Paul Geeleher
@pgeeleher.bsky.social
Compbio & precision medicine lab @stjude
Reposted by Paul Geeleher
Our paper identifying evidence of off-target probe binding in the 10x Genomics Xenium Breast Gene Panel is now available as a reviewed preprint at #eLife
elifesciences.org/reviewed-pre...
We look forward to revising the paper to incorporate reviewer recommendations and other updates 🧵👇
elifesciences.org/reviewed-pre...
We look forward to revising the paper to incorporate reviewer recommendations and other updates 🧵👇
August 29, 2025 at 4:36 PM
Our paper identifying evidence of off-target probe binding in the 10x Genomics Xenium Breast Gene Panel is now available as a reviewed preprint at #eLife
elifesciences.org/reviewed-pre...
We look forward to revising the paper to incorporate reviewer recommendations and other updates 🧵👇
elifesciences.org/reviewed-pre...
We look forward to revising the paper to incorporate reviewer recommendations and other updates 🧵👇
Reposted by Paul Geeleher
Retinoic acid effectively treats metastasized neuroblastoma by exploiting the BMP signaling pathway in the bone marrow microenvironment, offering insights for future combination therapies. doi.org/g86pzp
Scientists solve mystery of how the drug retinoic acid works to treat neuroblastoma
Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10–15%.
medicalxpress.com
February 28, 2025 at 6:32 PM
Retinoic acid effectively treats metastasized neuroblastoma by exploiting the BMP signaling pathway in the bone marrow microenvironment, offering insights for future combination therapies. doi.org/g86pzp
Reposted by Paul Geeleher
Nature research paper: An integrated large-scale photonic accelerator with ultralow latency
https://go.nature.com/3R7tyvL
https://go.nature.com/3R7tyvL
An integrated large-scale photonic accelerator with ultralow latency - Nature
A large-scale photonic accelerator comprising more than 16,000 components integrated on a single chip to process MAC operations is described, demonstrating ultralow latency and reduced computing time compared with a commercially available GPU.
go.nature.com
April 10, 2025 at 10:32 AM
Nature research paper: An integrated large-scale photonic accelerator with ultralow latency
https://go.nature.com/3R7tyvL
https://go.nature.com/3R7tyvL
Reposted by Paul Geeleher
The April (and #AACR25) issue of Cancer Discovery is now online! The cover features work by Ling Cai, Nia Hammond, @faubert.bsky.social, @rjdlab.bsky.social & colleagues showing high glucose contribution to the TCA cycle is a feature of aggressive NSCLC - more here: aacrjournals.org/cancerdiscov...
April 2, 2025 at 8:34 PM
The April (and #AACR25) issue of Cancer Discovery is now online! The cover features work by Ling Cai, Nia Hammond, @faubert.bsky.social, @rjdlab.bsky.social & colleagues showing high glucose contribution to the TCA cycle is a feature of aggressive NSCLC - more here: aacrjournals.org/cancerdiscov...
Reposted by Paul Geeleher
Nature research paper: A natural experiment on the effect of herpes zoster vaccination on dementia
https://go.nature.com/3XHRhq5
https://go.nature.com/3XHRhq5
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of 7 years by approximately one-fifth.
go.nature.com
April 2, 2025 at 5:18 PM
Nature research paper: A natural experiment on the effect of herpes zoster vaccination on dementia
https://go.nature.com/3XHRhq5
https://go.nature.com/3XHRhq5
Reposted by Paul Geeleher
Itai Yanai is now putting together with Oded Rechavi and others the Woodstock of Biology 2 & Night Science conference to integrate some of Itai's ideas into a scientific meeting. #theconferencetoendallconferences
More info & registration here: woodstock.img.cas.cz
More info & registration here: woodstock.img.cas.cz
March 30, 2025 at 9:15 PM
Itai Yanai is now putting together with Oded Rechavi and others the Woodstock of Biology 2 & Night Science conference to integrate some of Itai's ideas into a scientific meeting. #theconferencetoendallconferences
More info & registration here: woodstock.img.cas.cz
More info & registration here: woodstock.img.cas.cz
Reposted by Paul Geeleher
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 6:05 PM
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
Reposted by Paul Geeleher
Polar bear fur remains ice-free in the Arctic cold thanks to the unique array of ingredients in its fur sebum, or hair grease, a #ScienceAdvances study finds.
Learn more on #WorldBearDay:
Learn more on #WorldBearDay:
Anti-icing properties of polar bear fur
Polar bears are able to minimize ice accumulation thanks to their hair oil.
scim.ag
March 23, 2025 at 2:07 PM
Polar bear fur remains ice-free in the Arctic cold thanks to the unique array of ingredients in its fur sebum, or hair grease, a #ScienceAdvances study finds.
Learn more on #WorldBearDay:
Learn more on #WorldBearDay:
Reposted by Paul Geeleher
Experiments suggest that an unusual magnetic material can help harness energy from the planet’s rotation. But not everyone is convinced.
https://go.nature.com/4ixBNxj
https://go.nature.com/4ixBNxj
Can Earth’s rotation generate power? Physicists divided over controversial claim
Experiments suggest that an unusual magnetic material can help harness energy from the planet’s rotation. But not everyone is convinced.
go.nature.com
March 19, 2025 at 9:22 PM
Experiments suggest that an unusual magnetic material can help harness energy from the planet’s rotation. But not everyone is convinced.
https://go.nature.com/4ixBNxj
https://go.nature.com/4ixBNxj
Reposted by Paul Geeleher
So proud of this work, this was a great collaboration and I highly recommend this read and tool. My own tweetorial shortly but @steglelab.bsky.social tutorial is great.
1/ New preprint! 🍳
@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!
doi.org/10.1101/2025...
@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!
doi.org/10.1101/2025...
March 19, 2025 at 10:53 AM
So proud of this work, this was a great collaboration and I highly recommend this read and tool. My own tweetorial shortly but @steglelab.bsky.social tutorial is great.
Reposted by Paul Geeleher
An Australian man in his forties has become the first person in the world to leave hospital with an artificial heart made of titanium
The device could be a temporary measure for those waiting for a donor organ
https://go.nature.com/427bLLh
The device could be a temporary measure for those waiting for a donor organ
https://go.nature.com/427bLLh
Man survives with titanium heart for 100 days – a world first
Nature - The device, to be tested in more people, could be used as a temporary measure for those waiting for a donor organ.
go.nature.com
March 16, 2025 at 5:38 PM
An Australian man in his forties has become the first person in the world to leave hospital with an artificial heart made of titanium
The device could be a temporary measure for those waiting for a donor organ
https://go.nature.com/427bLLh
The device could be a temporary measure for those waiting for a donor organ
https://go.nature.com/427bLLh
Reposted by Paul Geeleher
This is very much fitting, and exciting, for my first Blusky post 🤩
Thrilled to share our new study on CAFs and NK cells, now online 🌟 in CD_AACR!! t.co/vmq8ZyQ3KV
Thrilled to share our new study on CAFs and NK cells, now online 🌟 in CD_AACR!! t.co/vmq8ZyQ3KV
March 13, 2025 at 4:51 PM
This is very much fitting, and exciting, for my first Blusky post 🤩
Thrilled to share our new study on CAFs and NK cells, now online 🌟 in CD_AACR!! t.co/vmq8ZyQ3KV
Thrilled to share our new study on CAFs and NK cells, now online 🌟 in CD_AACR!! t.co/vmq8ZyQ3KV
Reposted by Paul Geeleher
Bone morphogenetic protein signaling reported to be responsible for determining neuroblastoma cell fate and sensitivity to retinoic acid treatment doi.org/10.1038/s414... #CancerResearch
March 12, 2025 at 5:47 PM
Bone morphogenetic protein signaling reported to be responsible for determining neuroblastoma cell fate and sensitivity to retinoic acid treatment doi.org/10.1038/s414... #CancerResearch
Reposted by Paul Geeleher
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
openrxiv.org
March 11, 2025 at 1:20 PM
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Reposted by Paul Geeleher
Delighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Clonal dynamics and somatic evolution of haematopoiesis in mouse - Nature
Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using labo...
www.nature.com
March 6, 2025 at 1:58 PM
Delighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Paul Geeleher
A physicist has published an analysis that pokes holes in the protocol that underpins Microsoft’s claim to have created the first topological qubits. The critique comes amid mounting speculation about the validity of Microsoft’s claim.
https://go.nature.com/4byvwyl
https://go.nature.com/4byvwyl
Microsoft quantum computing 'breakthrough' faces fresh challenge
Analysis pokes holes in protocol that underpins Microsoft’s claim to have created the first topological qubits.
go.nature.com
March 7, 2025 at 11:30 AM
A physicist has published an analysis that pokes holes in the protocol that underpins Microsoft’s claim to have created the first topological qubits. The critique comes amid mounting speculation about the validity of Microsoft’s claim.
https://go.nature.com/4byvwyl
https://go.nature.com/4byvwyl
Reposted by Paul Geeleher
1) I am delighted to share a manuscript long in the making (7 years), elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm www.biorxiv.org/content/10.1...
Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer
Metastasis is the leading cause of cancer deaths; nonetheless, how tumor cells adapt to vastly different organ contexts is largely unknown. To investigate this question, we generated a transcriptomic ...
www.biorxiv.org
March 7, 2025 at 11:26 AM
1) I am delighted to share a manuscript long in the making (7 years), elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm www.biorxiv.org/content/10.1...
Reposted by Paul Geeleher
Seven New Cancer Grand Challenges Announced
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
March 5, 2025 at 3:16 PM
Seven New Cancer Grand Challenges Announced
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
Can we treat cancer by forcing cancer cells to differentiate?
Retinoids are unique cancer drugs that, according to textbooks, make cancer cells mature and lose their malignant behavior. In our new paper, we reveal there’s more to how they really work… 1/n
www.nature.com/articles/s41...
Retinoids are unique cancer drugs that, according to textbooks, make cancer cells mature and lose their malignant behavior. In our new paper, we reveal there’s more to how they really work… 1/n
www.nature.com/articles/s41...
Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid - Nature Communications
Retinoic acid is known to be effective against bone marrow metastatic neuroblastoma cells, but not primary tumors. Here, authors discover that bone morphogenetic protein signaling is responsible for d...
www.nature.com
March 3, 2025 at 4:52 PM
Can we treat cancer by forcing cancer cells to differentiate?
Retinoids are unique cancer drugs that, according to textbooks, make cancer cells mature and lose their malignant behavior. In our new paper, we reveal there’s more to how they really work… 1/n
www.nature.com/articles/s41...
Retinoids are unique cancer drugs that, according to textbooks, make cancer cells mature and lose their malignant behavior. In our new paper, we reveal there’s more to how they really work… 1/n
www.nature.com/articles/s41...
Reposted by Paul Geeleher
Researchers at St. Jude Children's Research Hospital have uncovered the mechanism behind retinoic acid's selective killing of metastatic neuroblastoma cells. This discovery may pave the way for improved combination therapies. ow.ly/PgBl50V8hZn
St. Jude scientists solve mystery of how the drug retinoic acid works to treat neuroblastoma
Find new research showing how retinoic acid hijacks a developmental pathway in metastasized neuroblastoma in the bone marrow, solving a 50 year-long mystery.
ow.ly
February 28, 2025 at 7:45 PM
Researchers at St. Jude Children's Research Hospital have uncovered the mechanism behind retinoic acid's selective killing of metastatic neuroblastoma cells. This discovery may pave the way for improved combination therapies. ow.ly/PgBl50V8hZn
Reposted by Paul Geeleher
The February issue of Cancer Discovery is now online! The cover features "The Evolutionary Forest of Pancreatic Cancer" by Katelyn Mullen, @braphael.bsky.social, Christine Iacobuzio-Donahue, and colleagues. Read the paper and much more here: aacrjournals.org/cancerdiscov...
February 7, 2025 at 5:59 PM
The February issue of Cancer Discovery is now online! The cover features "The Evolutionary Forest of Pancreatic Cancer" by Katelyn Mullen, @braphael.bsky.social, Christine Iacobuzio-Donahue, and colleagues. Read the paper and much more here: aacrjournals.org/cancerdiscov...
Reposted by Paul Geeleher
Implantation of engineered adipocytes suppresses tumor progression in cancer models - @nadavahituv.bsky.social go.nature.com/4gqhxvw
Implantation of engineered adipocytes suppresses tumor progression in cancer models - Nature Biotechnology
Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.
go.nature.com
February 4, 2025 at 3:48 PM
Implantation of engineered adipocytes suppresses tumor progression in cancer models - @nadavahituv.bsky.social go.nature.com/4gqhxvw
Reposted by Paul Geeleher
Insanely good news if this holds up.
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
www.science.org/doi/10.1126/...
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
www.science.org/doi/10.1126/...
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts...
www.science.org
February 5, 2025 at 4:12 AM
Insanely good news if this holds up.
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
www.science.org/doi/10.1126/...
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
www.science.org/doi/10.1126/...
Reposted by Paul Geeleher
Online now!
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states
🖊️by Ilaria Panzeri & John Andrew Pospisilik and colleagues
@ilariapanzeri.bsky.social @andrewpospisilik.bsky.social
👇
www.nature.com/articles/s43...
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states
🖊️by Ilaria Panzeri & John Andrew Pospisilik and colleagues
@ilariapanzeri.bsky.social @andrewpospisilik.bsky.social
👇
www.nature.com/articles/s43...
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states - Nature Cancer
Panzeri et al. use a Trim28+/D9 mouse model with intrinsic developmental heterogeneity to show that ‘heavy’ and ‘light’ developmental morphs exhibit different timing, type and severity of cancer, link...
www.nature.com
January 26, 2025 at 1:23 PM
Online now!
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states
🖊️by Ilaria Panzeri & John Andrew Pospisilik and colleagues
@ilariapanzeri.bsky.social @andrewpospisilik.bsky.social
👇
www.nature.com/articles/s43...
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states
🖊️by Ilaria Panzeri & John Andrew Pospisilik and colleagues
@ilariapanzeri.bsky.social @andrewpospisilik.bsky.social
👇
www.nature.com/articles/s43...