental Health
Reinforcement learning task-based behavioral and computational measures displayed low test–retest reliability at the individual level. Also in contrast to self-assessed personality measures, behaviora...
doi.org
May 26, 2025 at 6:34 PM
New in Nature MentalHealth! with Vrizzi, Najar, Lemogne, and @mael-lebreton.bsky.social
We tested whether behavioural and RL-based model parameters are test-retest reliable and predict mental health traits.
The result? Not really.
A cautionary tale for comp. psychiatry
doi.org/10.1038/s442...
We tested whether behavioural and RL-based model parameters are test-retest reliable and predict mental health traits.
The result? Not really.
A cautionary tale for comp. psychiatry
doi.org/10.1038/s442...
Reposted by Philippe Domenech
New paper in Imaging Neuroscience by Britta U. Westner, Tim M. Tierney, et al:
Cycling on the Freeway: The perilous state of open-source neuroscience software
doi.org/10.1162/imag...
Cycling on the Freeway: The perilous state of open-source neuroscience software
doi.org/10.1162/imag...
May 7, 2025 at 7:25 AM
New paper in Imaging Neuroscience by Britta U. Westner, Tim M. Tierney, et al:
Cycling on the Freeway: The perilous state of open-source neuroscience software
doi.org/10.1162/imag...
Cycling on the Freeway: The perilous state of open-source neuroscience software
doi.org/10.1162/imag...
Reposted by Philippe Domenech
#OTD 1920 Edward Kaplan b (d 26 Sep 2006) Best known for 1958 "sleeper hit" paper describing what is now known as the Kaplan–Meier product-limit statistic for survival & lifetime data. Now one of the most cited statistics papers of modern times, it took >12 yrs to catch on. 🧵/6
May 11, 2025 at 10:26 AM
#OTD 1920 Edward Kaplan b (d 26 Sep 2006) Best known for 1958 "sleeper hit" paper describing what is now known as the Kaplan–Meier product-limit statistic for survival & lifetime data. Now one of the most cited statistics papers of modern times, it took >12 yrs to catch on. 🧵/6
Reposted by Philippe Domenech
$500 million is… less than 1.25% of the NIH’s 2024 budget.
When I say there is no capacity to absorb the shock, I mean it.
When I say there is no capacity to absorb the shock, I mean it.
We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers.
As well as ambitious proposals for R&I in the next EU budget.
We will also offer the best and brightest the right incentives to come to Europe ↓
As well as ambitious proposals for R&I in the next EU budget.
We will also offer the best and brightest the right incentives to come to Europe ↓
May 5, 2025 at 1:13 PM
$500 million is… less than 1.25% of the NIH’s 2024 budget.
When I say there is no capacity to absorb the shock, I mean it.
When I say there is no capacity to absorb the shock, I mean it.
Reposted by Philippe Domenech
Reposted by Philippe Domenech
Breaking News: A federal prosecutor interrogated the The New England Journal of Medicine — which is considered the world’s most prestigious medical journal — in what its editor described as a “vaguely threatening” letter.
‘Vaguely Threatening’: Federal Prosecutor Queries Leading Medical Journal
The New England Journal of Medicine received a letter suggesting that it was biased and compromised by external pressure. Other journals have also received the letter.
www.nytimes.com
April 25, 2025 at 9:17 PM
Breaking News: A federal prosecutor interrogated the The New England Journal of Medicine — which is considered the world’s most prestigious medical journal — in what its editor described as a “vaguely threatening” letter.
Reposted by Philippe Domenech
New study in JAMA. Modelling shows that at current state-level vaccination rates, measles may become endemic again in the USA. If rates continue to decline, ditto for rubella, poliomyelitis and diphtheria, leading to many preventable hospitalisations and deaths.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Modeling Reemergence of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination in the US
This study estimates the number of cases and complications in the US under scenarios of declining childhood vaccination for measles, rubella, poliomyelitis, and diphtheria.
jamanetwork.com
April 25, 2025 at 1:08 AM
New study in JAMA. Modelling shows that at current state-level vaccination rates, measles may become endemic again in the USA. If rates continue to decline, ditto for rubella, poliomyelitis and diphtheria, leading to many preventable hospitalisations and deaths.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Philippe Domenech
Thrilled to share our state-of-the-art method for in vivo cell-type classification and brain region localization, NEMO, which is now now a spotlight at @iclr-conf.bsky.social !
We use NEMO to characterize the electrophysiological diversity of cell-types across the entire mouse brain. 🐭 🧪 🧠
We use NEMO to characterize the electrophysiological diversity of cell-types across the entire mouse brain. 🐭 🧪 🧠
April 21, 2025 at 5:34 PM
Thrilled to share our state-of-the-art method for in vivo cell-type classification and brain region localization, NEMO, which is now now a spotlight at @iclr-conf.bsky.social !
We use NEMO to characterize the electrophysiological diversity of cell-types across the entire mouse brain. 🐭 🧪 🧠
We use NEMO to characterize the electrophysiological diversity of cell-types across the entire mouse brain. 🐭 🧪 🧠
Reposted by Philippe Domenech
Such a dangerous idea.
US attorney demands scientific journal explain how it ensures 'viewpoint diversity' www.nbcnews.com/science/scie...
Process of science – a human endeavour – full of biases. Key to recognize & counter.
But can’t let false balance & middle ground fallacies taint research.
US attorney demands scientific journal explain how it ensures 'viewpoint diversity' www.nbcnews.com/science/scie...
Process of science – a human endeavour – full of biases. Key to recognize & counter.
But can’t let false balance & middle ground fallacies taint research.
U.S. attorney demands scientific journal explain how it ensures 'viewpoint diversity'
The unusual letter caught the attention of First Amendment groups and some scientists, who raised concerns it was designed to suppress academic and scientific freedom.
www.nbcnews.com
April 20, 2025 at 3:14 PM
Such a dangerous idea.
US attorney demands scientific journal explain how it ensures 'viewpoint diversity' www.nbcnews.com/science/scie...
Process of science – a human endeavour – full of biases. Key to recognize & counter.
But can’t let false balance & middle ground fallacies taint research.
US attorney demands scientific journal explain how it ensures 'viewpoint diversity' www.nbcnews.com/science/scie...
Process of science – a human endeavour – full of biases. Key to recognize & counter.
But can’t let false balance & middle ground fallacies taint research.
Reposted by Philippe Domenech
Trump proposes massive NIH budget cut and reorganization
www.science.org/content/arti...
www.science.org/content/arti...
Trump proposes massive NIH budget cut and reorganization
Will Republican-led Congress support a 44% decrease for world’s largest medical research funder?
www.science.org
April 20, 2025 at 12:18 PM
Trump proposes massive NIH budget cut and reorganization
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Philippe Domenech
Reposted by Philippe Domenech
My first Saturday morning coffee on my deck this season 😎☕️
April 19, 2025 at 1:25 PM
My first Saturday morning coffee on my deck this season 😎☕️
Reposted by Philippe Domenech
Intéressante tribune sur l'illusion d'une université française attractive pour les chercheurs américains tentés par l'exil.
Ou de l'incapacité de regarder en face les conséquences de sa propre politique. Terrible absence de sens des responsabilités...
www.lemonde.fr/sciences/art...
Ou de l'incapacité de regarder en face les conséquences de sa propre politique. Terrible absence de sens des responsabilités...
www.lemonde.fr/sciences/art...
Accueillir les chercheurs américains en France , « une ambition louable, mais irréaliste »
TRIBUNE. L’universitaire Théo Besson rappelle, dans une tribune au « Monde », que le manque criant d’investissement ainsi que le niveau des salaires dans la recherche française interdisent de fantasme...
www.lemonde.fr
April 17, 2025 at 4:52 AM
Intéressante tribune sur l'illusion d'une université française attractive pour les chercheurs américains tentés par l'exil.
Ou de l'incapacité de regarder en face les conséquences de sa propre politique. Terrible absence de sens des responsabilités...
www.lemonde.fr/sciences/art...
Ou de l'incapacité de regarder en face les conséquences de sa propre politique. Terrible absence de sens des responsabilités...
www.lemonde.fr/sciences/art...
Reposted by Philippe Domenech
"The work we reviewed here supports an alternative view that the manifold and circuit approaches to cognition are inseparable." Can I get an amen? 😊
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A unifying perspective on neural manifolds and circuits for cognition - Nature Reviews Neuroscience
Neural manifolds can shed light on how heterogeneous neuronal population activity drives neural computations, but linking these insights to the underlying neuronal connectivity is challenging. Engel a...
www.nature.com
April 13, 2025 at 2:40 PM
"The work we reviewed here supports an alternative view that the manifold and circuit approaches to cognition are inseparable." Can I get an amen? 😊
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Philippe Domenech
"Quand Nicolas Demorand "révèle" qu'il souffre de trouble bipolaire de type 2, il ne dit rien de son affaire" 😡
En tant que psychiatre, je suis vraiment très en colère à la lecture de cet article de Charlie Hebdo de cette semaine.
Un post n'est pas suffisant pour l'exprimer⬇️
En tant que psychiatre, je suis vraiment très en colère à la lecture de cet article de Charlie Hebdo de cette semaine.
Un post n'est pas suffisant pour l'exprimer⬇️
April 12, 2025 at 8:30 PM
"Quand Nicolas Demorand "révèle" qu'il souffre de trouble bipolaire de type 2, il ne dit rien de son affaire" 😡
En tant que psychiatre, je suis vraiment très en colère à la lecture de cet article de Charlie Hebdo de cette semaine.
Un post n'est pas suffisant pour l'exprimer⬇️
En tant que psychiatre, je suis vraiment très en colère à la lecture de cet article de Charlie Hebdo de cette semaine.
Un post n'est pas suffisant pour l'exprimer⬇️
Reposted by Philippe Domenech
Tips for getting started with Bayesian statistics dx.plos.org/10.1371/jour...
Ten quick tips to get you started with Bayesian statistics
dx.plos.org
April 11, 2025 at 6:58 AM
Tips for getting started with Bayesian statistics dx.plos.org/10.1371/jour...
Reposted by Philippe Domenech
Registrations for the Symposium for the Biology of decision making (SBDM) in Lyon 2025 are finally open! sbdm2025.github.io Please spread the message!
April 8, 2025 at 6:18 PM
Registrations for the Symposium for the Biology of decision making (SBDM) in Lyon 2025 are finally open! sbdm2025.github.io Please spread the message!