Jack Kosmicki
@jakphd.bsky.social
Statistical geneticist @ Regeneron
tweets are my own | he/him/his
tweets are my own | he/him/his
Reposted by Jack Kosmicki
Our paper on imputation of ancient goat genomes is now available at GBE - congratulations to @jolijnerven.bsky.social #aDNA
Inferring Domestic Goat Demographic History Through Ancient Genome Imputation
Abstract. Goats were among the earliest managed animals, making them a natural model to explore the genetic consequences of domestication. However, a chall
academic.oup.com
November 10, 2025 at 6:49 PM
Our paper on imputation of ancient goat genomes is now available at GBE - congratulations to @jolijnerven.bsky.social #aDNA
🚨I did my PhD at Harvard and it fundamentally shaped who I am today. It's extremely sad to see their PhD admission cuts for the next 2 years.
- Science ⬇️75%
- Arts & Humanities ⬇️60%
- Social Sciences ⬇️50–70%
- History ⬇️60%
- Org. & Evo. Bio. ⬇️75%
- German ⬇️100%
www.thecrimson.com/article/2025...
- Science ⬇️75%
- Arts & Humanities ⬇️60%
- Social Sciences ⬇️50–70%
- History ⬇️60%
- Org. & Evo. Bio. ⬇️75%
- German ⬇️100%
www.thecrimson.com/article/2025...
Harvard FAS Cuts Ph.D. Seats By More Than Half Across Next Two Admissions Cycles | News | The Harvard Crimson
The Faculty of Arts and Sciences slashed the number of Ph.D. student admissions slots for the Science division by more than 75 percent and for the Arts & Humanities division by about 60 percent for th...
www.thecrimson.com
October 21, 2025 at 9:22 PM
🚨I did my PhD at Harvard and it fundamentally shaped who I am today. It's extremely sad to see their PhD admission cuts for the next 2 years.
- Science ⬇️75%
- Arts & Humanities ⬇️60%
- Social Sciences ⬇️50–70%
- History ⬇️60%
- Org. & Evo. Bio. ⬇️75%
- German ⬇️100%
www.thecrimson.com/article/2025...
- Science ⬇️75%
- Arts & Humanities ⬇️60%
- Social Sciences ⬇️50–70%
- History ⬇️60%
- Org. & Evo. Bio. ⬇️75%
- German ⬇️100%
www.thecrimson.com/article/2025...
Reposted by Jack Kosmicki
Just in time for #ASHG2025, a new FinnGen public data release is live!
This release features the first clinical laboratory value association results. Analyses cover 383 lab measurements (OMOPIDs) with data from ≥1,000 participants each.
Access the results here: www.finngen.fi/en/access_re...
This release features the first clinical laboratory value association results. Analyses cover 383 lab measurements (OMOPIDs) with data from ≥1,000 participants each.
Access the results here: www.finngen.fi/en/access_re...
October 14, 2025 at 2:17 PM
Just in time for #ASHG2025, a new FinnGen public data release is live!
This release features the first clinical laboratory value association results. Analyses cover 383 lab measurements (OMOPIDs) with data from ≥1,000 participants each.
Access the results here: www.finngen.fi/en/access_re...
This release features the first clinical laboratory value association results. Analyses cover 383 lab measurements (OMOPIDs) with data from ≥1,000 participants each.
Access the results here: www.finngen.fi/en/access_re...
Reposted by Jack Kosmicki
We’re getting ready for an exciting week at #ASHG2025 in Boston! Come meet the FinnGen team at booth 147 - we’ll be sharing updates and showcasing new public resources and tools. Plus, don’t miss the various presentations featuring FinnGen results across the program!
www.finngen.fi/en/meet-finn...
www.finngen.fi/en/meet-finn...
Meet FinnGen at the ASHG 2025! | FinnGen
Results based on the FinnGen data are presented in almost 40 talks or posters during the 2025 Annual Meeting of the American Society of Human Genetics (ASHG) in Boston, October 14-18. We also have a b...
www.finngen.fi
October 10, 2025 at 11:59 AM
We’re getting ready for an exciting week at #ASHG2025 in Boston! Come meet the FinnGen team at booth 147 - we’ll be sharing updates and showcasing new public resources and tools. Plus, don’t miss the various presentations featuring FinnGen results across the program!
www.finngen.fi/en/meet-finn...
www.finngen.fi/en/meet-finn...
Reposted by Jack Kosmicki
📃 We’re excited to share our latest work, now published in Nature Communications — a major update to the Genome Aggregation Database (gnomAD) that improves allele frequency resolution for two gnomAD-defined genetic ancestry groups using local ancestry inference (LAI).
Improved allele frequencies in gnomAD through local ancestry inference - Nature Communications
This study incorporates local ancestry into the Genome Aggregation Database (gnomAD) to improve allele frequency estimates for admixed populations, enhancing variant interpretation and enabling more accurate and equitable genomic research and clinical care.
www.nature.com
October 6, 2025 at 6:31 PM
📃 We’re excited to share our latest work, now published in Nature Communications — a major update to the Genome Aggregation Database (gnomAD) that improves allele frequency resolution for two gnomAD-defined genetic ancestry groups using local ancestry inference (LAI).
Reposted by Jack Kosmicki
Very happy to see our pre-print on ancient Irish goat genetics on bioRxiv #aDNA #spiergorm
I want to acknowledge this was only possible through the work of the late Dr. Judith Findlater, along with Prof. Eileen Murphy at @qubelfastofficial.bsky.social.
I want to acknowledge this was only possible through the work of the late Dr. Judith Findlater, along with Prof. Eileen Murphy at @qubelfastofficial.bsky.social.
Old Goats: 3,000 years of genetic connectivity of the domestic goat in Ireland
The domestic goat likely first arrived to the island of Ireland as part of the introduction of agriculture approximately 5,900 years ago, and remains a part of the island's biocultural heritage. Howev...
www.biorxiv.org
September 28, 2025 at 9:49 AM
Very happy to see our pre-print on ancient Irish goat genetics on bioRxiv #aDNA #spiergorm
I want to acknowledge this was only possible through the work of the late Dr. Judith Findlater, along with Prof. Eileen Murphy at @qubelfastofficial.bsky.social.
I want to acknowledge this was only possible through the work of the late Dr. Judith Findlater, along with Prof. Eileen Murphy at @qubelfastofficial.bsky.social.
Reposted by Jack Kosmicki
Interested in goats 🐐? Read our pre-print on ancient Irish goats and their connection to the Old Irish goat breed
Just look at this dashing individual, courtesy of the Old Irish Goat society
Just look at this dashing individual, courtesy of the Old Irish Goat society
September 29, 2025 at 8:47 AM
Interested in goats 🐐? Read our pre-print on ancient Irish goats and their connection to the Old Irish goat breed
Just look at this dashing individual, courtesy of the Old Irish Goat society
Just look at this dashing individual, courtesy of the Old Irish Goat society
Reposted by Jack Kosmicki
I'd like to announce the medRxiv preprint of our latest work:
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
www.medrxiv.org/content/10.1...
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
www.medrxiv.org/content/10.1...
September 22, 2025 at 11:44 PM
I'd like to announce the medRxiv preprint of our latest work:
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
www.medrxiv.org/content/10.1...
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
www.medrxiv.org/content/10.1...
Kristin Tsuo, @genetisaur.bsky.social, & Mark Daly just wrote the best proteomics paper I've read.
They convincingly show how smoking and alcohol (aka, the environment) dramatically influences proteomics data.
Some 🤯 results
1) proteomics predicts frequency (5a) & quanity (5b) of alcohol consumed
They convincingly show how smoking and alcohol (aka, the environment) dramatically influences proteomics data.
Some 🤯 results
1) proteomics predicts frequency (5a) & quanity (5b) of alcohol consumed
September 11, 2025 at 3:03 PM
Kristin Tsuo, @genetisaur.bsky.social, & Mark Daly just wrote the best proteomics paper I've read.
They convincingly show how smoking and alcohol (aka, the environment) dramatically influences proteomics data.
Some 🤯 results
1) proteomics predicts frequency (5a) & quanity (5b) of alcohol consumed
They convincingly show how smoking and alcohol (aka, the environment) dramatically influences proteomics data.
Some 🤯 results
1) proteomics predicts frequency (5a) & quanity (5b) of alcohol consumed
Reposted by Jack Kosmicki
I will be recruiting two PhDs for my ERC Project HERDPATH - let's discover out how livestock and pathogens evolved together using #aDNA. Projects will be animal or pathogen focused but will be in dialogue.
Details at my quaint website below. Deadline 3rd October.
kevingdaly.github.io
Details at my quaint website below. Deadline 3rd October.
kevingdaly.github.io
Ruminant Palaeogenomics - Kevin G. Daly: Ruminant Palaeogenomics
kevingdaly.github.io
September 5, 2025 at 10:57 AM
I will be recruiting two PhDs for my ERC Project HERDPATH - let's discover out how livestock and pathogens evolved together using #aDNA. Projects will be animal or pathogen focused but will be in dialogue.
Details at my quaint website below. Deadline 3rd October.
kevingdaly.github.io
Details at my quaint website below. Deadline 3rd October.
kevingdaly.github.io
Reposted by Jack Kosmicki
Second craziest thing you'll read today: from 2026 I will be leading an @erc.europa.eu Starter Grant project. HERDPATH will explore how livestock and their pathogens co-evolved during the last 10,000 years. PhD advertisements to come!
Press release below with one of the few good photos of me.
Press release below with one of the few good photos of me.
| UCD Research
www.ucd.ie
September 4, 2025 at 10:14 AM
Second craziest thing you'll read today: from 2026 I will be leading an @erc.europa.eu Starter Grant project. HERDPATH will explore how livestock and their pathogens co-evolved during the last 10,000 years. PhD advertisements to come!
Press release below with one of the few good photos of me.
Press release below with one of the few good photos of me.
😂 A WashU professor embezzled $412k and used the money to buy . . . *checks notes* . . . collectible trading cards
www.justice.gov/usao-edmo/pr...
www.justice.gov/usao-edmo/pr...
a close up of a pokemon card with foreign writing
ALT: a close up of a pokemon card with foreign writing
media.tenor.com
August 29, 2025 at 4:26 PM
😂 A WashU professor embezzled $412k and used the money to buy . . . *checks notes* . . . collectible trading cards
www.justice.gov/usao-edmo/pr...
www.justice.gov/usao-edmo/pr...
Reposted by Jack Kosmicki
Shameless promotion from #isba11 - I'll be hiring PhDs to start early 2026 (plus postdocs starting later), using #adna to study livestock and pathogen coevolution, particularly looking at inbreeding and immune gene evolution!
Contact me at kevin[at]palaeome.org, full ad to come. Please share!
Contact me at kevin[at]palaeome.org, full ad to come. Please share!
August 27, 2025 at 3:44 PM
Reposted by Jack Kosmicki
As for other fields, like human genetics and neuroimaging, it is clear that small, under-powered studies (often with uncorrected stats and no replication sample) JUST GENERATE NOISE.
July 27, 2025 at 9:11 AM
As for other fields, like human genetics and neuroimaging, it is clear that small, under-powered studies (often with uncorrected stats and no replication sample) JUST GENERATE NOISE.
A tale of two DTC DNA companies.
While 23andMe is dealing with the bankruptcy fallout, Ancestry is sponsoring Ryan Reynolds' and Rob McElhenney's Welsh football club, Wrexham AFC.
PS: I loved watching Welcome to Wrexham ❤️
www.wrexhamafc.co.uk/news/2025/ju...
While 23andMe is dealing with the bankruptcy fallout, Ancestry is sponsoring Ryan Reynolds' and Rob McElhenney's Welsh football club, Wrexham AFC.
PS: I loved watching Welcome to Wrexham ❤️
www.wrexhamafc.co.uk/news/2025/ju...
COMMERCIAL | Ancestry Confirmed as Wrexham AFC Official Club Partner
Wrexham AFC are pleased to announce Ancestry as our new official family history partner, with the company’s brand to feature on the front of our new 2025/26 training wear – as worn for the first time ...
www.wrexhamafc.co.uk
July 8, 2025 at 1:44 PM
A tale of two DTC DNA companies.
While 23andMe is dealing with the bankruptcy fallout, Ancestry is sponsoring Ryan Reynolds' and Rob McElhenney's Welsh football club, Wrexham AFC.
PS: I loved watching Welcome to Wrexham ❤️
www.wrexhamafc.co.uk/news/2025/ju...
While 23andMe is dealing with the bankruptcy fallout, Ancestry is sponsoring Ryan Reynolds' and Rob McElhenney's Welsh football club, Wrexham AFC.
PS: I loved watching Welcome to Wrexham ❤️
www.wrexhamafc.co.uk/news/2025/ju...
In the latest update to the 23andMe, Anne Wojcicki (i.e., not REGN) won the bidding war.
www.wsj.com/tech/biotech...
www.wsj.com/tech/biotech...
Exclusive | Anne Wojcicki Wins Bidding for 23andMe
Regeneron is backing away from buying the DNA-testing company after a nonprofit controlled by co-founder Wojcicki made a higher bid.
www.wsj.com
June 13, 2025 at 9:15 PM
In the latest update to the 23andMe, Anne Wojcicki (i.e., not REGN) won the bidding war.
www.wsj.com/tech/biotech...
www.wsj.com/tech/biotech...
Year ago, the prevailing attitude was that deep learning would significantly improve polygenic risk scores (or anything else, to be fair).
A rather important set of negative results indicating that isn't the case (though I imagine many will still try).
nature.com/articles/s41...
A rather important set of negative results indicating that isn't the case (though I imagine many will still try).
nature.com/articles/s41...
June 6, 2025 at 1:36 PM
Year ago, the prevailing attitude was that deep learning would significantly improve polygenic risk scores (or anything else, to be fair).
A rather important set of negative results indicating that isn't the case (though I imagine many will still try).
nature.com/articles/s41...
A rather important set of negative results indicating that isn't the case (though I imagine many will still try).
nature.com/articles/s41...
Whelp, the sale was premature. Former CEO, Anne Wojcicki, reopened the 23andMe auction with a new $305 million bid.
www.bloomberg.com/news/article...
www.bloomberg.com/news/article...
June 5, 2025 at 9:09 PM
Whelp, the sale was premature. Former CEO, Anne Wojcicki, reopened the 23andMe auction with a new $305 million bid.
www.bloomberg.com/news/article...
www.bloomberg.com/news/article...
Reposted by Jack Kosmicki
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.
It's not just budgets but research, institutions, expertise, and training the next generation.
May 31, 2025 at 4:43 AM
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.
It's not just budgets but research, institutions, expertise, and training the next generation.
Reposted by Jack Kosmicki
The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.
May 28, 2025 at 10:18 AM
The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.
Reposted by Jack Kosmicki
I didn't have much hope that we'd find genetic determinants of long-COVID, but after years of work, Vilma Aho, Tomoko Nakanisha, Hugo Zeberg and Hanna Ollila made it happen! (Among a few others :-))
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genome-wide association study of long COVID - Nature Genetics
A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.
www.nature.com
May 22, 2025 at 5:55 PM
I didn't have much hope that we'd find genetic determinants of long-COVID, but after years of work, Vilma Aho, Tomoko Nakanisha, Hugo Zeberg and Hanna Ollila made it happen! (Among a few others :-))
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congrats to everyone involved in the long COVID GWAS - diligence and perseverance paid off with an association near FOXP4 that increases risk (OR=1.63; P=1.76e-10).
nature.com/articles/s41...
nature.com/articles/s41...
May 22, 2025 at 7:01 PM
Congrats to everyone involved in the long COVID GWAS - diligence and perseverance paid off with an association near FOXP4 that increases risk (OR=1.63; P=1.76e-10).
nature.com/articles/s41...
nature.com/articles/s41...
Wow, Regeneron bought 23andMe for $256 million.
www.cnn.com/2025/05/19/b...
www.cnn.com/2025/05/19/b...
Regeneron to buy bankrupt DNA testing firm 23andMe for $256 million | CNN Business
Drugmaker Regeneron Pharmaceuticals will buy genetic testing firm 23andMe for $256 million through a bankruptcy auction, the companies said Monday.
www.cnn.com
May 19, 2025 at 1:15 PM
Wow, Regeneron bought 23andMe for $256 million.
www.cnn.com/2025/05/19/b...
www.cnn.com/2025/05/19/b...
Kári Stefánsson steps down as CEO of deCODE genetics - RÚV.is
RÚV.is
www.ruv.is
May 8, 2025 at 3:22 AM
Reposted by Jack Kosmicki
Nobody who has ever played Civ or SimCity would misunderstand trade this badly.
May 4, 2025 at 4:53 PM
Nobody who has ever played Civ or SimCity would misunderstand trade this badly.