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opentargets.org
Open Targets
@opentargets.org
610 followers 38 following 180 posts
Public-private partnership using human genetics and genomics data for systematic drug target identification and prioritisation. http://blog.opentargets.org
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opentargets.org
And that's the Open Targets Hackathon done! 🧬🖥️

Thank you to everyone who joined in person and online, and who contributed to make this event a success

Particular thanks to our sponsors: Gates Foundation, Google Cloud, and @thehyvenl.bsky.social 🎉
A large group of people sat on steps in a building, smiling at the camera. The front row is holding bunting with the Open Targets logo.
October 23, 2025 at 12:26 PM
opentargets.org
Open Targets Hackathon Day 1!

Following our official kick off yesterday, there was some incredible energy and focus in the room

Thanks to our sponsors Gates Foundation, Google Cloud, and @thehyvenl.bsky.social for making this possible!
People are sat in groups, working at laptops arranged. They are engaged in individual and small group work. The room looks busy, with whiteboards covered in writing along the back wall. In a busy meeting room, participants are seated at white tables working on laptops, working independently or in groups. Three people are engaged in conversation while looking at a whiteboard covered with diagrams and notes. A blue banner or bunting is visible above.
October 22, 2025 at 9:39 AM
opentargets.org
The Open Targets Hackathon is today! 🎉

We're super excited to kick off this event celebrating 10 years of the Open Targets Platform

Thank you to Google Cloud for sponsoring our compute and Hariprasad Radhakrishnan for mentoring our teams and sharing this video — made with Google Veo 3! 🖥️🧬
October 21, 2025 at 11:24 AM
opentargets.org
At #ASHG25 and want to find out more about the largest and most comprehensive systematic analysis of common variation in humans?

Go find Daniel at poster board 1014T!
A man stands beside a poster board labelled 1014
October 16, 2025 at 2:50 PM
opentargets.org
We're at #ASHG2025!

Come say hello and find out more about Open Targets projects 👋
Find us at ASHG 2025. The graphic lists speakers in the Featured Symposium, beyond transcriptomics: can imaging bridge the gap in variant interpretation, and poster presenters. The two speakers are Gosia Trynka and Helena Kilpinen. The four poster presenters are: Catherine Sutherland, Haerin Jang, Annalisa Buniello, and Daniel Considine. Four Open
October 14, 2025 at 9:44 AM
opentargets.org
CLOSING: Postdoc in @francescoiorio.bsky.social's lab at @humantechnopole.bsky.social

Apply through LinkedIn by 5 October: www.linkedin.com/jobs/view/43...

#scienceJobs #AcademicSky #postdocJobs
Closing job ad for a postdoc in CRISPR meta-analytics and AI, from Open Targets and the Human Technopole. The role is in the Iorio Lab, salary up to 40k euros, apply by 5 October. The description reads: The Perturbation Catalogue project aims to create an online repository of data from post-perturbational experiments. You will focus on a meta-analytics project, developing computational methods for the reproducibility assessment, harmonisation and analysis or inter-study CRISPR datasets, aggregating data and developing and using innovative AI-based methods for therapeutic target prioritisation pipelines.
October 3, 2025 at 9:54 AM
opentargets.org
Out now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type!

An Open Targets team led by Krista Freimann and @kauralasoo.bsky.social analysed 3,734 lymphoblastoid cell line samples across nine cohorts, identifying four robust loci

www.nature.com/articles/s41...
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus - Nature Communications | Open Targets
Out now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type! An Open Targets team led by Krista Freimann and Kaur Alasoo analysed 3,734 lymphoblastoid cell line samples across...
www.linkedin.com
October 2, 2025 at 11:59 AM
opentargets.org
CLOSING:

➡️ Senior Bioinformatician with Roser Vento Tormo
sanger.wd103.myworkdayjobs.com/en-US/Wellco...

➡️ Technical Specialist (neuro) with Omer Ali Bayraktar
sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Both @sangerinstitute.bsky.social roles close on 2 October
Technical Specialist: Neurodegenerative Disease Spatial Transcriptomics and Data Generation
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
September 25, 2025 at 9:27 AM
Reposted by Open Targets
jengreitz.bsky.social
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:

The E2G Portal! e2g.stanford.edu

This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.

Uses cases 👇

1/
September 18, 2025 at 4:14 PM
opentargets.org
The Open Targets Platform autumn release is out! 🍂

We have ingested the full dataset of over 13 million enhancer-gene regulatory interactions in the human genome across 1,458 DNase-seq experiments covering 369 cell types and tissues from the ENCODE-rE2G model

blog.opentargets.org/open-targets...
Open Targets Platform 25.09 has been released!
The September 25 release includes enhancer-gene data predicted by ENCODE-rE2G, molQTL credible sets for targets, new options for the variant structural viewer, and a number of data updates from GWAS C...
blog.opentargets.org
September 18, 2025 at 10:39 AM
Reposted by Open Targets
gwascatalog.bsky.social
🚩1 MILLION curated associations!!! 🚩
Launched in 2008, took us 15 years to reach 500K, and thanks to your research and collaboration, we doubled the number in less than 3 years!
See some data insights tinyurl.com/mw53njbb
#OpenAccess
September 16, 2025 at 1:12 PM
opentargets.org
Last call to submit a project for the Open Targets Hackathon!

Submit a project by 12 September: docs.google.com/forms/d/e/1F...

We will prioritise projects where the project leads have signed up to attend the hackathon. Registrations are currently full but you can sign up to the waiting list
Open Targets Hackathon: one week left to submit a project
September 4, 2025 at 10:54 AM
opentargets.org
Out now on bioRxiv! 🧬🖥️

A team from the Cowley, Bassett, and @gosiatrynka.bsky.social labs integrate pooled iPSC phenotyping, transcriptomics, and CRISPR perturbations to identify genetic drivers of molecular and cellular phenotypes in microglia

www.biorxiv.org/content/10.1...
#neuroskyence
Integrated QTL mapping and CRISPR screening in pooled iPSC-derived microglia reveals genetic drivers of neurodegenerative risk
Mounting evidence implicates microglia in neurodegeneration, but linking disease-associated genetic variants to target genes and cellular phenotypes is hindered by the inaccessibility of these cells. ...
www.biorxiv.org
August 26, 2025 at 10:16 AM
opentargets.org
Out now! 🧬

Lewis Evans and the team at @sangerinstitute.bsky.social and UCL define the pathways for tau entry into human neurons, a key mechanism for the progression of tauopathies associated with Parkinson’s and Alzheimer’s disease

www.embopress.org/doi/full/10....

#neuroscience #neuroskyence
Tau uptake by human neurons depends on receptor LRP1 and kinase LRRK2 | The EMBO Journal
imageimageNeuronal uptake of extracellular tau protein is thought to propagate intracellular protein aggregation between neurons, contributing to the pathogenesis of Alzheimer’s and other neurodegener...
www.embopress.org
August 19, 2025 at 10:31 AM
opentargets.org
CLOSING: Front end developer for the Open Targets Platform

Join @carcruz.dev's team and help us turn complex data into powerful discovery tools, working closely with our industry and academic partners

Apply by 19 August

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

#ReactJobs #DevJobs
Front-End Web Developer
We are looking for an exceptional Web Developer to join Open Targets at EMBL-EBI. Join Open Targets at EMBL-EBI as a Web Developer and help transform vast biomedical data into insights that drive safe...
embl.wd103.myworkdayjobs.com
August 12, 2025 at 10:09 AM
opentargets.org
NEW: Front-End Web Dev @ebi.embl.org

Join the Open Targets Platform team!

Design and build this cloud-first, open-source application, used to explore and prioritise potential drug targets

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
Front-End Web Developer
We are looking for an exceptional Web Developer to join Open Targets at EMBL-EBI. Join Open Targets at EMBL-EBI as a Web Developer and help transform vast biomedical data into insights that drive safe...
embl.wd103.myworkdayjobs.com
August 7, 2025 at 9:59 AM
opentargets.org
“It’s been a very collaborative experience.”

@malloryfreeberg.bsky.social talks to us about developing the Perturbation Catalogue

The beta version is available to explore now, and the team are keen to hear your feedback!
www.ebi.ac.uk/perturbation...

blog.opentargets.org/creating-a-p...
Why Mallory Freeberg is creating a perturbation catalogue
The Perturbation Catalogue is an Open Targets project which aims to bring genetic perturbation data into one curated, harmonised, and discoverable platform. Mallory Freeberg, one of the project leads,...
blog.opentargets.org
August 5, 2025 at 11:54 AM
opentargets.org
Google Cloud is sponsoring the compute for the Open Targets hackathon!

There is now a waiting list to attend the event in person, but project submissions and online registrations are still open.

The two-day hackathon will explore data, analyses, and tools for target discovery
Text reads: Open Targets hackathon, 21-22 October 2025, compute sponsored by Google Cloud
July 31, 2025 at 9:09 AM
opentargets.org
Meet Carlos Cruz! Carlos joined the Open Targets Platform team in 2021 🖥️🧬

@carcruz.dev, what is your role in Open Targets?
Carlos Cruz smiles at the camera from a bridge over a small river in a European town on a cloudy day.
July 29, 2025 at 9:46 AM
opentargets.org
We're proud to play our part in diversifying genetic and genomic datasets by supporting this important work in Latin America co-led by Open Targets Science Director @gosiatrynka.bsky.social

Greater genetic diversity improves discovery and brings us closer to better, more inclusive medicines
July 28, 2025 at 8:39 AM
Reposted by Open Targets
malloryfreeberg.bsky.social
🧬 New @emblebi.bsky.social service beta launched:
Perturbation Catalogue

🔎 Browse genetic perturbation datasets
🧠 Train models
🧬 Interpret variant function
🧭 Explore gene dependencies

Search, test APIs, suggest datasets, send feedback!
🔗 www.ebi.ac.uk/perturbation...

Funded by @opentargets.org
July 23, 2025 at 10:06 AM
opentargets.org
We have now deprecated Open Targets Genetics — it has been superseded by the Open Targets Platform

The team said goodbye to Open Targets Genetics, through the medium of memes

Enjoy!
Meme: Jeremy Clarkson and Richard Hammond comparing two cars. In the first image, Jeremy points to one labelled "Open Targets Genetics" saying, This is brilliant. In the second image, he points to another labelled "Merged Open Targets Platform" saying, "But I like this".
July 10, 2025 at 9:17 AM
Reposted by Open Targets
europepmc.org
Open licenses power discovery!

Melissa Harrison shares a @opentargets.org use case:

Open Targets identifies and prioritises drug targets using AI to extract gene, drug, and disease mentions and relationships to building drug development evidence

#ChooseOpenWebinar for updates 💡
#MedLib #PhDsky
July 9, 2025 at 4:16 PM
opentargets.org
Open Targets Genetics has now been deprecated

It has been superseded by the Open Targets Platform
Comic with four squares. Death, a skull in a black cloak, carrying a scythe, takes Open Targets Genetics by the hand, saying "It's time to go". Open Targets Genetics asks, "Was I a good platform?", and Death says "yes. They leave together, side by side.
July 9, 2025 at 1:25 PM
Reposted by Open Targets
bradleyomics.bsky.social
Delighted to share the first preprint of my postdoc in the @carlanderson.bsky.social lab www.medrxiv.org/content/10.1...! 🚨 A super exciting study I co-led with the very talented @tobioinformatics.bsky.social . Stay tuned to see what we learned about genetic susceptibility to complex disease. 🧬🧵 1/
Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk
Most genetic variants associated with complex diseases lie in non-coding regions, complicating efforts to identify effector genes and relevant cell types. Here, we map cis-eQTLs across 2.2 million sin...
www.medrxiv.org
July 8, 2025 at 8:51 AM