Brian Beliveau
@oligopain.bsky.social
PI @ UW Genome Sciences | chromosome biology | 3D genome | chromatin | single cell & spatial biology
We develop technologies to study genomes and the things that are made from them. Avid FISHer.
beliveau.io
We develop technologies to study genomes and the things that are made from them. Avid FISHer.
beliveau.io
Reposted by Brian Beliveau
🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇
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July 7, 2025 at 2:44 AM
🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇
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Reposted by Brian Beliveau
This @zohrankmamdani.bsky.social video is absolutely INCREDIBLE. The numbers he cites, the strategy and results they produced — it’s the future. When have you heard *any* campaign talk about this, ever? (Video split in 2 to fit in Bluesky’s limits)
July 1, 2025 at 4:45 PM
This @zohrankmamdani.bsky.social video is absolutely INCREDIBLE. The numbers he cites, the strategy and results they produced — it’s the future. When have you heard *any* campaign talk about this, ever? (Video split in 2 to fit in Bluesky’s limits)
Reposted by Brian Beliveau
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
June 30, 2025 at 9:15 PM
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
Reposted by Brian Beliveau
Jay, please stop gaslighting early career researchers.
June 20, 2025 at 11:51 AM
Jay, please stop gaslighting early career researchers.
Reposted by Brian Beliveau
Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cell–cell adhesion.
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
www.biorxiv.org
June 16, 2025 at 11:50 AM
Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cell–cell adhesion.
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
Reposted by Brian Beliveau
Today, my NIH colleagues and I did something scary but really important. We spoke up about egregious harms we are seeing happen to research participants and public health through thoughtless and politicized policies at NIH. 🧵1/3
apnews.com/article/nih-...
apnews.com/article/nih-...
June 10, 2025 at 4:10 AM
Today, my NIH colleagues and I did something scary but really important. We spoke up about egregious harms we are seeing happen to research participants and public health through thoughtless and politicized policies at NIH. 🧵1/3
apnews.com/article/nih-...
apnews.com/article/nih-...
Reposted by Brian Beliveau
. @pnas.org just published the final version of our manuscript on how generation time and effective population size interact to shape vertebrate germline mutation rates, led by Luke Zhu and Annabel Beichman: www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
May 21, 2025 at 7:33 PM
. @pnas.org just published the final version of our manuscript on how generation time and effective population size interact to shape vertebrate germline mutation rates, led by Luke Zhu and Annabel Beichman: www.pnas.org/doi/10.1073/...
Reposted by Brian Beliveau
The fantastically successful NIGMS MIRA R35 "expired" on May 17, after the most recent deadline--these removals are the most aggressive attack on American science in the current series of devastating actions 🧪
NIH moved up the expiration date for some funding opportunities, effectively *canceling* the next application date without removing it from the standard table. I can't even imagine how many people are still prepping these grants.
👀 List of impacted opportunities:
grants.nih.gov/grants/guide...
👀 List of impacted opportunities:
grants.nih.gov/grants/guide...
May 20, 2025 at 11:18 PM
The fantastically successful NIGMS MIRA R35 "expired" on May 17, after the most recent deadline--these removals are the most aggressive attack on American science in the current series of devastating actions 🧪
Reposted by Brian Beliveau
🤩
And this is why hate will never win.
And this is why hate will never win.
Letter from a girl in Maine who finished second to a trans athlete in Cross country. I've always thought cross country kids are the best sports athletes.
H/t: Craig Calcaterra
H/t: Craig Calcaterra
May 17, 2025 at 5:11 AM
🤩
And this is why hate will never win.
And this is why hate will never win.
Reposted by Brian Beliveau
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
May 13, 2025 at 11:37 PM
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
Reposted by Brian Beliveau
With NIH director Jayanta Bhattacharya dismissing my reporting as "false" and "spreading rumors" hours before releasing a policy that confirmed said "rumors," I feel compelled to respond.
Here's an inside look into how this story was reported. It was a weird one. 🧵
www.nature.com/articles/d41...
Here's an inside look into how this story was reported. It was a weird one. 🧵
www.nature.com/articles/d41...
May 6, 2025 at 12:15 PM
With NIH director Jayanta Bhattacharya dismissing my reporting as "false" and "spreading rumors" hours before releasing a policy that confirmed said "rumors," I feel compelled to respond.
Here's an inside look into how this story was reported. It was a weird one. 🧵
www.nature.com/articles/d41...
Here's an inside look into how this story was reported. It was a weird one. 🧵
www.nature.com/articles/d41...
Reposted by Brian Beliveau
As a follow-up to the Kaiser interview, here is my exchange with Dr. Bhattacharya starting Sunday evening...
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May 6, 2025 at 12:33 PM
As a follow-up to the Kaiser interview, here is my exchange with Dr. Bhattacharya starting Sunday evening...
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Reposted by Brian Beliveau
THIS is what NIH funding means for real people, and why we can't lose it.
I sat down with Emily & her daughter Charlie to discuss how NIH-funded clinical trials at Seattle Children's led to a cure for Charlie's cancer.
This is why we have to speak up, this is who we're fighting for.
I sat down with Emily & her daughter Charlie to discuss how NIH-funded clinical trials at Seattle Children's led to a cure for Charlie's cancer.
This is why we have to speak up, this is who we're fighting for.
May 5, 2025 at 9:05 PM
THIS is what NIH funding means for real people, and why we can't lose it.
I sat down with Emily & her daughter Charlie to discuss how NIH-funded clinical trials at Seattle Children's led to a cure for Charlie's cancer.
This is why we have to speak up, this is who we're fighting for.
I sat down with Emily & her daughter Charlie to discuss how NIH-funded clinical trials at Seattle Children's led to a cure for Charlie's cancer.
This is why we have to speak up, this is who we're fighting for.
Reposted by Brian Beliveau
Hi, everyone! My name is Alex. I'm a microbiologist/cell biologist/biochemist, and I'm sharing some of my career biography today for #YoungScientistNetworking.
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April 24, 2025 at 4:41 PM
Hi, everyone! My name is Alex. I'm a microbiologist/cell biologist/biochemist, and I'm sharing some of my career biography today for #YoungScientistNetworking.
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Reposted by Brian Beliveau
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
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Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
the word alert is in a purple circle
ALT: the word alert is in a purple circle
media.tenor.com
April 23, 2025 at 6:03 PM
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Reposted by Brian Beliveau
Reposted by Brian Beliveau
Seattle protests.
April 5, 2025 at 7:14 PM
Seattle protests.
Reposted by Brian Beliveau
New lawsuit filed today in Massachusetts aginst NIH from many state Attorneys General
First, plaintiffs seek relief for the unreasonable and intentional delays currently plaguing the grant-application process
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First, plaintiffs seek relief for the unreasonable and intentional delays currently plaguing the grant-application process
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April 4, 2025 at 4:33 PM
New lawsuit filed today in Massachusetts aginst NIH from many state Attorneys General
First, plaintiffs seek relief for the unreasonable and intentional delays currently plaguing the grant-application process
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First, plaintiffs seek relief for the unreasonable and intentional delays currently plaguing the grant-application process
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Reposted by Brian Beliveau
Excited to see CellCycleNet featured by @LSAjournal! CellCycleNet is a new 3D deep learning model that enables cell cycle staging using only a nuclear stain (DAPI), achieving 95% classification accuracy @oligopain.bsky.social @uwgenome.bsky.social
www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/8/6/...
April 4, 2025 at 6:32 PM
Excited to see CellCycleNet featured by @LSAjournal! CellCycleNet is a new 3D deep learning model that enables cell cycle staging using only a nuclear stain (DAPI), achieving 95% classification accuracy @oligopain.bsky.social @uwgenome.bsky.social
www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/8/6/...
Reposted by Brian Beliveau
Director of the Nat'l Institute of Child Health and Human Development (NICHD) was summarily dismissed yesterday. So here's your reminder that birth defects kill twice as many American kids as cancer. But there is no St. Jude's for birth defects. Only the NICHD.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
‘One of the darkest days’: NIH purges agency leadership amid mass layoffs
In shock move, four institute directors at the US biomedical agency are removed from their posts.
www.nature.com
April 2, 2025 at 3:38 PM
Director of the Nat'l Institute of Child Health and Human Development (NICHD) was summarily dismissed yesterday. So here's your reminder that birth defects kill twice as many American kids as cancer. But there is no St. Jude's for birth defects. Only the NICHD.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Brian Beliveau
BREAKING: We're suing the National Institutes of Health over their politically-motivated purge of research grants.
This is an unlawful attack on scientific progress that puts lives at risk.
This is an unlawful attack on scientific progress that puts lives at risk.
April 2, 2025 at 8:03 PM
BREAKING: We're suing the National Institutes of Health over their politically-motivated purge of research grants.
This is an unlawful attack on scientific progress that puts lives at risk.
This is an unlawful attack on scientific progress that puts lives at risk.
Reposted by Brian Beliveau
If the goal was to decimate U.S. leadership in biomedical innovation & fire scientists developing cutting-edge treatments—the Trump Administration is succeeding.
Trump & Elon are setting America back decades, undercutting research to discover lifesaving cures.
It's inexcusable.
Trump & Elon are setting America back decades, undercutting research to discover lifesaving cures.
It's inexcusable.
NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...
Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH
Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration's latest firing blitz.
www.wired.com
April 2, 2025 at 5:47 PM
If the goal was to decimate U.S. leadership in biomedical innovation & fire scientists developing cutting-edge treatments—the Trump Administration is succeeding.
Trump & Elon are setting America back decades, undercutting research to discover lifesaving cures.
It's inexcusable.
Trump & Elon are setting America back decades, undercutting research to discover lifesaving cures.
It's inexcusable.
Reposted by Brian Beliveau
Dr. Richard Youle was fired today. He is an eminent scientist who has done important work on brain diseases like dementia and Parkinson’s.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...
Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH
Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration's latest firing blitz.
www.wired.com
April 2, 2025 at 12:28 AM
Dr. Richard Youle was fired today. He is an eminent scientist who has done important work on brain diseases like dementia and Parkinson’s.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.