Nicole Krentz 🇨🇦
@nkrentz.bsky.social
Diabetes researcher at the University of British Columbia
Hey Mom, wanna do something spontaneous?
December 6, 2025 at 7:17 PM
Hey Mom, wanna do something spontaneous?
Reposted by Nicole Krentz 🇨🇦
🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.
November 17, 2025 at 11:26 PM
🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.
Reposted by Nicole Krentz 🇨🇦
CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta.
youtu.be/UlHn_1Fz3ck?...
youtu.be/UlHn_1Fz3ck?...
#1 Islets in a Pod with Dr. Patrick MacDonald
YouTube video by CIRTN-R2FIC
youtu.be
November 25, 2025 at 4:01 PM
CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta.
youtu.be/UlHn_1Fz3ck?...
youtu.be/UlHn_1Fz3ck?...
Reposted by Nicole Krentz 🇨🇦
Apply for the 'Dr. Connie Eaves Chair in Cancer Cell Research' at UBC. Come join the dynamic research community in Vancouver 🇨🇦!
Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research
Academic Job Category Faculty Bargaining Job Title Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research Department School of Biomedical Engineering | ...
ubc.wd10.myworkdayjobs.com
November 18, 2025 at 11:52 PM
Apply for the 'Dr. Connie Eaves Chair in Cancer Cell Research' at UBC. Come join the dynamic research community in Vancouver 🇨🇦!
Reposted by Nicole Krentz 🇨🇦
Very proud to see the main thesis work of the intrepid Dr. Mohammad Pourhosseinzadeh come out in @pnas.org today! In this paper, Mohammad assesses how crosstalk between insulin-secreting beta and somatostatin-secreting delta cells in the islet actually happens, in near real-time. A quick thread 1/10
September 16, 2025 at 9:21 PM
Very proud to see the main thesis work of the intrepid Dr. Mohammad Pourhosseinzadeh come out in @pnas.org today! In this paper, Mohammad assesses how crosstalk between insulin-secreting beta and somatostatin-secreting delta cells in the islet actually happens, in near real-time. A quick thread 1/10
Reposted by Nicole Krentz 🇨🇦
Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes.
Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.
Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.
September 12, 2025 at 9:12 PM
Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes.
Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.
Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.
Reposted by Nicole Krentz 🇨🇦
Our department at The University of British Columbia in Vancouver (Canada) is running two faculty searches. One is a joint hire with the Institute for Healthy Aging, one a cohire with the Math Dept cps.med.ubc.ca/careers-2/ Click on “Faculty Positions” on the page. Please help spread the word!
Careers | Department of Cellular & Physiological Sciences
cps.med.ubc.ca
July 30, 2025 at 5:11 PM
Our department at The University of British Columbia in Vancouver (Canada) is running two faculty searches. One is a joint hire with the Institute for Healthy Aging, one a cohire with the Math Dept cps.med.ubc.ca/careers-2/ Click on “Faculty Positions” on the page. Please help spread the word!
Reposted by Nicole Krentz 🇨🇦
Official posting coming soon, but here's a heads-up:
#Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome!
www.bcell.org
#Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome!
www.bcell.org
July 24, 2025 at 10:00 PM
Official posting coming soon, but here's a heads-up:
#Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome!
www.bcell.org
#Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome!
www.bcell.org
Reposted by Nicole Krentz 🇨🇦
Bringing this thread back since this paper is currently featured as the Endocrinology Article of the Week! 🎉This paper was the result of years of hard work during my PhD and it wouldn't have been possible without the excellent mentorship from Francis and the collaborative efforts of all co-authors.
Thrilled to share our latest work, which was the outstanding doctoral work of @samanthajsyoon.bsky.social academic.oup.com/endo/advance... 1/12
NPAS4 depletion in POMC neurons protects from obesity and alters the feeding-regulated transcriptome in male mice
Abstract. Immediate Early Genes (IEGs), such as Neuronal PAS domain protein 4 (Npas4), are induced as part of the response to environmental stimuli. In the
academic.oup.com
July 15, 2025 at 6:08 PM
Bringing this thread back since this paper is currently featured as the Endocrinology Article of the Week! 🎉This paper was the result of years of hard work during my PhD and it wouldn't have been possible without the excellent mentorship from Francis and the collaborative efforts of all co-authors.
Reposted by Nicole Krentz 🇨🇦
We are launching a new initiative to support experimental design, data management/analysis and bioinformatics. Early days yet, but check it out here.
www.bcell.org/adi-datasci....
www.bcell.org/adi-datasci....
July 8, 2025 at 10:01 PM
We are launching a new initiative to support experimental design, data management/analysis and bioinformatics. Early days yet, but check it out here.
www.bcell.org/adi-datasci....
www.bcell.org/adi-datasci....
Reposted by Nicole Krentz 🇨🇦
Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...
research.ubc.ca
July 7, 2025 at 8:07 PM
Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...
It was a pleasure to be able to contribute to this paper on a novel cause of transient neonatal diabetes. Check it out👇🏻
Really proud of this Exeter–Stanford collaboration identifying bi-allelic variants in PAX4 as a novel cause of transient neonatal diabetes—the first new genetic cause of this subtype described in over a decade. This work expands our understanding of beta cell development.
🔗 doi.org/10.1016/j.mo...
🔗 doi.org/10.1016/j.mo...
Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans
Gene discovery studies in individuals with diabetes diagnosed within 6 months of life (neonatal diabetes, NDM) can provide unique insights into the de…
www.sciencedirect.com
July 3, 2025 at 3:31 PM
It was a pleasure to be able to contribute to this paper on a novel cause of transient neonatal diabetes. Check it out👇🏻
Reposted by Nicole Krentz 🇨🇦
Homozygous loss-of-function variants in PAX4 are a novel genetic cause of transient neonatal #diabetes www.sciencedirect.com/science/arti...
July 3, 2025 at 12:22 AM
Homozygous loss-of-function variants in PAX4 are a novel genetic cause of transient neonatal #diabetes www.sciencedirect.com/science/arti...
Reposted by Nicole Krentz 🇨🇦
I will be opening my new lab in September at UBC! if you’re coming to #Worm25 and are looking for graduate studies or a postdoc position, let’s meet! Vancouver + worms = perfect vibes. www.zoology.ubc.ca/~yeecs/labsi... Please share! 🙌
June 25, 2025 at 1:48 PM
I will be opening my new lab in September at UBC! if you’re coming to #Worm25 and are looking for graduate studies or a postdoc position, let’s meet! Vancouver + worms = perfect vibes. www.zoology.ubc.ca/~yeecs/labsi... Please share! 🙌
Reposted by Nicole Krentz 🇨🇦
Pharmacological targeting of SOS1-RAS interaction triggers pancreatic β-cell proliferation and sustainably reverses diabetic hyperglycemia https://www.biorxiv.org/content/10.1101/2025.06.03.657628v1
June 4, 2025 at 5:30 AM
Pharmacological targeting of SOS1-RAS interaction triggers pancreatic β-cell proliferation and sustainably reverses diabetic hyperglycemia https://www.biorxiv.org/content/10.1101/2025.06.03.657628v1
Reposted by Nicole Krentz 🇨🇦
I'm very excited to share that I'll be starting as an Assistant Professor at the University of Alberta this fall 🎉 !!
I'm very grateful to mentors, colleagues, friends, and family who have supported me along the way ❤️.
www.ualberta.ca/en/physiolog...
I'm very grateful to mentors, colleagues, friends, and family who have supported me along the way ❤️.
www.ualberta.ca/en/physiolog...
Jelena Kolic
www.ualberta.ca
June 2, 2025 at 5:28 PM
I'm very excited to share that I'll be starting as an Assistant Professor at the University of Alberta this fall 🎉 !!
I'm very grateful to mentors, colleagues, friends, and family who have supported me along the way ❤️.
www.ualberta.ca/en/physiolog...
I'm very grateful to mentors, colleagues, friends, and family who have supported me along the way ❤️.
www.ualberta.ca/en/physiolog...
Reposted by Nicole Krentz 🇨🇦
Wang et al. show that, unlike other stem cell-derived endocrine cells, there is a progressive loss of cell identity and metabolic function in stem cell-derived β cells when exposed to hypoxia. 🧪
#PancSky
www.nature.com/articles/s41...
#PancSky
www.nature.com/articles/s41...
Improving cellular fitness of human stem cell-derived islets under hypoxia - Nature Communications
Hypoxia impairs the efficacy of stem cell-derived islet cell therapy, making it a potential barrier for treatment of type 1 diabetes. Wang et al. identify EDN3 as a key factor that preserves β cell id...
www.nature.com
May 23, 2025 at 5:29 AM
Wang et al. show that, unlike other stem cell-derived endocrine cells, there is a progressive loss of cell identity and metabolic function in stem cell-derived β cells when exposed to hypoxia. 🧪
#PancSky
www.nature.com/articles/s41...
#PancSky
www.nature.com/articles/s41...
Congratulations, @annagloyn.bsky.social! A very well-deserved recognition of a brilliant scientist and mentor 🎉
Honoured to have been elected to the fellowship and excited to contribute to the academy’s mission. This recognition reflects the amazing scientific community I am part of and the incredible trainees and collaborators I’m privileged to work with. Thankful 🙏
Congratulations to the 54 exceptional scientists who have been elected to the Academy Fellowship today in recognition of their remarkable contributions to biomedical and health sciences 🎉
👉 Discover more: ow.ly/Cf7K50VWSRi
#HealthResearch #HealthInnovation #AcademyFellows
👉 Discover more: ow.ly/Cf7K50VWSRi
#HealthResearch #HealthInnovation #AcademyFellows
May 23, 2025 at 3:18 AM
Congratulations, @annagloyn.bsky.social! A very well-deserved recognition of a brilliant scientist and mentor 🎉
Reposted by Nicole Krentz 🇨🇦
Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal!
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
May 15, 2025 at 7:27 PM
Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal!
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
Reposted by Nicole Krentz 🇨🇦
New study from @mayoclinic.org uses #stemcells to model diabetic alpha cell dysfunction. SC-α cells mimic glucagon hypersecretion and sunitinib (tyrosine kinase inhibitor) protects against ER stress-induced dysfunction
ow.ly/CWmV50VPsVt
@isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social
ow.ly/CWmV50VPsVt
@isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social
May 8, 2025 at 7:48 PM
New study from @mayoclinic.org uses #stemcells to model diabetic alpha cell dysfunction. SC-α cells mimic glucagon hypersecretion and sunitinib (tyrosine kinase inhibitor) protects against ER stress-induced dysfunction
ow.ly/CWmV50VPsVt
@isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social
ow.ly/CWmV50VPsVt
@isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social
Reposted by Nicole Krentz 🇨🇦
Excited to announce our newest #Immunology recruitment 🎉🥳
This is for a Canada Research Chair (Tier 1)🇨🇦, a position that isnt offered often when 7yr term incl full salary (+renewable)!
Please share widely when broad immunology focus. Happy to answer any dept Q & note date 👇
@umanitoba.bsky.social
This is for a Canada Research Chair (Tier 1)🇨🇦, a position that isnt offered often when 7yr term incl full salary (+renewable)!
Please share widely when broad immunology focus. Happy to answer any dept Q & note date 👇
@umanitoba.bsky.social
May 1, 2025 at 8:50 PM
Excited to announce our newest #Immunology recruitment 🎉🥳
This is for a Canada Research Chair (Tier 1)🇨🇦, a position that isnt offered often when 7yr term incl full salary (+renewable)!
Please share widely when broad immunology focus. Happy to answer any dept Q & note date 👇
@umanitoba.bsky.social
This is for a Canada Research Chair (Tier 1)🇨🇦, a position that isnt offered often when 7yr term incl full salary (+renewable)!
Please share widely when broad immunology focus. Happy to answer any dept Q & note date 👇
@umanitoba.bsky.social
Reposted by Nicole Krentz 🇨🇦
Thrilled to share our latest work, which was the outstanding doctoral work of @samanthajsyoon.bsky.social academic.oup.com/endo/advance... 1/12
NPAS4 depletion in POMC neurons protects from obesity and alters the feeding-regulated transcriptome in male mice
Abstract. Immediate Early Genes (IEGs), such as Neuronal PAS domain protein 4 (Npas4), are induced as part of the response to environmental stimuli. In the
academic.oup.com
April 29, 2025 at 7:25 PM
Thrilled to share our latest work, which was the outstanding doctoral work of @samanthajsyoon.bsky.social academic.oup.com/endo/advance... 1/12
Reposted by Nicole Krentz 🇨🇦
A group of scholars and I had a chance to share our experiences with the MOSAIC program being terminated 🧪
www.npr.org/sections/sho...
www.npr.org/sections/sho...
As a diversity grant dies, young scientists fear it will haunt their careers
The Trump administration defunded the National Institute of Health's MOSAIC grant program, which launched the careers of scientists from diverse backgrounds.
www.npr.org
April 28, 2025 at 12:16 PM
A group of scholars and I had a chance to share our experiences with the MOSAIC program being terminated 🧪
www.npr.org/sections/sho...
www.npr.org/sections/sho...
Reposted by Nicole Krentz 🇨🇦
GLP-1-based therapies for diabetes, obesity and beyond tinyurl.com/ph3fn4eh
rdcu.be/ejIM2
This new review by @danieljdrucker.bsky.social profiles GLP-1-based medicines, discussing optimization of pharmacokinetics and tolerability, engagement of new therapeutically useful pathways and safety aspects
rdcu.be/ejIM2
This new review by @danieljdrucker.bsky.social profiles GLP-1-based medicines, discussing optimization of pharmacokinetics and tolerability, engagement of new therapeutically useful pathways and safety aspects
April 28, 2025 at 2:58 PM
GLP-1-based therapies for diabetes, obesity and beyond tinyurl.com/ph3fn4eh
rdcu.be/ejIM2
This new review by @danieljdrucker.bsky.social profiles GLP-1-based medicines, discussing optimization of pharmacokinetics and tolerability, engagement of new therapeutically useful pathways and safety aspects
rdcu.be/ejIM2
This new review by @danieljdrucker.bsky.social profiles GLP-1-based medicines, discussing optimization of pharmacokinetics and tolerability, engagement of new therapeutically useful pathways and safety aspects
Reposted by Nicole Krentz 🇨🇦
“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is”
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y
April 19, 2025 at 12:12 PM
“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is”
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y