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Open Targets
@opentargets.org
630 followers 38 following 190 posts
Public-private partnership using human genetics and genomics data for systematic drug target identification and prioritisation. http://blog.opentargets.org
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opentargets.org
The Wellcome Genome Campus lit up for the holidays ✨

📸 Helena Cornu
A brightly lit Christmas tree at night, with a building in the background. Pathways leading to the building are illuminated with lights dotted on each side.
December 18, 2025 at 2:22 PM
opentargets.org
NEW: NLP data scientists/scientific data engineers at @ebi.embl.org

Develop a comprehensive open source side effect resource and standardised AI/ML training sets to improve early identification of safety liabilities

Apply by 11 January
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
NLP Data Scientist/Scientific Data Engineer
About the team/job Safety and toxicology concerns remain one of the most persistent challenges in drug discovery. This is an exciting opportunity to join a multi-disciplinary team on a project to deve...
embl.wd103.myworkdayjobs.com
December 11, 2025 at 1:44 PM
opentargets.org
Open Targets Platform 25.12 is out now!

Thanks to a GWAS Catalog update including 3 major studies using UK Biobank data, we now have over 1.4 million GWAS credible sets in the Platform.

Discover the data, feature, and technical updates in this release: blog.opentargets.org/open-targets... 🧬🖥️
Open Targets Platform 25.12 has been released!
The latest release of the Platform, and our last one of the year — 25.12 — is now available at platform.opentargets.org. Key points * Following a GWAS Catalog update, this release contains over 1....
blog.opentargets.org
December 10, 2025 at 1:01 PM
opentargets.org
NEW: multiple (senior) postdoctoral fellow roles in Mo Lotfollahi's group at @sangerinstitute.bsky.social

There are many research focus areas available, including Open Targets translational AI projects

Apply now: sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Postdoctoral Fellow- Computational Biology and Machine Learning
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
December 9, 2025 at 10:04 AM
opentargets.org
#OnThisDay 10 years ago, we launched the Open Targets Platform! 🎂 🧬🖥️
Graphic with a 10 surrounded by fireworks and the Open Targets Platform logo
December 8, 2025 at 10:21 AM
opentargets.org
NEW: Technical Specialist @sangerinstitute.bsky.social

Perform large-scale phenotypic CRISPR screens on human iPSC-derived microglia to identify modifiers of immune dysfunction relating to neurodegeneration 🧬

Apply by 11 January: sanger.wd103.myworkdayjobs.com/en-US/Wellco...

#ScienceJobs
Technical Specialist -CRISPR Screening in Neurodegeneration
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
December 4, 2025 at 11:54 AM
Reposted by Open Targets
epetsalaki.bsky.social
#Postdoc alert! We are looking for motivated individual with experience in computational systems biology to join our NetworkCommons initiative to benchmark and democratise network contextualisation methods across multiple applications. Deadline Dec 17th link here: tinyurl.com/yrrzxa94
Postdoctoral fellow - Petsalaki Group - NetworkCommons
Your group The Petsalaki, Saez-Rodriguez (EMBL-EBI) and Korcsmáros (Imperial College) groups develop cutting-edge computational and AI approaches to unravel cellular signalling and gene regulation fro...
tinyurl.com
November 26, 2025 at 5:05 PM
Reposted by Open Targets
handle.invalid
Can we use #AI to revolutionise drug discovery?

Meet Lit-OTAR, a deep learning framework built by Europe PMC and @opentargets.org

It’s identified >48.5 million unique associations, accelerating the drug discovery process!

Read the thread for a paper summary👇

#AI4Science #BioNLP #DrugDiscovery
December 3, 2025 at 9:24 AM
opentargets.org
NEW: Postdoc with @epetsalaki.bsky.social @juliosaezrod.bsky.social and Tamas Korcsmáros

Benchmark and integrate state-of-the-art network contextualisation methods, combining large-scale transcriptomics, proteomics, and single-cell data

Apply by 17 Dec

embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Postdoctoral fellow - Petsalaki Group - NetworkCommons
Your group The Petsalaki, Saez-Rodriguez (EMBL-EBI) and Korcsmáros (Imperial College) groups develop cutting-edge computational and AI approaches to unravel cellular signalling and gene regulation fro...
embl.wd103.myworkdayjobs.com
November 26, 2025 at 11:07 AM
opentargets.org
The recently-announced Open Psychiatry Project is the first initiative to jointly analyse UK mental health research data

Findings from this project will be integrated into the Open Targets Platform to help identify and prioritise the most promising therapeutic targets.
Quote accompanying a photo of Ellen McDonagh, Open Targets Translational Informatics Director and EMBL-EBI co-lead for the Open Psychiatry Project: The Open Psychiatry Project will translate the power of omics data into identifying potential new treatments for mental health conditions. This is the first major initiative to bring together mental health data for multiple stakeholders in an accessible way, and analysing this information collectively is a key step towards finding new targets for drug development.
November 24, 2025 at 11:14 AM
Reposted by Open Targets
ebi.embl.org
Millions of people are affected by mental health conditions, yet progress in treatment has been slow.

The Open Psychiatry Project aims to change that with a secure platform linking genetic and clinical mental health data.

@cam.ac.uk @opentargets.org

www.ebi.ac.uk/about/news/a...
New data initiative accelerates discovery and personalised care for mental health conditions
EMBL-EBI receives UKRI Medical Research Council (MRC) and National Institute for Health and Care Research (NIHR) funding for enhancing and translating mental-health omics data into the Open Targets Pl...
www.ebi.ac.uk
November 24, 2025 at 10:22 AM
opentargets.org
And that's the Open Targets Hackathon done! 🧬🖥️

Thank you to everyone who joined in person and online, and who contributed to make this event a success

Particular thanks to our sponsors: Gates Foundation, Google Cloud, and @thehyvenl.bsky.social 🎉
A large group of people sat on steps in a building, smiling at the camera. The front row is holding bunting with the Open Targets logo.
October 23, 2025 at 12:26 PM
opentargets.org
Open Targets Hackathon Day 1!

Following our official kick off yesterday, there was some incredible energy and focus in the room

Thanks to our sponsors Gates Foundation, Google Cloud, and @thehyvenl.bsky.social for making this possible!
People are sat in groups, working at laptops arranged. They are engaged in individual and small group work. The room looks busy, with whiteboards covered in writing along the back wall. In a busy meeting room, participants are seated at white tables working on laptops, working independently or in groups. Three people are engaged in conversation while looking at a whiteboard covered with diagrams and notes. A blue banner or bunting is visible above.
October 22, 2025 at 9:39 AM
opentargets.org
The Open Targets Hackathon is today! 🎉

We're super excited to kick off this event celebrating 10 years of the Open Targets Platform

Thank you to Google Cloud for sponsoring our compute and Hariprasad Radhakrishnan for mentoring our teams and sharing this video — made with Google Veo 3! 🖥️🧬
October 21, 2025 at 11:24 AM
opentargets.org
At #ASHG25 and want to find out more about the largest and most comprehensive systematic analysis of common variation in humans?

Go find Daniel at poster board 1014T!
A man stands beside a poster board labelled 1014
October 16, 2025 at 2:50 PM
opentargets.org
We're at #ASHG2025!

Come say hello and find out more about Open Targets projects 👋
Find us at ASHG 2025. The graphic lists speakers in the Featured Symposium, beyond transcriptomics: can imaging bridge the gap in variant interpretation, and poster presenters. The two speakers are Gosia Trynka and Helena Kilpinen. The four poster presenters are: Catherine Sutherland, Haerin Jang, Annalisa Buniello, and Daniel Considine. Four Open
October 14, 2025 at 9:44 AM
opentargets.org
CLOSING: Postdoc in @francescoiorio.bsky.social's lab at @humantechnopole.bsky.social

Apply through LinkedIn by 5 October: www.linkedin.com/jobs/view/43...

#scienceJobs #AcademicSky #postdocJobs
Closing job ad for a postdoc in CRISPR meta-analytics and AI, from Open Targets and the Human Technopole. The role is in the Iorio Lab, salary up to 40k euros, apply by 5 October. The description reads: The Perturbation Catalogue project aims to create an online repository of data from post-perturbational experiments. You will focus on a meta-analytics project, developing computational methods for the reproducibility assessment, harmonisation and analysis or inter-study CRISPR datasets, aggregating data and developing and using innovative AI-based methods for therapeutic target prioritisation pipelines.
October 3, 2025 at 9:54 AM
opentargets.org
Out now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type!

An Open Targets team led by Krista Freimann and @kauralasoo.bsky.social analysed 3,734 lymphoblastoid cell line samples across nine cohorts, identifying four robust loci

www.nature.com/articles/s41...
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus - Nature Communications | Open Targets
Out now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type! An Open Targets team led by Krista Freimann and Kaur Alasoo analysed 3,734 lymphoblastoid cell line samples across...
www.linkedin.com
October 2, 2025 at 11:59 AM
opentargets.org
CLOSING:

➡️ Senior Bioinformatician with Roser Vento Tormo
sanger.wd103.myworkdayjobs.com/en-US/Wellco...

➡️ Technical Specialist (neuro) with Omer Ali Bayraktar
sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Both @sangerinstitute.bsky.social roles close on 2 October
Technical Specialist: Neurodegenerative Disease Spatial Transcriptomics and Data Generation
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
September 25, 2025 at 9:27 AM
Reposted by Open Targets
jengreitz.bsky.social
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:

The E2G Portal! e2g.stanford.edu

This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.

Uses cases 👇

1/
September 18, 2025 at 4:14 PM
opentargets.org
The Open Targets Platform autumn release is out! 🍂

We have ingested the full dataset of over 13 million enhancer-gene regulatory interactions in the human genome across 1,458 DNase-seq experiments covering 369 cell types and tissues from the ENCODE-rE2G model

blog.opentargets.org/open-targets...
Open Targets Platform 25.09 has been released!
The September 25 release includes enhancer-gene data predicted by ENCODE-rE2G, molQTL credible sets for targets, new options for the variant structural viewer, and a number of data updates from GWAS C...
blog.opentargets.org
September 18, 2025 at 10:39 AM
Reposted by Open Targets
gwascatalog.bsky.social
🚩1 MILLION curated associations!!! 🚩
Launched in 2008, took us 15 years to reach 500K, and thanks to your research and collaboration, we doubled the number in less than 3 years!
See some data insights tinyurl.com/mw53njbb
#OpenAccess
September 16, 2025 at 1:12 PM
opentargets.org
Last call to submit a project for the Open Targets Hackathon!

Submit a project by 12 September: docs.google.com/forms/d/e/1F...

We will prioritise projects where the project leads have signed up to attend the hackathon. Registrations are currently full but you can sign up to the waiting list
Open Targets Hackathon: one week left to submit a project
September 4, 2025 at 10:54 AM
opentargets.org
Out now on bioRxiv! 🧬🖥️

A team from the Cowley, Bassett, and @gosiatrynka.bsky.social labs integrate pooled iPSC phenotyping, transcriptomics, and CRISPR perturbations to identify genetic drivers of molecular and cellular phenotypes in microglia

www.biorxiv.org/content/10.1...
#neuroskyence
Integrated QTL mapping and CRISPR screening in pooled iPSC-derived microglia reveals genetic drivers of neurodegenerative risk
Mounting evidence implicates microglia in neurodegeneration, but linking disease-associated genetic variants to target genes and cellular phenotypes is hindered by the inaccessibility of these cells. ...
www.biorxiv.org
August 26, 2025 at 10:16 AM
opentargets.org
Out now! 🧬

Lewis Evans and the team at @sangerinstitute.bsky.social and UCL define the pathways for tau entry into human neurons, a key mechanism for the progression of tauopathies associated with Parkinson’s and Alzheimer’s disease

www.embopress.org/doi/full/10....

#neuroscience #neuroskyence
Tau uptake by human neurons depends on receptor LRP1 and kinase LRRK2 | The EMBO Journal
imageimageNeuronal uptake of extracellular tau protein is thought to propagate intracellular protein aggregation between neurons, contributing to the pathogenesis of Alzheimer’s and other neurodegener...
www.embopress.org
August 19, 2025 at 10:31 AM