Open Targets
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opentargets.org
Open Targets
@opentargets.org
Public-private partnership using human genetics and genomics data for systematic drug target identification and prioritisation. http://blog.opentargets.org
🧬🖥️ Our latest publication reveals a shift in strategies to discover novel drug targets over the past 20 years:
after 2015, biomedical evidence supporting a target-disease indication increasingly appears before the approval year

www.nature.com/articles/s41...
Temporal trends in evidence supporting novel drug target discovery - Nature Communications
Here the authors implement a comprehensive timestamping across millions of pieces of biomedical evidence supporting target–disease associations in the Open Targets Platform and analyse trends in evide...
www.nature.com
February 4, 2026 at 10:06 AM
Open Targets Platform data is now available on @amazonwebservices.bsky.social through the Open Data Program!

registry.opendata.aws/opentargets/
February 2, 2026 at 2:35 PM
Reposted by Open Targets
🔬New Perturbation Catalogue update!
With a redesigned interface, richer datasets and powerful analysis workflows, it’s now easier than ever to explore genetic perturbation data. www.ebi.ac.uk/perturbation...
#Bioinformatics #FunctionalGenomics
@training.ebi.embl.org @opentargets.org
January 27, 2026 at 4:00 PM
The Perturbation Catalogue is live! 🧬🔎🖥️

It aims to bring genetic perturbation data into one curated, harmonised, and discoverable platform.

Take a look! www.ebi.ac.uk/perturbation...
January 27, 2026 at 3:30 PM
🧬🖥️ "This integration is a great example of bringing leading AI to platforms and data that are already widely used across the industry.” — Jonah Cool, Head of Life Sciences Partnerships, Anthropic

Find out more about the Open Targets Platform MCP server: blog.opentargets.org/official-ope...
Introducing the official Open Targets Platform Model Context Protocol
We have released the first iteration of a dedicated MCP server to bring our systematic target discovery capabilities to Large Language Model (LLM)-based workflows.
blog.opentargets.org
January 26, 2026 at 5:09 PM
Reposted by Open Targets
The needle in the haystack problem: spotting novel drug targets among redundant evidence.

Our solution? A time-series novelty metric for Open Targets Platform associations.

Thanks to Coté Falaguera & @opentargets.org partners for making this happen.
Out now in Nature Communications! 🧬🖥️

An Open Targets team developed a metric for the novelty of a target in the context of a disease, according to current available knowledge.

This allows drug discovery scientists to easily identify potentially novel targets

www.nature.com/articles/s41...
Temporal trends in evidence supporting novel drug target discovery - Nature Communications
Here the authors implement a comprehensive timestamping across millions of pieces of biomedical evidence supporting target–disease associations in the Open Targets Platform and analyse trends in evide...
www.nature.com
January 23, 2026 at 10:34 AM
Out now in Nature Communications! 🧬🖥️

An Open Targets team developed a metric for the novelty of a target in the context of a disease, according to current available knowledge.

This allows drug discovery scientists to easily identify potentially novel targets

www.nature.com/articles/s41...
Temporal trends in evidence supporting novel drug target discovery - Nature Communications
Here the authors implement a comprehensive timestamping across millions of pieces of biomedical evidence supporting target–disease associations in the Open Targets Platform and analyse trends in evide...
www.nature.com
January 22, 2026 at 11:30 AM
Out now! 🧬

Loss of CHD1 and MAP3K7 creates an acquired cancer vulnerability, highlighting these genes as potential biomarkers of immune checkpoint blockade response

Find out more: www.cell.com/cell-reports...
CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance
Immunotherapies only provide benefit for a subset of individuals with cancer, highlighting the need for biomarkers of response. Using whole-genome CRISPR-Cas9 screens, Watterson et al. map genetic dep...
www.cell.com
January 21, 2026 at 10:26 AM
Reposted by Open Targets
New biomarkers for cancer immunotherapy have been identified. 🔎

Researchers found that loss of two genes, CHD1 and MAP3K7, makes tumours more likely to respond to immunotherapy.

The findings could help support more personalised cancer treatment 👇

bit.ly/4sMBTq2
Immunotherapy success could be predicted with new biomarkers
Scientists pinpoint two cancer genes that when deleted, improve the vulnerability of tumour cells to immunotherapy.
bit.ly
January 20, 2026 at 4:35 PM
We're recruiting 3 roles through @sangerinstitute.bsky.social 👩‍🔬🧬💻

NEW:
➡ Postdoc with @carlanderson.bsky.social
➡ Technical Specialist with @bayraktarlab.bsky.social

ALSO:
➡ (Senior) Postdoc in Mo Lotfollahi’s lab

More information in the thread
See all available jobs: opentargets.org/jobs
Jobs - Open Targets
Open Targets is a public-private initiative to generate evidence on the validity of therapeutic targets based on genome-scale experiments and analysis.
opentargets.org
January 20, 2026 at 11:23 AM
Reposted by Open Targets
🚀 Announcing the Official @opentargets.org MCP!
We've partnered with @anthropic.com to give AI seamless access to high-quality genetic and target-discovery data. Open for the entire community to accelerate therapeutic development.
Read more at blog.opentargets.org/official-ope...
January 12, 2026 at 1:12 PM
Introducing the official Open Targets Platform Model Context Protocol 🧬🖥️

In partnership with @anthropic.com, we’ve created an MCP server making Open Targets Platform data accessible to AI-powered tools and agents

Try it out and watch out for future releases: mcp.platform.opentargets.org/mcp
January 12, 2026 at 12:26 PM
The Wellcome Genome Campus lit up for the holidays ✨

📸 Helena Cornu
December 18, 2025 at 2:22 PM
NEW: NLP data scientists/scientific data engineers at @ebi.embl.org

Develop a comprehensive open source side effect resource and standardised AI/ML training sets to improve early identification of safety liabilities

Apply by 11 January
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
NLP Data Scientist/Scientific Data Engineer
About the team/job Safety and toxicology concerns remain one of the most persistent challenges in drug discovery. This is an exciting opportunity to join a multi-disciplinary team on a project to deve...
embl.wd103.myworkdayjobs.com
December 11, 2025 at 1:44 PM
Open Targets Platform 25.12 is out now!

Thanks to a GWAS Catalog update including 3 major studies using UK Biobank data, we now have over 1.4 million GWAS credible sets in the Platform.

Discover the data, feature, and technical updates in this release: blog.opentargets.org/open-targets... 🧬🖥️
Open Targets Platform 25.12 has been released!
The latest release of the Platform, and our last one of the year — 25.12 — is now available at platform.opentargets.org. Key points * Following a GWAS Catalog update, this release contains over 1....
blog.opentargets.org
December 10, 2025 at 1:01 PM
NEW: multiple (senior) postdoctoral fellow roles in Mo Lotfollahi's group at @sangerinstitute.bsky.social

There are many research focus areas available, including Open Targets translational AI projects

Apply now: sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Postdoctoral Fellow- Computational Biology and Machine Learning
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
December 9, 2025 at 10:04 AM
#OnThisDay 10 years ago, we launched the Open Targets Platform! 🎂 🧬🖥️
December 8, 2025 at 10:21 AM
NEW: Technical Specialist @sangerinstitute.bsky.social

Perform large-scale phenotypic CRISPR screens on human iPSC-derived microglia to identify modifiers of immune dysfunction relating to neurodegeneration 🧬

Apply by 11 January: sanger.wd103.myworkdayjobs.com/en-US/Wellco...

#ScienceJobs
Technical Specialist -CRISPR Screening in Neurodegeneration
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
December 4, 2025 at 11:54 AM
Reposted by Open Targets
#Postdoc alert! We are looking for motivated individual with experience in computational systems biology to join our NetworkCommons initiative to benchmark and democratise network contextualisation methods across multiple applications. Deadline Dec 17th link here: tinyurl.com/yrrzxa94
Postdoctoral fellow - Petsalaki Group - NetworkCommons
Your group The Petsalaki, Saez-Rodriguez (EMBL-EBI) and Korcsmáros (Imperial College) groups develop cutting-edge computational and AI approaches to unravel cellular signalling and gene regulation fro...
tinyurl.com
November 26, 2025 at 5:05 PM
Reposted by Open Targets
Can we use #AI to revolutionise drug discovery?

Meet Lit-OTAR, a deep learning framework built by Europe PMC and @opentargets.org

It’s identified >48.5 million unique associations, accelerating the drug discovery process!

Read the thread for a paper summary👇

#AI4Science #BioNLP #DrugDiscovery
December 3, 2025 at 9:24 AM
NEW: Postdoc with @epetsalaki.bsky.social @juliosaezrod.bsky.social and Tamas Korcsmáros

Benchmark and integrate state-of-the-art network contextualisation methods, combining large-scale transcriptomics, proteomics, and single-cell data

Apply by 17 Dec

embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Postdoctoral fellow - Petsalaki Group - NetworkCommons
Your group The Petsalaki, Saez-Rodriguez (EMBL-EBI) and Korcsmáros (Imperial College) groups develop cutting-edge computational and AI approaches to unravel cellular signalling and gene regulation fro...
embl.wd103.myworkdayjobs.com
November 26, 2025 at 11:07 AM
The recently-announced Open Psychiatry Project is the first initiative to jointly analyse UK mental health research data

Findings from this project will be integrated into the Open Targets Platform to help identify and prioritise the most promising therapeutic targets.
November 24, 2025 at 11:14 AM
Reposted by Open Targets
Millions of people are affected by mental health conditions, yet progress in treatment has been slow.

The Open Psychiatry Project aims to change that with a secure platform linking genetic and clinical mental health data.

@cam.ac.uk @opentargets.org

www.ebi.ac.uk/about/news/a...
New data initiative accelerates discovery and personalised care for mental health conditions
EMBL-EBI receives UKRI Medical Research Council (MRC) and National Institute for Health and Care Research (NIHR) funding for enhancing and translating mental-health omics data into the Open Targets Pl...
www.ebi.ac.uk
November 24, 2025 at 10:22 AM
And that's the Open Targets Hackathon done! 🧬🖥️

Thank you to everyone who joined in person and online, and who contributed to make this event a success

Particular thanks to our sponsors: Gates Foundation, Google Cloud, and @thehyvenl.bsky.social 🎉
October 23, 2025 at 12:26 PM
Open Targets Hackathon Day 1!

Following our official kick off yesterday, there was some incredible energy and focus in the room

Thanks to our sponsors Gates Foundation, Google Cloud, and @thehyvenl.bsky.social for making this possible!
October 22, 2025 at 9:39 AM