Pierre Gladieux
@pgladieux.bsky.social
Research professor (Directeur de Recherche), INRAE, Plant Health Institute Montpellier. Population genomics. Ascomycetes. Mycophagous bacteria. Virulence. Immunity. Guitars. Football.
Reposted by Pierre Gladieux
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Bacterial immune systems as causes and consequences of microbiome structure
Bacterial immune systems have evolved in response to diverse molecular "parasites", yet their ecological roles remain poorly understood. This Essay explores how interactions between mobile genetic ele...
journals.plos.org
November 19, 2025 at 6:35 PM
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Pierre Gladieux
Seeking a postdoc position?
Balancing selection is a fascinating process: malaria resistance, self-incompatibility,etc. Yet, countless examples remain hidden in genomes!
If this question intrigues you, the project led by Laure Segurel and Violaine Llaurens (Paris + Lyon) is perfect! urlr.me/Huj2De
Balancing selection is a fascinating process: malaria resistance, self-incompatibility,etc. Yet, countless examples remain hidden in genomes!
If this question intrigues you, the project led by Laure Segurel and Violaine Llaurens (Paris + Lyon) is perfect! urlr.me/Huj2De
Portail Emploi CNRS - Offre d'emploi - Post-doctoral fellow (M/F): Assessing the power of current methods to detect balancing selection in population genomic datasets
urlr.me
November 18, 2025 at 10:16 AM
Seeking a postdoc position?
Balancing selection is a fascinating process: malaria resistance, self-incompatibility,etc. Yet, countless examples remain hidden in genomes!
If this question intrigues you, the project led by Laure Segurel and Violaine Llaurens (Paris + Lyon) is perfect! urlr.me/Huj2De
Balancing selection is a fascinating process: malaria resistance, self-incompatibility,etc. Yet, countless examples remain hidden in genomes!
If this question intrigues you, the project led by Laure Segurel and Violaine Llaurens (Paris + Lyon) is perfect! urlr.me/Huj2De
Reposted by Pierre Gladieux
When colonizing a new habitat, organisms adapt to maximize their reproductive success via #LifeHistory #evolution. @ecoevodevolab.bsky.social @cbank.bsky.social show that life history evolution facilitates niche diversification across a range of theoretical models @plosbiology.org 🧪 plos.io/4p7YT0a
November 13, 2025 at 5:30 PM
When colonizing a new habitat, organisms adapt to maximize their reproductive success via #LifeHistory #evolution. @ecoevodevolab.bsky.social @cbank.bsky.social show that life history evolution facilitates niche diversification across a range of theoretical models @plosbiology.org 🧪 plos.io/4p7YT0a
Reposted by Pierre Gladieux
Revisiting the evidence for long-lived balancing selection in humans. https://www.biorxiv.org/content/10.1101/2025.11.10.687682v1
November 11, 2025 at 1:35 PM
Revisiting the evidence for long-lived balancing selection in humans. https://www.biorxiv.org/content/10.1101/2025.11.10.687682v1
Reposted by Pierre Gladieux
Lifestyles shape genome size and gene content in fungal pathogens.
buff.ly/tec1Tds
buff.ly/tec1Tds
November 7, 2025 at 9:21 AM
Lifestyles shape genome size and gene content in fungal pathogens.
buff.ly/tec1Tds
buff.ly/tec1Tds
Reposted by Pierre Gladieux
Thrilled to share that the first chapter of my PhD thesis has just been published!
Our study shows that interactions between wheat varieties can modulate both the mean and variance of susceptibility to Septoria tritici blotch. 🌱↔️🌱
📖 Read the full article here:
doi.org/10.1093/jxb/...
Our study shows that interactions between wheat varieties can modulate both the mean and variance of susceptibility to Septoria tritici blotch. 🌱↔️🌱
📖 Read the full article here:
doi.org/10.1093/jxb/...
Plant–plant interactions in wheat mixtures modulate mean and variance of susceptibility to Septoria tritici blotch
Wheat varietal mixtures modulate the mean and variance of Septoria tritici blotch disease symptoms through specific plant–plant interactions, with mixtures
doi.org
October 21, 2025 at 4:17 PM
Thrilled to share that the first chapter of my PhD thesis has just been published!
Our study shows that interactions between wheat varieties can modulate both the mean and variance of susceptibility to Septoria tritici blotch. 🌱↔️🌱
📖 Read the full article here:
doi.org/10.1093/jxb/...
Our study shows that interactions between wheat varieties can modulate both the mean and variance of susceptibility to Septoria tritici blotch. 🌱↔️🌱
📖 Read the full article here:
doi.org/10.1093/jxb/...
Reposted by Pierre Gladieux
Tracking the evolutionary trajectory of a young hybrid plant pathogen. New preprint on how triticale powdery mildew evolved in the ~25 years since its emergence. Congrats to @jigisha1.bsky.social and all coauthors! doi.org/10.1101/2025...
Tracking the evolutionary trajectory of a young hybrid plant pathogen
A common mechanism by which emerging plant pathogens gain the ability to infect new hosts is hybridization. Despite its widespread occurrence, the outcomes of hybridization remain largely unpredictabl...
doi.org
October 13, 2025 at 6:47 AM
Tracking the evolutionary trajectory of a young hybrid plant pathogen. New preprint on how triticale powdery mildew evolved in the ~25 years since its emergence. Congrats to @jigisha1.bsky.social and all coauthors! doi.org/10.1101/2025...
Reposted by Pierre Gladieux
A research team led by the @leibnizipk.bsky.social has revealed that modern barley has a “mosaic origin”, meaning it stems from several wild populations across the Fertile Crescent. The findings were published in @nature.com.
➡️Paper: tinyurl.com/ytzyn4re
➡️PR: tinyurl.com/5e2v7cp5
➡️Paper: tinyurl.com/ytzyn4re
➡️PR: tinyurl.com/5e2v7cp5
September 24, 2025 at 2:58 PM
A research team led by the @leibnizipk.bsky.social has revealed that modern barley has a “mosaic origin”, meaning it stems from several wild populations across the Fertile Crescent. The findings were published in @nature.com.
➡️Paper: tinyurl.com/ytzyn4re
➡️PR: tinyurl.com/5e2v7cp5
➡️Paper: tinyurl.com/ytzyn4re
➡️PR: tinyurl.com/5e2v7cp5
Reposted by Pierre Gladieux
Effector-triggered immunity (ETI) indirectly detects pathogen effector activity on the host cell.
Kevin Barthes,Tanita Wein and I examine how prokaryotic and eukaryotic viruses deploy similar effectors that activate ETI, underscoring its central role across the tree of life.
tinyurl.com/mr3a3xh2
Kevin Barthes,Tanita Wein and I examine how prokaryotic and eukaryotic viruses deploy similar effectors that activate ETI, underscoring its central role across the tree of life.
tinyurl.com/mr3a3xh2
Viral effectors trigger innate immunity across the tree of life | Philosophical Transactions of the Royal Society B: Biological Sciences
Viruses are ubiquitous biological entities that exert immense selective pressures
on their hosts, driving the evolution of diverse innate immune mechanisms across all
domains of life. While innate imm...
royalsocietypublishing.org
September 5, 2025 at 12:05 PM
Effector-triggered immunity (ETI) indirectly detects pathogen effector activity on the host cell.
Kevin Barthes,Tanita Wein and I examine how prokaryotic and eukaryotic viruses deploy similar effectors that activate ETI, underscoring its central role across the tree of life.
tinyurl.com/mr3a3xh2
Kevin Barthes,Tanita Wein and I examine how prokaryotic and eukaryotic viruses deploy similar effectors that activate ETI, underscoring its central role across the tree of life.
tinyurl.com/mr3a3xh2
Reposted by Pierre Gladieux
Preprint: De-novo design of proteins that inhibit bacterial defenses
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection
Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...
www.biorxiv.org
September 2, 2025 at 10:48 AM
Preprint: De-novo design of proteins that inhibit bacterial defenses
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Reposted by Pierre Gladieux
Preprint: “Structural modeling reveals viral proteins that manipulate host immune signaling”
Using AI-guided structural modeling, we find new families of viral proteins that sequester or cleave host immune signaling molecules
Congrats Nitzan Tal!
www.biorxiv.org/content/10.1...
Using AI-guided structural modeling, we find new families of viral proteins that sequester or cleave host immune signaling molecules
Congrats Nitzan Tal!
www.biorxiv.org/content/10.1...
July 14, 2025 at 7:36 AM
Preprint: “Structural modeling reveals viral proteins that manipulate host immune signaling”
Using AI-guided structural modeling, we find new families of viral proteins that sequester or cleave host immune signaling molecules
Congrats Nitzan Tal!
www.biorxiv.org/content/10.1...
Using AI-guided structural modeling, we find new families of viral proteins that sequester or cleave host immune signaling molecules
Congrats Nitzan Tal!
www.biorxiv.org/content/10.1...
Reposted by Pierre Gladieux
Reposted by Pierre Gladieux
Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.
Functional amyloid proteins confer defence against predatory bacteria
Nature - Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a...
rdcu.be
July 2, 2025 at 8:10 PM
Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.
Reposted by Pierre Gladieux
I enjoyed Carl Bergstrom's @carlbergstrom.com talk today @unswbabs.bsky.social on the current 'Peer review meltdown' phenomenon. Misery loves company, so I was glad to find out I'm not the only editor struggling to find reviewers. Carl et al. have narrow it down to a few factors including ->
June 23, 2025 at 8:40 AM
I enjoyed Carl Bergstrom's @carlbergstrom.com talk today @unswbabs.bsky.social on the current 'Peer review meltdown' phenomenon. Misery loves company, so I was glad to find out I'm not the only editor struggling to find reviewers. Carl et al. have narrow it down to a few factors including ->
Reposted by Pierre Gladieux
Our structural core gene pipeline Unicode is now published at GBE
📄 doi.org/10.1093/gbe/...
Please also check out @dongwookkim.bsky.social’s
🧵 bsky.app/profile/dong...
📄 doi.org/10.1093/gbe/...
Please also check out @dongwookkim.bsky.social’s
🧵 bsky.app/profile/dong...
June 3, 2025 at 5:19 PM
Our structural core gene pipeline Unicode is now published at GBE
📄 doi.org/10.1093/gbe/...
Please also check out @dongwookkim.bsky.social’s
🧵 bsky.app/profile/dong...
📄 doi.org/10.1093/gbe/...
Please also check out @dongwookkim.bsky.social’s
🧵 bsky.app/profile/dong...
Reposted by Pierre Gladieux
Our new paper is out!
We observed a loss of function in mating compatibility for HD genes for the first time in basidiomycete fungi, and new evolutionary strata in the absence of sexually antagonistic selection!
@tatianagiraud.bsky.social
More details here 👉 www.nature.com/articles/s41...
We observed a loss of function in mating compatibility for HD genes for the first time in basidiomycete fungi, and new evolutionary strata in the absence of sexually antagonistic selection!
@tatianagiraud.bsky.social
More details here 👉 www.nature.com/articles/s41...
Repeated loss of function at HD mating-type genes and of recombination in anther-smut fungi - Nature Communications
Basidiomycete fungi typically have two mating-type loci located on different chromosomes. Here, Lucotte et al. report the convergent loss-of-function of mating-type genes across several species of phy...
www.nature.com
June 3, 2025 at 11:18 AM
Our new paper is out!
We observed a loss of function in mating compatibility for HD genes for the first time in basidiomycete fungi, and new evolutionary strata in the absence of sexually antagonistic selection!
@tatianagiraud.bsky.social
More details here 👉 www.nature.com/articles/s41...
We observed a loss of function in mating compatibility for HD genes for the first time in basidiomycete fungi, and new evolutionary strata in the absence of sexually antagonistic selection!
@tatianagiraud.bsky.social
More details here 👉 www.nature.com/articles/s41...
Reposted by Pierre Gladieux
Very happy to see our paper online: "Population genomics and molecular epidemiology of wheat powdery mildew in Europe". Congrats to @jigisha1.bsky.social and all coauthors! doi.org/10.1371/jour...
Population genomics and molecular epidemiology of wheat powdery mildew in Europe
Agricultural diseases are a major threat to sustainable food production. This study of wheat powdery mildew, a disease caused by the fungus Blumeria graminis, shows that the population structure can b...
doi.org
May 5, 2025 at 2:09 PM
Very happy to see our paper online: "Population genomics and molecular epidemiology of wheat powdery mildew in Europe". Congrats to @jigisha1.bsky.social and all coauthors! doi.org/10.1371/jour...
Reposted by Pierre Gladieux
I am delighted to share our latest review on the processes involved in disease control within varietal mixtures.
To read the article: onlinelibrary.wiley.com/doi/10.1111/...
To read the article: onlinelibrary.wiley.com/doi/10.1111/...
April 10, 2025 at 7:23 AM
I am delighted to share our latest review on the processes involved in disease control within varietal mixtures.
To read the article: onlinelibrary.wiley.com/doi/10.1111/...
To read the article: onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Pierre Gladieux
Nous avons publié une présentation de Venturia inaequalis, le champignon responsable de la tavelure du pommier, ainsi que de son impact sur la production de pommes. Découvrez les enjeux de cette maladie et les défis qu'elle pose pour la filière arboricole ! 🍏🌿
theconversation.com/la-pomme-rei...
theconversation.com/la-pomme-rei...
La pomme, reine des vergers et des pesticides
Afin de lutter contre la maladie de la tavelure, les pommiers sont les cultures les plus traitées en France. Comment réduire cette dépendance aux traitements ?
theconversation.com
March 26, 2025 at 4:25 PM
Nous avons publié une présentation de Venturia inaequalis, le champignon responsable de la tavelure du pommier, ainsi que de son impact sur la production de pommes. Découvrez les enjeux de cette maladie et les défis qu'elle pose pour la filière arboricole ! 🍏🌿
theconversation.com/la-pomme-rei...
theconversation.com/la-pomme-rei...
Reposted by Pierre Gladieux
Structure-guided insights into the biology of fungal effectors
nph.onlinelibrary.wiley.com/doi/full/10....
nph.onlinelibrary.wiley.com/doi/full/10....
Structure‐guided insights into the biology of fungal effectors
Phytopathogenic fungi cause enormous yield losses in many crops, threatening both agricultural production and global food security. To infect plants, they secrete effectors targeting various cellular...
nph.onlinelibrary.wiley.com
March 26, 2025 at 6:00 PM
Structure-guided insights into the biology of fungal effectors
nph.onlinelibrary.wiley.com/doi/full/10....
nph.onlinelibrary.wiley.com/doi/full/10....
Reposted by Pierre Gladieux
In our new paper we discuss how modern coexistence theory can help microbial ecologists tackle fundamental & applied questions, and how microbial systems can help to push coexistence theory forward! With Andrew Letten and Dave Armitage (@darmitage.bsky.social). doi.org/10.1111/1462...
Coexistence Theory for Microbial Ecology, and Vice Versa
Classical models from theoretical ecology are seeing increasing uptake in microbial ecology, but there remains rich potential for closer cross-pollination. Here we explore opportunities for stronger ....
doi.org
March 12, 2025 at 5:35 AM
In our new paper we discuss how modern coexistence theory can help microbial ecologists tackle fundamental & applied questions, and how microbial systems can help to push coexistence theory forward! With Andrew Letten and Dave Armitage (@darmitage.bsky.social). doi.org/10.1111/1462...
Reposted by Pierre Gladieux
Three 2025 papers (so far). First: we used transposons to disrupt most genes of the malaria-causing parasite Plasmodium knowlesi, revealing the essential genes for survival, either in general or under antimalarial drugs, providing clues to how parasites can be killed. www.science.org/doi/10.1126/...
February 18, 2025 at 6:06 PM
Three 2025 papers (so far). First: we used transposons to disrupt most genes of the malaria-causing parasite Plasmodium knowlesi, revealing the essential genes for survival, either in general or under antimalarial drugs, providing clues to how parasites can be killed. www.science.org/doi/10.1126/...
Reposted by Pierre Gladieux
Now online! Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins
Hybrid structure-sequence mining and biochemical/structural characterization trace the evolutionary origins of CRISPR-Cas13, elucidating how their RNA-guided mechanism likely evolved from an ancient scaffold comprising an RNase toxin and an ncRNA…
dlvr.it
February 18, 2025 at 3:59 PM
Now online! Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins
Reposted by Pierre Gladieux
‼️These #PSMC #peaks are #artifacts‼️
Seen #PSMC results like this🤔?
They are caused by ill-set parameters, #very #common, and #easy #to #solve!
For details see 🧵& OA paper @currentbiology.bsky.social
🙂🐢🧬🎉!
cell.com/current-biol...
Seen #PSMC results like this🤔?
They are caused by ill-set parameters, #very #common, and #easy #to #solve!
For details see 🧵& OA paper @currentbiology.bsky.social
🙂🐢🧬🎉!
cell.com/current-biol...
Avoidable false PSMC population size peaks occur across numerous studies
Hilgers et al. detect and solve a common artifact in PSMC and related methods for
historical population size inference. Analyses of real and simulated genomes show
that ill-set default parameters fals...
cell.com
February 7, 2025 at 8:14 AM
‼️These #PSMC #peaks are #artifacts‼️
Seen #PSMC results like this🤔?
They are caused by ill-set parameters, #very #common, and #easy #to #solve!
For details see 🧵& OA paper @currentbiology.bsky.social
🙂🐢🧬🎉!
cell.com/current-biol...
Seen #PSMC results like this🤔?
They are caused by ill-set parameters, #very #common, and #easy #to #solve!
For details see 🧵& OA paper @currentbiology.bsky.social
🙂🐢🧬🎉!
cell.com/current-biol...
Reposted by Pierre Gladieux
Foldseek-Multimer—now published in @naturemethods.bsky.social—our fast multimer search tool, enables complex comparisons against the full PDB in seconds. It comes with BFMD, a collection of 300K+ predictions gathered from community projects.
📄 nature.com/articles/s41...
🌐 search.foldseek.com
📄 nature.com/articles/s41...
🌐 search.foldseek.com
February 6, 2025 at 8:25 AM
Foldseek-Multimer—now published in @naturemethods.bsky.social—our fast multimer search tool, enables complex comparisons against the full PDB in seconds. It comes with BFMD, a collection of 300K+ predictions gathered from community projects.
📄 nature.com/articles/s41...
🌐 search.foldseek.com
📄 nature.com/articles/s41...
🌐 search.foldseek.com