@paupuigdevall.bsky.social
D'Olot, vivint a Hèlsinki. Post-doc al FIMM/NC.
Reposted
The thickness of #Arctic sea ice dropped to a new all-time record low this year around the North Pole (data from PIOMAS). More in my latest 'climate viz of the month' blog: zacklabe.com/climate-viz-... #OpenScience #SciComm #DataViz #OpenData
Climate Viz of the Month
November 2025 Hi! I am happy to share the first of (hopefully) some new graphics in this ‘climate viz of the month’ blog. For quite a few years now, I’ve been procrastinating on figuring out an eff…
zacklabe.com
December 27, 2025 at 7:40 PM
The thickness of #Arctic sea ice dropped to a new all-time record low this year around the North Pole (data from PIOMAS). More in my latest 'climate viz of the month' blog: zacklabe.com/climate-viz-... #OpenScience #SciComm #DataViz #OpenData
Reposted
Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it.
PhD students: choose someone you like to talk to!
PhD students: choose someone you like to talk to!
December 19, 2025 at 4:35 PM
Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it.
PhD students: choose someone you like to talk to!
PhD students: choose someone you like to talk to!
Reposted
Incredible resource of ~1M single-cell transcriptomes, NeuRoDev, that captures temporal and cellular variation across human brain development. Congrats to Asia Zonca and Erik Bot from the Davila-Velderrain group at @humantechnopole.bsky.social for leading this work!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 19, 2025 at 7:25 AM
Incredible resource of ~1M single-cell transcriptomes, NeuRoDev, that captures temporal and cellular variation across human brain development. Congrats to Asia Zonca and Erik Bot from the Davila-Velderrain group at @humantechnopole.bsky.social for leading this work!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted
Tommy Vierbuchen @tvierbuchen.bsky.social shared his work with us today: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". see the recording at: www.youtube.com/playlist?lis... (more info at www.carlocolantuoni.org/seminar)
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
December 16, 2025 at 9:14 PM
Tommy Vierbuchen @tvierbuchen.bsky.social shared his work with us today: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". see the recording at: www.youtube.com/playlist?lis... (more info at www.carlocolantuoni.org/seminar)
Reposted
Getting Rosalind Franklin’s story right is crucial, because she has become a role model for women going into science
www.nature.com/articles/d41...
www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 10, 2025 at 9:44 AM
Getting Rosalind Franklin’s story right is crucial, because she has become a role model for women going into science
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted
Incredible Arctic heat in October. Highest average temperature on record for land and seas north of 60ºN. In Canada, Yukon Territory and Nunavut second warmest, Northwest Territories third warmest. Alaska and Svalbard fourth warmest. Data courtesy ERA5. #akwx #Arctic #Canada #Climate
November 5, 2025 at 4:28 AM
Reposted
Lineage-resolved atlas of the developing human cortex www.nature.com/articles/s41...
Lineage-resolved atlas of the developing human cortex - Nature
Lineage tracing in human tissue samples from gestational weeks 16 to 24 provides insight into lineage relationships between cortical cell types and shows a switch in progenitor output from glutamaterg...
www.nature.com
November 6, 2025 at 11:54 AM
Lineage-resolved atlas of the developing human cortex www.nature.com/articles/s41...
Reposted
Under the RCP4.5 scenario and collapsed AMOC, René van Westen shows how especially the cold extremes would get worse in the Nordics.
-47 °C in Helsinki would be once in a 10 year event!
-47 °C in Helsinki would be once in a 10 year event!
October 21, 2025 at 11:20 AM
Under the RCP4.5 scenario and collapsed AMOC, René van Westen shows how especially the cold extremes would get worse in the Nordics.
-47 °C in Helsinki would be once in a 10 year event!
-47 °C in Helsinki would be once in a 10 year event!
Reposted
When your year runs from October to September, this is what annual temperatures up to 2025 look like.
We are reaching the point that anyone eyeballing graphs can see acceleration of global warming.
No more statistics and natural variability corrections needed.
We are reaching the point that anyone eyeballing graphs can see acceleration of global warming.
No more statistics and natural variability corrections needed.
October 16, 2025 at 7:04 AM
When your year runs from October to September, this is what annual temperatures up to 2025 look like.
We are reaching the point that anyone eyeballing graphs can see acceleration of global warming.
No more statistics and natural variability corrections needed.
We are reaching the point that anyone eyeballing graphs can see acceleration of global warming.
No more statistics and natural variability corrections needed.
Reposted
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
The functional landscape of the human ubiquitinome
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
www.biorxiv.org
October 9, 2025 at 7:07 AM
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
Reposted
Finland's regionally averaged temperature in September was the 3rd highest on record, but here you can see how Septembers 2023–2025 surpass all previous years since 1900.
October 1, 2025 at 10:58 AM
Finland's regionally averaged temperature in September was the 3rd highest on record, but here you can see how Septembers 2023–2025 surpass all previous years since 1900.
Reposted
🚀 Thrilled to share our new review on how structural variants reshape 3D genome architecture and cause disease! 🧬🔀
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Structural variants in the 3D genome as drivers of disease - Nature Reviews Genetics
Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects ...
www.nature.com
July 7, 2025 at 11:12 AM
🚀 Thrilled to share our new review on how structural variants reshape 3D genome architecture and cause disease! 🧬🔀
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Reposted
Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.
September 24, 2025 at 12:23 PM
Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.
Reposted
Una, dues i tres vegades. Històric.
September 22, 2025 at 11:10 PM
Una, dues i tres vegades. Històric.
Reposted
Latest from the lab: the immensely talented Johnny Bou Rouphael and Laila El Khattabi in the team report the discovery and functional analysis defective splicing in a human developmental disorder. www.linkedin.com/posts/bassem...
Heterozygous pathogenic variants in the splicing factor SF1 lead to a large spectrum of neurodevelopmental disorders | Bassem Hassan
Latest from the lab: the immensely talented Johnny Bou Rouphael and Laila El Khattabi in the team report the discovery and functional analysis defective splicing in a human developmental disorder.
www.linkedin.com
September 22, 2025 at 5:54 PM
Latest from the lab: the immensely talented Johnny Bou Rouphael and Laila El Khattabi in the team report the discovery and functional analysis defective splicing in a human developmental disorder. www.linkedin.com/posts/bassem...
Reposted
George Orwell went to Spain to fight fascism. Literally. Not to take holidays, but to stand against the likes of Robinson and Musk.
Orwell saw in Spain how fascist "leaders" turned resentment into organised cruelty. That is why he bled in the trenches there.
Orwell saw in Spain how fascist "leaders" turned resentment into organised cruelty. That is why he bled in the trenches there.
September 13, 2025 at 10:37 PM
George Orwell went to Spain to fight fascism. Literally. Not to take holidays, but to stand against the likes of Robinson and Musk.
Orwell saw in Spain how fascist "leaders" turned resentment into organised cruelty. That is why he bled in the trenches there.
Orwell saw in Spain how fascist "leaders" turned resentment into organised cruelty. That is why he bled in the trenches there.
Reposted
Global military expenditure is increasing, draining money from vital areas such as #ClimateAction.
This new UN report calls for countries to make a shift and invest in sustainable development to build a future that is truly secure for everyone: www.un.org/en/peace-and...
This new UN report calls for countries to make a shift and invest in sustainable development to build a future that is truly secure for everyone: www.un.org/en/peace-and...
September 12, 2025 at 12:54 PM
Global military expenditure is increasing, draining money from vital areas such as #ClimateAction.
This new UN report calls for countries to make a shift and invest in sustainable development to build a future that is truly secure for everyone: www.un.org/en/peace-and...
This new UN report calls for countries to make a shift and invest in sustainable development to build a future that is truly secure for everyone: www.un.org/en/peace-and...
Reposted
I am beyond excited to announce that ggplot2 4.0.0 has just landed on CRAN.
It's not every day we have a new major #ggplot2 release but it is a fitting 18 year birthday present for the package.
Get an overview of the release in this blog post and be on the lookout for more in-depth posts #rstats
It's not every day we have a new major #ggplot2 release but it is a fitting 18 year birthday present for the package.
Get an overview of the release in this blog post and be on the lookout for more in-depth posts #rstats
ggplot2 4.0.0
A new major version of ggplot2 has been released on CRAN. Find out what is new here.
www.tidyverse.org
September 11, 2025 at 11:20 AM
Reposted
A map of DNA methylation changes in human organs could help researchers to discover more targets for anti-ageing therapies.
go.nature.com/4nazaTV
go.nature.com/4nazaTV
How ageing changes our genes — huge epigenetic atlas gives clearest picture yet
A map of DNA methylation changes in human organs could help researchers to discover more targets for anti-ageing therapies.
go.nature.com
September 1, 2025 at 5:10 PM
A map of DNA methylation changes in human organs could help researchers to discover more targets for anti-ageing therapies.
go.nature.com/4nazaTV
go.nature.com/4nazaTV
Reposted
Another preprint from the TenK10K program! This work, led by @alberthenry.bsky.social and Anne Senabouth, leverages the unprecedented power of this WGS/single cell RNA-seq cohort to explore causal influences of blood gene expression on immune diseases and traits. Thread:
1. 🚨New preprint: tinyurl.com/tenk10k-causal.
We explored causal effects of gene expression in immune cell types on complex traits and diseases by combining single-cell expression quantitative trait loci (sc-eQTL) mapping in 5M+ cells from 1,925 donors in TenK10K study and GWAS. 🧵
We explored causal effects of gene expression in immune cell types on complex traits and diseases by combining single-cell expression quantitative trait loci (sc-eQTL) mapping in 5M+ cells from 1,925 donors in TenK10K study and GWAS. 🧵
Single-cell genetics identifies cell type-specific causal mechanisms in complex traits and diseases
Genome-wide association studies (GWAS) have been instrumental in uncovering the genetic basis of complex traits. When integrated with expression quantitative trait loci (eQTL) mapping, they can elucid...
tinyurl.com
September 1, 2025 at 7:42 AM
Another preprint from the TenK10K program! This work, led by @alberthenry.bsky.social and Anne Senabouth, leverages the unprecedented power of this WGS/single cell RNA-seq cohort to explore causal influences of blood gene expression on immune diseases and traits. Thread:
Reposted
Summer 2025 in Finland in short: cool, hot, cool.
Not many of the past summers have been as clearly divided into three parts as this one.
Not many of the past summers have been as clearly divided into three parts as this one.
August 28, 2025 at 1:05 PM
Summer 2025 in Finland in short: cool, hot, cool.
Not many of the past summers have been as clearly divided into three parts as this one.
Not many of the past summers have been as clearly divided into three parts as this one.
Reposted
Long-term study suggests that the more heatwaves people are exposed to, the more it accelerates body ageing.
go.nature.com/45y7hiG
go.nature.com/45y7hiG
Repeated heatwaves can age you as much as smoking or drinking
Long-term study suggests that the more heatwaves people are exposed to, the more it accelerates body ageing.
go.nature.com
August 26, 2025 at 8:50 AM
Long-term study suggests that the more heatwaves people are exposed to, the more it accelerates body ageing.
go.nature.com/45y7hiG
go.nature.com/45y7hiG
Reposted
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…
www.sciencedirect.com
August 26, 2025 at 8:28 AM
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Reposted
What difference a heatwave makes! 🔥🌡️
15 days in the life (and almost death) of Aneto Glacier (3100-3300 m asl), which will be gone in less than 9 years... ✝️
resolve.cambridge.org/core/journal...
Via CryoPyr 🙏
15 days in the life (and almost death) of Aneto Glacier (3100-3300 m asl), which will be gone in less than 9 years... ✝️
resolve.cambridge.org/core/journal...
Via CryoPyr 🙏
August 24, 2025 at 1:56 PM
What difference a heatwave makes! 🔥🌡️
15 days in the life (and almost death) of Aneto Glacier (3100-3300 m asl), which will be gone in less than 9 years... ✝️
resolve.cambridge.org/core/journal...
Via CryoPyr 🙏
15 days in the life (and almost death) of Aneto Glacier (3100-3300 m asl), which will be gone in less than 9 years... ✝️
resolve.cambridge.org/core/journal...
Via CryoPyr 🙏
Reposted
Out now! 🧬
Lewis Evans and the team at @sangerinstitute.bsky.social and UCL define the pathways for tau entry into human neurons, a key mechanism for the progression of tauopathies associated with Parkinson’s and Alzheimer’s disease
www.embopress.org/doi/full/10....
#neuroscience #neuroskyence
Lewis Evans and the team at @sangerinstitute.bsky.social and UCL define the pathways for tau entry into human neurons, a key mechanism for the progression of tauopathies associated with Parkinson’s and Alzheimer’s disease
www.embopress.org/doi/full/10....
#neuroscience #neuroskyence
Tau uptake by human neurons depends on receptor LRP1 and kinase LRRK2 | The EMBO Journal
imageimageNeuronal uptake of extracellular tau protein is thought to propagate intracellular
protein aggregation between neurons, contributing to the pathogenesis of Alzheimer’s
and other neurodegener...
www.embopress.org
August 19, 2025 at 10:31 AM
Out now! 🧬
Lewis Evans and the team at @sangerinstitute.bsky.social and UCL define the pathways for tau entry into human neurons, a key mechanism for the progression of tauopathies associated with Parkinson’s and Alzheimer’s disease
www.embopress.org/doi/full/10....
#neuroscience #neuroskyence
Lewis Evans and the team at @sangerinstitute.bsky.social and UCL define the pathways for tau entry into human neurons, a key mechanism for the progression of tauopathies associated with Parkinson’s and Alzheimer’s disease
www.embopress.org/doi/full/10....
#neuroscience #neuroskyence