Santiago Rodríguez Seguí
@rseguilab.bsky.social
Bioengineer. Group leader at the IFYBINE, CONICET-Universidad de Buenos Aires. @ifibyne #betacell #pancreas #development #regeneration
Opinions are my own.
Opinions are my own.
Pinned
Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal!
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
Reposted by Santiago Rodríguez Seguí
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas
Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.
doi.org
November 13, 2025 at 3:56 PM
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
Reposted by Santiago Rodríguez Seguí
“You are here to learn to ride a bicycle, not to invent a bicycle.” 🚲🧪
Read my story in Science Magazine on how I dealt with my "Mid-PhD Crisis".
www.science.org/content/arti...
@science.org
@sciencecareers.bsky.social
#ScienceWorkingLife
#AcademicChatter
#AcademicTwitter
#ScienceTwitter
Read my story in Science Magazine on how I dealt with my "Mid-PhD Crisis".
www.science.org/content/arti...
@science.org
@sciencecareers.bsky.social
#ScienceWorkingLife
#AcademicChatter
#AcademicTwitter
#ScienceTwitter
"For half an hour, I vented everything I had been holding in for months … my supervisor … then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." https://scim.ag/4lt1Ru0
August 19, 2025 at 1:45 PM
“You are here to learn to ride a bicycle, not to invent a bicycle.” 🚲🧪
Read my story in Science Magazine on how I dealt with my "Mid-PhD Crisis".
www.science.org/content/arti...
@science.org
@sciencecareers.bsky.social
#ScienceWorkingLife
#AcademicChatter
#AcademicTwitter
#ScienceTwitter
Read my story in Science Magazine on how I dealt with my "Mid-PhD Crisis".
www.science.org/content/arti...
@science.org
@sciencecareers.bsky.social
#ScienceWorkingLife
#AcademicChatter
#AcademicTwitter
#ScienceTwitter
Neurons and β-cells share many similarities, including the expression of very specific transcription factors. This prompted a long-standing search for connections between diabetes and mental disorders. This amazing discovery finally reveals a mechanistic link!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors - Nature Neuroscience
The mechanisms linking neuropsychiatric and metabolic disorders remain unclear. The authors show a pancreas–hippocampus feedback loop whereby metabolic and circadian factors drive behavioral fluctuati...
www.nature.com
August 13, 2025 at 3:30 PM
Neurons and β-cells share many similarities, including the expression of very specific transcription factors. This prompted a long-standing search for connections between diabetes and mental disorders. This amazing discovery finally reveals a mechanistic link!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Santiago Rodríguez Seguí
Can amylin-based drugs upstage GLP-1 agonists? They could avoid muscle loss and gastrointestinal side effects of current obesity therapies. My latest for @natbiotech.nature.com rdcu.be/ezwbM
Can amylin-based drugs upstage GLP-1 agonists?
Nature Biotechnology - Analogs of the pancreatic peptide hormone amylin are making strides in obesity as developers zoom in on oral drugs that can emulate or even improve on injectable GLP-1...
rdcu.be
August 6, 2025 at 1:09 PM
Can amylin-based drugs upstage GLP-1 agonists? They could avoid muscle loss and gastrointestinal side effects of current obesity therapies. My latest for @natbiotech.nature.com rdcu.be/ezwbM
Hoy sábado a medianoche sale nuestra entrevista en el programa "Desde el Conocimiento" por #C5N ¡Gracias a la producción del canal por la invitación para difundir nuestro trabajo en el #IFIBYNE! Transmisión online: www.c5n.com/vivo
August 2, 2025 at 4:33 PM
Hoy sábado a medianoche sale nuestra entrevista en el programa "Desde el Conocimiento" por #C5N ¡Gracias a la producción del canal por la invitación para difundir nuestro trabajo en el #IFIBYNE! Transmisión online: www.c5n.com/vivo
Reposted by Santiago Rodríguez Seguí
Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @natcomms.nature.com www.nature.com/articles/s41...
A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics - Nature Communications
Here the authors show that human pancreatic islets adapt during pregnancy with increased α-cell area and GLP-1 abundance, while key differences from islet adaptations in mouse pregnancy include unchan...
www.nature.com
July 21, 2025 at 10:37 AM
Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @natcomms.nature.com www.nature.com/articles/s41...
Reposted by Santiago Rodríguez Seguí
💥 A single infusion into the portal vein of embryonic stem cell-derived pancreatic islet result in 12/12 patients free of severe hypoglycemic and 83% with insulin independence at one year.
However, one death due to the immunosuppressive treatment.
buff.ly/ZI14m2i
However, one death due to the immunosuppressive treatment.
buff.ly/ZI14m2i
July 10, 2025 at 1:30 PM
💥 A single infusion into the portal vein of embryonic stem cell-derived pancreatic islet result in 12/12 patients free of severe hypoglycemic and 83% with insulin independence at one year.
However, one death due to the immunosuppressive treatment.
buff.ly/ZI14m2i
However, one death due to the immunosuppressive treatment.
buff.ly/ZI14m2i
¡Gracias a la Agencia de Difusión de la Universidad Nacional de San Martin por ayudarnos con la difusión de nuestro trabajo en el #IFIBYNE, y de la difícil situación por la que está atravesando el sistema científico-tecnológico de Argentina!
www.agenciatss.com.ar/una-hormona-...
www.agenciatss.com.ar/una-hormona-...
Una hormona del estrés contra la diabetes – Agencia TSS Noticias de ciencia y tecnología
www.agenciatss.com.ar
June 24, 2025 at 8:33 PM
¡Gracias a la Agencia de Difusión de la Universidad Nacional de San Martin por ayudarnos con la difusión de nuestro trabajo en el #IFIBYNE, y de la difícil situación por la que está atravesando el sistema científico-tecnológico de Argentina!
www.agenciatss.com.ar/una-hormona-...
www.agenciatss.com.ar/una-hormona-...
Missed our @eisg2025.bsky.social post? If you study beta cell function using rat islets or INS-1 cells, check out Ri-lnc1! Strongly linked to mature beta cells but missing from current rat genome annotations. Overlooked? Happy to collaborate—just contact us!
Great opening yesterday @eisg2025.bsky.social meeting! Glad to see many interesting talks using INS-1 rat cells to study β-cell function—I couldn’t help but wonder how these treatments might affect Ri-lnc1 expression, our recently reported novel rat long non-coding RNA enriched in mature β-cells 👇
June 23, 2025 at 5:02 PM
Missed our @eisg2025.bsky.social post? If you study beta cell function using rat islets or INS-1 cells, check out Ri-lnc1! Strongly linked to mature beta cells but missing from current rat genome annotations. Overlooked? Happy to collaborate—just contact us!
Reposted by Santiago Rodríguez Seguí
Stem cell islets for those living with T1D! www.nejm.org/doi/full/10....
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety
and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted
a phase 1–2 study of zimisle...
www.nejm.org
June 20, 2025 at 11:45 PM
Stem cell islets for those living with T1D! www.nejm.org/doi/full/10....
Already on my way back to Argentina! Every trip must come to an end, but this one has truly been an amazing experience that will leave a lasting mark. Looking forward to consolidating the exciting new collaborations that will drive future work!
June 13, 2025 at 7:28 PM
Already on my way back to Argentina! Every trip must come to an end, but this one has truly been an amazing experience that will leave a lasting mark. Looking forward to consolidating the exciting new collaborations that will drive future work!
Amazing talks by @diegobalboa.bsky.social, @labspagnoli.bsky.social, Simona Chera and many other colleagues yesterday at @eisg2025.bsky.social ! I'm also really glad for the opportunity to share our recently published work. Looking forward to more exciting talks today!
June 13, 2025 at 6:30 AM
Amazing talks by @diegobalboa.bsky.social, @labspagnoli.bsky.social, Simona Chera and many other colleagues yesterday at @eisg2025.bsky.social ! I'm also really glad for the opportunity to share our recently published work. Looking forward to more exciting talks today!
Great opening yesterday @eisg2025.bsky.social meeting! Glad to see many interesting talks using INS-1 rat cells to study β-cell function—I couldn’t help but wonder how these treatments might affect Ri-lnc1 expression, our recently reported novel rat long non-coding RNA enriched in mature β-cells 👇
June 12, 2025 at 8:23 AM
Great opening yesterday @eisg2025.bsky.social meeting! Glad to see many interesting talks using INS-1 rat cells to study β-cell function—I couldn’t help but wonder how these treatments might affect Ri-lnc1 expression, our recently reported novel rat long non-coding RNA enriched in mature β-cells 👇
Did you know that the glucocorticoid receptor fine-tunes physiological pancreas development from the earliest progenitor stages? Below, an image worth a thousand words. Want to know more? Visit us at Poster #135 @eisg2025.bsky.social today, Wednesday, at 16:55!
June 11, 2025 at 9:03 AM
Did you know that the glucocorticoid receptor fine-tunes physiological pancreas development from the earliest progenitor stages? Below, an image worth a thousand words. Want to know more? Visit us at Poster #135 @eisg2025.bsky.social today, Wednesday, at 16:55!
Thank you, Philip Allan Seymour, for the great meeting today in Copenhagen and for contributing key experiments to our follow-up work on the role of glucocorticoids in pancreas development. Looking forward to getting this continuation story out soon!
June 10, 2025 at 10:05 PM
Thank you, Philip Allan Seymour, for the great meeting today in Copenhagen and for contributing key experiments to our follow-up work on the role of glucocorticoids in pancreas development. Looking forward to getting this continuation story out soon!
Finally! All the pieces are in place for the last stage of an amazing trip. Excited to share our results @eisg2025.bsky.social, showing that endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in pancreatic progenitors of mice and humans!
June 9, 2025 at 7:45 AM
Finally! All the pieces are in place for the last stage of an amazing trip. Excited to share our results @eisg2025.bsky.social, showing that endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in pancreatic progenitors of mice and humans!
It was an honor to present our most recent results on the characterization of Procr-like cells in #pancreas #development at the Shanghai Institute of Biochemistry and Cell Biology. Thank you, Dr. Yi Zeng and team, for the warm reception and the engaging perspectives!
June 7, 2025 at 2:59 AM
It was an honor to present our most recent results on the characterization of Procr-like cells in #pancreas #development at the Shanghai Institute of Biochemistry and Cell Biology. Thank you, Dr. Yi Zeng and team, for the warm reception and the engaging perspectives!
Everything is ready for the second stage of my trip. Shanghai awaits—looking forward to interesting discussions on the characterization and role of Procr-like cells in #pancreas #development! @ifibyne @ubaglobal #DiabetesResearch
June 3, 2025 at 11:42 PM
Everything is ready for the second stage of my trip. Shanghai awaits—looking forward to interesting discussions on the characterization and role of Procr-like cells in #pancreas #development! @ifibyne @ubaglobal #DiabetesResearch
It was a pleasure discussing our latest results with Prof. Cheng-Ran Xu today at Peking University and learning more about his breakthrough advances in endocrine cell specification in mice and humans. Looking forward to a productive follow-up! #StemCells #DiabetesResearch
May 30, 2025 at 8:37 AM
It was a pleasure discussing our latest results with Prof. Cheng-Ran Xu today at Peking University and learning more about his breakthrough advances in endocrine cell specification in mice and humans. Looking forward to a productive follow-up! #StemCells #DiabetesResearch
You can say it louder, but not clearer.
"Scienticide" = the systematic eradication of any possible trace of scientific work in Argentina.
www.nature.com/articles/d41...
"Scienticide" = the systematic eradication of any possible trace of scientific work in Argentina.
www.nature.com/articles/d41...
‘Scienticide’ in Argentina sparks huge protest by researchers
Hundreds of activists wearing gas masks took to the streets to call out their government for slashing science funding.
www.nature.com
May 30, 2025 at 12:41 AM
You can say it louder, but not clearer.
"Scienticide" = the systematic eradication of any possible trace of scientific work in Argentina.
www.nature.com/articles/d41...
"Scienticide" = the systematic eradication of any possible trace of scientific work in Argentina.
www.nature.com/articles/d41...
¡Gracias @CONICETDialoga y Bruno Geller por esta excelente nota difundiendo los principales resultados de nuestro trabajo
@ifibyne publicado recientemente en Development!
www.conicet.gov.ar/diabetes-tip...
--
Thank you @CONICETDialoga for this excellent note!
@ifibyne publicado recientemente en Development!
www.conicet.gov.ar/diabetes-tip...
--
Thank you @CONICETDialoga for this excellent note!
INICIO
Organismo dedicado a la promoción de la ciencia y la tecnología en la Argentina.
conicet.gov.ar
May 27, 2025 at 3:35 PM
¡Gracias @CONICETDialoga y Bruno Geller por esta excelente nota difundiendo los principales resultados de nuestro trabajo
@ifibyne publicado recientemente en Development!
www.conicet.gov.ar/diabetes-tip...
--
Thank you @CONICETDialoga for this excellent note!
@ifibyne publicado recientemente en Development!
www.conicet.gov.ar/diabetes-tip...
--
Thank you @CONICETDialoga for this excellent note!
Thank you, Jorge! Your support, along with Miguel Angel's expertise with the immunos, was instrumental during the initial steps of this project. Looking forward to exploring potential follow-ups together!
Congratulations for this study in @Dev_journal, no small feat in Argentina's anti-Science climate
Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal!
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
May 27, 2025 at 3:26 PM
Thank you, Jorge! Your support, along with Miguel Angel's expertise with the immunos, was instrumental during the initial steps of this project. Looking forward to exploring potential follow-ups together!
It was great to present the work of our lab at #IFIBYNE, for the Endocrinology Department at #PekingUniversity . Thank you, Wei Rui and team, for the warm welcome and very interesting feedback! Thank you #UBAInternacional for supporting this #InternationalResearch between #Argentina & #China.
May 26, 2025 at 2:44 PM
It was great to present the work of our lab at #IFIBYNE, for the Endocrinology Department at #PekingUniversity . Thank you, Wei Rui and team, for the warm welcome and very interesting feedback! Thank you #UBAInternacional for supporting this #InternationalResearch between #Argentina & #China.
Ten years ago we reported TEAD/YAP as pancreas development gatekeepers in mouse and human. Now we propose adding Glucocorticoid Receptor (GR) to this selective club - with one key difference! It plays the opposite role: GR activation (→ nuclear localization) promotes progenitor differentiation.
May 26, 2025 at 6:11 AM
Ten years ago we reported TEAD/YAP as pancreas development gatekeepers in mouse and human. Now we propose adding Glucocorticoid Receptor (GR) to this selective club - with one key difference! It plays the opposite role: GR activation (→ nuclear localization) promotes progenitor differentiation.