😬😬😬😬

Until I saw this was related to #TraitorsIRL, I thought this was a joke related to an entirely other event 😂

I'm 100% serious - these are eye-opening results!

The idea that the PPP captures environment is horrendously under-appreciated and your paper very convincingly demonstrates this. Showing stratification based on HOW LONG since quit smoking is both insane, but also such a chef's kiss moment!!

4) >50% of proteins predictive of disease also predict smoking (this does vary significantly by disease).

www.medrxiv.org/content/10.1...

2) proteomics stratifies smokers, prior smokers, & non smokers (Fig. 4a)
3) proteomics even stratifies how LONG it has been since you quit smoking (Fig. 4b)🤯

🎉🎉🎉Congratulations Kevin!!!!! Very well-deserved!!!!!!

As for other fields, like human genetics and neuroimaging, it is clear that small, under-powered studies (often with uncorrected stats and no replication sample) JUST GENERATE NOISE.

I really appreciate it James! I'm rather disappointed myself. C'est la vie!

I am curious if TTAM will have to reconsent all the data 🧐

That's a very fair question! I suppose the answer depends on whether you asked someone on the DL hype train or not 😅.

Remember when DL was supposed to transform drug development and every other field haha?